Topotecan Gene Set

Dataset CTD Gene-Chemical Interactions
Category physical interactions
Type chemical
Description A pyranoindolizinoquinoline used as an antineoplastic agent. It is a derivative of camptothecin and works by binding to the topoisomerase I-DNA complex and preventing religation of these 328 single strand breaks. (Chemical Entities of Biological Interest Ontology, CHEBI_63632)
External Link http://ctdbase.org/detail.go?type=chem&acc=D019772
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Genes

244 genes/proteins interacting with the chemical Topotecan from the curated CTD Gene-Chemical Interactions dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACAT2 acetyl-CoA acetyltransferase 2
ACSL3 acyl-CoA synthetase long-chain family member 3
ACTG2 actin, gamma 2, smooth muscle, enteric
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADD3 adducin 3 (gamma)
AIM1 absent in melanoma 1
AKT3 v-akt murine thymoma viral oncogene homolog 3
ALAD aminolevulinate dehydratase
ANKRD10 ankyrin repeat domain 10
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
AOX1 aldehyde oxidase 1
AP5M1 adaptor-related protein complex 5, mu 1 subunit
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C
ARGLU1 arginine and glutamate rich 1
ASS1 argininosuccinate synthase 1
AUTS2 autism susceptibility candidate 2
BCKDHA branched chain keto acid dehydrogenase E1, alpha polypeptide
BCL2L1 BCL2-like 1
BID BH3 interacting domain death agonist
BIRC2 baculoviral IAP repeat containing 2
BIRC5 baculoviral IAP repeat containing 5
BOP1 block of proliferation 1
BORA bora, aurora kinase A activator
C11ORF49 chromosome 11 open reading frame 49
CABYR calcium binding tyrosine-(Y)-phosphorylation regulated
CAMK1 calcium/calmodulin-dependent protein kinase I
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2
CASP2 caspase 2, apoptosis-related cysteine peptidase
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP6 caspase 6, apoptosis-related cysteine peptidase
CASP7 caspase 7, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CAT catalase
CCNB2 cyclin B2
CCNE1 cyclin E1
CCNF cyclin F
CCNG2 cyclin G2
CD24 CD24 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CENPU centromere protein U
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CKAP2 cytoskeleton associated protein 2
CLCN3 chloride channel, voltage-sensitive 3
COL6A1 collagen, type VI, alpha 1
COL6A2 collagen, type VI, alpha 2
COX17 COX17 cytochrome c oxidase copper chaperone
CSF2RA colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)
CSTF2T cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTSL cathepsin L
CUL4A cullin 4A
CYB5A cytochrome b5 type A (microsomal)
DDIT4 DNA-damage-inducible transcript 4
DKK3 dickkopf WNT signaling pathway inhibitor 3
DLC1 DLC1 Rho GTPase activating protein
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha)
DSE dermatan sulfate epimerase
DSP desmoplakin
DUSP3 dual specificity phosphatase 3
DZIP1 DAZ interacting zinc finger protein 1
EGFR epidermal growth factor receptor
EIF5A eukaryotic translation initiation factor 5A
ELL3 elongation factor RNA polymerase II-like 3
ENOPH1 enolase-phosphatase 1
EPCAM epithelial cell adhesion molecule
ERBB3 erb-b2 receptor tyrosine kinase 3
ESRP1 epithelial splicing regulatory protein 1
EVA1B eva-1 homolog B (C. elegans)
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FAM111A family with sequence similarity 111, member A
FAM129A family with sequence similarity 129, member A
FAM171A1 family with sequence similarity 171, member A1
FANCI Fanconi anemia, complementation group I
FANCL Fanconi anemia, complementation group L
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FGD1 FYVE, RhoGEF and PH domain containing 1
FGF2 fibroblast growth factor 2 (basic)
FHL1 four and a half LIM domains 1
FIG4 FIG4 phosphoinositide 5-phosphatase
FJX1 four jointed box 1 (Drosophila)
FLNC filamin C, gamma
FOXD1 forkhead box D1
FRMD4A FERM domain containing 4A
FTH1 ferritin, heavy polypeptide 1
FUCA1 fucosidase, alpha-L- 1, tissue
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GCA grancalcin, EF-hand calcium binding protein
GCH1 GTP cyclohydrolase 1
GJA1 gap junction protein, alpha 1, 43kDa
GMDS GDP-mannose 4,6-dehydratase
GPSM2 G-protein signaling modulator 2
GSPT2 G1 to S phase transition 2
GTF2I general transcription factor IIi
H2AFV H2A histone family, member V
H2AFX H2A histone family, member X
HADH hydroxyacyl-CoA dehydrogenase
HDAC9 histone deacetylase 9
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HMGA1 high mobility group AT-hook 1
HMGA2 high mobility group AT-hook 2
HMGB1 high mobility group box 1
HMGB2 high mobility group box 2
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMGN3 high mobility group nucleosomal binding domain 3
HN1L hematological and neurological expressed 1-like
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like
HOXB2 homeobox B2
HSPA2 heat shock 70kDa protein 2
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IGFBP3 insulin-like growth factor binding protein 3
IGFBP7 insulin-like growth factor binding protein 7
IL1RAPL1 interleukin 1 receptor accessory protein-like 1
INHBA inhibin, beta A
INSIG1 insulin induced gene 1
ISG15 ISG15 ubiquitin-like modifier
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
JUN jun proto-oncogene
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KCTD3 potassium channel tetramerization domain containing 3
KRT19 keratin 19, type I
LAMC1 laminin, gamma 1 (formerly LAMB2)
LARP6 La ribonucleoprotein domain family, member 6
LEPR leptin receptor
LIMK2 LIM domain kinase 2
LIN7C lin-7 homolog C (C. elegans)
LOXL2 lysyl oxidase-like 2
LTBP2 latent transforming growth factor beta binding protein 2
MACF1 microtubule-actin crosslinking factor 1
MAGED1 melanoma antigen family D1
MBD4 methyl-CpG binding domain protein 4
MBP myelin basic protein
MCTP2 multiple C2 domains, transmembrane 2
MEST mesoderm specific transcript
MKNK2 MAP kinase interacting serine/threonine kinase 2
MMP1 matrix metallopeptidase 1
MOK MOK protein kinase
MPZL2 myelin protein zero-like 2
MRPL57 mitochondrial ribosomal protein L57
MSMO1 methylsterol monooxygenase 1
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MTUS1 microtubule associated tumor suppressor 1
MYO1D myosin ID
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1)
NCAPH non-SMC condensin I complex, subunit H
NMT2 N-myristoyltransferase 2
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae)
NRIP3 nuclear receptor interacting protein 3
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
NUDT4 nudix (nucleoside diphosphate linked moiety X)-type motif 4
OPTN optineurin
PCNA proliferating cell nuclear antigen
PDE8A phosphodiesterase 8A
PDGFC platelet derived growth factor C
PIN4 peptidylprolyl cis/trans isomerase, NIMA-interacting 4
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PNMAL1 paraneoplastic Ma antigen family-like 1
PTPRK protein tyrosine phosphatase, receptor type, K
PTRF polymerase I and transcript release factor
PTX3 pentraxin 3, long
QKI QKI, KH domain containing, RNA binding
RAB13 RAB13, member RAS oncogene family
RAB20 RAB20, member RAS oncogene family
RAB29 RAB29, member RAS oncogene family
RAI14 retinoic acid induced 14
RANBP1 RAN binding protein 1
RDX radixin
RFTN1 raftlin, lipid raft linker 1
RGS20 regulator of G-protein signaling 20
RIPK2 receptor-interacting serine-threonine kinase 2
RNF219 ring finger protein 219
RPA1 replication protein A1, 70kDa
SAP18 Sin3A-associated protein, 18kDa
SAR1A secretion associated, Ras related GTPase 1A
SATB1 SATB homeobox 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCRN1 secernin 1
SEC14L1 SEC14-like 1 (S. cerevisiae)
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFRP1 secreted frizzled-related protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC35G2 solute carrier family 35, member G2
SLC38A6 solute carrier family 38, member 6
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SNRPA1 small nuclear ribonucleoprotein polypeptide A'
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPAG9 sperm associated antigen 9
SPP1 secreted phosphoprotein 1
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
SRGN serglycin
SRI sorcin
ST7 suppression of tumorigenicity 7
STC1 stanniocalcin 1
SUV420H1 suppressor of variegation 4-20 homolog 1 (Drosophila)
TBC1D4 TBC1 domain family, member 4
TCF3 transcription factor 3
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TGM2 transglutaminase 2
TIA1 TIA1 cytotoxic granule-associated RNA binding protein
TMC6 transmembrane channel-like 6
TMEM80 transmembrane protein 80
TMEM97 transmembrane protein 97
TNFAIP8 tumor necrosis factor, alpha-induced protein 8
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy
TOP1 topoisomerase (DNA) I
TP53 tumor protein p53
TPK1 thiamin pyrophosphokinase 1
TPM1 tropomyosin 1 (alpha)
TREX1 three prime repair exonuclease 1
TRIM2 tripartite motif containing 2
TRPC1 transient receptor potential cation channel, subfamily C, member 1
TSPAN13 tetraspanin 13
TSPAN8 tetraspanin 8
TST thiosulfate sulfurtransferase (rhodanese)
TUBB6 tubulin, beta 6 class V
TUBGCP3 tubulin, gamma complex associated protein 3
TXNIP thioredoxin interacting protein
UBA1 ubiquitin-like modifier activating enzyme 1
UBE2I ubiquitin-conjugating enzyme E2I
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
ULK2 unc-51 like autophagy activating kinase 2
UNG uracil-DNA glycosylase
URI1 URI1, prefoldin-like chaperone
VCAN versican
VEGFA vascular endothelial growth factor A
VIM vimentin
WEE1 WEE1 G2 checkpoint kinase
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
XIST X inactive specific transcript (non-protein coding)
ZBED5 zinc finger, BED-type containing 5
ZEB1 zinc finger E-box binding homeobox 1
ZNF710 zinc finger protein 710