| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Topotecan (hydrochloride) perturbation in SW 900 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Topotecan (hydrochloride)_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.104682 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0813117 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0811144 |
| TPR | translocated promoter region, nuclear basket protein | 0.0691447 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0676783 |
| SMAD3 | SMAD family member 3 | 0.0601999 |
| OGA | O-GlcNAcase | 0.0571514 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.053211 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0530887 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0473745 |
| CALR | calreticulin | 0.0442502 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0405997 |
| APP | amyloid beta (A4) precursor protein | 0.039289 |
| ETV6 | ets variant 6 | 0.0392305 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0379247 |
| CSF2 | colony stimulating factor 2 (granulocyte-macrophage) | 0.0377015 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0370654 |
| ETNK1 | ethanolamine kinase 1 | 0.0364603 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0363639 |
| TENT2 | terminal nucleotidyltransferase 2 | 0.0362906 |
| DENND5B | DENN/MADD domain containing 5B | 0.0350468 |
| PELO | pelota homolog (Drosophila) | 0.0343502 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0338482 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | 0.0334967 |
| MKI67 | marker of proliferation Ki-67 | 0.0321529 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.032141 |
| OSMR | oncostatin M receptor | 0.031578 |
| CAB39 | calcium binding protein 39 | 0.0313577 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0312857 |
| AHR | aryl hydrocarbon receptor | 0.0312123 |
| PRPF8 | pre-mRNA processing factor 8 | 0.0309394 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0308869 |
| PIP5K1A | phosphatidylinositol-4-phosphate 5-kinase, type I, alpha | 0.0295735 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0295615 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0294668 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0293344 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.029223 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.0290462 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0289032 |
| SMOX | spermine oxidase | 0.0286187 |
| FLNA | filamin A, alpha | 0.0285113 |
| IRAK3 | interleukin-1 receptor-associated kinase 3 | 0.0283286 |
| TMSB4X | thymosin beta 4, X-linked | 0.0281512 |
| SNRNP200 | small nuclear ribonucleoprotein 200kDa (U5) | 0.0281053 |
| ZC3H11A | zinc finger CCCH-type containing 11A | 0.0280839 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0280815 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0278689 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0277375 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0275901 |
| FBXL5 | F-box and leucine-rich repeat protein 5 | 0.0274222 |
| MCTP2 | multiple C2 domains, transmembrane 2 | 0.027356 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0270132 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0269807 |
| RBM39 | RNA binding motif protein 39 | 0.0269237 |
| TPM3 | tropomyosin 3 | 0.0267864 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0264845 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0263242 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0262391 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0259943 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0257145 |
| SDC4 | syndecan 4 | 0.0255453 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0254309 |
| RBM25 | RNA binding motif protein 25 | 0.0254128 |
| CLTC | clathrin, heavy chain (Hc) | 0.0253626 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0250815 |
| TNFAIP2 | tumor necrosis factor, alpha-induced protein 2 | 0.0250506 |
| TIAL1 | TIA1 cytotoxic granule-associated RNA binding protein-like 1 | 0.0249321 |
| SUCO | SUN domain containing ossification factor | 0.0247786 |
| VEGFA | vascular endothelial growth factor A | 0.0245099 |
| MAP3K9 | mitogen-activated protein kinase kinase kinase 9 | 0.0242418 |
| PNN | pinin, desmosome associated protein | 0.024192 |
| POLR2B | polymerase (RNA) II (DNA directed) polypeptide B, 140kDa | 0.0240555 |
| FAT1 | FAT atypical cadherin 1 | 0.0238616 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0237625 |
| ZC3H12C | zinc finger CCCH-type containing 12C | 0.0233118 |
| RUNX2 | runt-related transcription factor 2 | 0.0232939 |
| PRPF3 | pre-mRNA processing factor 3 | 0.0232598 |
| ZNF841 | zinc finger protein 841 | 0.0232522 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0232126 |
| HELZ | helicase with zinc finger | 0.0231497 |
| LIFR | leukemia inhibitory factor receptor alpha | 0.0230834 |
| SFTPA2 | surfactant protein A2 | 0.0229185 |
| ADAR | adenosine deaminase, RNA-specific | 0.0227022 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0225317 |
| RANBP2 | RAN binding protein 2 | 0.0225302 |
| ZNF160 | zinc finger protein 160 | 0.0225027 |
| COG5 | component of oligomeric golgi complex 5 | 0.022288 |
| CD109 | CD109 molecule | 0.0218977 |
| PPP1R15B | protein phosphatase 1, regulatory subunit 15B | 0.0218519 |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | 0.0218358 |
| COPA | coatomer protein complex, subunit alpha | 0.0217652 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 0.0216631 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0214962 |
| ADD3 | adducin 3 (gamma) | 0.0214856 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | 0.0213394 |
| CLINT1 | clathrin interactor 1 | 0.0211252 |
| EYA1 | EYA transcriptional coactivator and phosphatase 1 | 0.021124 |
| PRELID2 | PRELI domain containing 2 | 0.0210583 |
| AFDN | afadin, adherens junction formation factor | 0.0208509 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0207443 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.381859 |
| NRG1 | neuregulin 1 | -0.196264 |
| FTL | ferritin, light polypeptide | -0.128318 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.1283 |
| TMSB10 | thymosin beta 10 | -0.101261 |
| HMGA2 | high mobility group AT-hook 2 | -0.0960715 |
| FN1 | fibronectin 1 | -0.0944548 |
| NDRG1 | N-myc downstream regulated 1 | -0.0913539 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0913119 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0873629 |
| ASPH | aspartate beta-hydroxylase | -0.0838391 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0830795 |
| VIM | vimentin | -0.0776876 |
| S100A6 | S100 calcium binding protein A6 | -0.0761153 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0728088 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0724654 |
| VCL | vinculin | -0.0655111 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0648411 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0630313 |
| PLIN2 | perilipin 2 | -0.0608161 |
| EGR1 | early growth response 1 | -0.0545786 |
| HMGA1 | high mobility group AT-hook 1 | -0.0544066 |
| S100A10 | S100 calcium binding protein A10 | -0.0536947 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.0528738 |
| MT2A | metallothionein 2A | -0.0521422 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0513735 |
| PTMA | prothymosin, alpha | -0.0478103 |
| ENO1 | enolase 1, (alpha) | -0.0451287 |
| SYT1 | synaptotagmin I | -0.0450819 |
| MAP1B | microtubule-associated protein 1B | -0.0422221 |
| RPL35A | ribosomal protein L35a | -0.0418759 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0413486 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -0.0405513 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0401413 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0400014 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.039905 |
| RPLP1 | ribosomal protein, large, P1 | -0.039729 |
| NTN4 | netrin 4 | -0.0388444 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | -0.0383131 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0379494 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0377498 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.037327 |
| IER3 | immediate early response 3 | -0.0372821 |
| LMNA | lamin A/C | -0.0364947 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0354429 |
| RAI14 | retinoic acid induced 14 | -0.0351966 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0339809 |
| DSTN | destrin (actin depolymerizing factor) | -0.0339338 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0337243 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0332586 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.032991 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0317915 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0317467 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0308012 |
| NRP1 | neuropilin 1 | -0.0307706 |
| FBXO11 | F-box protein 11 | -0.0302223 |
| STC2 | stanniocalcin 2 | -0.0301587 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0301373 |
| LDHA | lactate dehydrogenase A | -0.029676 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0292759 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0284029 |
| RPL34 | ribosomal protein L34 | -0.0283015 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0281925 |
| ACTG1 | actin gamma 1 | -0.028166 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0281443 |
| CTSD | cathepsin D | -0.0278107 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0273693 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0272257 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.026988 |
| SQSTM1 | sequestosome 1 | -0.0268914 |
| PALLD | palladin, cytoskeletal associated protein | -0.0268355 |
| INTS6 | integrator complex subunit 6 | -0.0267214 |
| TAGLN2 | transgelin 2 | -0.0264038 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0263309 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0262344 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0260154 |
| POTEF | POTE ankyrin domain family, member F | -0.0259144 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0257799 |
| TPI1 | triosephosphate isomerase 1 | -0.0256811 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0253746 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0251227 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0251146 |
| PFN1 | profilin 1 | -0.0248958 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0237612 |
| UBC | ubiquitin C | -0.0235969 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.023591 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0233936 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0232953 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0232141 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0226538 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0225716 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.022522 |
| TPM4 | tropomyosin 4 | -0.0225087 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0224821 |
| RPL28 | ribosomal protein L28 | -0.0217478 |
| MYADM | myeloid-associated differentiation marker | -0.0214826 |
| RASAL2 | RAS protein activator like 2 | -0.0214225 |
| S100A9 | S100 calcium binding protein A9 | -0.0210021 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0209833 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0209745 |
