| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Topotecan (hydrochloride) perturbation in SNU-1 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Topotecan (hydrochloride)_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB4X | thymosin beta 4, X-linked | 0.25039 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.170114 |
| PTMA | prothymosin, alpha | 0.122754 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.104896 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.079456 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0783304 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0674834 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0644875 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.061778 |
| FLNB | filamin B, beta | 0.061545 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0600747 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0567162 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | 0.0533779 |
| PLEKHA4 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 | 0.0532088 |
| PLXNA1 | plexin A1 | 0.0530105 |
| RPL7A | ribosomal protein L7a | 0.0517416 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0511836 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0507966 |
| ACTG1 | actin gamma 1 | 0.0484516 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0477229 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0457973 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0454703 |
| RPL3 | ribosomal protein L3 | 0.0447966 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | 0.0432899 |
| NFKB2 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) | 0.0430552 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0422345 |
| HLA-B | major histocompatibility complex, class I, B | 0.0421834 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0390381 |
| B2M | beta-2-microglobulin | 0.0387322 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0380271 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0373755 |
| DDB2 | damage-specific DNA binding protein 2, 48kDa | 0.0371779 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0370939 |
| CD47 | CD47 molecule | 0.0352802 |
| YEATS2 | YEATS domain containing 2 | 0.0338646 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0337326 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0334357 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0332942 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0331624 |
| FAM13A | family with sequence similarity 13, member A | 0.0327878 |
| PYGB | phosphorylase, glycogen; brain | 0.0327437 |
| PRPF38B | pre-mRNA processing factor 38B | 0.0323621 |
| APP | amyloid beta (A4) precursor protein | 0.0319047 |
| FAT1 | FAT atypical cadherin 1 | 0.0314904 |
| OGA | O-GlcNAcase | 0.0307948 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0306849 |
| TMEM65 | transmembrane protein 65 | 0.0306722 |
| MYOF | myoferlin | 0.0301999 |
| AMOTL2 | angiomotin like 2 | 0.0301933 |
| LOXL3 | lysyl oxidase-like 3 | 0.0298903 |
| FBLN2 | fibulin 2 | 0.0297176 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0297117 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.029379 |
| FNIP1 | folliculin interacting protein 1 | 0.0292523 |
| INSIG2 | insulin induced gene 2 | 0.0290775 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0289434 |
| FLNA | filamin A, alpha | 0.0285966 |
| CALR | calreticulin | 0.0284996 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.028467 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0282546 |
| PARP6 | poly (ADP-ribose) polymerase family, member 6 | 0.028233 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0280469 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0279858 |
| RPL37A | ribosomal protein L37a | 0.0278591 |
| DDX39B | DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B | 0.027623 |
| GLI2 | GLI family zinc finger 2 | 0.0275284 |
| ZNF160 | zinc finger protein 160 | 0.0274177 |
| MDN1 | MDN1, midasin homolog (yeast) | 0.0272457 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0270115 |
| CASC3 | cancer susceptibility candidate 3 | 0.0269894 |
| EHBP1L1 | EH domain binding protein 1-like 1 | 0.0269506 |
| SGMS1 | sphingomyelin synthase 1 | 0.0266414 |
| EIF3E | eukaryotic translation initiation factor 3, subunit E | 0.0265458 |
| EZR | ezrin | 0.0265418 |
| PLEKHB2 | pleckstrin homology domain containing, family B (evectins) member 2 | 0.0265244 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | 0.0263855 |
| RBM26 | RNA binding motif protein 26 | 0.0262032 |
| FKBP10 | FK506 binding protein 10, 65 kDa | 0.0261346 |
| ANK2 | ankyrin 2, neuronal | 0.0253301 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | 0.0252321 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | 0.0250758 |
| ARHGEF10 | Rho guanine nucleotide exchange factor (GEF) 10 | 0.0250437 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0249631 |
| ADAR | adenosine deaminase, RNA-specific | 0.0247941 |
| USP36 | ubiquitin specific peptidase 36 | 0.0243526 |
| PMM2 | phosphomannomutase 2 | 0.0243359 |
| FNBP4 | formin binding protein 4 | 0.0241209 |
| MAP3K14 | mitogen-activated protein kinase kinase kinase 14 | 0.024016 |
| SLC1A3 | solute carrier family 1 (glial high affinity glutamate transporter), member 3 | 0.023987 |
| TENT4A | terminal nucleotidyltransferase 4A | 0.0239746 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0239294 |
| EWSR1 | EWS RNA-binding protein 1 | 0.0238756 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0238712 |
| SP100 | SP100 nuclear antigen | 0.0236127 |
| SLCO5A1 | solute carrier organic anion transporter family, member 5A1 | 0.0234134 |
| WDR43 | WD repeat domain 43 | 0.0230991 |
| DDX3Y | DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked | 0.0230677 |
| RBM25 | RNA binding motif protein 25 | 0.023034 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | 0.023025 |
| SMAD3 | SMAD family member 3 | 0.0230049 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.182812 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.143236 |
| ADAM10 | ADAM metallopeptidase domain 10 | -0.122007 |
| PKM | pyruvate kinase, muscle | -0.106957 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0943937 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0925922 |
| VCL | vinculin | -0.0874207 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0807266 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | -0.0791277 |
| SSBP2 | single-stranded DNA binding protein 2 | -0.0783036 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0757926 |
| FOXP1 | forkhead box P1 | -0.0755664 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0703112 |
| EGFR | epidermal growth factor receptor | -0.0679777 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0656012 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0654004 |
| CPED1 | cadherin-like and PC-esterase domain containing 1 | -0.0629693 |
| NBEA | neurobeachin | -0.0548545 |
| TJP1 | tight junction protein 1 | -0.0539765 |
| MACROD2 | MACRO domain containing 2 | -0.0474505 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0457776 |
| TXNRD1 | thioredoxin reductase 1 | -0.0456037 |
| BMP10 | bone morphogenetic protein 10 | -0.0455459 |
| DSTN | destrin (actin depolymerizing factor) | -0.0448724 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | -0.0448555 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0427755 |
| PFN1 | profilin 1 | -0.0427481 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0425374 |
| RPL34 | ribosomal protein L34 | -0.0409026 |
| POTEF | POTE ankyrin domain family, member F | -0.0406839 |
| RHOA | ras homolog family member A | -0.0404816 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0396826 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0369884 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0369788 |
| SOX6 | SRY (sex determining region Y)-box 6 | -0.0364886 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0360337 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0356879 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0355696 |
| S100A4 | S100 calcium binding protein A4 | -0.0342922 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0336809 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0335563 |
| RPLP1 | ribosomal protein, large, P1 | -0.0331307 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0331163 |
| TNFRSF11B | tumor necrosis factor receptor superfamily, member 11b | -0.0330543 |
| RPLP0 | ribosomal protein, large, P0 | -0.0329297 |
| PGK1 | phosphoglycerate kinase 1 | -0.0312702 |
| SMYD3 | SET and MYND domain containing 3 | -0.0309605 |
| DIAPH2 | diaphanous-related formin 2 | -0.0306652 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.030401 |
| RPL27A | ribosomal protein L27a | -0.0299463 |
| DGKH | diacylglycerol kinase, eta | -0.0296561 |
| FHIT | fragile histidine triad | -0.0296427 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0294075 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | -0.0290377 |
| ROCK1 | Rho-associated, coiled-coil containing protein kinase 1 | -0.0289101 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0285234 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0282645 |
| SEPTIN7 | septin 7 | -0.0276553 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0275313 |
| RAD51B | RAD51 paralog B | -0.027358 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0271812 |
| CDKAL1 | CDK5 regulatory subunit associated protein 1-like 1 | -0.0270467 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | -0.0269817 |
| CYB5B | cytochrome b5 type B (outer mitochondrial membrane) | -0.0268961 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.0268339 |
| PDE7B | phosphodiesterase 7B | -0.0266415 |
| BBS9 | Bardet-Biedl syndrome 9 | -0.0265478 |
| EXOC6B | exocyst complex component 6B | -0.0263318 |
| GLI3 | GLI family zinc finger 3 | -0.026221 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0257026 |
| EXOC4 | exocyst complex component 4 | -0.0254225 |
| DIAPH3 | diaphanous-related formin 3 | -0.0253238 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0252343 |
| TUBA1B | tubulin, alpha 1b | -0.025152 |
| SCAPER | S-phase cyclin A-associated protein in the ER | -0.0243753 |
| PIAS1 | protein inhibitor of activated STAT, 1 | -0.0239429 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0238815 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0238648 |
| CAMKMT | calmodulin-lysine N-methyltransferase | -0.0238469 |
| GOLM2 | golgi membrane protein 2 | -0.0237823 |
| FER | fer (fps/fes related) tyrosine kinase | -0.0237497 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0237356 |
| QKI | QKI, KH domain containing, RNA binding | -0.0236081 |
| HP1BP3 | heterochromatin protein 1, binding protein 3 | -0.0235894 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.023497 |
| FMN1 | formin 1 | -0.0233104 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.023219 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0227227 |
| CUX1 | cut-like homeobox 1 | -0.0224853 |
| MKI67 | marker of proliferation Ki-67 | -0.0219185 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | -0.0218611 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0216173 |
| DUSP6 | dual specificity phosphatase 6 | -0.0215221 |
| XPO1 | exportin 1 | -0.0213967 |
| LDHA | lactate dehydrogenase A | -0.0212123 |
| WAC | WW domain containing adaptor with coiled-coil | -0.0209944 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0206441 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0205689 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.020485 |
| PRUNE2 | prune homolog 2 (Drosophila) | -0.0203354 |
