| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Topotecan (hydrochloride) perturbation in RPMI-7951 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Topotecan (hydrochloride)_RPMI-7951 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| STC1 | stanniocalcin 1 | 0.221965 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.107624 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.106433 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0861102 |
| VEGFA | vascular endothelial growth factor A | 0.079592 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.0739035 |
| FN1 | fibronectin 1 | 0.0682259 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0668757 |
| FAM13A | family with sequence similarity 13, member A | 0.0650997 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0631894 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0588578 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0569416 |
| MCTP2 | multiple C2 domains, transmembrane 2 | 0.0559008 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0510358 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0505761 |
| MMP12 | matrix metallopeptidase 12 | 0.0496723 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0486447 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0484441 |
| B2M | beta-2-microglobulin | 0.048014 |
| RPS2 | ribosomal protein S2 | 0.0479868 |
| PTMA | prothymosin, alpha | 0.0479687 |
| ATP13A3 | ATPase type 13A3 | 0.0477107 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0464583 |
| RPL37A | ribosomal protein L37a | 0.0461064 |
| PGK1 | phosphoglycerate kinase 1 | 0.045975 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0443159 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.0442351 |
| H1-4 | H1.4 linker histone, cluster member | 0.0432477 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0430728 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0428004 |
| IL1B | interleukin 1, beta | 0.041396 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | 0.0410654 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0404061 |
| NGLY1 | N-glycanase 1 | 0.040278 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0402723 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0392909 |
| TMF1 | TATA element modulatory factor 1 | 0.0390116 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0383832 |
| CLIP4 | CAP-GLY domain containing linker protein family, member 4 | 0.0383242 |
| FMNL2 | formin-like 2 | 0.0375995 |
| RPS6 | ribosomal protein S6 | 0.0367257 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0364354 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.0361879 |
| INHBA | inhibin, beta A | 0.0356677 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0355584 |
| EYA1 | EYA transcriptional coactivator and phosphatase 1 | 0.035516 |
| XPO1 | exportin 1 | 0.0347319 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.0344786 |
| MT2A | metallothionein 2A | 0.0341207 |
| GOLGA4 | golgin A4 | 0.033333 |
| ARL4C | ADP-ribosylation factor-like 4C | 0.0332164 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0323714 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0320429 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0320042 |
| EIF5B | eukaryotic translation initiation factor 5B | 0.0316032 |
| HLA-B | major histocompatibility complex, class I, B | 0.0315004 |
| EML5 | echinoderm microtubule associated protein like 5 | 0.0312167 |
| YEATS2 | YEATS domain containing 2 | 0.0311289 |
| SETD5 | SET domain containing 5 | 0.0308352 |
| DSTN | destrin (actin depolymerizing factor) | 0.0308212 |
| CDCP1 | CUB domain containing protein 1 | 0.0306326 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0295214 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0292342 |
| PLEKHA4 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 | 0.0286284 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0284883 |
| MKI67 | marker of proliferation Ki-67 | 0.0282576 |
| RNF145 | ring finger protein 145 | 0.0281215 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0278163 |
| SUCO | SUN domain containing ossification factor | 0.0277692 |
| RPL11 | ribosomal protein L11 | 0.0277454 |
| SKAP2 | src kinase associated phosphoprotein 2 | 0.0276213 |
| FGFR1 | fibroblast growth factor receptor 1 | 0.0272784 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0271214 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0270442 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.027009 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0269556 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0269108 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0267517 |
| TPM1 | tropomyosin 1 (alpha) | 0.0262413 |
| WNT5A | wingless-type MMTV integration site family, member 5A | 0.0257306 |
| MTSS1 | metastasis suppressor 1 | 0.0257034 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0253435 |
| NCKAP1 | NCK-associated protein 1 | 0.025338 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0252646 |
| ELP2 | elongator acetyltransferase complex subunit 2 | 0.0252583 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | 0.0250128 |
| CALR | calreticulin | 0.0248914 |
| RPS8 | ribosomal protein S8 | 0.0248723 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.024805 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0247796 |
| GYS1 | glycogen synthase 1 (muscle) | 0.0245047 |
| ATP2C1 | ATPase, Ca++ transporting, type 2C, member 1 | 0.0244876 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0244553 |
| IRAK3 | interleukin-1 receptor-associated kinase 3 | 0.0244213 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | 0.0241209 |
| RPS12 | ribosomal protein S12 | 0.0240744 |
| SFXN1 | sideroflexin 1 | 0.0240492 |
| PPME1 | protein phosphatase methylesterase 1 | 0.0240194 |
| ZFR | zinc finger RNA binding protein | 0.0239172 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0238537 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.248538 |
| VIM | vimentin | -0.20607 |
| CD44 | CD44 molecule (Indian blood group) | -0.113526 |
| POTEF | POTE ankyrin domain family, member F | -0.106985 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0973986 |
| FTL | ferritin, light polypeptide | -0.084829 |
| EGR1 | early growth response 1 | -0.0830713 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0819544 |
| PKM | pyruvate kinase, muscle | -0.0784923 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0749942 |
| UBC | ubiquitin C | -0.0674536 |
| TMSB10 | thymosin beta 10 | -0.0615091 |
| RPLP1 | ribosomal protein, large, P1 | -0.0599233 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0598532 |
| CLIC4 | chloride intracellular channel 4 | -0.0591573 |
| ANXA2 | annexin A2 | -0.0577887 |
| FRMD4A | FERM domain containing 4A | -0.0561954 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0561056 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0559078 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | -0.050666 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0501836 |
| ACTN4 | actinin, alpha 4 | -0.0492509 |
| LDHA | lactate dehydrogenase A | -0.0484068 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0480315 |
| VCL | vinculin | -0.0480037 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | -0.0473834 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.046969 |
| SVIL | supervillin | -0.0445199 |
| FKBP1A | FK506 binding protein 1A, 12kDa | -0.0445088 |
| H1-0 | H1.0 linker histone | -0.044198 |
| NRP1 | neuropilin 1 | -0.042831 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0417968 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0412514 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0411294 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | -0.0410546 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0407954 |
| YBX1 | Y box binding protein 1 | -0.0407542 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0404751 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.039844 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0396407 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0393554 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0390384 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | -0.0382157 |
| ICAM1 | intercellular adhesion molecule 1 | -0.038176 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | -0.0377462 |
| PFN1 | profilin 1 | -0.0372084 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0370708 |
| TGM2 | transglutaminase 2 | -0.0358987 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0354027 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0352847 |
| HPCAL1 | hippocalcin-like 1 | -0.0341835 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0334565 |
| INTS6 | integrator complex subunit 6 | -0.0330262 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0329231 |
| MAP1B | microtubule-associated protein 1B | -0.0315278 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | -0.030663 |
| RTN4 | reticulon 4 | -0.030438 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0302702 |
| LARP4B | La ribonucleoprotein domain family, member 4B | -0.029848 |
| ADNP | activity-dependent neuroprotector homeobox | -0.0296993 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0294229 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.0294082 |
| ZNF644 | zinc finger protein 644 | -0.0289139 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0286908 |
| TAPBP | TAP binding protein (tapasin) | -0.0286311 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.0284792 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0284009 |
| TXNRD1 | thioredoxin reductase 1 | -0.0282295 |
| MORF4L2 | mortality factor 4 like 2 | -0.0281067 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0280758 |
| HM13 | histocompatibility (minor) 13 | -0.0278162 |
| FBXO11 | F-box protein 11 | -0.027737 |
| SHISA5 | shisa family member 5 | -0.0276194 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0275394 |
| EHD2 | EH-domain containing 2 | -0.0272354 |
| NPTN | neuroplastin | -0.0270967 |
| RPLP0 | ribosomal protein, large, P0 | -0.0267422 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0267353 |
| PEAK1 | pseudopodium-enriched atypical kinase 1 | -0.0265641 |
| LOX | lysyl oxidase | -0.026127 |
| TMEM178B | transmembrane protein 178B | -0.0259491 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0259262 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0258945 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0257849 |
| BZW2 | basic leucine zipper and W2 domains 2 | -0.0257752 |
| MYO1E | myosin IE | -0.0256957 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0253887 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0253098 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0252761 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | -0.0251176 |
| NDRG1 | N-myc downstream regulated 1 | -0.0249936 |
| PHF14 | PHD finger protein 14 | -0.0249708 |
| S100A6 | S100 calcium binding protein A6 | -0.0246273 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0246262 |
| TPM4 | tropomyosin 4 | -0.0245466 |
| PAX3 | paired box 3 | -0.0244983 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.0241366 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.024038 |
| TNNC1 | troponin C type 1 (slow) | -0.0240167 |
| AGO3 | argonaute RISC catalytic component 3 | -0.0239281 |
