| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Topotecan (hydrochloride) perturbation in SW48 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Topotecan (hydrochloride)_SW48 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.157817 |
| PTMA | prothymosin, alpha | 0.152573 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.151203 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.11152 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0950641 |
| SEMA3B | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B | 0.0903687 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0860467 |
| RPL7A | ribosomal protein L7a | 0.0767774 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | 0.0704776 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0703963 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0690102 |
| WDR43 | WD repeat domain 43 | 0.0611204 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0578183 |
| IER3 | immediate early response 3 | 0.0568592 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0562324 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0552088 |
| ANXA2 | annexin A2 | 0.0547061 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0516971 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0516046 |
| RNF145 | ring finger protein 145 | 0.05135 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0505443 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0495089 |
| DSPP | dentin sialophosphoprotein | 0.0492617 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0491969 |
| WAC | WW domain containing adaptor with coiled-coil | 0.046759 |
| OXSR1 | oxidative stress responsive 1 | 0.046286 |
| CD36 | CD36 molecule (thrombospondin receptor) | 0.0462615 |
| GDF15 | growth differentiation factor 15 | 0.0451632 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0445762 |
| FMNL2 | formin-like 2 | 0.0445518 |
| RCOR1 | REST corepressor 1 | 0.0442351 |
| DIAPH1 | diaphanous-related formin 1 | 0.042535 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0423901 |
| DDB2 | damage-specific DNA binding protein 2, 48kDa | 0.0423247 |
| NEMF | nuclear export mediator factor | 0.0420911 |
| RPL37A | ribosomal protein L37a | 0.041382 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | 0.0408647 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0406069 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0396227 |
| RREB1 | ras responsive element binding protein 1 | 0.0395055 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.0392335 |
| RBM25 | RNA binding motif protein 25 | 0.0388557 |
| HLA-B | major histocompatibility complex, class I, B | 0.0380924 |
| RPL3 | ribosomal protein L3 | 0.037865 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0373463 |
| VEGFA | vascular endothelial growth factor A | 0.0373063 |
| CDC42BPB | CDC42 binding protein kinase beta (DMPK-like) | 0.0370761 |
| RPS3 | ribosomal protein S3 | 0.037042 |
| COL17A1 | collagen, type XVII, alpha 1 | 0.0358992 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.035869 |
| NUP58 | nucleoporin 58 | 0.0356624 |
| STRN3 | striatin, calmodulin binding protein 3 | 0.0356205 |
| EPHA2 | EPH receptor A2 | 0.0352823 |
| SERPINB5 | serpin peptidase inhibitor, clade B (ovalbumin), member 5 | 0.0350738 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0349444 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0348546 |
| CALR | calreticulin | 0.0343954 |
| OSBPL3 | oxysterol binding protein-like 3 | 0.0343351 |
| RPL19 | ribosomal protein L19 | 0.0342352 |
| RPS17 | ribosomal protein S17 | 0.033588 |
| DDX39B | DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B | 0.0331722 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0330615 |
| RPS19 | ribosomal protein S19 | 0.0328232 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0323979 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0314337 |
| RPL23 | ribosomal protein L23 | 0.0310736 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0309779 |
| RPS12 | ribosomal protein S12 | 0.0303536 |
| FOSL1 | FOS-like antigen 1 | 0.0300476 |
| SRSF11 | serine/arginine-rich splicing factor 11 | 0.0300272 |
| KCMF1 | potassium channel modulatory factor 1 | 0.0299469 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0295993 |
| COPB1 | coatomer protein complex, subunit beta 1 | 0.0292515 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0289968 |
| COPA | coatomer protein complex, subunit alpha | 0.0288637 |
| NFXL1 | nuclear transcription factor, X-box binding-like 1 | 0.0287481 |
| ANXA1 | annexin A1 | 0.0285946 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0284854 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0284469 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0281754 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0281046 |
| ELP2 | elongator acetyltransferase complex subunit 2 | 0.0280682 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0277791 |
| HDAC2 | histone deacetylase 2 | 0.0276148 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | 0.0273758 |
| PDLIM5 | PDZ and LIM domain 5 | 0.027282 |
| YBX1 | Y box binding protein 1 | 0.0271467 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.027136 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0269958 |
| GNAI1 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | 0.0269613 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0268739 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0268617 |
| CCNL1 | cyclin L1 | 0.0267918 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0266891 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0266842 |
| EIF3B | eukaryotic translation initiation factor 3, subunit B | 0.0265411 |
| CTBP2 | C-terminal binding protein 2 | 0.0262978 |
| PNN | pinin, desmosome associated protein | 0.0262047 |
| CYP51A1 | cytochrome P450, family 51, subfamily A, polypeptide 1 | 0.0260012 |
| DDX56 | DEAD (Asp-Glu-Ala-Asp) box helicase 56 | 0.0259666 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ATXN1 | ataxin 1 | -0.137868 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.133203 |
| HMGA2 | high mobility group AT-hook 2 | -0.125612 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0968914 |
| RAD51B | RAD51 paralog B | -0.0895935 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0887697 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.085444 |
| CCSER1 | coiled-coil serine-rich protein 1 | -0.0827363 |
| EGFR | epidermal growth factor receptor | -0.074216 |
| SMYD3 | SET and MYND domain containing 3 | -0.0657645 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0586063 |
| LAMC2 | laminin, gamma 2 | -0.0576283 |
| FHIT | fragile histidine triad | -0.0560953 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0546925 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | -0.053616 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0508328 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0491815 |
| RPLP1 | ribosomal protein, large, P1 | -0.0448965 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0434458 |
| SGPP2 | sphingosine-1-phosphate phosphatase 2 | -0.0431776 |
| VCL | vinculin | -0.0428627 |
| EXOC6B | exocyst complex component 6B | -0.0422901 |
| CD44 | CD44 molecule (Indian blood group) | -0.0421511 |
| EXOC4 | exocyst complex component 4 | -0.0412588 |
| FERMT1 | fermitin family member 1 | -0.0405555 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.039195 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0384087 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0381246 |
| HMGB2 | high mobility group box 2 | -0.0379552 |
| CENPF | centromere protein F, 350/400kDa | -0.0377379 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.037479 |
| NAV2 | neuron navigator 2 | -0.0374202 |
| LMO7 | LIM domain 7 | -0.0362376 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0353459 |
| ITPKC | inositol-trisphosphate 3-kinase C | -0.0352724 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0350744 |
| KLF6 | Kruppel-like factor 6 | -0.0341289 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0340362 |
| MTAP | methylthioadenosine phosphorylase | -0.0325163 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0324185 |
| RPLP0 | ribosomal protein, large, P0 | -0.0319233 |
| YAP1 | Yes-associated protein 1 | -0.031647 |
| ACTG1 | actin gamma 1 | -0.031534 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0306216 |
| GPHN | gephyrin | -0.03051 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0304923 |
| TENM3 | teneurin transmembrane protein 3 | -0.0303549 |
| DOCK1 | dedicator of cytokinesis 1 | -0.0293326 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0291839 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | -0.0289409 |
| RPL34 | ribosomal protein L34 | -0.0286222 |
| FBXL17 | F-box and leucine-rich repeat protein 17 | -0.0284345 |
| VTI1A | vesicle transport through interaction with t-SNAREs 1A | -0.028118 |
| CDK13 | cyclin-dependent kinase 13 | -0.0280982 |
| MPP2 | membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) | -0.0280769 |
| PRELID2 | PRELI domain containing 2 | -0.0279812 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0277319 |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase | -0.0277188 |
| ASPH | aspartate beta-hydroxylase | -0.0270765 |
| DST | dystonin | -0.026967 |
| TXNRD1 | thioredoxin reductase 1 | -0.0269524 |
| SLTM | SAFB-like, transcription modulator | -0.0268024 |
| ARHGAP42 | Rho GTPase activating protein 42 | -0.0265692 |
| TCF12 | transcription factor 12 | -0.0264748 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0262054 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0261778 |
| RSRC1 | arginine/serine-rich coiled-coil 1 | -0.0257075 |
| USP34 | ubiquitin specific peptidase 34 | -0.0254346 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0250821 |
| TUBB4B | tubulin, beta 4B class IVb | -0.0250731 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0250361 |
| PARD3B | par-3 family cell polarity regulator beta | -0.0249539 |
| FHL2 | four and a half LIM domains 2 | -0.0249163 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0245988 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0243812 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0241517 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | -0.0241038 |
| ARF1 | ADP-ribosylation factor 1 | -0.0240274 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.0237889 |
| UGDH | UDP-glucose 6-dehydrogenase | -0.0236387 |
| RPS24 | ribosomal protein S24 | -0.0235174 |
| SPATA13 | spermatogenesis associated 13 | -0.0234538 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | -0.0229514 |
| DIAPH2 | diaphanous-related formin 2 | -0.0229405 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0229003 |
| RPS21 | ribosomal protein S21 | -0.022792 |
| SGMS2 | sphingomyelin synthase 2 | -0.022623 |
| MAPK8 | mitogen-activated protein kinase 8 | -0.0226091 |
| DIAPH3 | diaphanous-related formin 3 | -0.0225437 |
| MKI67 | marker of proliferation Ki-67 | -0.0222615 |
| BBX | bobby sox homolog (Drosophila) | -0.0221757 |
| PKP4 | plakophilin 4 | -0.0218214 |
| LDHA | lactate dehydrogenase A | -0.0217637 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | -0.0216643 |
| ARL5B | ADP-ribosylation factor-like 5B | -0.0216479 |
| PDXK | pyridoxal (pyridoxine, vitamin B6) kinase | -0.0214916 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.0212957 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0212647 |
| FUS | FUS RNA binding protein | -0.0209861 |
| SCLT1 | sodium channel and clathrin linker 1 | -0.0208771 |
