Topotecan (hydrochloride)_RKO Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Topotecan (hydrochloride) perturbation in RKO cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Topotecan (hydrochloride)_RKO drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RPL7A ribosomal protein L7a 0.125311
RPL37A ribosomal protein L37a 0.0782643
OGA O-GlcNAcase 0.0757576
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0696159
PRRC2C proline-rich coiled-coil 2C 0.0686202
SRRM2 serine/arginine repetitive matrix 2 0.0661268
MT2A metallothionein 2A 0.0652887
NAV2 neuron navigator 2 0.0623312
SETD5 SET domain containing 5 0.060033
CAMTA1 calmodulin binding transcription activator 1 0.0597357
RPS12 ribosomal protein S12 0.0580799
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0577997
PNISR PNN-interacting serine/arginine-rich protein 0.0571048
MCL1 myeloid cell leukemia 1 0.0569396
ATP13A3 ATPase type 13A3 0.0561424
RASA2 RAS p21 protein activator 2 0.0549698
FMNL2 formin-like 2 0.0547667
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0547159
RPL23 ribosomal protein L23 0.0530917
LAMB3 laminin, beta 3 0.0513908
SRSF11 serine/arginine-rich splicing factor 11 0.0500681
ANKRD11 ankyrin repeat domain 11 0.0500482
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0490421
ZNF292 zinc finger protein 292 0.0489167
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.048763
RAD51B RAD51 paralog B 0.0486481
CAPRIN2 caprin family member 2 0.048643
RPL26 ribosomal protein L26 0.0485771
SET SET nuclear proto-oncogene 0.0477794
WDR43 WD repeat domain 43 0.045367
DGKI diacylglycerol kinase, iota 0.0423349
RPS17 ribosomal protein S17 0.0423111
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0421749
ARGLU1 arginine and glutamate rich 1 0.0418947
EIF4B eukaryotic translation initiation factor 4B 0.0418096
EWSR1 EWS RNA-binding protein 1 0.04174
DENND1A DENN/MADD domain containing 1A 0.0412037
WAC WW domain containing adaptor with coiled-coil 0.0408089
RPL11 ribosomal protein L11 0.0407559
LPP LIM domain containing preferred translocation partner in lipoma 0.0404704
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0403127
EIF3E eukaryotic translation initiation factor 3, subunit E 0.0392253
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0390373
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0389112
ECT2 epithelial cell transforming 2 0.0387568
PTBP2 polypyrimidine tract binding protein 2 0.0386514
CTNND1 catenin (cadherin-associated protein), delta 1 0.0385647
PNN pinin, desmosome associated protein 0.0382245
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.0374099
RPL5 ribosomal protein L5 0.0371756
SRPK2 SRSF protein kinase 2 0.0368102
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha 0.0365194
ANO6 anoctamin 6 0.035779
NUP58 nucleoporin 58 0.035477
CALR calreticulin 0.0348172
DNMT1 DNA (cytosine-5-)-methyltransferase 1 0.0344783
CASC3 cancer susceptibility candidate 3 0.0344753
HELZ helicase with zinc finger 0.0341417
ADAM17 ADAM metallopeptidase domain 17 0.0341065
KLC1 kinesin light chain 1 0.034054
ABI1 abl-interactor 1 0.0336671
KMT2E lysine (K)-specific methyltransferase 2E 0.0332961
TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1 0.0332497
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.0331971
USP3 ubiquitin specific peptidase 3 0.0330764
AKAP12 A kinase (PRKA) anchor protein 12 0.032936
LUC7L LUC7-like (S. cerevisiae) 0.0328305
RAD23B RAD23 homolog B (S. cerevisiae) 0.0325807
CTBP2 C-terminal binding protein 2 0.0325425
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.032362
CAND1 cullin-associated and neddylation-dissociated 1 0.0320154
RBM17 RNA binding motif protein 17 0.0315081
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0314478
RBM33 RNA binding motif protein 33 0.0313221
FUBP3 far upstream element (FUSE) binding protein 3 0.0309823
SNX14 sorting nexin 14 0.0309315
BHLHE40 basic helix-loop-helix family, member e40 0.0308533
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B 0.0306541
RBM5 RNA binding motif protein 5 0.0305871
RPL9 ribosomal protein L9 0.0304124
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0303196
ANKRD12 ankyrin repeat domain 12 0.0302601
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa 0.0299456
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0298009
PRELID2 PRELI domain containing 2 0.0297178
RPS21 ribosomal protein S21 0.0296221
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0294801
DENR density-regulated protein 0.0293976
SRSF4 serine/arginine-rich splicing factor 4 0.0293934
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa 0.0290999
NAP1L1 nucleosome assembly protein 1-like 1 0.0287577
NAA35 N(alpha)-acetyltransferase 35, NatC auxiliary subunit 0.0283824
RBM25 RNA binding motif protein 25 0.028374
RRAS2 related RAS viral (r-ras) oncogene homolog 2 0.0283735
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0283658
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0283525
PITPNB phosphatidylinositol transfer protein, beta 0.0283346
GIGYF2 GRB10 interacting GYF protein 2 0.0281116
RNMT RNA (guanine-7-) methyltransferase 0.0281088
RPS4X ribosomal protein S4, X-linked 0.028096

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.193011
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.158472
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.139446
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.135843
IARS1 isoleucyl-tRNA synthetase 1 -0.110984
MCTP1 multiple C2 domains, transmembrane 1 -0.103226
JMJD1C jumonji domain containing 1C -0.0966187
LOC112694756 uncharaterized LOC112694756 -0.0933219
ACTG1 actin gamma 1 -0.0839206
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0783148
FTL ferritin, light polypeptide -0.0734649
FRMD6 FERM domain containing 6 -0.0692564
PDIA3 protein disulfide isomerase family A, member 3 -0.0668269
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0663112
POTEF POTE ankyrin domain family, member F -0.0635836
TXNRD1 thioredoxin reductase 1 -0.0630091
RPLP1 ribosomal protein, large, P1 -0.0599008
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0598093
HMGA1 high mobility group AT-hook 1 -0.0593793
SETX senataxin -0.058815
LDHA lactate dehydrogenase A -0.0586158
RAB7A RAB7A, member RAS oncogene family -0.0582234
EGR1 early growth response 1 -0.0568733
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0564906
ZFP36L1 ZFP36 ring finger protein-like 1 -0.056307
RPLP0 ribosomal protein, large, P0 -0.0525118
CANX calnexin -0.0496599
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0461991
CALU calumenin -0.0444672
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -0.0444539
JUN jun proto-oncogene -0.04297
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.041458
UBC ubiquitin C -0.0407093
WNK1 WNK lysine deficient protein kinase 1 -0.0398479
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0395214
SLC38A2 solute carrier family 38, member 2 -0.0394352
BLZF1 basic leucine zipper nuclear factor 1 -0.0394159
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 -0.0388045
PFN1 profilin 1 -0.0383625
NDRG1 N-myc downstream regulated 1 -0.0379635
CD44 CD44 molecule (Indian blood group) -0.0375246
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0354349
DGKH diacylglycerol kinase, eta -0.0349958
CREB5 cAMP responsive element binding protein 5 -0.0346343
MYC v-myc avian myelocytomatosis viral oncogene homolog -0.0343266
TCF12 transcription factor 12 -0.0338995
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0336595
LATS2 large tumor suppressor kinase 2 -0.033394
TIMP1 TIMP metallopeptidase inhibitor 1 -0.033001
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0326863
TTC3 tetratricopeptide repeat domain 3 -0.0316014
CLTC clathrin, heavy chain (Hc) -0.0312931
RPL27A ribosomal protein L27a -0.0306594
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -0.0303973
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.030253
SPRY4 sprouty homolog 4 (Drosophila) -0.0302171
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase -0.0301419
TMBIM6 transmembrane BAX inhibitor motif containing 6 -0.030122
SGMS2 sphingomyelin synthase 2 -0.0300777
VDAC1 voltage-dependent anion channel 1 -0.0300116
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0299546
BRD2 bromodomain containing 2 -0.0297481
C2CD2 C2 calcium-dependent domain containing 2 -0.0290747
CD68 CD68 molecule -0.028968
PTPRG protein tyrosine phosphatase, receptor type, G -0.0278575
RPL28 ribosomal protein L28 -0.0277031
RPL7 ribosomal protein L7 -0.0277011
EIF1 eukaryotic translation initiation factor 1 -0.0273492
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0272207
FKBP15 FK506 binding protein 15, 133kDa -0.0271176
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.0270096
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0268067
NPR2 natriuretic peptide receptor 2 -0.026805
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme -0.026673
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0266688
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.026527
ARF4 ADP-ribosylation factor 4 -0.0263377
TNIK TRAF2 and NCK interacting kinase -0.0261883
DARS1 aspartyl-tRNA synthetase 1 -0.0261397
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0261105
GLG1 golgi glycoprotein 1 -0.0257166
PTPN1 protein tyrosine phosphatase, non-receptor type 1 -0.0256896
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.0255941
ADAR adenosine deaminase, RNA-specific -0.025583
ANXA2 annexin A2 -0.0255756
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0254882
ZNF438 zinc finger protein 438 -0.0251154
RAD21 RAD21 homolog (S. pombe) -0.0249652
STARD13 StAR-related lipid transfer (START) domain containing 13 -0.0249021
ZBTB38 zinc finger and BTB domain containing 38 -0.0247484
SQLE squalene epoxidase -0.024687
MAPK8 mitogen-activated protein kinase 8 -0.024613
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase -0.0244223
PDIA6 protein disulfide isomerase family A, member 6 -0.0243475
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 -0.0242971
HMGA2 high mobility group AT-hook 2 -0.0241584
ARF1 ADP-ribosylation factor 1 -0.0241335
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0240691
GTF2B general transcription factor IIB -0.0239998
HDAC9 histone deacetylase 9 -0.0237274