| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Topotecan (hydrochloride) perturbation in PANC-1 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Topotecan (hydrochloride)_PANC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.175151 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.144254 |
| ACTG1 | actin gamma 1 | 0.0979261 |
| ZFP36 | ZFP36 ring finger protein | 0.0882082 |
| PTMA | prothymosin, alpha | 0.0670269 |
| CD44 | CD44 molecule (Indian blood group) | 0.0659508 |
| TMEM41B | transmembrane protein 41B | 0.0615684 |
| MT2A | metallothionein 2A | 0.0600396 |
| PLEKHG2 | pleckstrin homology domain containing, family G (with RhoGef domain) member 2 | 0.0456644 |
| ANXA2 | annexin A2 | 0.044723 |
| BIRC2 | baculoviral IAP repeat containing 2 | 0.0428092 |
| SMAD3 | SMAD family member 3 | 0.0421398 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0418939 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0417931 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0411908 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | 0.0398554 |
| RTN4 | reticulon 4 | 0.0391579 |
| SFTPA2 | surfactant protein A2 | 0.0383308 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0380476 |
| TMSB4X | thymosin beta 4, X-linked | 0.0372705 |
| FOSL1 | FOS-like antigen 1 | 0.0369307 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0362917 |
| SLC16A3 | solute carrier family 16 (monocarboxylate transporter), member 3 | 0.035467 |
| KLF6 | Kruppel-like factor 6 | 0.0326435 |
| THOC2 | THO complex 2 | 0.0322673 |
| ITGB5 | integrin, beta 5 | 0.0320694 |
| FBL | fibrillarin | 0.0316049 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0313135 |
| YBX3 | Y box binding protein 3 | 0.0312893 |
| RPL11 | ribosomal protein L11 | 0.0311279 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.03036 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.030266 |
| CACNG8 | calcium channel, voltage-dependent, gamma subunit 8 | 0.0300486 |
| RPL7A | ribosomal protein L7a | 0.0296425 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0295556 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.0294812 |
| RPL35A | ribosomal protein L35a | 0.0294132 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0293737 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.029256 |
| FHL2 | four and a half LIM domains 2 | 0.0292243 |
| GCNT2 | glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) | 0.0291768 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0291292 |
| JMJD1C | jumonji domain containing 1C | 0.0290706 |
| KNOP1 | lysine-rich nucleolar protein 1 | 0.0287231 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0278527 |
| RAP1B | RAP1B, member of RAS oncogene family | 0.0276365 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.0273351 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.0269229 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | 0.0267775 |
| DDX39B | DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B | 0.0266111 |
| KRT18 | keratin 18, type I | 0.025654 |
| TRA2B | transformer 2 beta homolog (Drosophila) | 0.0255325 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0242774 |
| ANLN | anillin, actin binding protein | 0.0241586 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0240603 |
| RPS19 | ribosomal protein S19 | 0.0238669 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0236568 |
| BMAL2 | basic helix-loop-helix ARNT like 2 | 0.0233431 |
| EIF3E | eukaryotic translation initiation factor 3, subunit E | 0.0231683 |
| RPS21 | ribosomal protein S21 | 0.0229328 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0228335 |
| ONECUT3 | one cut homeobox 3 | 0.0227581 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.022726 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0226324 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0226218 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.022461 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.0222834 |
| HNRNPL | heterogeneous nuclear ribonucleoprotein L | 0.022237 |
| CCNL1 | cyclin L1 | 0.0220593 |
| MKI67 | marker of proliferation Ki-67 | 0.0219918 |
| EHBP1L1 | EH domain binding protein 1-like 1 | 0.0218539 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0218524 |
| ANGPTL4 | angiopoietin-like 4 | 0.0218271 |
| CTPS1 | CTP synthase 1 | 0.0217662 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.021674 |
| TPR | translocated promoter region, nuclear basket protein | 0.0213239 |
| ZNF780A | zinc finger protein 780A | 0.0209417 |
| HELLS | helicase, lymphoid-specific | 0.0209152 |
| RPL26 | ribosomal protein L26 | 0.0205953 |
| HEATR1 | HEAT repeat containing 1 | 0.0205742 |
| RPL12 | ribosomal protein L12 | 0.0204239 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0203176 |
| CCNL2 | cyclin L2 | 0.0201153 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | 0.0200178 |
| ATP13A3 | ATPase type 13A3 | 0.0197545 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0194307 |
| CD47 | CD47 molecule | 0.0191646 |
| CNBP | CCHC-type zinc finger, nucleic acid binding protein | 0.0191214 |
| RRM2 | ribonucleotide reductase M2 | 0.0189002 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | 0.018715 |
| BCL2L1 | BCL2-like 1 | 0.0183222 |
| CDK5RAP3 | CDK5 regulatory subunit associated protein 3 | 0.0183099 |
| FDPS | farnesyl diphosphate synthase | 0.0183047 |
| ANO9 | anoctamin 9 | 0.0182985 |
| FRMD5 | FERM domain containing 5 | 0.0182406 |
| CASC3 | cancer susceptibility candidate 3 | 0.0181669 |
| PDE10A | phosphodiesterase 10A | 0.0181278 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0179288 |
| EGR1 | early growth response 1 | 0.0178639 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0177268 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.286922 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.209975 |
| UBC | ubiquitin C | -0.17605 |
| AHNAK | AHNAK nucleoprotein | -0.154142 |
| FNDC3B | fibronectin type III domain containing 3B | -0.141348 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.13666 |
| VIM | vimentin | -0.124186 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.107416 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.10671 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.101755 |
| ENO1 | enolase 1, (alpha) | -0.0972169 |
| CANX | calnexin | -0.0929334 |
| RPS27A | ribosomal protein S27a | -0.0845692 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0760188 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0755961 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | -0.074401 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0709471 |
| PKM | pyruvate kinase, muscle | -0.063256 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0630636 |
| INTS6 | integrator complex subunit 6 | -0.06193 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0575327 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0539677 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0537924 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0515914 |
| TNS3 | tensin 3 | -0.0503012 |
| PCBP2 | poly(rC) binding protein 2 | -0.0482912 |
| NAV2 | neuron navigator 2 | -0.0476958 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0465325 |
| DST | dystonin | -0.0462773 |
| PTK2 | protein tyrosine kinase 2 | -0.0457087 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0450522 |
| LDHA | lactate dehydrogenase A | -0.0444638 |
| VCL | vinculin | -0.0441265 |
| USP34 | ubiquitin specific peptidase 34 | -0.0439597 |
| ZNF207 | zinc finger protein 207 | -0.0426918 |
| GOLGB1 | golgin B1 | -0.0420858 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0420418 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0419805 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.0418247 |
| DIAPH2 | diaphanous-related formin 2 | -0.0416762 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0411422 |
| PSMC4 | proteasome (prosome, macropain) 26S subunit, ATPase, 4 | -0.0411383 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0410262 |
| SBF2 | SET binding factor 2 | -0.0408395 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.040707 |
| NF1 | neurofibromin 1 | -0.0394744 |
| ATXN1 | ataxin 1 | -0.0392523 |
| MYOF | myoferlin | -0.0385634 |
| FTL | ferritin, light polypeptide | -0.036637 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0361836 |
| CTSD | cathepsin D | -0.0357408 |
| SETX | senataxin | -0.0354825 |
| RPLP1 | ribosomal protein, large, P1 | -0.0354134 |
| GOLGA4 | golgin A4 | -0.0349959 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | -0.0345706 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.033877 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0338746 |
| MYO1E | myosin IE | -0.0337076 |
| ATP2A2 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | -0.0336743 |
| ASPH | aspartate beta-hydroxylase | -0.0336651 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0336163 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0333881 |
| EEPD1 | endonuclease/exonuclease/phosphatase family domain containing 1 | -0.0329083 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | -0.0325427 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0322515 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0314553 |
| JUN | jun proto-oncogene | -0.0314496 |
| CTBP2 | C-terminal binding protein 2 | -0.0314102 |
| C6ORF62 | chromosome 6 open reading frame 62 | -0.030425 |
| TAOK1 | TAO kinase 1 | -0.0301574 |
| MAGT1 | magnesium transporter 1 | -0.029829 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0297943 |
| PRG2 | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) | -0.0297852 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0294786 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0288484 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0288257 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.028795 |
| PRKCA | protein kinase C, alpha | -0.0285734 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0284975 |
| ZNF638 | zinc finger protein 638 | -0.0282935 |
| EXOC4 | exocyst complex component 4 | -0.027938 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.02771 |
| RNF220 | ring finger protein 220 | -0.0274821 |
| CDK13 | cyclin-dependent kinase 13 | -0.0272358 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | -0.0272148 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0271351 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0270573 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0266807 |
| RAD51B | RAD51 paralog B | -0.0266321 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.0264399 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.026128 |
| HM13 | histocompatibility (minor) 13 | -0.0259269 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0258777 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0256641 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0253264 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0251323 |
| PACS1 | phosphofurin acidic cluster sorting protein 1 | -0.0250231 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0248403 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.024756 |
| UBAP2 | ubiquitin associated protein 2 | -0.024742 |
