| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Topotecan (hydrochloride) perturbation in SW1417 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Topotecan (hydrochloride)_SW1417 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| KRT8 | keratin 8, type II | 0.142633 |
| PTMA | prothymosin, alpha | 0.137181 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.106504 |
| TMSB4X | thymosin beta 4, X-linked | 0.103051 |
| SEMA3B | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B | 0.0920814 |
| KRT18 | keratin 18, type I | 0.0873799 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0866946 |
| PLEC | plectin | 0.0697888 |
| ACTN4 | actinin, alpha 4 | 0.0645375 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0612965 |
| SDC4 | syndecan 4 | 0.0609837 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0586974 |
| CCND1 | cyclin D1 | 0.0550535 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0505416 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0505351 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0490161 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0484659 |
| FLNA | filamin A, alpha | 0.047283 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | 0.0469167 |
| PRPF6 | pre-mRNA processing factor 6 | 0.0461497 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0461439 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0456567 |
| RPL13A | ribosomal protein L13a | 0.045268 |
| CALR | calreticulin | 0.0451304 |
| ACTG1 | actin gamma 1 | 0.0447022 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | 0.0442604 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0431644 |
| AHNAK | AHNAK nucleoprotein | 0.0423312 |
| HLA-A | major histocompatibility complex, class I, A | 0.0412769 |
| RPL7A | ribosomal protein L7a | 0.0407022 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | 0.0405715 |
| DDX39B | DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B | 0.0391889 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0390558 |
| KRT20 | keratin 20, type I | 0.0369267 |
| HLA-C | major histocompatibility complex, class I, C | 0.0366747 |
| TMSB10 | thymosin beta 10 | 0.036146 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0355342 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0353121 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0352106 |
| EWSR1 | EWS RNA-binding protein 1 | 0.0349159 |
| DIDO1 | death inducer-obliterator 1 | 0.0346432 |
| PLEKHA4 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 | 0.0344985 |
| ZNF841 | zinc finger protein 841 | 0.0343356 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0339858 |
| BCL2L1 | BCL2-like 1 | 0.0338098 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0333025 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0331553 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.032518 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | 0.0320163 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0318029 |
| MATR3 | matrin 3 | 0.0309468 |
| EIF3B | eukaryotic translation initiation factor 3, subunit B | 0.030662 |
| RRAS2 | related RAS viral (r-ras) oncogene homolog 2 | 0.0304647 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0296997 |
| HNRNPA3 | heterogeneous nuclear ribonucleoprotein A3 | 0.0290069 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0289291 |
| OGFR | opioid growth factor receptor | 0.0289162 |
| ADAR | adenosine deaminase, RNA-specific | 0.028608 |
| OGA | O-GlcNAcase | 0.0284592 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0280116 |
| SET | SET nuclear proto-oncogene | 0.0278278 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0273934 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0271431 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0270528 |
| SRSF11 | serine/arginine-rich splicing factor 11 | 0.0263792 |
| RBM5 | RNA binding motif protein 5 | 0.026263 |
| HLA-B | major histocompatibility complex, class I, B | 0.0262594 |
| B2M | beta-2-microglobulin | 0.0258841 |
| CPLX2 | complexin 2 | 0.025775 |
| HDAC9 | histone deacetylase 9 | 0.0254754 |
| SP3 | Sp3 transcription factor | 0.0254718 |
| ARGLU1 | arginine and glutamate rich 1 | 0.0253209 |
| MAPRE1 | microtubule-associated protein, RP/EB family, member 1 | 0.0251205 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0250987 |
| RPL37A | ribosomal protein L37a | 0.0250115 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0247337 |
| SERINC3 | serine incorporator 3 | 0.0246938 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0245347 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0245242 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.024506 |
| RPL4 | ribosomal protein L4 | 0.0244337 |
| CCDC14 | coiled-coil domain containing 14 | 0.0242735 |
| SNRNP200 | small nuclear ribonucleoprotein 200kDa (U5) | 0.0242461 |
| ZKSCAN1 | zinc finger with KRAB and SCAN domains 1 | 0.0237321 |
| HLA-E | major histocompatibility complex, class I, E | 0.0235973 |
| CEP95 | centrosomal protein 95kDa | 0.0234692 |
| ONECUT3 | one cut homeobox 3 | 0.0231527 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0230452 |
| CHMP4B | charged multivesicular body protein 4B | 0.0227518 |
| IST1 | increased sodium tolerance 1 homolog (yeast) | 0.0224838 |
| ZNF706 | zinc finger protein 706 | 0.0224514 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | 0.0224448 |
| VPS37B | vacuolar protein sorting 37 homolog B (S. cerevisiae) | 0.02242 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | 0.022267 |
| MAL2 | mal, T-cell differentiation protein 2 (gene/pseudogene) | 0.0221454 |
| VSNL1 | visinin-like 1 | 0.0220871 |
| LAMB3 | laminin, beta 3 | 0.0220603 |
| HOXB3 | homeobox B3 | 0.0220519 |
| SLC3A2 | solute carrier family 3 (amino acid transporter heavy chain), member 2 | 0.0220481 |
| SF3A1 | splicing factor 3a, subunit 1, 120kDa | 0.022033 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GOLGA4 | golgin A4 | -0.160891 |
| FTL | ferritin, light polypeptide | -0.148462 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.123957 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.109351 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.102395 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0976263 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0972269 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0959905 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.095864 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.0934171 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.0912817 |
| MED13L | mediator complex subunit 13-like | -0.0732838 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0665064 |
| NDRG1 | N-myc downstream regulated 1 | -0.0658888 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0644362 |
| EGR1 | early growth response 1 | -0.0588445 |
| BBX | bobby sox homolog (Drosophila) | -0.0572057 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0561925 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0542771 |
| MACC1 | metastasis associated in colon cancer 1 | -0.0534745 |
| RYBP | RING1 and YY1 binding protein | -0.0528292 |
| SBF2 | SET binding factor 2 | -0.0527804 |
| LDHA | lactate dehydrogenase A | -0.0524783 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0515591 |
| COG5 | component of oligomeric golgi complex 5 | -0.0515252 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0505571 |
| WWC1 | WW and C2 domain containing 1 | -0.0504478 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0501411 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0491951 |
| SPAG9 | sperm associated antigen 9 | -0.0490503 |
| VCL | vinculin | -0.0488945 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0484329 |
| FAT1 | FAT atypical cadherin 1 | -0.0475394 |
| IFRD1 | interferon-related developmental regulator 1 | -0.0470412 |
| NEBL | nebulette | -0.0466556 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | -0.0465721 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0464659 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | -0.0464548 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0461143 |
| GOLGB1 | golgin B1 | -0.0456915 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0452356 |
| EXOC4 | exocyst complex component 4 | -0.0451154 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0450694 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0448125 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0445748 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0443889 |
| YAP1 | Yes-associated protein 1 | -0.0440582 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0440268 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0438711 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0422618 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | -0.039393 |
| SETD5 | SET domain containing 5 | -0.0392363 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0379695 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0377302 |
| RAD51B | RAD51 paralog B | -0.0375676 |
| NF1 | neurofibromin 1 | -0.0375602 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.037435 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | -0.0373435 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0371147 |
| EZR | ezrin | -0.0367735 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.0365824 |
| ZNF292 | zinc finger protein 292 | -0.0358983 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0356169 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | -0.0356051 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | -0.0354398 |
| NFIA | nuclear factor I/A | -0.0344022 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0343678 |
| PCSK5 | proprotein convertase subtilisin/kexin type 5 | -0.0343126 |
| DIAPH2 | diaphanous-related formin 2 | -0.0339399 |
| SMYD3 | SET and MYND domain containing 3 | -0.0339317 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0338006 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0335502 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0334429 |
| USP34 | ubiquitin specific peptidase 34 | -0.0334324 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0334321 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0333729 |
| MYO1E | myosin IE | -0.0333079 |
| TXNRD1 | thioredoxin reductase 1 | -0.0332593 |
| STT3B | STT3B, subunit of the oligosaccharyltransferase complex (catalytic) | -0.0331195 |
| PARD3B | par-3 family cell polarity regulator beta | -0.0330937 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | -0.0328228 |
| MAP4 | microtubule-associated protein 4 | -0.0327674 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0325012 |
| CTDSPL | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like | -0.0320995 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0317986 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0315845 |
| EHBP1 | EH domain binding protein 1 | -0.0315491 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.031087 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0310203 |
| XPO1 | exportin 1 | -0.0307728 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0307251 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | -0.03056 |
| GPHN | gephyrin | -0.0303852 |
| OSBPL8 | oxysterol binding protein-like 8 | -0.0303704 |
| VTI1A | vesicle transport through interaction with t-SNAREs 1A | -0.0301977 |
| PCLO | piccolo presynaptic cytomatrix protein | -0.0300697 |
| PGK1 | phosphoglycerate kinase 1 | -0.0299644 |
| MSI2 | musashi RNA-binding protein 2 | -0.0295715 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0295008 |
| FHIT | fragile histidine triad | -0.0292839 |
