Topotecan (hydrochloride)_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Topotecan (hydrochloride) perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Topotecan (hydrochloride)_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SET SET nuclear proto-oncogene 0.0886777
ZNF292 zinc finger protein 292 0.0853213
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0728741
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0724509
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0715102
RBM25 RNA binding motif protein 25 0.0705115
EEF2 eukaryotic translation elongation factor 2 0.066654
WAC WW domain containing adaptor with coiled-coil 0.0637092
SETD5 SET domain containing 5 0.0623394
NUP58 nucleoporin 58 0.0600926
GOLGA4 golgin A4 0.0599055
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0580748
ANKRD12 ankyrin repeat domain 12 0.054374
RNF145 ring finger protein 145 0.0512171
FMNL2 formin-like 2 0.0497283
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0494178
PNISR PNN-interacting serine/arginine-rich protein 0.0485179
ZNF148 zinc finger protein 148 0.0472141
GIGYF2 GRB10 interacting GYF protein 2 0.046684
SEPTIN2 septin 2 0.0464966
CDCP1 CUB domain containing protein 1 0.045576
CHD1 chromodomain helicase DNA binding protein 1 0.0451964
RPS17 ribosomal protein S17 0.0451873
TRA2A transformer 2 alpha homolog (Drosophila) 0.045091
RPL35 ribosomal protein L35 0.0443979
CCNL1 cyclin L1 0.0438215
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0437825
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0431563
MRE11 MRE11 homolog, double strand break repair nuclease 0.0429292
CEP250 centrosomal protein 250kDa 0.042164
DGKD diacylglycerol kinase, delta 130kDa 0.0417902
MSN moesin 0.0417157
ATP13A3 ATPase type 13A3 0.0415442
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0409892
MBNL1 muscleblind-like splicing regulator 1 0.0409239
TXNIP thioredoxin interacting protein 0.0408844
CASC3 cancer susceptibility candidate 3 0.0405801
NKTR natural killer cell triggering receptor 0.0405104
ZNF638 zinc finger protein 638 0.0402023
CCDC88A coiled-coil domain containing 88A 0.0401753
PUM2 pumilio RNA-binding family member 2 0.0388766
GGNBP2 gametogenetin binding protein 2 0.0385576
ARRDC3 arrestin domain containing 3 0.0383529
PTK2 protein tyrosine kinase 2 0.0382671
TPM3 tropomyosin 3 0.0381953
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide 0.0375912
NAP1L1 nucleosome assembly protein 1-like 1 0.0373914
CNOT4 CCR4-NOT transcription complex, subunit 4 0.0372236
SEC23A Sec23 homolog A (S. cerevisiae) 0.0370512
UBE2K ubiquitin-conjugating enzyme E2K 0.0369238
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0361687
CSNK1G1 casein kinase 1, gamma 1 0.0360397
ITCH itchy E3 ubiquitin protein ligase 0.0357659
TFG TRK-fused gene 0.0356852
PIKFYVE phosphoinositide kinase, FYVE finger containing 0.0356401
DST dystonin 0.0355126
BAZ2A bromodomain adjacent to zinc finger domain, 2A 0.0351193
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0350644
TENT2 terminal nucleotidyltransferase 2 0.0347571
BRD2 bromodomain containing 2 0.0346799
RPL26 ribosomal protein L26 0.0346479
RAD23B RAD23 homolog B (S. cerevisiae) 0.0344555
PICALM phosphatidylinositol binding clathrin assembly protein 0.0338514
RBM5 RNA binding motif protein 5 0.0338494
TOP2B topoisomerase (DNA) II beta 180kDa 0.0338017
RAP1B RAP1B, member of RAS oncogene family 0.0331211
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56 0.0330704
SDC4 syndecan 4 0.0329892
UBE2B ubiquitin-conjugating enzyme E2B 0.0329402
CEP192 centrosomal protein 192kDa 0.0329194
ELP2 elongator acetyltransferase complex subunit 2 0.0329161
CNBP CCHC-type zinc finger, nucleic acid binding protein 0.0324723
HIPK1 homeodomain interacting protein kinase 1 0.0322314
GPBP1 GC-rich promoter binding protein 1 0.0321992
RTN4 reticulon 4 0.0320671
RAB6A RAB6A, member RAS oncogene family 0.0319039
YME1L1 YME1-like 1 ATPase 0.0318305
RPL37 ribosomal protein L37 0.0316472
RPS20 ribosomal protein S20 0.0315439
TPX2 TPX2, microtubule-associated 0.031299
RNMT RNA (guanine-7-) methyltransferase 0.031245
CNTRL centriolin 0.0311317
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0309061
UBA6 ubiquitin-like modifier activating enzyme 6 0.0306881
EIF4B eukaryotic translation initiation factor 4B 0.0306411
SPAG5 sperm associated antigen 5 0.0305866
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.0302226
LDHB lactate dehydrogenase B 0.0299605
EXOC5 exocyst complex component 5 0.0299603
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein 0.0299588
MATR3 matrin 3 0.0298541
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0297995
SFXN1 sideroflexin 1 0.0297762
PRPF8 pre-mRNA processing factor 8 0.0297535
RBM27 RNA binding motif protein 27 0.0296956
BAZ1B bromodomain adjacent to zinc finger domain, 1B 0.0295077
EIF1 eukaryotic translation initiation factor 1 0.0294371
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0294082
H1-4 H1.4 linker histone, cluster member 0.0293846
ARPP19 cAMP-regulated phosphoprotein, 19kDa 0.0292882

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.106192
MT2A metallothionein 2A -0.100787
HMGA2 high mobility group AT-hook 2 -0.0847763
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0790622
LOC112694756 uncharaterized LOC112694756 -0.0750659
EGR1 early growth response 1 -0.0713282
IER3 immediate early response 3 -0.0664599
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0631051
BBX bobby sox homolog (Drosophila) -0.0578138
VCL vinculin -0.056763
FNDC3B fibronectin type III domain containing 3B -0.0563388
TPT1 tumor protein, translationally-controlled 1 -0.0544222
LDHA lactate dehydrogenase A -0.0538298
IGF2 insulin-like growth factor 2 -0.0519507
NCOR1 nuclear receptor corepressor 1 -0.0515098
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.047727
DEK DEK proto-oncogene -0.0475793
POTEF POTE ankyrin domain family, member F -0.0460362
DPYD dihydropyrimidine dehydrogenase -0.0454103
INTS6 integrator complex subunit 6 -0.0434802
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0432327
ZFAND3 zinc finger, AN1-type domain 3 -0.0429883
ANXA2 annexin A2 -0.0420248
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.041531
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0414727
OASL 2'-5'-oligoadenylate synthetase-like -0.0413711
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0402787
HDAC9 histone deacetylase 9 -0.0401911
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0400168
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0398668
ARHGAP26 Rho GTPase activating protein 26 -0.0396641
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0389628
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0387973
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.038607
RSF1 remodeling and spacing factor 1 -0.0378132
MAPKAP1 mitogen-activated protein kinase associated protein 1 -0.0371696
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0371166
EPAS1 endothelial PAS domain protein 1 -0.0364679
FTL ferritin, light polypeptide -0.0356861
RERE arginine-glutamic acid dipeptide (RE) repeats -0.03568
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0349243
JMJD1C jumonji domain containing 1C -0.0348699
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0348065
CD44 CD44 molecule (Indian blood group) -0.0340482
MT1X metallothionein 1X -0.0338128
BIRC3 baculoviral IAP repeat containing 3 -0.0336738
SUN1 Sad1 and UNC84 domain containing 1 -0.0335248
GPC6 glypican 6 -0.0330821
COMMD10 COMM domain containing 10 -0.0329003
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.032864
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0328432
CCDC91 coiled-coil domain containing 91 -0.0327642
ARF1 ADP-ribosylation factor 1 -0.0323716
AFF4 AF4/FMR2 family, member 4 -0.0323204
TM4SF1 transmembrane 4 L six family member 1 -0.0320441
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) -0.0320242
FBXL17 F-box and leucine-rich repeat protein 17 -0.0318676
GNAQ guanine nucleotide binding protein (G protein), q polypeptide -0.0308115
RPL8 ribosomal protein L8 -0.0305752
PFN1 profilin 1 -0.0304709
C6ORF62 chromosome 6 open reading frame 62 -0.0297684
CDK13 cyclin-dependent kinase 13 -0.0293849
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0293174
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0292629
CLIC1 chloride intracellular channel 1 -0.0292597
ATF7IP activating transcription factor 7 interacting protein -0.0291853
RPL38 ribosomal protein L38 -0.0291203
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0289497
GPATCH2L G patch domain containing 2-like -0.0287252
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 -0.0287155
BMERB1 bMERB domain containing 1 -0.0283486
USP34 ubiquitin specific peptidase 34 -0.0282478
DOCK5 dedicator of cytokinesis 5 -0.0278424
EPC2 enhancer of polycomb homolog 2 (Drosophila) -0.0277522
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) -0.0275233
SETX senataxin -0.0273855
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0272846
DTNA dystrobrevin, alpha -0.0271909
ARL8B ADP-ribosylation factor-like 8B -0.0269095
AHNAK AHNAK nucleoprotein -0.0268319
TBCA tubulin folding cofactor A -0.0267375
NR1D2 nuclear receptor subfamily 1, group D, member 2 -0.0263842
PPP1R10 protein phosphatase 1, regulatory subunit 10 -0.0262821
VIM vimentin -0.0261488
RPS11 ribosomal protein S11 -0.0261291
CELF1 CUGBP, Elav-like family member 1 -0.0260853
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0260279
CANX calnexin -0.025971
NPC1 Niemann-Pick disease, type C1 -0.0259454
RPS24 ribosomal protein S24 -0.025827
CKS2 CDC28 protein kinase regulatory subunit 2 -0.0257386
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0256569
RPS19 ribosomal protein S19 -0.0254935
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0254725
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0254095
ZC3H12B zinc finger CCCH-type containing 12B -0.0251964
ARF4 ADP-ribosylation factor 4 -0.0251036
PURA purine-rich element binding protein A -0.0250927
H1-0 H1.0 linker histone -0.024902
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 -0.0248906