| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Topotecan (hydrochloride) perturbation in NCI-H596 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Topotecan (hydrochloride)_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.173863 |
| PGK1 | phosphoglycerate kinase 1 | 0.160958 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.145786 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.124462 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.124325 |
| COL5A2 | collagen, type V, alpha 2 | 0.117873 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.113689 |
| NDRG1 | N-myc downstream regulated 1 | 0.107441 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.10201 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0981437 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0960535 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.0947761 |
| PHF3 | PHD finger protein 3 | 0.0944859 |
| CENPF | centromere protein F, 350/400kDa | 0.0890196 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0882551 |
| HELZ | helicase with zinc finger | 0.0881502 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0857196 |
| SLC38A1 | solute carrier family 38, member 1 | 0.0847616 |
| NEK7 | NIMA-related kinase 7 | 0.0842077 |
| MKI67 | marker of proliferation Ki-67 | 0.0829112 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0783226 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0770735 |
| B2M | beta-2-microglobulin | 0.0745549 |
| ADAR | adenosine deaminase, RNA-specific | 0.0732785 |
| TXNRD1 | thioredoxin reductase 1 | 0.0702166 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0694986 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0665564 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.0627325 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0627191 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | 0.0616594 |
| STC1 | stanniocalcin 1 | 0.060772 |
| RPLP1 | ribosomal protein, large, P1 | 0.0606902 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0603663 |
| HLA-B | major histocompatibility complex, class I, B | 0.0601362 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0589865 |
| MT2A | metallothionein 2A | 0.0589798 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0589701 |
| TCF12 | transcription factor 12 | 0.0567563 |
| ACTG1 | actin gamma 1 | 0.0560072 |
| JMJD1C | jumonji domain containing 1C | 0.0550576 |
| LMO7 | LIM domain 7 | 0.052727 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0500889 |
| POTEF | POTE ankyrin domain family, member F | 0.0483709 |
| ENAH | enabled homolog (Drosophila) | 0.0481896 |
| SENP5 | SUMO1/sentrin specific peptidase 5 | 0.0477746 |
| FBXO11 | F-box protein 11 | 0.045883 |
| ZNF292 | zinc finger protein 292 | 0.044638 |
| NSMCE2 | non-SMC element 2, MMS21 homolog (S. cerevisiae) | 0.0442174 |
| RPL23 | ribosomal protein L23 | 0.0438998 |
| FLNB | filamin B, beta | 0.043685 |
| OGA | O-GlcNAcase | 0.0424592 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0420513 |
| PTMA | prothymosin, alpha | 0.0419463 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0417103 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0412993 |
| CUX1 | cut-like homeobox 1 | 0.0411679 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0411024 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0409373 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0401668 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0395503 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0393084 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0389792 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0384367 |
| RPS6 | ribosomal protein S6 | 0.0382705 |
| CANX | calnexin | 0.0372046 |
| ZMYM2 | zinc finger, MYM-type 2 | 0.0360946 |
| TPD52 | tumor protein D52 | 0.0355686 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0340303 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0335587 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0333952 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0311168 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.0307776 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0292221 |
| EFNA5 | ephrin-A5 | 0.0290866 |
| RPS3 | ribosomal protein S3 | 0.0288731 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0286838 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0283515 |
| DST | dystonin | 0.0266019 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0261335 |
| ADAM10 | ADAM metallopeptidase domain 10 | 0.0257809 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0248083 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0238282 |
| LDHA | lactate dehydrogenase A | 0.0237948 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0233106 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0232507 |
| RPL26 | ribosomal protein L26 | 0.021059 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0203941 |
| CALR | calreticulin | 0.0197629 |
| UBC | ubiquitin C | 0.0194858 |
| RPL9 | ribosomal protein L9 | 0.0189707 |
| SGIP1 | SH3-domain GRB2-like (endophilin) interacting protein 1 | 0.0180426 |
| RBM39 | RNA binding motif protein 39 | 0.0175567 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0175047 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0174338 |
| YBX1 | Y box binding protein 1 | 0.0168785 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0156311 |
| RUNX1 | runt-related transcription factor 1 | 0.0155612 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | 0.0151707 |
| RPL7 | ribosomal protein L7 | 0.0150624 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.0142217 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.271435 |
| TBC1D22A | TBC1 domain family, member 22A | -0.139389 |
| PDE10A | phosphodiesterase 10A | -0.138779 |
| VIM | vimentin | -0.136135 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.134732 |
| CDH13 | cadherin 13 | -0.130162 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.120436 |
| IGF2 | insulin-like growth factor 2 | -0.11838 |
| MYO1E | myosin IE | -0.112961 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.100805 |
| EGR1 | early growth response 1 | -0.0934322 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0907847 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0884055 |
| VCL | vinculin | -0.0839082 |
| ASPH | aspartate beta-hydroxylase | -0.0774904 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.075211 |
| BPTF | bromodomain PHD finger transcription factor | -0.0738837 |
| MAP1B | microtubule-associated protein 1B | -0.073425 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0720718 |
| FN1 | fibronectin 1 | -0.0716128 |
| TMSB10 | thymosin beta 10 | -0.070685 |
| HDLBP | high density lipoprotein binding protein | -0.0705052 |
| GRIK1 | glutamate receptor, ionotropic, kainate 1 | -0.0655493 |
| LAMA4 | laminin, alpha 4 | -0.0644792 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0633618 |
| SMYD3 | SET and MYND domain containing 3 | -0.0632099 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0614282 |
| NAV2 | neuron navigator 2 | -0.0610948 |
| MORF4L2 | mortality factor 4 like 2 | -0.0608711 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.060578 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0588017 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0573606 |
| CCNI | cyclin I | -0.057168 |
| RPL11 | ribosomal protein L11 | -0.055809 |
| RBM25 | RNA binding motif protein 25 | -0.0547001 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0531636 |
| SYT1 | synaptotagmin I | -0.0526453 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.0508507 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.050692 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.0474273 |
| INTS6 | integrator complex subunit 6 | -0.0473784 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0472136 |
| NF1 | neurofibromin 1 | -0.0462922 |
| TOR1AIP2 | torsin A interacting protein 2 | -0.0452934 |
| TXNIP | thioredoxin interacting protein | -0.0441412 |
| RPS8 | ribosomal protein S8 | -0.0425267 |
| ENO1 | enolase 1, (alpha) | -0.0423634 |
| PRKCA | protein kinase C, alpha | -0.0422415 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.0419755 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0416789 |
| RPS19 | ribosomal protein S19 | -0.0380542 |
| FAM13A | family with sequence similarity 13, member A | -0.0378479 |
| VMP1 | vacuole membrane protein 1 | -0.0378108 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0363812 |
| CARD16 | caspase recruitment domain family, member 16 | -0.0359814 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0351742 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0334835 |
| FTL | ferritin, light polypeptide | -0.0334468 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0330476 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0319296 |
| MYOF | myoferlin | -0.0301595 |
| PARD3 | par-3 family cell polarity regulator | -0.0299771 |
| AHNAK | AHNAK nucleoprotein | -0.0298819 |
| GOLGA4 | golgin A4 | -0.0294726 |
| RPL15 | ribosomal protein L15 | -0.0290663 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0286608 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0285439 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0283637 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0271254 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | -0.0262874 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.026242 |
| SRP54 | signal recognition particle 54kDa | -0.0259762 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | -0.0257296 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | -0.0248556 |
| SLTM | SAFB-like, transcription modulator | -0.0247724 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0245382 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.0245172 |
| ATF4 | activating transcription factor 4 | -0.0236717 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0226616 |
| RORA | RAR-related orphan receptor A | -0.0222932 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0219588 |
| HMGA2 | high mobility group AT-hook 2 | -0.0218484 |
| CMIP | c-Maf inducing protein | -0.0216289 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0202095 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0198312 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0194552 |
| PRELID2 | PRELI domain containing 2 | -0.0190154 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0182764 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0178325 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0178003 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0176005 |
| RPS2 | ribosomal protein S2 | -0.0173584 |
| FNIP1 | folliculin interacting protein 1 | -0.016618 |
| STAG2 | stromal antigen 2 | -0.0135442 |
| S100A9 | S100 calcium binding protein A9 | -0.0113668 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | -0.01098 |
| RPS17 | ribosomal protein S17 | -0.0105345 |
| ATXN1 | ataxin 1 | -0.0103494 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.00961118 |
| PKM | pyruvate kinase, muscle | -0.00865476 |
