| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Topotecan (hydrochloride) perturbation in SK-MEL-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Topotecan (hydrochloride)_SK-MEL-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | 0.191301 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.102449 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0794649 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0753473 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0751366 |
| FMNL2 | formin-like 2 | 0.0734718 |
| CLIP4 | CAP-GLY domain containing linker protein family, member 4 | 0.0718802 |
| MSN | moesin | 0.065737 |
| NAV2 | neuron navigator 2 | 0.0651882 |
| XRCC6 | X-ray repair complementing defective repair in Chinese hamster cells 6 | 0.0611247 |
| OGA | O-GlcNAcase | 0.0606661 |
| SETD5 | SET domain containing 5 | 0.060628 |
| NOTCH2 | notch 2 | 0.0560289 |
| SLC39A11 | solute carrier family 39, member 11 | 0.0549586 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0547203 |
| PRELID2 | PRELI domain containing 2 | 0.0534084 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0531675 |
| SPAG9 | sperm associated antigen 9 | 0.0529315 |
| NGLY1 | N-glycanase 1 | 0.0524846 |
| RPL3 | ribosomal protein L3 | 0.0512393 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0508476 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0507849 |
| TPM3 | tropomyosin 3 | 0.0497789 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.049292 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0486594 |
| HELZ | helicase with zinc finger | 0.0483037 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0482713 |
| CTTN | cortactin | 0.0482547 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0460736 |
| SFTPA2 | surfactant protein A2 | 0.0459335 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0447347 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0436325 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0434478 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0434153 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0434076 |
| FLNB | filamin B, beta | 0.0433539 |
| CCNL1 | cyclin L1 | 0.0433538 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.0424053 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0415905 |
| XPO1 | exportin 1 | 0.0413617 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0412192 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | 0.0410578 |
| FLNA | filamin A, alpha | 0.0409912 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0404428 |
| ANKRD11 | ankyrin repeat domain 11 | 0.040389 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0403516 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | 0.0402028 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0401916 |
| SMAD3 | SMAD family member 3 | 0.0392465 |
| POM121 | POM121 transmembrane nucleoporin | 0.0386696 |
| YEATS2 | YEATS domain containing 2 | 0.0385344 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0378587 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0375335 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.037073 |
| PTMA | prothymosin, alpha | 0.0369896 |
| MCL1 | myeloid cell leukemia 1 | 0.0368601 |
| PTK2 | protein tyrosine kinase 2 | 0.0365935 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0364592 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0363528 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0362228 |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | 0.036191 |
| RTN4 | reticulon 4 | 0.0352317 |
| FAM13A | family with sequence similarity 13, member A | 0.0349895 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0349461 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | 0.0347795 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0346496 |
| PALS2 | protein associated with LIN7 2, MAGUK p55 family member | 0.0342555 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0339351 |
| NBAS | neuroblastoma amplified sequence | 0.0337396 |
| CLINT1 | clathrin interactor 1 | 0.0336277 |
| USP3 | ubiquitin specific peptidase 3 | 0.033581 |
| CEP250 | centrosomal protein 250kDa | 0.0329475 |
| CALR | calreticulin | 0.0329401 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0328655 |
| PHF21A | PHD finger protein 21A | 0.0328653 |
| RNF145 | ring finger protein 145 | 0.0324315 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0322144 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0317181 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0315579 |
| FAM219A | family with sequence similarity 219, member A | 0.0314962 |
| CCNY | cyclin Y | 0.031354 |
| SET | SET nuclear proto-oncogene | 0.0313409 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.0313016 |
| ANXA5 | annexin A5 | 0.0312635 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0311813 |
| NCKAP1 | NCK-associated protein 1 | 0.031154 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0309551 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0306484 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0305359 |
| TRIM33 | tripartite motif containing 33 | 0.0305028 |
| GOLGA4 | golgin A4 | 0.0304383 |
| ZNF292 | zinc finger protein 292 | 0.0303173 |
| ATP13A3 | ATPase type 13A3 | 0.0302353 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0302062 |
| B2M | beta-2-microglobulin | 0.0302014 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0301926 |
| MAFF | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F | 0.02996 |
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | 0.0297533 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0293574 |
| EIF5 | eukaryotic translation initiation factor 5 | 0.0290849 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.145963 |
| FMN1 | formin 1 | -0.129578 |
| VIM | vimentin | -0.121301 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.118531 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0661516 |
| NLGN1 | neuroligin 1 | -0.0625089 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0524996 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0514659 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0477869 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0469235 |
| CCND1 | cyclin D1 | -0.0452756 |
| EHBP1 | EH domain binding protein 1 | -0.0445954 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0424115 |
| FTL | ferritin, light polypeptide | -0.0402113 |
| LINC02798 | long intergenic non-protein coding RNA 2798 | -0.0396529 |
| SP100 | SP100 nuclear antigen | -0.0390853 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0379827 |
| HDAC9 | histone deacetylase 9 | -0.0376611 |
| RPS6 | ribosomal protein S6 | -0.0366281 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0360717 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0354282 |
| CDK6 | cyclin-dependent kinase 6 | -0.0351327 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0332824 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0330954 |
| RPL35A | ribosomal protein L35a | -0.0323871 |
| RPLP1 | ribosomal protein, large, P1 | -0.0320743 |
| TMSB10 | thymosin beta 10 | -0.0317039 |
| ENO1 | enolase 1, (alpha) | -0.0313016 |
| COMMD10 | COMM domain containing 10 | -0.0299769 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.0297665 |
| WNT2B | wingless-type MMTV integration site family, member 2B | -0.0295393 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0278426 |
| HMGA1 | high mobility group AT-hook 1 | -0.0275515 |
| CTSD | cathepsin D | -0.0267992 |
| DST | dystonin | -0.0265996 |
| RPL34 | ribosomal protein L34 | -0.0254237 |
| SOX6 | SRY (sex determining region Y)-box 6 | -0.0252966 |
| BZW2 | basic leucine zipper and W2 domains 2 | -0.0247495 |
| SCAPER | S-phase cyclin A-associated protein in the ER | -0.0244757 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.024392 |
| INTS6 | integrator complex subunit 6 | -0.0236006 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -0.0231797 |
| LDHA | lactate dehydrogenase A | -0.0231775 |
| SQSTM1 | sequestosome 1 | -0.0231526 |
| RPL27A | ribosomal protein L27a | -0.0230694 |
| RPLP2 | ribosomal protein, large, P2 | -0.0230147 |
| S100A9 | S100 calcium binding protein A9 | -0.0227005 |
| POTEF | POTE ankyrin domain family, member F | -0.022627 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0225535 |
| RPL31 | ribosomal protein L31 | -0.0220741 |
| RPS24 | ribosomal protein S24 | -0.0215222 |
| CADM1 | cell adhesion molecule 1 | -0.0212971 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0211548 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0209861 |
| MACROD2 | MACRO domain containing 2 | -0.0209809 |
| TNRC6B | trinucleotide repeat containing 6B | -0.0209049 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0208503 |
| KLF6 | Kruppel-like factor 6 | -0.0207357 |
| SHISA5 | shisa family member 5 | -0.020735 |
| RPL37A | ribosomal protein L37a | -0.0205974 |
| NDRG1 | N-myc downstream regulated 1 | -0.0204861 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0202633 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0202062 |
| FRMD4A | FERM domain containing 4A | -0.0201617 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.020089 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0197373 |
| MT2A | metallothionein 2A | -0.0196132 |
| RPS13 | ribosomal protein S13 | -0.0195872 |
| CD96 | CD96 molecule | -0.0194222 |
| DMXL1 | Dmx-like 1 | -0.01941 |
| NRXN3 | neurexin 3 | -0.0193949 |
| PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) | -0.0193715 |
| PLSCR1 | phospholipid scramblase 1 | -0.0191655 |
| RPS27A | ribosomal protein S27a | -0.0191623 |
| TP63 | tumor protein p63 | -0.0190791 |
| IER3 | immediate early response 3 | -0.0190785 |
| EGR1 | early growth response 1 | -0.0189861 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0189294 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0189134 |
| FBXL17 | F-box and leucine-rich repeat protein 17 | -0.0187825 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.0187772 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0187095 |
| TBCA | tubulin folding cofactor A | -0.0185759 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0185572 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0185089 |
| BPTF | bromodomain PHD finger transcription factor | -0.0183256 |
| RPS16 | ribosomal protein S16 | -0.0182334 |
| DIAPH2 | diaphanous-related formin 2 | -0.0181986 |
| RPL37 | ribosomal protein L37 | -0.0180689 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0179565 |
| RPL28 | ribosomal protein L28 | -0.017769 |
| PMP22 | peripheral myelin protein 22 | -0.0176068 |
| RPS8 | ribosomal protein S8 | -0.0174371 |
| TAPBP | TAP binding protein (tapasin) | -0.0174093 |
| EXOC4 | exocyst complex component 4 | -0.0173715 |
| ASTN2 | astrotactin 2 | -0.0172938 |
| ULK4 | unc-51 like kinase 4 | -0.0172233 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0171765 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0171013 |
| LRRC23 | leucine rich repeat containing 23 | -0.0170914 |
