| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Torkinib perturbation in A-172 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Torkinib_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| POTEF | POTE ankyrin domain family, member F | 0.162316 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.145878 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.141544 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.107622 |
| SQSTM1 | sequestosome 1 | 0.101974 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.094332 |
| CALR | calreticulin | 0.0936099 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0833623 |
| VIM | vimentin | 0.0831515 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0793383 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0774427 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0739033 |
| LDHA | lactate dehydrogenase A | 0.071404 |
| HDAC9 | histone deacetylase 9 | 0.0676387 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0593456 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0589704 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0566353 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0563983 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0562402 |
| CENPF | centromere protein F, 350/400kDa | 0.0550817 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0550756 |
| ENO1 | enolase 1, (alpha) | 0.0544685 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0515224 |
| MSN | moesin | 0.0492073 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0484349 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0480852 |
| ASPH | aspartate beta-hydroxylase | 0.0479374 |
| TPM3 | tropomyosin 3 | 0.0479226 |
| NAV2 | neuron navigator 2 | 0.0479113 |
| RHOBTB3 | Rho-related BTB domain containing 3 | 0.0463934 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0462141 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0453069 |
| DSPP | dentin sialophosphoprotein | 0.0452109 |
| SET | SET nuclear proto-oncogene | 0.0429973 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0417823 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.0403011 |
| RPS12 | ribosomal protein S12 | 0.0391148 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0388091 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0381331 |
| EZR | ezrin | 0.0378221 |
| RPL12 | ribosomal protein L12 | 0.0373471 |
| PTMA | prothymosin, alpha | 0.0373184 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0354199 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | 0.0341621 |
| PRKAG2 | protein kinase, AMP-activated, gamma 2 non-catalytic subunit | 0.0341409 |
| DST | dystonin | 0.0339721 |
| RPL37A | ribosomal protein L37a | 0.0331349 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0328276 |
| GADD45A | growth arrest and DNA-damage-inducible, alpha | 0.0327838 |
| AP2M1 | adaptor-related protein complex 2, mu 1 subunit | 0.0325983 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0324884 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0323186 |
| RND3 | Rho family GTPase 3 | 0.0321914 |
| ZC3H11A | zinc finger CCCH-type containing 11A | 0.0320715 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0320167 |
| FSTL1 | follistatin-like 1 | 0.0316409 |
| RACK1 | receptor for activated C kinase 1 | 0.0315132 |
| GOLGA4 | golgin A4 | 0.0313356 |
| RPS3 | ribosomal protein S3 | 0.0313256 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0312626 |
| B2M | beta-2-microglobulin | 0.0308861 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0307938 |
| CYLD | cylindromatosis (turban tumor syndrome) | 0.0304863 |
| TLN1 | talin 1 | 0.0304048 |
| CANX | calnexin | 0.0299593 |
| ANO6 | anoctamin 6 | 0.0299483 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0294127 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0292813 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0292712 |
| GADD45B | growth arrest and DNA-damage-inducible, beta | 0.0292135 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0285404 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | 0.0284296 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0282588 |
| CDK6 | cyclin-dependent kinase 6 | 0.0281543 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0280775 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0277801 |
| KIF5B | kinesin family member 5B | 0.0273639 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0270418 |
| SFTPA2 | surfactant protein A2 | 0.0268788 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0263412 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0261315 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0257948 |
| TPM4 | tropomyosin 4 | 0.0253508 |
| LNPEP | leucyl/cystinyl aminopeptidase | 0.0248512 |
| AFF4 | AF4/FMR2 family, member 4 | 0.0245452 |
| SUPT6H | suppressor of Ty 6 homolog (S. cerevisiae) | 0.0244587 |
| FAM107B | family with sequence similarity 107, member B | 0.0242745 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0242684 |
| HMGB2 | high mobility group box 2 | 0.024228 |
| MYOF | myoferlin | 0.0240762 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0239419 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0239376 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0236534 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0236272 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0235345 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0232307 |
| NEDD4 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | 0.0230934 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.022853 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0227359 |
| GDI2 | GDP dissociation inhibitor 2 | 0.0226425 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.343858 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.223701 |
| PLAT | plasminogen activator, tissue | -0.111764 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.108343 |
| COL8A1 | collagen, type VIII, alpha 1 | -0.0960267 |
| MT2A | metallothionein 2A | -0.095664 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0955532 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0897838 |
| COL1A2 | collagen, type I, alpha 2 | -0.0842915 |
| TMSB10 | thymosin beta 10 | -0.0821041 |
| COL5A1 | collagen, type V, alpha 1 | -0.074817 |
| NAV1 | neuron navigator 1 | -0.0721833 |
| HLA-B | major histocompatibility complex, class I, B | -0.0714887 |
| LOX | lysyl oxidase | -0.0684211 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.068102 |
| FBN1 | fibrillin 1 | -0.0588302 |
| FN1 | fibronectin 1 | -0.0558165 |
| LOXL2 | lysyl oxidase-like 2 | -0.0556617 |
| SUCNR1 | succinate receptor 1 | -0.055241 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0538847 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.053466 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0517382 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0505994 |
| CD99 | CD99 molecule | -0.0503386 |
| NDRG1 | N-myc downstream regulated 1 | -0.0494475 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | -0.0492732 |
| MT1X | metallothionein 1X | -0.0483076 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0463726 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0451376 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0403727 |
| HLA-C | major histocompatibility complex, class I, C | -0.0389742 |
| MYADM | myeloid-associated differentiation marker | -0.0384862 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0381277 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0381119 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0380836 |
| TAPBP | TAP binding protein (tapasin) | -0.0359657 |
| BSG | basigin (Ok blood group) | -0.0358354 |
| ARL4C | ADP-ribosylation factor-like 4C | -0.0355178 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0345511 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | -0.0345004 |
| MAP1B | microtubule-associated protein 1B | -0.0340547 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0340182 |
| LMNA | lamin A/C | -0.0324596 |
| RRBP1 | ribosome binding protein 1 | -0.0321877 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0318853 |
| AUTS2 | autism susceptibility candidate 2 | -0.0308242 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.0305613 |
| AHNAK | AHNAK nucleoprotein | -0.0298859 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0291591 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0287475 |
| ACTN4 | actinin, alpha 4 | -0.0286866 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0284325 |
| GNAS | GNAS complex locus | -0.0281803 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0276538 |
| RTN4 | reticulon 4 | -0.026617 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | -0.0265256 |
| CUX1 | cut-like homeobox 1 | -0.0255514 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0254161 |
| JAZF1 | JAZF zinc finger 1 | -0.0249728 |
| GLIS3 | GLIS family zinc finger 3 | -0.024892 |
| FNDC3B | fibronectin type III domain containing 3B | -0.024392 |
| RBM25 | RNA binding motif protein 25 | -0.0238066 |
| PXDN | peroxidasin | -0.0236733 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.0236095 |
| TAGLN2 | transgelin 2 | -0.0234306 |
| MX2 | MX dynamin-like GTPase 2 | -0.0234139 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.02332 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.0230034 |
| PODXL | podocalyxin-like | -0.0226981 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | -0.0224677 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.021787 |
| SLC8A1 | solute carrier family 8 (sodium/calcium exchanger), member 1 | -0.0217358 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0214717 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.0213255 |
| SP3 | Sp3 transcription factor | -0.0212187 |
| DIRAS3 | DIRAS family, GTP-binding RAS-like 3 | -0.021092 |
| RNF213 | ring finger protein 213 | -0.0210523 |
| SMIM44 | small integral membrane protein 44 | -0.0209996 |
| FRMD4A | FERM domain containing 4A | -0.0205484 |
| NPR2 | natriuretic peptide receptor 2 | -0.0203975 |
| NKTR | natural killer cell triggering receptor | -0.0201583 |
| CKAP4 | cytoskeleton-associated protein 4 | -0.0200909 |
| PRSS23 | protease, serine, 23 | -0.0200866 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0199018 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0195477 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0195107 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0193229 |
| COL6A2 | collagen, type VI, alpha 2 | -0.0193173 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0191647 |
| SEPTIN9 | septin 9 | -0.0190365 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0189228 |
| FAM114A1 | family with sequence similarity 114, member A1 | -0.0189083 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | -0.018886 |
| CCL5 | chemokine (C-C motif) ligand 5 | -0.0187886 |
| CDC42EP3 | CDC42 effector protein (Rho GTPase binding) 3 | -0.018704 |
| SBF2 | SET binding factor 2 | -0.018441 |
| NF1 | neurofibromin 1 | -0.0184162 |
| LAMA5 | laminin, alpha 5 | -0.0183787 |
| TENM3 | teneurin transmembrane protein 3 | -0.0183508 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0181927 |
