| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Topotecan (hydrochloride) perturbation in SW 1088 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Topotecan (hydrochloride)_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.113164 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0832322 |
| B2M | beta-2-microglobulin | 0.0800052 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0742601 |
| PTN | pleiotrophin | 0.0687603 |
| MT2A | metallothionein 2A | 0.064494 |
| PTMA | prothymosin, alpha | 0.0593943 |
| STC1 | stanniocalcin 1 | 0.0569647 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0548514 |
| EGFR | epidermal growth factor receptor | 0.0547236 |
| SETD5 | SET domain containing 5 | 0.0541345 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0514088 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0495073 |
| GOLGB1 | golgin B1 | 0.0492249 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0477948 |
| PARD3 | par-3 family cell polarity regulator | 0.0468458 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | 0.046807 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.046751 |
| RNF145 | ring finger protein 145 | 0.0466017 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.044494 |
| PTGES2 | prostaglandin E synthase 2 | 0.0437118 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0433258 |
| SP3 | Sp3 transcription factor | 0.0419923 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | 0.0416178 |
| COPA | coatomer protein complex, subunit alpha | 0.0411189 |
| RPS5 | ribosomal protein S5 | 0.040764 |
| TPR | translocated promoter region, nuclear basket protein | 0.0398919 |
| FMNL2 | formin-like 2 | 0.0398416 |
| CYLD | cylindromatosis (turban tumor syndrome) | 0.0398109 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0382834 |
| IL6 | interleukin 6 | 0.0382647 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0379313 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0378306 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0376686 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0371954 |
| HLA-B | major histocompatibility complex, class I, B | 0.0369009 |
| IGFBP7 | insulin-like growth factor binding protein 7 | 0.0368907 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0368232 |
| MED13 | mediator complex subunit 13 | 0.0365831 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0359912 |
| KIF13A | kinesin family member 13A | 0.0354075 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.034737 |
| WDFY2 | WD repeat and FYVE domain containing 2 | 0.0347228 |
| TENT2 | terminal nucleotidyltransferase 2 | 0.0343794 |
| ITGB3BP | integrin beta 3 binding protein (beta3-endonexin) | 0.0334104 |
| TPM3 | tropomyosin 3 | 0.033329 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0332663 |
| MPZL1 | myelin protein zero-like 1 | 0.0331574 |
| MIER1 | mesoderm induction early response 1, transcriptional regulator | 0.0329067 |
| WDR43 | WD repeat domain 43 | 0.0321681 |
| RNF114 | ring finger protein 114 | 0.0320887 |
| PRPF4B | pre-mRNA processing factor 4B | 0.0316312 |
| PPP1R12B | protein phosphatase 1, regulatory subunit 12B | 0.031525 |
| ASXL1 | additional sex combs like transcriptional regulator 1 | 0.030976 |
| PTK2 | protein tyrosine kinase 2 | 0.0308607 |
| CHMP5 | charged multivesicular body protein 5 | 0.0306231 |
| TPM2 | tropomyosin 2 (beta) | 0.0305179 |
| RSRC1 | arginine/serine-rich coiled-coil 1 | 0.0303204 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | 0.0296527 |
| MDN1 | MDN1, midasin homolog (yeast) | 0.0295331 |
| MSN | moesin | 0.029533 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0293693 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0292091 |
| HEATR5B | HEAT repeat containing 5B | 0.0288511 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0288156 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.028804 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0287357 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.0285031 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | 0.0284957 |
| NBAS | neuroblastoma amplified sequence | 0.0282346 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0280628 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0278317 |
| OGA | O-GlcNAcase | 0.0275579 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.027356 |
| ARHGEF10 | Rho guanine nucleotide exchange factor (GEF) 10 | 0.0271762 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0270933 |
| ARRDC3 | arrestin domain containing 3 | 0.0268518 |
| HOOK3 | hook microtubule-tethering protein 3 | 0.0267775 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0264303 |
| SLMAP | sarcolemma associated protein | 0.026352 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.0262189 |
| IL1RAP | interleukin 1 receptor accessory protein | 0.0258165 |
| BTBD9 | BTB (POZ) domain containing 9 | 0.0257862 |
| SRBD1 | S1 RNA binding domain 1 | 0.0256518 |
| SUCLG2 | succinate-CoA ligase, GDP-forming, beta subunit | 0.0256098 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0255774 |
| SCAMP1 | secretory carrier membrane protein 1 | 0.0254596 |
| FGFR1 | fibroblast growth factor receptor 1 | 0.0254197 |
| PAPSS2 | 3'-phosphoadenosine 5'-phosphosulfate synthase 2 | 0.0253962 |
| FAM13A | family with sequence similarity 13, member A | 0.0253292 |
| RAI14 | retinoic acid induced 14 | 0.0251019 |
| PFKP | phosphofructokinase, platelet | 0.0249547 |
| RPS8 | ribosomal protein S8 | 0.0248901 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | 0.0248779 |
| ADAR | adenosine deaminase, RNA-specific | 0.0248195 |
| EFNA5 | ephrin-A5 | 0.0248039 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.0243597 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0242834 |
| ANXA1 | annexin A1 | 0.0242242 |
| VPS41 | vacuolar protein sorting 41 homolog (S. cerevisiae) | 0.024217 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.343238 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.204075 |
| VIM | vimentin | -0.147967 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.093967 |
| LDHA | lactate dehydrogenase A | -0.0873744 |
| TMSB10 | thymosin beta 10 | -0.082562 |
| NDRG1 | N-myc downstream regulated 1 | -0.0775885 |
| LOX | lysyl oxidase | -0.0707087 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0668871 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0640765 |
| WASF2 | WAS protein family, member 2 | -0.0634898 |
| MAP1B | microtubule-associated protein 1B | -0.0632153 |
| FTL | ferritin, light polypeptide | -0.0627641 |
| CALU | calumenin | -0.0599368 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0591479 |
| POTEF | POTE ankyrin domain family, member F | -0.0573617 |
| MEF2A | myocyte enhancer factor 2A | -0.0564586 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0549899 |
| COL1A1 | collagen, type I, alpha 1 | -0.0538316 |
| CCNI | cyclin I | -0.0538112 |
| ZNF292 | zinc finger protein 292 | -0.0531286 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0512648 |
| GLIS3 | GLIS family zinc finger 3 | -0.0478334 |
| S100A10 | S100 calcium binding protein A10 | -0.0475484 |
| NRXN3 | neurexin 3 | -0.0468259 |
| CADM1 | cell adhesion molecule 1 | -0.046578 |
| ANLN | anillin, actin binding protein | -0.0457973 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0452339 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0450843 |
| RRBP1 | ribosome binding protein 1 | -0.0441468 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0437201 |
| VCL | vinculin | -0.0435801 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0434332 |
| FAM162A | family with sequence similarity 162, member A | -0.0431591 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0428611 |
| CANX | calnexin | -0.0427263 |
| SEC24D | SEC24 family member D | -0.0424459 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0419539 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0413513 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | -0.0413439 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0412701 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0412041 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0403886 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0383685 |
| HIBADH | 3-hydroxyisobutyrate dehydrogenase | -0.0383536 |
| IFRD1 | interferon-related developmental regulator 1 | -0.0382392 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.037378 |
| CENPF | centromere protein F, 350/400kDa | -0.0372619 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.0369541 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0367811 |
| SLC16A1 | solute carrier family 16 (monocarboxylate transporter), member 1 | -0.0367113 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0361751 |
| UBC | ubiquitin C | -0.0360683 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0360648 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0358097 |
| NOP58 | NOP58 ribonucleoprotein | -0.0357208 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0356964 |
| RTN4 | reticulon 4 | -0.0356953 |
| SEPTIN7 | septin 7 | -0.0352812 |
| GLG1 | golgi glycoprotein 1 | -0.035243 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0351517 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0348452 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0347958 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.0345256 |
| PAIP2 | poly(A) binding protein interacting protein 2 | -0.0342131 |
| H3-3B | H3.3 histone B | -0.0341639 |
| ERBIN | erbb2 interacting protein | -0.033709 |
| RPLP0 | ribosomal protein, large, P0 | -0.033548 |
| PFN1 | profilin 1 | -0.0330066 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0329093 |
| SRRM2 | serine/arginine repetitive matrix 2 | -0.0329075 |
| ECE1 | endothelin converting enzyme 1 | -0.0323982 |
| BSG | basigin (Ok blood group) | -0.0323877 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0320587 |
| SEPTIN2 | septin 2 | -0.0317909 |
| ZFC3H1 | zinc finger, C3H1-type containing | -0.0313649 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0313459 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0313438 |
| RUNX1 | runt-related transcription factor 1 | -0.0313082 |
| RACK1 | receptor for activated C kinase 1 | -0.0310037 |
| CD99 | CD99 molecule | -0.0306624 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0305564 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0304688 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0304271 |
| ATP6V1A | ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A | -0.0303772 |
| BZW2 | basic leucine zipper and W2 domains 2 | -0.0301218 |
| CTSD | cathepsin D | -0.0295857 |
| CALD1 | caldesmon 1 | -0.0295258 |
| FUBP1 | far upstream element (FUSE) binding protein 1 | -0.0294513 |
| MAP3K13 | mitogen-activated protein kinase kinase kinase 13 | -0.029417 |
| RPL34 | ribosomal protein L34 | -0.0293665 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0293451 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | -0.0292428 |
| PALLD | palladin, cytoskeletal associated protein | -0.0290827 |
| SLC8A1 | solute carrier family 8 (sodium/calcium exchanger), member 1 | -0.0288298 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0285046 |
| RNF216 | ring finger protein 216 | -0.0281762 |
| TLN1 | talin 1 | -0.027879 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0278093 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0275691 |
