Torin1 Gene Set

Dataset LINCS KinomeScan Kinase Inhibitor Targets
Category physical interactions
Type small molecule
Description A member of the class of pyridoquinolines that is 9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2-one bearing an additional 4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl substituent at position 1. (Chemical Entities of Biological Interest Ontology, CHEBI_84327)
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Genes

16 kinases inhibited by the Torin1 small molecule from the KinomeScan Kinase Inhibitor Targets dataset.

Symbol Name Standardized Value
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 1.3104
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 1.26209
CDC42BPG CDC42 binding protein kinase gamma (DMPK-like) 1.23916
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 1.21703
CDC42BPB CDC42 binding protein kinase beta (DMPK-like) 1.11767
CSNK1D casein kinase 1, delta 1.06639
HIPK4 homeodomain interacting protein kinase 4 1.05057
CDK8 cyclin-dependent kinase 8 1.05057
LIMK2 LIM domain kinase 2 1.04035
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 1.02071
NEK5 NIMA-related kinase 5 0.993117
CDK2 cyclin-dependent kinase 2 0.975893
TNK1 tyrosine kinase, non-receptor, 1 0.9517
INSR insulin receptor 0.922275
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.905385
TTK TTK protein kinase 0.860727