| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Torkinib perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Torkinib_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.192733 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.192184 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.144953 |
| HMGA2 | high mobility group AT-hook 2 | 0.134392 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.102749 |
| POTEF | POTE ankyrin domain family, member F | 0.0970793 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0813746 |
| VIM | vimentin | 0.0791435 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 0.0772528 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0725577 |
| YAP1 | Yes-associated protein 1 | 0.0725427 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0624789 |
| ADIPOR2 | adiponectin receptor 2 | 0.0581051 |
| PCDH7 | protocadherin 7 | 0.0578513 |
| ANXA1 | annexin A1 | 0.0576356 |
| ASPH | aspartate beta-hydroxylase | 0.0568936 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0560818 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0538047 |
| DST | dystonin | 0.0536608 |
| CUBN | cubilin (intrinsic factor-cobalamin receptor) | 0.0536023 |
| GJA1 | gap junction protein, alpha 1, 43kDa | 0.0535714 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0521412 |
| EHBP1 | EH domain binding protein 1 | 0.0515271 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0511812 |
| CALR | calreticulin | 0.049617 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0470951 |
| ENO1 | enolase 1, (alpha) | 0.0465805 |
| TPM3 | tropomyosin 3 | 0.0459782 |
| PCBP2 | poly(rC) binding protein 2 | 0.0443509 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0436381 |
| RPS12 | ribosomal protein S12 | 0.0435194 |
| IPO7 | importin 7 | 0.0430005 |
| EZR | ezrin | 0.042616 |
| INTS6 | integrator complex subunit 6 | 0.0419477 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0412698 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0410161 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0410006 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0407081 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0395871 |
| RRM2 | ribonucleotide reductase M2 | 0.0384543 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.036286 |
| JMJD1C | jumonji domain containing 1C | 0.03626 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0355411 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0355352 |
| NLGN1 | neuroligin 1 | 0.035365 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0340699 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0340536 |
| USP34 | ubiquitin specific peptidase 34 | 0.0340369 |
| SETX | senataxin | 0.0336979 |
| PCDH9 | protocadherin 9 | 0.0333349 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.032875 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0323793 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0317323 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.0315625 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0310646 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0309867 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0300486 |
| AFF4 | AF4/FMR2 family, member 4 | 0.0297743 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0296455 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0296273 |
| PRDX1 | peroxiredoxin 1 | 0.028852 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0288375 |
| TPI1 | triosephosphate isomerase 1 | 0.0285125 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0284792 |
| MSRB3 | methionine sulfoxide reductase B3 | 0.0281674 |
| EIF5 | eukaryotic translation initiation factor 5 | 0.0277244 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0275081 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0270718 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | 0.0270653 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0270163 |
| HDAC9 | histone deacetylase 9 | 0.0270149 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | 0.0267589 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | 0.0263765 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.026318 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0262239 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | 0.0258207 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0258003 |
| RPL3 | ribosomal protein L3 | 0.025555 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0255392 |
| DENND5A | DENN/MADD domain containing 5A | 0.0249507 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0248457 |
| FNIP1 | folliculin interacting protein 1 | 0.0245982 |
| DOCK1 | dedicator of cytokinesis 1 | 0.0244404 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0243003 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0241523 |
| SNCA | synuclein, alpha (non A4 component of amyloid precursor) | 0.0241028 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0238322 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0238246 |
| SMC1A | structural maintenance of chromosomes 1A | 0.0238059 |
| NAV3 | neuron navigator 3 | 0.0237332 |
| FAT1 | FAT atypical cadherin 1 | 0.023569 |
| PRIM2 | primase, DNA, polypeptide 2 (58kDa) | 0.0235373 |
| LRRC23 | leucine rich repeat containing 23 | 0.0231737 |
| ACTG1 | actin gamma 1 | 0.0230788 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0227122 |
| CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) | 0.0221608 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0221107 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0221041 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | 0.0216796 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | 0.0215644 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.234093 |
| TMSB10 | thymosin beta 10 | -0.0729938 |
| AREG | amphiregulin | -0.0724942 |
| RPL35A | ribosomal protein L35a | -0.0542387 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0528698 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0513824 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0478278 |
| MGAT4C | MGAT4 family, member C | -0.0447293 |
| RPL34 | ribosomal protein L34 | -0.0425039 |
| ZNF217 | zinc finger protein 217 | -0.038497 |
| YBX3 | Y box binding protein 3 | -0.0384613 |
| RPS24 | ribosomal protein S24 | -0.0377341 |
| CXADR | coxsackie virus and adenovirus receptor | -0.0364888 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0363555 |
| RPS21 | ribosomal protein S21 | -0.0352354 |
| TMEM41B | transmembrane protein 41B | -0.0351601 |
| FTL | ferritin, light polypeptide | -0.0346743 |
| HMGA1 | high mobility group AT-hook 1 | -0.033775 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | -0.0336488 |
| H1-0 | H1.0 linker histone | -0.0335339 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0324321 |
| BTG3 | BTG family, member 3 | -0.0319416 |
| THOC2 | THO complex 2 | -0.0315662 |
| RPLP1 | ribosomal protein, large, P1 | -0.0314814 |
| FUS | FUS RNA binding protein | -0.0311424 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | -0.0308098 |
| RPL8 | ribosomal protein L8 | -0.0307491 |
| RPS15 | ribosomal protein S15 | -0.0306788 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0305531 |
| PTMA | prothymosin, alpha | -0.030032 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0295942 |
| LMO7 | LIM domain 7 | -0.0289581 |
| WDR45B | WD repeat domain 45B | -0.0286206 |
| RPS29 | ribosomal protein S29 | -0.0285234 |
| PCNP | PEST proteolytic signal containing nuclear protein | -0.028102 |
| CPOX | coproporphyrinogen oxidase | -0.0280802 |
| RPS23 | ribosomal protein S23 | -0.0272628 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | -0.0272154 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0271853 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0269062 |
| NR5A2 | nuclear receptor subfamily 5, group A, member 2 | -0.0267815 |
| TMEM123 | transmembrane protein 123 | -0.0265767 |
| RPL26 | ribosomal protein L26 | -0.0263725 |
| CCNL1 | cyclin L1 | -0.0260845 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0260645 |
| TMEM131 | transmembrane protein 131 | -0.025971 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0258486 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0251317 |
| ZNF292 | zinc finger protein 292 | -0.0250086 |
| RBM25 | RNA binding motif protein 25 | -0.024843 |
| RPS8 | ribosomal protein S8 | -0.0247745 |
| YBX1 | Y box binding protein 1 | -0.0247284 |
| BIRC2 | baculoviral IAP repeat containing 2 | -0.0247176 |
| KLHL24 | kelch-like family member 24 | -0.0246202 |
| RBM27 | RNA binding motif protein 27 | -0.0245001 |
| CELF2 | CUGBP, Elav-like family member 2 | -0.0243738 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0243275 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0242161 |
| RPL32 | ribosomal protein L32 | -0.0241613 |
| YES1 | YES proto-oncogene 1, Src family tyrosine kinase | -0.0238133 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0237341 |
| CRISPLD1 | cysteine-rich secretory protein LCCL domain containing 1 | -0.0237283 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.0235507 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0233054 |
| GASK1B | golgi associated kinase 1B | -0.0232639 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0231674 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.023091 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0230746 |
| GNAS | GNAS complex locus | -0.0229662 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | -0.0229255 |
| RPL5 | ribosomal protein L5 | -0.0225782 |
| RPL38 | ribosomal protein L38 | -0.0224808 |
| OXR1 | oxidation resistance 1 | -0.0223631 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0221566 |
| TRMT112 | tRNA methyltransferase 11-2 homolog (S. cerevisiae) | -0.0219153 |
| RPS5 | ribosomal protein S5 | -0.0214257 |
| AXIN2 | axin 2 | -0.0214211 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0212582 |
| TIGAR | TP53 induced glycolysis regulatory phosphatase | -0.0212115 |
| RPS10 | ribosomal protein S10 | -0.0211623 |
| GNB4 | guanine nucleotide binding protein (G protein), beta polypeptide 4 | -0.0209945 |
| RPS19 | ribosomal protein S19 | -0.020969 |
| AHNAK | AHNAK nucleoprotein | -0.0207689 |
| MATR3 | matrin 3 | -0.02073 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | -0.0206202 |
| TWSG1 | twisted gastrulation BMP signaling modulator 1 | -0.0205841 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0205466 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0202173 |
| THOC1 | THO complex 1 | -0.0201904 |
| ARHGAP12 | Rho GTPase activating protein 12 | -0.0199842 |
| CDK17 | cyclin-dependent kinase 17 | -0.0197279 |
| ADNP | activity-dependent neuroprotector homeobox | -0.0196954 |
| RPL19 | ribosomal protein L19 | -0.019653 |
| TFG | TRK-fused gene | -0.0196386 |
| FBXO11 | F-box protein 11 | -0.0195428 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0194404 |
| RPS6 | ribosomal protein S6 | -0.0194171 |
| CDCA2 | cell division cycle associated 2 | -0.0193216 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0192812 |
| RBMX | RNA binding motif protein, X-linked | -0.0191402 |
