| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Topotecan (hydrochloride) perturbation in hTERT-HPNE cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Topotecan (hydrochloride)_hTERT-HPNE drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| STC1 | stanniocalcin 1 | 0.301947 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.138202 |
| FAM13A | family with sequence similarity 13, member A | 0.135736 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.106041 |
| ATP13A3 | ATPase type 13A3 | 0.105618 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.10515 |
| INHBA | inhibin, beta A | 0.0971105 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0944378 |
| ARHGAP21 | Rho GTPase activating protein 21 | 0.0889341 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0885031 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0804564 |
| GOLGA4 | golgin A4 | 0.0776867 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0717314 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0709554 |
| SPAG9 | sperm associated antigen 9 | 0.0687958 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0686617 |
| OGA | O-GlcNAcase | 0.0630827 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0619253 |
| MEIS1 | Meis homeobox 1 | 0.056032 |
| FNDC3B | fibronectin type III domain containing 3B | 0.05576 |
| DST | dystonin | 0.0539035 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0536039 |
| ADM | adrenomedullin | 0.0512692 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0511929 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0508438 |
| SETD5 | SET domain containing 5 | 0.0507803 |
| FMNL2 | formin-like 2 | 0.0496534 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | 0.0486989 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0478765 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0466585 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0462622 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0459164 |
| NGLY1 | N-glycanase 1 | 0.0456841 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0441865 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0439769 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0437943 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.043612 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0434148 |
| MMP1 | matrix metallopeptidase 1 | 0.042958 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0427561 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0422879 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0420936 |
| TMF1 | TATA element modulatory factor 1 | 0.0413894 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0412343 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0410599 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0404914 |
| TNPO1 | transportin 1 | 0.0404671 |
| RNF145 | ring finger protein 145 | 0.0402775 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0400521 |
| ZNF292 | zinc finger protein 292 | 0.0397674 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | 0.0396968 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0387008 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0386028 |
| SRP54 | signal recognition particle 54kDa | 0.0385601 |
| CANX | calnexin | 0.0384398 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0376747 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | 0.0371367 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0370863 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0370794 |
| NDRG1 | N-myc downstream regulated 1 | 0.0370457 |
| HELZ | helicase with zinc finger | 0.0359182 |
| ENO1 | enolase 1, (alpha) | 0.0356632 |
| COL4A1 | collagen, type IV, alpha 1 | 0.0354561 |
| RND3 | Rho family GTPase 3 | 0.0351914 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0341299 |
| MMP12 | matrix metallopeptidase 12 | 0.0340931 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0340867 |
| AFF3 | AF4/FMR2 family, member 3 | 0.0337549 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0334402 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0331807 |
| ANXA5 | annexin A5 | 0.0327587 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0324415 |
| FNIP1 | folliculin interacting protein 1 | 0.0324392 |
| RAB8B | RAB8B, member RAS oncogene family | 0.0321471 |
| APOLD1 | apolipoprotein L domain containing 1 | 0.0315616 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0312611 |
| CLINT1 | clathrin interactor 1 | 0.0311159 |
| FGFR1 | fibroblast growth factor receptor 1 | 0.0310078 |
| AHNAK | AHNAK nucleoprotein | 0.0309066 |
| USP3 | ubiquitin specific peptidase 3 | 0.0308896 |
| YBX3 | Y box binding protein 3 | 0.0307944 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0305698 |
| LCORL | ligand dependent nuclear receptor corepressor-like | 0.0305515 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0302676 |
| AMPD3 | adenosine monophosphate deaminase 3 | 0.0301213 |
| LMAN1 | lectin, mannose-binding, 1 | 0.0297726 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0296504 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0295078 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | 0.029459 |
| DSPP | dentin sialophosphoprotein | 0.0292854 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.0290125 |
| SQSTM1 | sequestosome 1 | 0.0287884 |
| RASA2 | RAS p21 protein activator 2 | 0.0287349 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | 0.0283765 |
| COPA | coatomer protein complex, subunit alpha | 0.0283475 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0282064 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | 0.0282041 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0281383 |
| ELP2 | elongator acetyltransferase complex subunit 2 | 0.0280656 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | 0.0279024 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.199617 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.155912 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.109177 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.102234 |
| TMSB10 | thymosin beta 10 | -0.080566 |
| COL6A3 | collagen, type VI, alpha 3 | -0.0733841 |
| FTL | ferritin, light polypeptide | -0.0687959 |
| CD44 | CD44 molecule (Indian blood group) | -0.0683588 |
| HMGA2 | high mobility group AT-hook 2 | -0.0528025 |
| MT2A | metallothionein 2A | -0.0521513 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0515615 |
| RPL35A | ribosomal protein L35a | -0.0465311 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0431962 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0374252 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0369986 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0362812 |
| EGR1 | early growth response 1 | -0.0345813 |
| ACTG1 | actin gamma 1 | -0.0340593 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0339842 |
| POTEF | POTE ankyrin domain family, member F | -0.0326851 |
| RPLP1 | ribosomal protein, large, P1 | -0.0316501 |
| HLA-B | major histocompatibility complex, class I, B | -0.0312327 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0309639 |
| MYO10 | myosin X | -0.0296086 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0271731 |
| NAV1 | neuron navigator 1 | -0.0269504 |
| CCND1 | cyclin D1 | -0.0267306 |
| COL1A1 | collagen, type I, alpha 1 | -0.0257129 |
| PRKG1 | protein kinase, cGMP-dependent, type I | -0.0255182 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0238709 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.0235 |
| B2M | beta-2-microglobulin | -0.0231026 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0220571 |
| PFN1 | profilin 1 | -0.0218185 |
| FBN1 | fibrillin 1 | -0.0217582 |
| MAP1B | microtubule-associated protein 1B | -0.0215717 |
| SLIT2 | slit homolog 2 (Drosophila) | -0.0212474 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0210926 |
| EMP1 | epithelial membrane protein 1 | -0.0208253 |
| PLPP3 | phospholipid phosphatase 3 | -0.0207999 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0207453 |
| RPL13A | ribosomal protein L13a | -0.0206946 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.0204453 |
| FUS | FUS RNA binding protein | -0.0197948 |
| CYB5R3 | cytochrome b5 reductase 3 | -0.0197873 |
| ASPH | aspartate beta-hydroxylase | -0.019596 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.019383 |
| VCL | vinculin | -0.019105 |
| FLNA | filamin A, alpha | -0.0184451 |
| ITGA11 | integrin, alpha 11 | -0.0183539 |
| OXR1 | oxidation resistance 1 | -0.0181595 |
| PKM | pyruvate kinase, muscle | -0.0181504 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0179891 |
| COTL1 | coactosin-like F-actin binding protein 1 | -0.0177408 |
| RPS19 | ribosomal protein S19 | -0.0175621 |
| GLIS3 | GLIS family zinc finger 3 | -0.0175462 |
| NRP1 | neuropilin 1 | -0.0171251 |
| HMGA1 | high mobility group AT-hook 1 | -0.0169889 |
| CTSB | cathepsin B | -0.016753 |
| IGF2 | insulin-like growth factor 2 | -0.0165288 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | -0.015889 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0158739 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0154167 |
| RFX8 | RFX family member 8, lacking RFX DNA binding domain | -0.0151254 |
| RPLP0 | ribosomal protein, large, P0 | -0.0150557 |
| BSG | basigin (Ok blood group) | -0.0148176 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0147138 |
| TAPBP | TAP binding protein (tapasin) | -0.0145426 |
| CST3 | cystatin C | -0.01408 |
| ADAMTS12 | ADAM metallopeptidase with thrombospondin type 1 motif, 12 | -0.0140778 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0140357 |
| CBX3 | chromobox homolog 3 | -0.0137881 |
| BRD2 | bromodomain containing 2 | -0.0137631 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0137146 |
| RCC1 | regulator of chromosome condensation 1 | -0.0135783 |
| GRIK5 | glutamate receptor, ionotropic, kainate 5 | -0.0133349 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0130999 |
| ACTN4 | actinin, alpha 4 | -0.0130851 |
| ATP6V0C | ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c | -0.0130823 |
| RPS16 | ribosomal protein S16 | -0.0130334 |
| SH3BGRL3 | SH3 domain binding glutamate-rich protein like 3 | -0.0129652 |
| PCF11 | PCF11 cleavage and polyadenylation factor subunit | -0.0128134 |
| TUBB4B | tubulin, beta 4B class IVb | -0.0128086 |
| S100A6 | S100 calcium binding protein A6 | -0.0127967 |
| CLIC4 | chloride intracellular channel 4 | -0.0127707 |
| CLMP | CXADR-like membrane protein | -0.0126673 |
| PDGFRB | platelet-derived growth factor receptor, beta polypeptide | -0.0126514 |
| JAG1 | jagged 1 | -0.0126142 |
| DGKI | diacylglycerol kinase, iota | -0.012561 |
| RPL8 | ribosomal protein L8 | -0.0124909 |
| CCT6A | chaperonin containing TCP1, subunit 6A (zeta 1) | -0.0124518 |
| FGF5 | fibroblast growth factor 5 | -0.0124193 |
| HLA-C | major histocompatibility complex, class I, C | -0.0123972 |
| MTCH1 | mitochondrial carrier 1 | -0.0123691 |
| SPRY4 | sprouty homolog 4 (Drosophila) | -0.0122931 |
| EGFR | epidermal growth factor receptor | -0.0122502 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0121478 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0121076 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0120366 |
| KIAA1549L | KIAA1549-like | -0.0118895 |
