| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Topotecan (hydrochloride) perturbation in SW480 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Topotecan (hydrochloride)_SW480 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.142992 |
| PDGFA | platelet-derived growth factor alpha polypeptide | 0.1281 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.124264 |
| PTMA | prothymosin, alpha | 0.112104 |
| ANLN | anillin, actin binding protein | 0.111859 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.109946 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.108439 |
| KRT8 | keratin 8, type II | 0.0992796 |
| KRT18 | keratin 18, type I | 0.092001 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0887939 |
| ITGA6 | integrin, alpha 6 | 0.0842829 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0820431 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.075197 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0684024 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0622449 |
| SET | SET nuclear proto-oncogene | 0.0606357 |
| ZNF292 | zinc finger protein 292 | 0.0599116 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0595358 |
| SETD5 | SET domain containing 5 | 0.0587169 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0576436 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0562734 |
| OGA | O-GlcNAcase | 0.0552038 |
| TMSB4X | thymosin beta 4, X-linked | 0.0521289 |
| ETNK1 | ethanolamine kinase 1 | 0.0519641 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0512914 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0507395 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0483975 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0481741 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0479245 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0478757 |
| FLNB | filamin B, beta | 0.0476921 |
| ABHD2 | abhydrolase domain containing 2 | 0.0472481 |
| SNX9 | sorting nexin 9 | 0.045844 |
| HELZ | helicase with zinc finger | 0.0450226 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0447588 |
| NUP58 | nucleoporin 58 | 0.0441068 |
| THOC2 | THO complex 2 | 0.0430918 |
| NAV2 | neuron navigator 2 | 0.0419898 |
| RBP1 | retinol binding protein 1, cellular | 0.0416256 |
| KIZ | kizuna centrosomal protein | 0.0410064 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0406107 |
| CEP95 | centrosomal protein 95kDa | 0.038987 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0379354 |
| FNIP1 | folliculin interacting protein 1 | 0.0376576 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0368619 |
| PLEC | plectin | 0.0363685 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0362469 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0360425 |
| INSIG2 | insulin induced gene 2 | 0.03604 |
| AFDN | afadin, adherens junction formation factor | 0.0359142 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0356276 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0353956 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0353476 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0351801 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.035077 |
| SPAG9 | sperm associated antigen 9 | 0.0347098 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0346972 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0345402 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0343885 |
| MSN | moesin | 0.0341113 |
| MKI67 | marker of proliferation Ki-67 | 0.0334658 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0332436 |
| HNRNPA3 | heterogeneous nuclear ribonucleoprotein A3 | 0.0331335 |
| CENPF | centromere protein F, 350/400kDa | 0.0328906 |
| NDRG1 | N-myc downstream regulated 1 | 0.0328766 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 0.0328551 |
| PDE8A | phosphodiesterase 8A | 0.0325174 |
| GOLGA4 | golgin A4 | 0.0324377 |
| HNRNPM | heterogeneous nuclear ribonucleoprotein M | 0.0324234 |
| PCBP2 | poly(rC) binding protein 2 | 0.0322826 |
| HSD17B12 | hydroxysteroid (17-beta) dehydrogenase 12 | 0.0322343 |
| NOP56 | NOP56 ribonucleoprotein | 0.0322302 |
| ZMYM2 | zinc finger, MYM-type 2 | 0.0322256 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0321952 |
| PGK1 | phosphoglycerate kinase 1 | 0.0321066 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0317477 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0313707 |
| TPX2 | TPX2, microtubule-associated | 0.0313397 |
| ZFC3H1 | zinc finger, C3H1-type containing | 0.0312511 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0310678 |
| ASPH | aspartate beta-hydroxylase | 0.0310394 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0310115 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0309992 |
| YEATS2 | YEATS domain containing 2 | 0.0308334 |
| CD46 | CD46 molecule, complement regulatory protein | 0.0308224 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0307405 |
| ARGLU1 | arginine and glutamate rich 1 | 0.0304865 |
| ARHGAP12 | Rho GTPase activating protein 12 | 0.0302009 |
| USP34 | ubiquitin specific peptidase 34 | 0.0300686 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.029875 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0288774 |
| RBM5 | RNA binding motif protein 5 | 0.028791 |
| TMEM41B | transmembrane protein 41B | 0.0287684 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | 0.028767 |
| SBF2 | SET binding factor 2 | 0.0287031 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0286578 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0281087 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0280929 |
| ZNF148 | zinc finger protein 148 | 0.0279677 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0276233 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.195809 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.185498 |
| SYT1 | synaptotagmin I | -0.131053 |
| RPLP1 | ribosomal protein, large, P1 | -0.0871877 |
| RPS6 | ribosomal protein S6 | -0.0829363 |
| EGR1 | early growth response 1 | -0.0823522 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0814206 |
| MT2A | metallothionein 2A | -0.0792848 |
| TNS3 | tensin 3 | -0.079143 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0727321 |
| RPLP2 | ribosomal protein, large, P2 | -0.0700908 |
| TMSB10 | thymosin beta 10 | -0.0604364 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0595723 |
| RPS19 | ribosomal protein S19 | -0.0586935 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0575627 |
| CDK6 | cyclin-dependent kinase 6 | -0.0564894 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0551348 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0532922 |
| INTS6 | integrator complex subunit 6 | -0.0526422 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0505224 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0499134 |
| RPS3 | ribosomal protein S3 | -0.0482046 |
| CDH13 | cadherin 13 | -0.0481286 |
| RPS13 | ribosomal protein S13 | -0.0470501 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0464355 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0462478 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0459792 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | -0.0447664 |
| RPL32 | ribosomal protein L32 | -0.0439654 |
| RPL31 | ribosomal protein L31 | -0.0426523 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0423403 |
| GRIK5 | glutamate receptor, ionotropic, kainate 5 | -0.041778 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0405985 |
| RPS23 | ribosomal protein S23 | -0.0401239 |
| LMO7 | LIM domain 7 | -0.0400697 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0396332 |
| RPL12 | ribosomal protein L12 | -0.0393822 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | -0.0387987 |
| RPL28 | ribosomal protein L28 | -0.0387787 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | -0.0385449 |
| DST | dystonin | -0.0377728 |
| VCL | vinculin | -0.0375238 |
| RPS29 | ribosomal protein S29 | -0.0372683 |
| WWOX | WW domain containing oxidoreductase | -0.0372355 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | -0.0370438 |
| MTAP | methylthioadenosine phosphorylase | -0.0362922 |
| RAD51B | RAD51 paralog B | -0.0356345 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.0356242 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0354737 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.035114 |
| HLCS | holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) | -0.0351065 |
| WNK1 | WNK lysine deficient protein kinase 1 | -0.0345553 |
| SMYD3 | SET and MYND domain containing 3 | -0.0340213 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | -0.0337538 |
| SPATA13 | spermatogenesis associated 13 | -0.0332308 |
| RPS16 | ribosomal protein S16 | -0.0320506 |
| RPL35A | ribosomal protein L35a | -0.0316699 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0315878 |
| RPL36 | ribosomal protein L36 | -0.0308204 |
| EHBP1 | EH domain binding protein 1 | -0.030578 |
| RPS24 | ribosomal protein S24 | -0.0305689 |
| YAP1 | Yes-associated protein 1 | -0.0305404 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0304807 |
| DNAH14 | dynein, axonemal, heavy chain 14 | -0.0300326 |
| BMP5 | bone morphogenetic protein 5 | -0.0298282 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | -0.0297646 |
| PCDH9 | protocadherin 9 | -0.0297382 |
| SERINC5 | serine incorporator 5 | -0.0295231 |
| MYO1E | myosin IE | -0.0294151 |
| RPL7 | ribosomal protein L7 | -0.0293725 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0290024 |
| ENO1 | enolase 1, (alpha) | -0.028985 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | -0.0287091 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0287076 |
| RPL27A | ribosomal protein L27a | -0.028514 |
| FOXP1 | forkhead box P1 | -0.0283578 |
| RACK1 | receptor for activated C kinase 1 | -0.028351 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | -0.0280662 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | -0.0273789 |
| TMEM123 | transmembrane protein 123 | -0.0268922 |
| RPL34 | ribosomal protein L34 | -0.0265667 |
| EMP1 | epithelial membrane protein 1 | -0.026072 |
| BCL2L1 | BCL2-like 1 | -0.0259856 |
| SKAP1 | src kinase associated phosphoprotein 1 | -0.0259511 |
| GPHN | gephyrin | -0.0251755 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0251121 |
| RPS2 | ribosomal protein S2 | -0.0250117 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0247813 |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog | -0.0246368 |
| RPS27 | ribosomal protein S27 | -0.0244474 |
| ETV6 | ets variant 6 | -0.0243548 |
| EXOC4 | exocyst complex component 4 | -0.0241821 |
| RPL38 | ribosomal protein L38 | -0.0237558 |
| HS3ST5 | heparan sulfate (glucosamine) 3-O-sulfotransferase 5 | -0.0236066 |
| FRAS1 | Fraser extracellular matrix complex subunit 1 | -0.0233591 |
| ARL15 | ADP-ribosylation factor-like 15 | -0.0233421 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0231257 |
| RPLP0 | ribosomal protein, large, P0 | -0.0230745 |
| TMEM163 | transmembrane protein 163 | -0.0229608 |
| PKP4 | plakophilin 4 | -0.0227915 |
