| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Topotecan (hydrochloride) perturbation in SNU-423 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Topotecan (hydrochloride)_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NAMPT | nicotinamide phosphoribosyltransferase | 0.225258 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.126501 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.121572 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.116117 |
| NAV2 | neuron navigator 2 | 0.108456 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0802835 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0784308 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0731325 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0720475 |
| OGA | O-GlcNAcase | 0.0693672 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.0681582 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0676949 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0676582 |
| ZNF292 | zinc finger protein 292 | 0.0654579 |
| VEGFA | vascular endothelial growth factor A | 0.0651376 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0626341 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0618711 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.0610026 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0596721 |
| PDE10A | phosphodiesterase 10A | 0.0596515 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0580006 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0577534 |
| MYOF | myoferlin | 0.0566051 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0561106 |
| MKI67 | marker of proliferation Ki-67 | 0.0530202 |
| ARRDC3 | arrestin domain containing 3 | 0.0528865 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0523377 |
| ATP13A3 | ATPase type 13A3 | 0.0522691 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0507412 |
| GOLGA4 | golgin A4 | 0.0498784 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0487517 |
| PRELID2 | PRELI domain containing 2 | 0.0482368 |
| MSN | moesin | 0.0459415 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0451433 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0449417 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0445873 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0444843 |
| STC1 | stanniocalcin 1 | 0.0439947 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0438766 |
| FLOT1 | flotillin 1 | 0.0416754 |
| CENPF | centromere protein F, 350/400kDa | 0.0412358 |
| ANLN | anillin, actin binding protein | 0.0410366 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0410002 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0403003 |
| CEP250 | centrosomal protein 250kDa | 0.0398802 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0398133 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0397664 |
| SNX9 | sorting nexin 9 | 0.0389882 |
| NGLY1 | N-glycanase 1 | 0.0382957 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0378221 |
| SETD5 | SET domain containing 5 | 0.0377871 |
| CADM1 | cell adhesion molecule 1 | 0.0370326 |
| DUSP5 | dual specificity phosphatase 5 | 0.0367208 |
| XRN1 | 5'-3' exoribonuclease 1 | 0.0347702 |
| CDCP1 | CUB domain containing protein 1 | 0.0345307 |
| WDFY1 | WD repeat and FYVE domain containing 1 | 0.0342723 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0341687 |
| SPAG9 | sperm associated antigen 9 | 0.0335204 |
| ARFGEF3 | ARFGEF family member 3 | 0.0330705 |
| OPTN | optineurin | 0.0328922 |
| MMP12 | matrix metallopeptidase 12 | 0.0328259 |
| HELZ | helicase with zinc finger | 0.0328211 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0320184 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0310432 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0309084 |
| RAI1 | retinoic acid induced 1 | 0.0307978 |
| WDR26 | WD repeat domain 26 | 0.0303571 |
| KIF4A | kinesin family member 4A | 0.0302286 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0299783 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.0298655 |
| AFDN | afadin, adherens junction formation factor | 0.029851 |
| YEATS2 | YEATS domain containing 2 | 0.0298277 |
| COL8A1 | collagen, type VIII, alpha 1 | 0.0297722 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0296293 |
| SMAD3 | SMAD family member 3 | 0.0294806 |
| CDK19 | cyclin-dependent kinase 19 | 0.0292307 |
| XPO1 | exportin 1 | 0.0291719 |
| ADM | adrenomedullin | 0.0291428 |
| AMPD3 | adenosine monophosphate deaminase 3 | 0.0291143 |
| TXNIP | thioredoxin interacting protein | 0.0283588 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0282063 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0281891 |
| FLNB | filamin B, beta | 0.0280598 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0280438 |
| SDC4 | syndecan 4 | 0.0279964 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0278516 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0278473 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0273431 |
| SYAP1 | synapse associated protein 1 | 0.0271419 |
| FAM13A | family with sequence similarity 13, member A | 0.0271174 |
| H1-4 | H1.4 linker histone, cluster member | 0.0268384 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0266455 |
| LOXL2 | lysyl oxidase-like 2 | 0.0266159 |
| IGF2R | insulin-like growth factor 2 receptor | 0.0262792 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0260009 |
| CCNL1 | cyclin L1 | 0.0257978 |
| UBR2 | ubiquitin protein ligase E3 component n-recognin 2 | 0.0257536 |
| ABCA5 | ATP-binding cassette, sub-family A (ABC1), member 5 | 0.0257279 |
| RBM39 | RNA binding motif protein 39 | 0.0255562 |
| JMJD1C | jumonji domain containing 1C | 0.0255039 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.189251 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.179393 |
| FTL | ferritin, light polypeptide | -0.112746 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.105769 |
| GLIS3 | GLIS family zinc finger 3 | -0.105232 |
| TMSB10 | thymosin beta 10 | -0.101509 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0995237 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | -0.092269 |
| HMGA2 | high mobility group AT-hook 2 | -0.0821983 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0752447 |
| IER3 | immediate early response 3 | -0.0727007 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.071851 |
| VCL | vinculin | -0.0692086 |
| EGR1 | early growth response 1 | -0.0685396 |
| LDHA | lactate dehydrogenase A | -0.0614438 |
| CTSD | cathepsin D | -0.0601924 |
| HLA-A | major histocompatibility complex, class I, A | -0.0593655 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0585229 |
| RPL35A | ribosomal protein L35a | -0.0576758 |
| RPLP1 | ribosomal protein, large, P1 | -0.0536692 |
| RPLP0 | ribosomal protein, large, P0 | -0.0510513 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0508653 |
| BICC1 | BicC family RNA binding protein 1 | -0.0483842 |
| INTS6 | integrator complex subunit 6 | -0.0478698 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0461212 |
| RPS24 | ribosomal protein S24 | -0.0445328 |
| TAPBP | TAP binding protein (tapasin) | -0.0416118 |
| POTEF | POTE ankyrin domain family, member F | -0.0411003 |
| CDH13 | cadherin 13 | -0.0407107 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0404953 |
| RPS6 | ribosomal protein S6 | -0.0398823 |
| PALLD | palladin, cytoskeletal associated protein | -0.0377445 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0376185 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.036464 |
| NABP1 | nucleic acid binding protein 1 | -0.0360154 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0352851 |
| LOX | lysyl oxidase | -0.0350985 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0347902 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0340595 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0334155 |
| SFRP1 | secreted frizzled-related protein 1 | -0.0333878 |
| RAB7A | RAB7A, member RAS oncogene family | -0.032151 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0320002 |
| PKM | pyruvate kinase, muscle | -0.0317186 |
| HLA-B | major histocompatibility complex, class I, B | -0.0315983 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0315893 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0315887 |
| HMGA1 | high mobility group AT-hook 1 | -0.0310501 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0306669 |
| CD44 | CD44 molecule (Indian blood group) | -0.0305666 |
| COL5A1 | collagen, type V, alpha 1 | -0.0301066 |
| HLA-E | major histocompatibility complex, class I, E | -0.0299831 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.0296565 |
| ASTN2 | astrotactin 2 | -0.0294597 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0288006 |
| RPL27A | ribosomal protein L27a | -0.0287255 |
| SAMD3 | sterile alpha motif domain containing 3 | -0.0281091 |
| RPL28 | ribosomal protein L28 | -0.0278058 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0274689 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0270665 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0270142 |
| ACTG1 | actin gamma 1 | -0.0267724 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0267128 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | -0.026132 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0256725 |
| GPC6 | glypican 6 | -0.0256391 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | -0.0255413 |
| RPL39 | ribosomal protein L39 | -0.0254869 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0251131 |
| UBC | ubiquitin C | -0.0249683 |
| RACK1 | receptor for activated C kinase 1 | -0.0248593 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.0244799 |
| LGALS3BP | lectin, galactoside-binding, soluble, 3 binding protein | -0.0243889 |
| YBX1 | Y box binding protein 1 | -0.0243037 |
| CANX | calnexin | -0.0241547 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0240512 |
| TPM1 | tropomyosin 1 (alpha) | -0.0232148 |
| S100A9 | S100 calcium binding protein A9 | -0.0231266 |
| RPL12 | ribosomal protein L12 | -0.0223667 |
| RPL34 | ribosomal protein L34 | -0.0221103 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | -0.0220869 |
| ADAM12 | ADAM metallopeptidase domain 12 | -0.0218477 |
| MAP1B | microtubule-associated protein 1B | -0.0217615 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0216973 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0212907 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0209653 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0208678 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0208642 |
| RPS13 | ribosomal protein S13 | -0.0208318 |
| KRT19 | keratin 19, type I | -0.0208021 |
| RPS8 | ribosomal protein S8 | -0.0205644 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0204851 |
| SMAD2 | SMAD family member 2 | -0.0203335 |
| EFNA5 | ephrin-A5 | -0.0202854 |
| RPS14 | ribosomal protein S14 | -0.0199752 |
| DDIT3 | DNA-damage-inducible transcript 3 | -0.0198922 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0198543 |
| TRIM55 | tripartite motif containing 55 | -0.0194274 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0193504 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0193182 |
