| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Topotecan (hydrochloride) perturbation in NCI-H661 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Topotecan (hydrochloride)_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB4X | thymosin beta 4, X-linked | 0.092979 |
| H1-4 | H1.4 linker histone, cluster member | 0.0834333 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0803399 |
| MYO10 | myosin X | 0.0800958 |
| PTMA | prothymosin, alpha | 0.0777637 |
| ADGRV1 | adhesion G protein-coupled receptor V1 | 0.0723645 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0720851 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0673585 |
| COL11A1 | collagen, type XI, alpha 1 | 0.0499292 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0485758 |
| THBS1 | thrombospondin 1 | 0.0484251 |
| CTNNA3 | catenin (cadherin-associated protein), alpha 3 | 0.0481121 |
| MKI67 | marker of proliferation Ki-67 | 0.0468276 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0458208 |
| SEMA3E | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E | 0.0425095 |
| FOXP2 | forkhead box P2 | 0.0411392 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0406903 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0406626 |
| SUPT16H | suppressor of Ty 16 homolog (S. cerevisiae) | 0.0400311 |
| USP3 | ubiquitin specific peptidase 3 | 0.0385108 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0382651 |
| HNRNPA3 | heterogeneous nuclear ribonucleoprotein A3 | 0.0381672 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0378154 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0371769 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0367256 |
| POLR2B | polymerase (RNA) II (DNA directed) polypeptide B, 140kDa | 0.0363668 |
| CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) | 0.035384 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0350206 |
| SRSF11 | serine/arginine-rich splicing factor 11 | 0.0339002 |
| PHF3 | PHD finger protein 3 | 0.0337456 |
| NPAS3 | neuronal PAS domain protein 3 | 0.0333533 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0324097 |
| RPS7 | ribosomal protein S7 | 0.0322455 |
| H1-2 | H1.2 linker histone, cluster member | 0.0317997 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | 0.0316902 |
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | 0.0315864 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0313425 |
| HNRNPH3 | heterogeneous nuclear ribonucleoprotein H3 (2H9) | 0.0312557 |
| SNRNP200 | small nuclear ribonucleoprotein 200kDa (U5) | 0.0311653 |
| PRELID2 | PRELI domain containing 2 | 0.0307159 |
| RABGGTB | Rab geranylgeranyltransferase, beta subunit | 0.030694 |
| DDX39B | DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B | 0.0306079 |
| CFL2 | cofilin 2 (muscle) | 0.0299818 |
| SET | SET nuclear proto-oncogene | 0.0299557 |
| CAMKMT | calmodulin-lysine N-methyltransferase | 0.0293128 |
| TNFRSF19 | tumor necrosis factor receptor superfamily, member 19 | 0.028989 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0287393 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.028286 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0280355 |
| H1-5 | H1.5 linker histone, cluster member | 0.0279006 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.027763 |
| LHFPL6 | LHFPL tetraspan subfamily member 6 | 0.0276489 |
| FOXG1 | forkhead box G1 | 0.0274459 |
| ZBTB35 | zinc finger and BTB domain containing 35 | 0.0273296 |
| NUDT3 | nudix (nucleoside diphosphate linked moiety X)-type motif 3 | 0.0270028 |
| THRAP3 | thyroid hormone receptor associated protein 3 | 0.0267689 |
| SSR1 | signal sequence receptor, alpha | 0.0267136 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0266521 |
| NR6A1 | nuclear receptor subfamily 6, group A, member 1 | 0.0266037 |
| TCEA1 | transcription elongation factor A (SII), 1 | 0.0265373 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0262825 |
| PGPEP1L | pyroglutamyl-peptidase I-like | 0.0262324 |
| TENM2 | teneurin transmembrane protein 2 | 0.0258137 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0257791 |
| OGA | O-GlcNAcase | 0.0257463 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0255737 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0255479 |
| CALU | calumenin | 0.0255321 |
| TP53BP1 | tumor protein p53 binding protein 1 | 0.0255221 |
| FUS | FUS RNA binding protein | 0.0254808 |
| RBM6 | RNA binding motif protein 6 | 0.0253291 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0252458 |
| ZNF608 | zinc finger protein 608 | 0.0252045 |
| PRKAG2 | protein kinase, AMP-activated, gamma 2 non-catalytic subunit | 0.0251905 |
| PPP4R1 | protein phosphatase 4, regulatory subunit 1 | 0.0251057 |
| FYTTD1 | forty-two-three domain containing 1 | 0.024876 |
| SOX5 | SRY (sex determining region Y)-box 5 | 0.0247509 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0244216 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0244162 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0241776 |
| ARHGAP21 | Rho GTPase activating protein 21 | 0.023723 |
| TPM3 | tropomyosin 3 | 0.0236715 |
| HEY1 | hes-related family bHLH transcription factor with YRPW motif 1 | 0.0236175 |
| MYH10 | myosin, heavy chain 10, non-muscle | 0.0233036 |
| STMN1 | stathmin 1 | 0.0232919 |
| YAP1 | Yes-associated protein 1 | 0.0230968 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0230004 |
| SNX6 | sorting nexin 6 | 0.0229555 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | 0.0229169 |
| TAF1 | TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa | 0.0229102 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0228489 |
| CALR | calreticulin | 0.0228313 |
| VGLL3 | vestigial-like family member 3 | 0.0228311 |
| TIAL1 | TIA1 cytotoxic granule-associated RNA binding protein-like 1 | 0.0226276 |
| MDN1 | MDN1, midasin homolog (yeast) | 0.0225514 |
| PGAP1 | post-GPI attachment to proteins 1 | 0.0224989 |
| XRCC6 | X-ray repair complementing defective repair in Chinese hamster cells 6 | 0.0224925 |
| RAI1 | retinoic acid induced 1 | 0.022485 |
| MGA | MGA, MAX dimerization protein | 0.0223938 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0223585 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.132035 |
| TMSB10 | thymosin beta 10 | -0.127835 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.125747 |
| PFN1 | profilin 1 | -0.0984488 |
| POTEF | POTE ankyrin domain family, member F | -0.0963602 |
| NRG1 | neuregulin 1 | -0.0779943 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0751637 |
| RPL35A | ribosomal protein L35a | -0.0725128 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0707226 |
| ACTG1 | actin gamma 1 | -0.068465 |
| MAP4 | microtubule-associated protein 4 | -0.0681242 |
| RPS6 | ribosomal protein S6 | -0.0674874 |
| GNAS | GNAS complex locus | -0.0659327 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0651823 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | -0.0637533 |
| RPLP0 | ribosomal protein, large, P0 | -0.0634709 |
| TXNRD1 | thioredoxin reductase 1 | -0.0614639 |
| RPLP1 | ribosomal protein, large, P1 | -0.0601956 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0600243 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0565367 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0545436 |
| ANKRD33B | ankyrin repeat domain 33B | -0.0543107 |
| RPS16 | ribosomal protein S16 | -0.052591 |
| UBC | ubiquitin C | -0.0525284 |
| PEG10 | paternally expressed 10 | -0.049639 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0482216 |
| CDK6 | cyclin-dependent kinase 6 | -0.0465187 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0460752 |
| CKAP2 | cytoskeleton associated protein 2 | -0.046012 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0447147 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | -0.0433666 |
| RPS24 | ribosomal protein S24 | -0.0432739 |
| ITGAV | integrin, alpha V | -0.0431056 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0430955 |
| RAB10 | RAB10, member RAS oncogene family | -0.043086 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0430103 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.042657 |
| RPS19 | ribosomal protein S19 | -0.0425107 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0422016 |
| RPL23 | ribosomal protein L23 | -0.0418973 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0418003 |
| HDAC9 | histone deacetylase 9 | -0.0417261 |
| HMGB1 | high mobility group box 1 | -0.041536 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0413264 |
| CDH19 | cadherin 19, type 2 | -0.040067 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0393559 |
| FBXO11 | F-box protein 11 | -0.0390261 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0387962 |
| PARD3 | par-3 family cell polarity regulator | -0.0386735 |
| HS3ST5 | heparan sulfate (glucosamine) 3-O-sulfotransferase 5 | -0.0386024 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0381494 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0381465 |
| RPL34 | ribosomal protein L34 | -0.0379423 |
| HMGA1 | high mobility group AT-hook 1 | -0.0374458 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0374109 |
| EPHA5 | EPH receptor A5 | -0.0367217 |
| SYT1 | synaptotagmin I | -0.0364933 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | -0.0363105 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0363076 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0355502 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | -0.0352777 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0347792 |
| RPL28 | ribosomal protein L28 | -0.0343352 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0338039 |
| RTN4 | reticulon 4 | -0.0336597 |
| YBX1 | Y box binding protein 1 | -0.0331445 |
| RPS8 | ribosomal protein S8 | -0.0328103 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0325993 |
| FTL | ferritin, light polypeptide | -0.0322922 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0321984 |
| CDH6 | cadherin 6, type 2, K-cadherin (fetal kidney) | -0.0321716 |
| RPS5 | ribosomal protein S5 | -0.0321029 |
| DCAF7 | DDB1 and CUL4 associated factor 7 | -0.0319581 |
| RBM25 | RNA binding motif protein 25 | -0.0315518 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0312072 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0311465 |
| RPL30 | ribosomal protein L30 | -0.0311223 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.031063 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | -0.0310095 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | -0.0309386 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | -0.0308362 |
| WNK1 | WNK lysine deficient protein kinase 1 | -0.0306219 |
| USP34 | ubiquitin specific peptidase 34 | -0.0304868 |
| OLA1 | Obg-like ATPase 1 | -0.030238 |
| ABI2 | abl-interactor 2 | -0.0300663 |
| RPS20 | ribosomal protein S20 | -0.0298623 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.029813 |
| PHLPP1 | PH domain and leucine rich repeat protein phosphatase 1 | -0.0294894 |
| PRKD1 | protein kinase D1 | -0.0293498 |
| SMARCA5 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 | -0.0292013 |
| BSG | basigin (Ok blood group) | -0.029141 |
| ENO1 | enolase 1, (alpha) | -0.02909 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | -0.0288619 |
| RTN3 | reticulon 3 | -0.0288534 |
| RASAL2 | RAS protein activator like 2 | -0.0288498 |
| PCLO | piccolo presynaptic cytomatrix protein | -0.0283122 |
| PHIP | pleckstrin homology domain interacting protein | -0.0281105 |
| MAP1B | microtubule-associated protein 1B | -0.0280749 |
| LYPLA1 | lysophospholipase I | -0.0278826 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | -0.0278379 |
