| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Torkinib perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Torkinib_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.173658 |
| FN1 | fibronectin 1 | 0.161377 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.149923 |
| LDHA | lactate dehydrogenase A | 0.111662 |
| MT2A | metallothionein 2A | 0.105475 |
| ENO1 | enolase 1, (alpha) | 0.0971498 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | 0.0827124 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0801762 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0747972 |
| STC1 | stanniocalcin 1 | 0.0712523 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.06818 |
| CALR | calreticulin | 0.0667116 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0636562 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0605958 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0584031 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.057509 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0562526 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0558292 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0551395 |
| ANXA2 | annexin A2 | 0.0538044 |
| CD44 | CD44 molecule (Indian blood group) | 0.0527782 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0521645 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.05133 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0481698 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0462821 |
| INHBA | inhibin, beta A | 0.0454354 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0452087 |
| CAVIN1 | caveolae associated protein 1 | 0.0415912 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0410082 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0409 |
| B2M | beta-2-microglobulin | 0.0396033 |
| RPL12 | ribosomal protein L12 | 0.0392192 |
| COL3A1 | collagen, type III, alpha 1 | 0.0388284 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0385017 |
| SP100 | SP100 nuclear antigen | 0.0383695 |
| APP | amyloid beta (A4) precursor protein | 0.0374193 |
| RPS12 | ribosomal protein S12 | 0.0366939 |
| SQSTM1 | sequestosome 1 | 0.0352223 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0345111 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0342628 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.033852 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0334198 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0327948 |
| RPS3 | ribosomal protein S3 | 0.0324392 |
| RPL7 | ribosomal protein L7 | 0.0323291 |
| CTSB | cathepsin B | 0.0319469 |
| POSTN | periostin, osteoblast specific factor | 0.0318287 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0317483 |
| RACK1 | receptor for activated C kinase 1 | 0.0315996 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0310029 |
| TMSB4X | thymosin beta 4, X-linked | 0.0308414 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.030568 |
| ARRDC3 | arrestin domain containing 3 | 0.0301469 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0291022 |
| IER3 | immediate early response 3 | 0.0288535 |
| MLF1 | myeloid leukemia factor 1 | 0.0283437 |
| FAT1 | FAT atypical cadherin 1 | 0.0279499 |
| LOX | lysyl oxidase | 0.0277934 |
| SMAD3 | SMAD family member 3 | 0.0277632 |
| FAM107B | family with sequence similarity 107, member B | 0.0275486 |
| RAD21 | RAD21 homolog (S. pombe) | 0.027155 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0271499 |
| RPL26 | ribosomal protein L26 | 0.0269596 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0264384 |
| CANX | calnexin | 0.0264377 |
| CALU | calumenin | 0.0260858 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0257545 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | 0.0256449 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0253912 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0251893 |
| RIGI | RNA sensor RIG-I | 0.0241092 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.023975 |
| SERINC1 | serine incorporator 1 | 0.0239528 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0238507 |
| HLA-E | major histocompatibility complex, class I, E | 0.0236817 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.023644 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0235294 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | 0.0233072 |
| ADM | adrenomedullin | 0.0228601 |
| POTEF | POTE ankyrin domain family, member F | 0.0226965 |
| RPL11 | ribosomal protein L11 | 0.0226221 |
| RPL19 | ribosomal protein L19 | 0.0221299 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0220307 |
| TLN1 | talin 1 | 0.021933 |
| VIM | vimentin | 0.021933 |
| SDC4 | syndecan 4 | 0.0216232 |
| IGFBP7 | insulin-like growth factor binding protein 7 | 0.0215452 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0214055 |
| RPLP0 | ribosomal protein, large, P0 | 0.0211584 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | 0.0211461 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0209155 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0208347 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0206448 |
| AHNAK | AHNAK nucleoprotein | 0.020601 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0205343 |
| ACTG1 | actin gamma 1 | 0.0204818 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.020399 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0203825 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0202573 |
| PKM | pyruvate kinase, muscle | 0.0199856 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.396887 |
| NDRG1 | N-myc downstream regulated 1 | -0.212504 |
| VEGFA | vascular endothelial growth factor A | -0.124538 |
| COL1A1 | collagen, type I, alpha 1 | -0.121914 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.109681 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.106605 |
| CDH13 | cadherin 13 | -0.0967457 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0857586 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0776121 |
| COL5A1 | collagen, type V, alpha 1 | -0.0753257 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.074546 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0697894 |
| COL1A2 | collagen, type I, alpha 2 | -0.0677521 |
| CADM1 | cell adhesion molecule 1 | -0.0643213 |
| COL7A1 | collagen, type VII, alpha 1 | -0.0556886 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0511937 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0473999 |
| PDE10A | phosphodiesterase 10A | -0.0467236 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0429625 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0402349 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0398686 |
| EGR1 | early growth response 1 | -0.0389378 |
| TMSB10 | thymosin beta 10 | -0.0362986 |
| TMEM165 | transmembrane protein 165 | -0.036286 |
| EGFR | epidermal growth factor receptor | -0.0357303 |
| SMYD3 | SET and MYND domain containing 3 | -0.03367 |
| JARID2 | jumonji, AT rich interactive domain 2 | -0.0336687 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.032869 |
| COL6A2 | collagen, type VI, alpha 2 | -0.0327402 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | -0.0320244 |
| GOLGA4 | golgin A4 | -0.0315468 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0304999 |
| EFNA5 | ephrin-A5 | -0.0301144 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0300819 |
| CMIP | c-Maf inducing protein | -0.0297485 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0296164 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0294873 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0291455 |
| HSPG2 | heparan sulfate proteoglycan 2 | -0.0288126 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0287328 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0277324 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0274628 |
| PRKCA | protein kinase C, alpha | -0.0269156 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.02635 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0261228 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0260277 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0259996 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0257657 |
| SBF2 | SET binding factor 2 | -0.0257362 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0255393 |
| KDM4C | lysine (K)-specific demethylase 4C | -0.0255307 |
| TENM3 | teneurin transmembrane protein 3 | -0.0249112 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.0247591 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0245903 |
| TRAM1 | translocation associated membrane protein 1 | -0.0245237 |
| RRBP1 | ribosome binding protein 1 | -0.0244012 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.024314 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0241439 |
| CYB5R3 | cytochrome b5 reductase 3 | -0.0240149 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0238897 |
| SEC61A1 | Sec61 alpha 1 subunit (S. cerevisiae) | -0.0237566 |
| CALD1 | caldesmon 1 | -0.0235792 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0233565 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.02282 |
| VCL | vinculin | -0.022737 |
| TPM2 | tropomyosin 2 (beta) | -0.0227295 |
| SGIP1 | SH3-domain GRB2-like (endophilin) interacting protein 1 | -0.0225716 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0225696 |
| MTDH | metadherin | -0.0225256 |
| GLIS3 | GLIS family zinc finger 3 | -0.0224898 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0223753 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0223634 |
| TBC1D23 | TBC1 domain family, member 23 | -0.0223459 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0222813 |
| RAB6A | RAB6A, member RAS oncogene family | -0.0221903 |
| ZFPM2 | zinc finger protein, FOG family member 2 | -0.02194 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | -0.0219143 |
| LAMA5 | laminin, alpha 5 | -0.0217609 |
| CD109 | CD109 molecule | -0.0214928 |
| KIF13A | kinesin family member 13A | -0.0211908 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.0210377 |
| ATXN1 | ataxin 1 | -0.020958 |
| SLC24A3 | solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 | -0.0209317 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0209208 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | -0.0208714 |
| RUNX1 | runt-related transcription factor 1 | -0.0208384 |
| FOXP1 | forkhead box P1 | -0.0208233 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.020703 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0205987 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.020569 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0205551 |
| MYADM | myeloid-associated differentiation marker | -0.0204248 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0201087 |
| TPM1 | tropomyosin 1 (alpha) | -0.0201078 |
| ZNF644 | zinc finger protein 644 | -0.0197822 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | -0.019725 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0196382 |
| PRELID2 | PRELI domain containing 2 | -0.0195006 |
| AFF3 | AF4/FMR2 family, member 3 | -0.0194461 |
| PTK2 | protein tyrosine kinase 2 | -0.0194192 |
