Torkinib_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Torkinib perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Torkinib_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FMN1 formin 1 0.232681
VCL vinculin 0.171017
ZSWIM6 zinc finger, SWIM-type containing 6 0.0796619
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0793547
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0723413
TLE4 transducin-like enhancer of split 4 0.0715848
AKAP12 A kinase (PRKA) anchor protein 12 0.0697208
KLHL13 kelch-like family member 13 0.0596332
PTPRD protein tyrosine phosphatase, receptor type, D 0.0585538
ITGA1 integrin, alpha 1 0.055951
FAM107B family with sequence similarity 107, member B 0.0552605
ACTG1 actin gamma 1 0.0512267
GLCCI1 glucocorticoid induced 1 0.0507767
HSPA8 heat shock 70kDa protein 8 0.0497731
TIMP3 TIMP metallopeptidase inhibitor 3 0.0492876
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0487912
TPM1 tropomyosin 1 (alpha) 0.0479773
SLITRK6 SLIT and NTRK-like family, member 6 0.0473225
SLIT2 slit homolog 2 (Drosophila) 0.0471781
THSD4 thrombospondin, type I, domain containing 4 0.0464618
LSAMP limbic system-associated membrane protein 0.0457632
MYO1E myosin IE 0.0445217
POTEF POTE ankyrin domain family, member F 0.0436435
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0432314
RPS6 ribosomal protein S6 0.0431738
SP100 SP100 nuclear antigen 0.041639
EXT1 exostosin glycosyltransferase 1 0.0415758
TPM4 tropomyosin 4 0.041413
COL4A1 collagen, type IV, alpha 1 0.0403284
RPS12 ribosomal protein S12 0.0401899
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0400918
RPLP0 ribosomal protein, large, P0 0.0399693
BPTF bromodomain PHD finger transcription factor 0.0398297
TPST1 tyrosylprotein sulfotransferase 1 0.0394955
RPL35A ribosomal protein L35a 0.0389907
CTSB cathepsin B 0.0388449
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0365857
LOC102724023 ES1 protein homolog, mitochondrial 0.0360464
RNF213 ring finger protein 213 0.0360332
PSD3 pleckstrin and Sec7 domain containing 3 0.0359296
BCAS3 breast carcinoma amplified sequence 3 0.0358516
RIGI RNA sensor RIG-I 0.0339697
LPP LIM domain containing preferred translocation partner in lipoma 0.0329199
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0323184
FTH1 ferritin, heavy polypeptide 1 0.0316005
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0315213
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0309882
PLAT plasminogen activator, tissue 0.0308993
PRKD1 protein kinase D1 0.0306253
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0300309
PTPRE protein tyrosine phosphatase, receptor type, E 0.0296645
NPAS2 neuronal PAS domain protein 2 0.0292116
HOMER1 homer scaffolding protein 1 0.0288409
RPS3 ribosomal protein S3 0.0288194
PDLIM5 PDZ and LIM domain 5 0.0280434
DNMBP dynamin binding protein 0.0274456
JUP junction plakoglobin 0.0274111
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.027362
BRAF B-Raf proto-oncogene, serine/threonine kinase 0.0273149
SMAD3 SMAD family member 3 0.0272564
DST dystonin 0.0272182
NFE2L2 nuclear factor, erythroid 2-like 2 0.0270224
RPL19 ribosomal protein L19 0.0270083
DUSP16 dual specificity phosphatase 16 0.0269756
RPL23 ribosomal protein L23 0.0269649
TPT1 tumor protein, translationally-controlled 1 0.0268962
TENM4 teneurin transmembrane protein 4 0.0268736
CXCL8 chemokine (C-X-C motif) ligand 8 0.0264637
ATRNL1 attractin-like 1 0.0263743
RET ret proto-oncogene 0.0256892
LRRC23 leucine rich repeat containing 23 0.0254773
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0252432
RPL7 ribosomal protein L7 0.0251691
LIMA1 LIM domain and actin binding 1 0.0250036
GPR183 G protein-coupled receptor 183 0.0247663
PLPP1 phospholipid phosphatase 1 0.0244758
SIK2 salt-inducible kinase 2 0.0242583
MYH9 myosin, heavy chain 9, non-muscle 0.0240745
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 0.0240221
PALLD palladin, cytoskeletal associated protein 0.0238772
SLFN5 schlafen family member 5 0.0238718
RPLP1 ribosomal protein, large, P1 0.0238231
ATF4 activating transcription factor 4 0.0237208
CCDC57 coiled-coil domain containing 57 0.0236942
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0234849
RPS27 ribosomal protein S27 0.0234309
CPNE8 copine VIII 0.0233857
FERMT2 fermitin family member 2 0.023375
AAK1 AP2 associated kinase 1 0.0233528
DGKH diacylglycerol kinase, eta 0.0233085
SFTPA2 surfactant protein A2 0.0232713
MRTFA myocardin related transcription factor A 0.0231144
SSH1 slingshot protein phosphatase 1 0.0231086
FNDC3A fibronectin type III domain containing 3A 0.0228704
RPL12 ribosomal protein L12 0.0228296
RGS4 regulator of G-protein signaling 4 0.0228027
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0226759
PRKCA protein kinase C, alpha 0.0226655
IER3 immediate early response 3 0.0225701
RPL7A ribosomal protein L7a 0.0225163

decreased expression

Symbol Name Standardized Value
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.269643
IGF2 insulin-like growth factor 2 -0.117812
NRG1 neuregulin 1 -0.0749762
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0738715
PTK2 protein tyrosine kinase 2 -0.0664044
DSCAM Down syndrome cell adhesion molecule -0.0655118
CEMIP cell migration inducing protein, hyaluronan binding -0.062639
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0590604
NAMPT nicotinamide phosphoribosyltransferase -0.0551158
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.054523
COL1A1 collagen, type I, alpha 1 -0.0544726
DTNA dystrobrevin, alpha -0.0537352
HELZ helicase with zinc finger -0.0534328
GOLGA4 golgin A4 -0.0532337
NALF1 NALCN channel auxiliary factor 1 -0.0515625
ZNF292 zinc finger protein 292 -0.04948
ANKRD17 ankyrin repeat domain 17 -0.0490473
SRPK2 SRSF protein kinase 2 -0.0485881
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0473382
KMT2C lysine (K)-specific methyltransferase 2C -0.0465431
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0452632
WDR45B WD repeat domain 45B -0.0452546
APP amyloid beta (A4) precursor protein -0.0449699
TRIB2 tribbles pseudokinase 2 -0.0448688
PTMA prothymosin, alpha -0.044193
RTN4 reticulon 4 -0.0427837
BIRC6 baculoviral IAP repeat containing 6 -0.0427678
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0423898
CD36 CD36 molecule (thrombospondin receptor) -0.0422649
NDRG1 N-myc downstream regulated 1 -0.0414721
MSI2 musashi RNA-binding protein 2 -0.0411746
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0399416
AHNAK AHNAK nucleoprotein -0.0391843
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0380456
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0379608
HMGB2 high mobility group box 2 -0.0375182
MBNL2 muscleblind-like splicing regulator 2 -0.037436
USP3 ubiquitin specific peptidase 3 -0.0373481
AOPEP aminopeptidase O (putative) -0.0372258
LCORL ligand dependent nuclear receptor corepressor-like -0.036349
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.0359818
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0356429
EYA1 EYA transcriptional coactivator and phosphatase 1 -0.0352722
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0349545
IGF1R insulin-like growth factor 1 receptor -0.0349231
CADM1 cell adhesion molecule 1 -0.0346373
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0345994
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0342153
CANX calnexin -0.034115
UBC ubiquitin C -0.0337194
CENPF centromere protein F, 350/400kDa -0.0331647
USP34 ubiquitin specific peptidase 34 -0.032871
NEK7 NIMA-related kinase 7 -0.032749
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0327138
BRWD1 bromodomain and WD repeat domain containing 1 -0.0325322
QKI QKI, KH domain containing, RNA binding -0.0320862
AUH AU RNA binding protein/enoyl-CoA hydratase -0.0319113
PDIA3 protein disulfide isomerase family A, member 3 -0.0316871
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0315957
NPEPPS aminopeptidase puromycin sensitive -0.0315243
LIMCH1 LIM and calponin homology domains 1 -0.0313258
WDR43 WD repeat domain 43 -0.0311826
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1 -0.0308184
CDC27 cell division cycle 27 -0.0307828
BBX bobby sox homolog (Drosophila) -0.0306535
SEPTIN7 septin 7 -0.0304931
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0304685
SETD5 SET domain containing 5 -0.0304473
GLG1 golgi glycoprotein 1 -0.0303159
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0301888
SCN9A sodium channel, voltage gated, type IX alpha subunit -0.0301733
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 -0.0300805
SSBP2 single-stranded DNA binding protein 2 -0.0299291
PCNX1 pecanex 1 -0.0298735
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0298039
MAP1B microtubule-associated protein 1B -0.0297826
FOXO3 forkhead box O3 -0.0297781
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0297663
MAML2 mastermind-like 2 (Drosophila) -0.0294478
HDLBP high density lipoprotein binding protein -0.0289165
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0286255
CEP95 centrosomal protein 95kDa -0.0284902
IARS1 isoleucyl-tRNA synthetase 1 -0.0284428
COPA coatomer protein complex, subunit alpha -0.0281532
NREP neuronal regeneration related protein -0.0280577
GARS1 glycyl-tRNA synthetase 1 -0.0276197
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0274995
KDM3A lysine (K)-specific demethylase 3A -0.0274593
FMNL2 formin-like 2 -0.0273983
UBE2K ubiquitin-conjugating enzyme E2K -0.0273329
FOXK2 forkhead box K2 -0.0272451
OGA O-GlcNAcase -0.027158
USP36 ubiquitin specific peptidase 36 -0.0271394
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0271125
XPO1 exportin 1 -0.0269307
FRMD4A FERM domain containing 4A -0.0266993
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0263125
CHD9 chromodomain helicase DNA binding protein 9 -0.0262208
CENPE centromere protein E, 312kDa -0.026103
AK1 adenylate kinase 1 -0.0258854