| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Topotecan (hydrochloride) perturbation in Panc 03.27 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Topotecan (hydrochloride)_Panc 03.27 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| LAMB3 | laminin, beta 3 | 0.175114 |
| PTMA | prothymosin, alpha | 0.156131 |
| TMSB4X | thymosin beta 4, X-linked | 0.150175 |
| RPS6 | ribosomal protein S6 | 0.100765 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.099252 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0846419 |
| PLAU | plasminogen activator, urokinase | 0.078901 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0770071 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0740279 |
| VEGFA | vascular endothelial growth factor A | 0.0711823 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.066068 |
| CCNL1 | cyclin L1 | 0.0639289 |
| MKI67 | marker of proliferation Ki-67 | 0.0622204 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0609107 |
| OGA | O-GlcNAcase | 0.0583967 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0581641 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0576464 |
| HLA-B | major histocompatibility complex, class I, B | 0.0550997 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0547972 |
| MUC4 | mucin 4, cell surface associated | 0.0541253 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.053657 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0534538 |
| CALR | calreticulin | 0.0514956 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0509335 |
| SMAD3 | SMAD family member 3 | 0.0488311 |
| RPL35A | ribosomal protein L35a | 0.0486182 |
| RIOK3 | RIO kinase 3 | 0.0484988 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.0474353 |
| ANLN | anillin, actin binding protein | 0.0470072 |
| RPS19 | ribosomal protein S19 | 0.0468767 |
| B2M | beta-2-microglobulin | 0.0467347 |
| RPL7A | ribosomal protein L7a | 0.0457972 |
| YBX3 | Y box binding protein 3 | 0.0455847 |
| DSPP | dentin sialophosphoprotein | 0.045295 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0452626 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0440193 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0435344 |
| RPS8 | ribosomal protein S8 | 0.0428335 |
| KRT18 | keratin 18, type I | 0.0426535 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0423734 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0421043 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0411459 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0408837 |
| TPM4 | tropomyosin 4 | 0.0405283 |
| RBM25 | RNA binding motif protein 25 | 0.0405027 |
| PNN | pinin, desmosome associated protein | 0.0397299 |
| PDE8A | phosphodiesterase 8A | 0.0395634 |
| SDC4 | syndecan 4 | 0.039451 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0394013 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0393711 |
| RPS2 | ribosomal protein S2 | 0.0391661 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0389044 |
| KIF5B | kinesin family member 5B | 0.0386555 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0386204 |
| RPL37A | ribosomal protein L37a | 0.0385643 |
| FOSL1 | FOS-like antigen 1 | 0.0384267 |
| G0S2 | G0/G1 switch 2 | 0.0380605 |
| MAL2 | mal, T-cell differentiation protein 2 (gene/pseudogene) | 0.0376932 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0371132 |
| TNFAIP2 | tumor necrosis factor, alpha-induced protein 2 | 0.0369265 |
| GOLGA4 | golgin A4 | 0.036365 |
| LAMC2 | laminin, gamma 2 | 0.0357975 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0355511 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0353276 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0350584 |
| RBM39 | RNA binding motif protein 39 | 0.0349247 |
| RTN4 | reticulon 4 | 0.0348997 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0347762 |
| ZNF292 | zinc finger protein 292 | 0.0345545 |
| SETD5 | SET domain containing 5 | 0.0343766 |
| RPS3 | ribosomal protein S3 | 0.0340439 |
| RPL12 | ribosomal protein L12 | 0.0340182 |
| TPR | translocated promoter region, nuclear basket protein | 0.0338743 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0338582 |
| AFDN | afadin, adherens junction formation factor | 0.0336996 |
| CD47 | CD47 molecule | 0.0328992 |
| ADAR | adenosine deaminase, RNA-specific | 0.032884 |
| ADM | adrenomedullin | 0.032803 |
| CNBP | CCHC-type zinc finger, nucleic acid binding protein | 0.0326593 |
| OPTN | optineurin | 0.0326211 |
| BAZ2A | bromodomain adjacent to zinc finger domain, 2A | 0.0325706 |
| RNF149 | ring finger protein 149 | 0.0318134 |
| HLA-C | major histocompatibility complex, class I, C | 0.0316348 |
| MIS18BP1 | MIS18 binding protein 1 | 0.0316315 |
| TMF1 | TATA element modulatory factor 1 | 0.0315872 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | 0.0315369 |
| RPS17 | ribosomal protein S17 | 0.0315347 |
| RLF | rearranged L-myc fusion | 0.0313728 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0311834 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0311449 |
| MTAP | methylthioadenosine phosphorylase | 0.0311403 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | 0.0310194 |
| KPNB1 | karyopherin (importin) beta 1 | 0.0308557 |
| C3 | complement component 3 | 0.0307674 |
| XPO1 | exportin 1 | 0.0305981 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0303819 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | 0.0303189 |
| RPL19 | ribosomal protein L19 | 0.0301266 |
| CABIN1 | calcineurin binding protein 1 | 0.0298927 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0295665 |
| Symbol | Name | Standardized Value |
|---|---|---|
| UBC | ubiquitin C | -0.129411 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.108074 |
| INTS6 | integrator complex subunit 6 | -0.0998892 |
| AHNAK | AHNAK nucleoprotein | -0.0976021 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0965467 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0871351 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0805857 |
| LMO7 | LIM domain 7 | -0.0711226 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0709625 |
| TMSB10 | thymosin beta 10 | -0.0709508 |
| VMP1 | vacuole membrane protein 1 | -0.0613908 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | -0.0593552 |
| LAMA4 | laminin, alpha 4 | -0.0574547 |
| ASPH | aspartate beta-hydroxylase | -0.0568318 |
| PLSCR1 | phospholipid scramblase 1 | -0.0549288 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0549049 |
| CANX | calnexin | -0.0542212 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0537022 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0525029 |
| EFNA5 | ephrin-A5 | -0.0502869 |
| LDHA | lactate dehydrogenase A | -0.0491755 |
| RPS27A | ribosomal protein S27a | -0.0489327 |
| TJP1 | tight junction protein 1 | -0.0462798 |
| PCBP2 | poly(rC) binding protein 2 | -0.0456732 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0454303 |
| SVIL | supervillin | -0.0440014 |
| SMYD3 | SET and MYND domain containing 3 | -0.0439214 |
| MYO1E | myosin IE | -0.0432931 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0431268 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0412422 |
| BPTF | bromodomain PHD finger transcription factor | -0.0412073 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.041016 |
| RASAL2 | RAS protein activator like 2 | -0.0398107 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.039316 |
| ENO1 | enolase 1, (alpha) | -0.0391577 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | -0.0386933 |
| S100A6 | S100 calcium binding protein A6 | -0.0378353 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0377037 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0372386 |
| RAD51B | RAD51 paralog B | -0.0372134 |
| FHIT | fragile histidine triad | -0.0354486 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0353603 |
| IL1RAP | interleukin 1 receptor accessory protein | -0.0346637 |
| POTEF | POTE ankyrin domain family, member F | -0.0344986 |
| ETV6 | ets variant 6 | -0.034216 |
| NF1 | neurofibromin 1 | -0.0341514 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -0.0338553 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 | -0.0336962 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.033542 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.033034 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0329299 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0328504 |
| THBS1 | thrombospondin 1 | -0.032287 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0321569 |
| HMGA2 | high mobility group AT-hook 2 | -0.0320456 |
| PLK2 | polo-like kinase 2 | -0.0317611 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0311413 |
| JUN | jun proto-oncogene | -0.0310027 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0309806 |
| TRAPPC9 | trafficking protein particle complex 9 | -0.0307586 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -0.0302928 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0302237 |
| EXOC4 | exocyst complex component 4 | -0.0299874 |
| MYOF | myoferlin | -0.0299749 |
| USP34 | ubiquitin specific peptidase 34 | -0.0299095 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.0298798 |
| SGMS2 | sphingomyelin synthase 2 | -0.0294363 |
| HMGA1 | high mobility group AT-hook 1 | -0.0293637 |
| ZDHHC13 | zinc finger, DHHC-type containing 13 | -0.028747 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | -0.0285563 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0281013 |
| EGFR | epidermal growth factor receptor | -0.027997 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | -0.0277465 |
| ACTN4 | actinin, alpha 4 | -0.0274599 |
| ERBIN | erbb2 interacting protein | -0.0273848 |
| NABP1 | nucleic acid binding protein 1 | -0.0273829 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0273644 |
| VIM | vimentin | -0.026753 |
| VTI1A | vesicle transport through interaction with t-SNAREs 1A | -0.0266979 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | -0.0260694 |
| SORBS2 | sorbin and SH3 domain containing 2 | -0.0257868 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0255391 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0255284 |
| EGR1 | early growth response 1 | -0.0254864 |
| CD44 | CD44 molecule (Indian blood group) | -0.0253021 |
| OSMR | oncostatin M receptor | -0.025041 |
| FBXL17 | F-box and leucine-rich repeat protein 17 | -0.0250006 |
| FER | fer (fps/fes related) tyrosine kinase | -0.0248296 |
| EHBP1 | EH domain binding protein 1 | -0.0247445 |
| ZNF638 | zinc finger protein 638 | -0.0246561 |
| CDK13 | cyclin-dependent kinase 13 | -0.0240289 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0237098 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0237061 |
| ARB2A | ARB2 cotranscriptional regulator A | -0.0236471 |
| VCL | vinculin | -0.023258 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0232547 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0232307 |
| FN1 | fibronectin 1 | -0.0232225 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0232148 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0231829 |
