Topotecan Gene Set

Dataset HMDB Metabolites of Enzymes
Category physical interactions
Type metabolite
Description A pyranoindolizinoquinoline used as an antineoplastic agent. It is a derivative of camptothecin and works by binding to the topoisomerase I-DNA complex and preventing religation of these 328 single strand breaks. (Chemical Entities of Biological Interest Ontology, CHEBI_63632)
External Link http://www.hmdb.ca/metabolites/HMDB15164
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Genes

4 interacting proteins for the Topotecan metabolite from the curated HMDB Metabolites of Enzymes dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
TOP1MT topoisomerase (DNA) I, mitochondrial