Topotecan (hydrochloride)_SHP-77 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Topotecan (hydrochloride) perturbation in SHP-77 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Topotecan (hydrochloride)_SHP-77 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0406547
VEGFA vascular endothelial growth factor A 0.0397351
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0376094
SMC1A structural maintenance of chromosomes 1A 0.0361119
SMOC1 SPARC related modular calcium binding 1 0.0344363
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0334826
SPTBN1 spectrin, beta, non-erythrocytic 1 0.032826
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0324718
CA8 carbonic anhydrase VIII 0.0324367
GRB10 growth factor receptor-bound protein 10 0.0321909
CHGB chromogranin B 0.0316676
NDRG1 N-myc downstream regulated 1 0.0312804
ZNF292 zinc finger protein 292 0.0309491
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0308738
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0308349
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0307107
MBNL2 muscleblind-like splicing regulator 2 0.0302063
TPM3 tropomyosin 3 0.0302061
PCM1 pericentriolar material 1 0.029318
NUP58 nucleoporin 58 0.029284
TSPYL2 TSPY-like 2 0.0271912
MYH9 myosin, heavy chain 9, non-muscle 0.0268328
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.026513
CCNY cyclin Y 0.0259678
SPAG5 sperm associated antigen 5 0.0250506
PPME1 protein phosphatase methylesterase 1 0.0250421
FAM13A family with sequence similarity 13, member A 0.0247765
XPO1 exportin 1 0.0244196
CKAP5 cytoskeleton associated protein 5 0.0243674
RNASE12 ribonuclease, RNase A family, 12 (non-active) 0.0243357
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0240133
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0228001
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0222588
IQGAP3 IQ motif containing GTPase activating protein 3 0.0220074
ECT2 epithelial cell transforming 2 0.0217491
LIFR leukemia inhibitory factor receptor alpha 0.0217237
JAM3 junctional adhesion molecule 3 0.0215093
PRPF8 pre-mRNA processing factor 8 0.0214672
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0214065
DTNA dystrobrevin, alpha 0.0213401
SRRM2 serine/arginine repetitive matrix 2 0.0212812
EEF2 eukaryotic translation elongation factor 2 0.020729
PNN pinin, desmosome associated protein 0.0206131
AFF1 AF4/FMR2 family, member 1 0.020585
PGAP1 post-GPI attachment to proteins 1 0.0204073
MPRIP myosin phosphatase Rho interacting protein 0.0201834
SET SET nuclear proto-oncogene 0.0201486
GRAMD4 GRAM domain containing 4 0.0197429
CCNL1 cyclin L1 0.0196897
CHD7 chromodomain helicase DNA binding protein 7 0.0194798
NUF2 NUF2, NDC80 kinetochore complex component 0.0194488
BHLHE40 basic helix-loop-helix family, member e40 0.0187635
ARGLU1 arginine and glutamate rich 1 0.0186408
MED13L mediator complex subunit 13-like 0.0185245
CDK5RAP2 CDK5 regulatory subunit associated protein 2 0.0183451
RPL3 ribosomal protein L3 0.018219
DOT1L DOT1-like histone H3K79 methyltransferase 0.0180164
KDM1A lysine (K)-specific demethylase 1A 0.0178235
MIS18BP1 MIS18 binding protein 1 0.0178085
CENPF centromere protein F, 350/400kDa 0.0171371
SSBP2 single-stranded DNA binding protein 2 0.0169851
ATAD2 ATPase family, AAA domain containing 2 0.0169634
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0167609
KMT2E lysine (K)-specific methyltransferase 2E 0.016687
LMNB1 lamin B1 0.0165997
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.016577
DNMT1 DNA (cytosine-5-)-methyltransferase 1 0.01643
NUMA1 nuclear mitotic apparatus protein 1 0.0163196
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0163163
DIAPH1 diaphanous-related formin 1 0.0162567
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0162202
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.016189
NBAS neuroblastoma amplified sequence 0.0160516
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0159682
EGLN1 egl-9 family hypoxia-inducible factor 1 0.015919
NCKAP1 NCK-associated protein 1 0.0158834
RIMBP2 RIMS binding protein 2 0.0157276
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0156768
INCENP inner centromere protein antigens 135/155kDa 0.0156269
FAT1 FAT atypical cadherin 1 0.0156147
RACGAP1 Rac GTPase activating protein 1 0.0155918
CEP152 centrosomal protein 152kDa 0.0155894
RPRD2 regulation of nuclear pre-mRNA domain containing 2 0.0155346
AHDC1 AT hook, DNA binding motif, containing 1 0.0155007
BCLAF1 BCL2-associated transcription factor 1 0.0154984
EIF4B eukaryotic translation initiation factor 4B 0.0154204
YY1AP1 YY1 associated protein 1 0.0154115
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.015398
PIAS2 protein inhibitor of activated STAT, 2 0.0153779
KDM3A lysine (K)-specific demethylase 3A 0.0153364
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0153059
ANLN anillin, actin binding protein 0.0152909
NT5C3A 5'-nucleotidase, cytosolic IIIA 0.0152687
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.015184
HOOK2 hook microtubule-tethering protein 2 0.0151258
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0150856
CASC3 cancer susceptibility candidate 3 0.0150692
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0150232
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0149791
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E 0.0149701

decreased expression

Symbol Name Standardized Value
NALF1 NALCN channel auxiliary factor 1 -0.157267
RIMS2 regulating synaptic membrane exocytosis 2 -0.122629
NRG1 neuregulin 1 -0.101147
GRIK1 glutamate receptor, ionotropic, kainate 1 -0.100314
GPC6 glypican 6 -0.0973983
FTL ferritin, light polypeptide -0.095719
SNTG1 syntrophin, gamma 1 -0.0908838
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.088505
MT2A metallothionein 2A -0.0855424
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.084136
CALCA calcitonin-related polypeptide alpha -0.0830736
PTMA prothymosin, alpha -0.0813142
PDE10A phosphodiesterase 10A -0.0754229
KCNB2 potassium channel, voltage gated Shab related subfamily B, member 2 -0.0738704
NKAIN2 Na+/K+ transporting ATPase interacting 2 -0.0679986
RPLP1 ribosomal protein, large, P1 -0.0651763
STC1 stanniocalcin 1 -0.0635976
SMYD3 SET and MYND domain containing 3 -0.0627689
ZBTB20 zinc finger and BTB domain containing 20 -0.0596041
SYT1 synaptotagmin I -0.0594211
RPS21 ribosomal protein S21 -0.0578164
STXBP5 syntaxin binding protein 5 (tomosyn) -0.055303
GPC5 glypican 5 -0.054358
ENO1 enolase 1, (alpha) -0.0541155
NBEA neurobeachin -0.0525984
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0518927
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0516146
FGF14 fibroblast growth factor 14 -0.0514352
NCKAP5 NCK-associated protein 5 -0.0489482
PTCHD4 patched domain containing 4 -0.0479606
CNKSR3 CNKSR family member 3 -0.0479564
INHBA inhibin, beta A -0.0463316
TXNRD1 thioredoxin reductase 1 -0.0461475
TMSB10 thymosin beta 10 -0.0458427
LOC112694756 uncharaterized LOC112694756 -0.045801
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.045366
TSHZ2 teashirt zinc finger homeobox 2 -0.0449422
RPS6 ribosomal protein S6 -0.0448389
RPS8 ribosomal protein S8 -0.0446942
TENM1 teneurin transmembrane protein 1 -0.0437893
CNTNAP2 contactin associated protein-like 2 -0.0430071
ACTG1 actin gamma 1 -0.0421469
KCND2 potassium channel, voltage gated Shal related subfamily D, member 2 -0.0408798
EGR1 early growth response 1 -0.0407029
RPL37 ribosomal protein L37 -0.0405198
IGFBP2 insulin-like growth factor binding protein 2, 36kDa -0.0401101
PDE4D phosphodiesterase 4D, cAMP-specific -0.0397562
S100A9 S100 calcium binding protein A9 -0.0397022
KIF26B kinesin family member 26B -0.0394398
ATP5F1E ATP synthase F1 subunit epsilon -0.0391349
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0389454
PEX5L peroxisomal biogenesis factor 5-like -0.0386791
RPL8 ribosomal protein L8 -0.0384908
UBB ubiquitin B -0.0379915
RPLP0 ribosomal protein, large, P0 -0.0376924
RPS16 ribosomal protein S16 -0.0376832
NOVA1 neuro-oncological ventral antigen 1 -0.0372985
IFI6 interferon, alpha-inducible protein 6 -0.0370398
TPT1 tumor protein, translationally-controlled 1 -0.0370304
RPL26 ribosomal protein L26 -0.0363431
RNF213 ring finger protein 213 -0.0362438
WWOX WW domain containing oxidoreductase -0.0362421
LSAMP limbic system-associated membrane protein -0.035737
DOCK5 dedicator of cytokinesis 5 -0.0356952
PHF14 PHD finger protein 14 -0.0355112
CHGA chromogranin A -0.034852
PEG10 paternally expressed 10 -0.0347021
ISG15 ISG15 ubiquitin-like modifier -0.034666
STXBP5L syntaxin binding protein 5-like -0.0344967
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0341554
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.0337718
RPL34 ribosomal protein L34 -0.0335562
IGFBP5 insulin-like growth factor binding protein 5 -0.0334157
CPE carboxypeptidase E -0.0330414
RPL23 ribosomal protein L23 -0.0329873
ST18 suppression of tumorigenicity 18, zinc finger -0.032893
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -0.0327643
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0327488
RPL38 ribosomal protein L38 -0.0324355
RPL31 ribosomal protein L31 -0.0322487
SCG2 secretogranin II -0.0319462
FNDC3A fibronectin type III domain containing 3A -0.0317579
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) -0.0315838
SLC35F4 solute carrier family 35, member F4 -0.0315793
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0315703
KPNB1 karyopherin (importin) beta 1 -0.0313162
RPS19 ribosomal protein S19 -0.0311723
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0310264
ARB2A ARB2 cotranscriptional regulator A -0.0309128
RPS5 ribosomal protein S5 -0.0308652
FBXL17 F-box and leucine-rich repeat protein 17 -0.0303212
GNAS GNAS complex locus -0.0302825
RPS3 ribosomal protein S3 -0.0300505
EFNA5 ephrin-A5 -0.0299855
RPL35 ribosomal protein L35 -0.0299481
RPL30 ribosomal protein L30 -0.0299339
RPS27A ribosomal protein S27a -0.0297007
GDAP1 ganglioside induced differentiation associated protein 1 -0.0295596
RPL32 ribosomal protein L32 -0.0295384
RPL35A ribosomal protein L35a -0.0292328