Topotecan Gene Set

Dataset DrugBank Drug Targets
Category physical interactions
Type drug
Description A pyranoindolizinoquinoline used as an antineoplastic agent. It is a derivative of camptothecin and works by binding to the topoisomerase I-DNA complex and preventing religation of these 328 single strand breaks. (Chemical Entities of Biological Interest Ontology, CHEBI_63632)
External Link http://www.drugbank.ca/drugs/DB01030
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Genes

3 interacting proteins for the Topotecan drug from the curated DrugBank Drug Targets dataset.

Symbol Name
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
TOP1 topoisomerase (DNA) I
TOP1MT topoisomerase (DNA) I, mitochondrial