| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| Description | An N-sulfonylurea obtained by formal condensation of [(3-methylphenyl)amino]pyridine-3-sulfonic acid with the free amino group of N-isopropylurea. (Chemical Entities of Biological Interest Ontology, CHEBI_9637) |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/41781 |
| Similar Terms | |
| Downloads & Tools |
199 proteins with high or low expression in Torasemide relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PPP1R12B | protein phosphatase 1, regulatory subunit 12B | 1.18 |
| CCDC158 | coiled-coil domain containing 158 | 1.02 |
| ZNF92 | zinc finger protein 92 | 0.68 |
| RPS25 | ribosomal protein S25 | 0.53 |
| ZMYND11 | zinc finger, MYND-type containing 11 | 0.52 |
| MIGA2 | mitoguardin 2 | 0.48 |
| MAGEA12 | melanoma antigen family A12 | 0.47 |
| ZNF431 | zinc finger protein 431 | 0.46 |
| ANKRD2 | ankyrin repeat domain 2 (stretch responsive muscle) | 0.45 |
| ANKRD13D | ankyrin repeat domain 13 family, member D | 0.41 |
| POLR2I | polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa | 0.41 |
| MED29 | mediator complex subunit 29 | 0.41 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.4 |
| HGH1 | HGH1 homolog (S. cerevisiae) | 0.4 |
| TMEM200A | transmembrane protein 200A | 0.39 |
| TRNP1 | TMF1-regulated nuclear protein 1 | 0.39 |
| ZSWIM7 | zinc finger, SWIM-type containing 7 | 0.38 |
| SPC24 | SPC24, NDC80 kinetochore complex component | 0.37 |
| PCBD1 | pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha | 0.37 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | 0.36 |
| TCHP | trichoplein, keratin filament binding | 0.35 |
| PROSER3 | proline and serine rich 3 | 0.35 |
| ZNF250 | zinc finger protein 250 | 0.35 |
| PPHLN1 | periphilin 1 | 0.35 |
| CRPPA | CDP-L-ribitol pyrophosphorylase A | 0.34 |
| BBS7 | Bardet-Biedl syndrome 7 | 0.34 |
| MCFD2 | multiple coagulation factor deficiency 2 | 0.34 |
| HPS4 | Hermansky-Pudlak syndrome 4 | 0.34 |
| PXN | paxillin | 0.33 |
| RTL8C | retrotransposon Gag like 8C | 0.33 |
| CLTCL1 | clathrin, heavy chain-like 1 | 0.33 |
| CETN1 | centrin, EF-hand protein, 1 | 0.32 |
| MARCHF7 | membrane associated ring-CH-type finger 7 | 0.32 |
| TRIM9 | tripartite motif containing 9 | 0.32 |
| DHRS13 | dehydrogenase/reductase (SDR family) member 13 | 0.31 |
| BCL6 | B-cell CLL/lymphoma 6 | 0.31 |
| UQCRFS1 | ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 | 0.31 |
| ZFAND2A | zinc finger, AN1-type domain 2A | 0.31 |
| RPE | ribulose-5-phosphate-3-epimerase | 0.31 |
| YY1AP1 | YY1 associated protein 1 | 0.31 |
| OPHN1 | oligophrenin 1 | 0.3 |
| STC2 | stanniocalcin 2 | 0.3 |
| BLOC1S4 | biogenesis of lysosomal organelles complex-1, subunit 4, cappuccino | 0.3 |
| MEGF6 | multiple EGF-like-domains 6 | 0.3 |
| HSBP1 | heat shock factor binding protein 1 | 0.3 |
| TRMT44 | tRNA methyltransferase 44 homolog (S. cerevisiae) | 0.3 |
| PER2 | period circadian clock 2 | 0.3 |
| CCHCR1 | coiled-coil alpha-helical rod protein 1 | 0.29 |
| EGR1 | early growth response 1 | 0.29 |
| PFDN1 | prefoldin subunit 1 | 0.29 |
| DST | dystonin | 0.29 |
| PLD6 | phospholipase D family, member 6 | 0.29 |
| EEF1A1P5 | eukaryotic translation elongation factor 1 alpha 1 pseudogene 5 | 0.29 |
| TMSB10 | thymosin beta 10 | 0.29 |
| PRMT6 | protein arginine methyltransferase 6 | 0.28 |
| MDP1 | magnesium-dependent phosphatase 1 | 0.28 |
| CENPM | centromere protein M | 0.28 |
| CTDSP1 | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 | 0.28 |
| CENPO | centromere protein O | 0.28 |
| RNF7 | ring finger protein 7 | 0.28 |
| KPNA5 | karyopherin alpha 5 (importin alpha 6) | 0.28 |
| HIST1H1T | histone cluster 1, H1t | 0.28 |
| ZNF362 | zinc finger protein 362 | 0.27 |
| DUSP22 | dual specificity phosphatase 22 | 0.27 |
| PRIMPOL | primase and polymerase (DNA-directed) | 0.27 |
| PRR3 | proline rich 3 | 0.27 |
| RELCH | RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing | 0.27 |
| LCORL | ligand dependent nuclear receptor corepressor-like | 0.27 |
| RPLP1 | ribosomal protein, large, P1 | 0.27 |
| ZBTB43 | zinc finger and BTB domain containing 43 | 0.27 |
| PLK1 | polo-like kinase 1 | 0.27 |
| SON | SON DNA binding protein | 0.27 |
| HACD1 | 3-hydroxyacyl-CoA dehydratase 1 | 0.26 |
| TMCO6 | transmembrane and coiled-coil domains 6 | 0.26 |
| MADD | MAP-kinase activating death domain | 0.26 |
| NRM | nurim (nuclear envelope membrane protein) | 0.26 |
| GID8 | GID complex subunit 8 | 0.26 |
| MACC1 | metastasis associated in colon cancer 1 | 0.26 |
| BCAS2 | breast carcinoma amplified sequence 2 | 0.26 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 | 0.26 |
| N4BP2 | NEDD4 binding protein 2 | 0.26 |
| PEMT | phosphatidylethanolamine N-methyltransferase | 0.26 |
| TBC1D32 | TBC1 domain family, member 32 | 0.25 |
| GINS2 | GINS complex subunit 2 (Psf2 homolog) | 0.25 |
| ATXN7 | ataxin 7 | 0.25 |
| PRKCG | protein kinase C, gamma | 0.25 |
| FAAP24 | FA core complex associated protein 24 | 0.25 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.25 |
| ZBTB39 | zinc finger and BTB domain containing 39 | 0.25 |
| SP2 | Sp2 transcription factor | 0.25 |
| MAGEF1 | melanoma antigen family F1 | 0.24 |
| NAA50 | N(alpha)-acetyltransferase 50, NatE catalytic subunit | 0.24 |
| FKTN | fukutin | 0.24 |
| NDST1 | N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 | 0.24 |
| MYO7B | myosin VIIB | 0.24 |
| HERC3 | HECT and RLD domain containing E3 ubiquitin protein ligase 3 | 0.24 |
| IKZF5 | IKAROS family zinc finger 5 (Pegasus) | 0.24 |
| FAT4 | FAT atypical cadherin 4 | 0.24 |
| CNTRL | centriolin | 0.24 |
| FAM234B | family with sequence similarity 234 member B | 0.24 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FTL | ferritin, light polypeptide | -0.95 |
| PIP | prolactin-induced protein | -0.88 |
| OSTM1 | osteopetrosis associated transmembrane protein 1 | -0.73 |
| LZTS1 | leucine zipper, putative tumor suppressor 1 | -0.65 |
| ANGPTL4 | angiopoietin-like 4 | -0.53 |
| FN1 | fibronectin 1 | -0.52 |
| FGB | fibrinogen beta chain | -0.51 |
| NIPA1 | non imprinted in Prader-Willi/Angelman syndrome 1 | -0.5 |
| DMD | dystrophin | -0.44 |
| COX7A2 | cytochrome c oxidase subunit VIIa polypeptide 2 (liver) | -0.44 |
| IFI30 | interferon, gamma-inducible protein 30 | -0.44 |
| GNPTAB | N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits | -0.43 |
| C1ORF52 | chromosome 1 open reading frame 52 | -0.43 |
| HMBOX1 | homeobox containing 1 | -0.42 |
| TPK1 | thiamin pyrophosphokinase 1 | -0.42 |
| JPT1 | Jupiter microtubule associated homolog 1 | -0.41 |
| DTWD2 | DTW domain containing 2 | -0.41 |
| CARD19 | caspase recruitment domain family member 19 | -0.4 |
| TMEM104 | transmembrane protein 104 | -0.39 |
| UBTD1 | ubiquitin domain containing 1 | -0.38 |
| CDC42EP3 | CDC42 effector protein (Rho GTPase binding) 3 | -0.37 |
| ADGRE2 | adhesion G protein-coupled receptor E2 | -0.37 |
| SLC31A1 | solute carrier family 31 (copper transporter), member 1 | -0.37 |
| GATA2 | GATA binding protein 2 | -0.37 |
| LCP1 | lymphocyte cytosolic protein 1 (L-plastin) | -0.36 |
| VGLL4 | vestigial-like family member 4 | -0.36 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.36 |
| PRMT2 | protein arginine methyltransferase 2 | -0.36 |
| PEX16 | peroxisomal biogenesis factor 16 | -0.35 |
| MIER2 | mesoderm induction early response 1, family member 2 | -0.34 |
| GRAMD2A | GRAM domain containing 2A | -0.34 |
| ABHD4 | abhydrolase domain containing 4 | -0.34 |
| NRBF2 | nuclear receptor binding factor 2 | -0.34 |
| RCN1 | reticulocalbin 1, EF-hand calcium binding domain | -0.33 |
| COL14A1 | collagen, type XIV, alpha 1 | -0.33 |
| NDFIP1 | Nedd4 family interacting protein 1 | -0.33 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.33 |
| ADCY6 | adenylate cyclase 6 | -0.33 |
| EPHX4 | epoxide hydrolase 4 | -0.32 |
| BSDC1 | BSD domain containing 1 | -0.31 |
| FASTK | Fas-activated serine/threonine kinase | -0.31 |
| SMIM19 | small integral membrane protein 19 | -0.31 |
| RNF13 | ring finger protein 13 | -0.31 |
| TPP1 | tripeptidyl peptidase I | -0.31 |
| ZNF503 | zinc finger protein 503 | -0.31 |
| ICA1 | islet cell autoantigen 1, 69kDa | -0.31 |
| MARCKSL1 | MARCKS-like 1 | -0.3 |
| PDE3B | phosphodiesterase 3B, cGMP-inhibited | -0.3 |
| MAX | MYC associated factor X | -0.3 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.29 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -0.29 |
| TM7SF3 | transmembrane 7 superfamily member 3 | -0.29 |
| MSLN | mesothelin | -0.29 |
| WWC3 | WWC family member 3 | -0.29 |
| GLMP | glycosylated lysosomal membrane protein | -0.29 |
| DNAJC22 | DnaJ (Hsp40) homolog, subfamily C, member 22 | -0.29 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.29 |
| STX1A | syntaxin 1A (brain) | -0.29 |
| PDCD2L | programmed cell death 2-like | -0.28 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.28 |
| ZNF658 | zinc finger protein 658 | -0.28 |
| SPPL2B | signal peptide peptidase like 2B | -0.28 |
| IL13RA1 | interleukin 13 receptor, alpha 1 | -0.28 |
| ZNF580 | zinc finger protein 580 | -0.27 |
| TSPAN3 | tetraspanin 3 | -0.27 |
| GDF15 | growth differentiation factor 15 | -0.27 |
| DERPC | DERPC proline and glycine rich nuclear protein | -0.27 |
| CIAO2A | cytosolic iron-sulfur assembly component 2A | -0.27 |
| PSEN2 | presenilin 2 | -0.27 |
| ERICH5 | glutamate-rich 5 | -0.27 |
| TMEM222 | transmembrane protein 222 | -0.27 |
| MLXIPL | MLX interacting protein-like | -0.26 |
| DOHH | deoxyhypusine hydroxylase/monooxygenase | -0.26 |
| HBA1 | hemoglobin, alpha 1 | -0.26 |
| MCOLN3 | mucolipin 3 | -0.26 |
| SGK3 | serum/glucocorticoid regulated kinase family, member 3 | -0.26 |
| MYO18B | myosin XVIIIB | -0.26 |
| VPS54 | vacuolar protein sorting 54 homolog (S. cerevisiae) | -0.25 |
| YPEL5 | yippee-like 5 (Drosophila) | -0.25 |
| C6ORF47 | chromosome 6 open reading frame 47 | -0.25 |
| CYBA | cytochrome b-245, alpha polypeptide | -0.25 |
| CBR1 | carbonyl reductase 1 | -0.25 |
| PEX26 | peroxisomal biogenesis factor 26 | -0.25 |
| POLR2M | polymerase (RNA) II (DNA directed) polypeptide M | -0.25 |
| PRKCSH | protein kinase C substrate 80K-H | -0.25 |
| RAB24 | RAB24, member RAS oncogene family | -0.25 |
| GLRX | glutaredoxin (thioltransferase) | -0.24 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | -0.24 |
| METTL22 | methyltransferase like 22 | -0.24 |
| CD63 | CD63 molecule | -0.24 |
| MNX1 | motor neuron and pancreas homeobox 1 | -0.24 |
| SLC25A16 | solute carrier family 25 (mitochondrial carrier), member 16 | -0.24 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.24 |
| FAM124A | family with sequence similarity 124A | -0.24 |
| CCDC15 | coiled-coil domain containing 15 | -0.23 |
| ABTB1 | ankyrin repeat and BTB (POZ) domain containing 1 | -0.23 |
| CDS1 | CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1 | -0.23 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | -0.23 |
| CALU | calumenin | -0.23 |
