Torkinib_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Torkinib perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Torkinib_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SVIL supervillin 0.106199
ERRFI1 ERBB receptor feedback inhibitor 1 0.0951444
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0747222
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.0738599
CCL20 chemokine (C-C motif) ligand 20 0.0736254
FAM107B family with sequence similarity 107, member B 0.0626634
APOB apolipoprotein B 0.056578
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0563995
POTEF POTE ankyrin domain family, member F 0.0432846
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0428622
FAT1 FAT atypical cadherin 1 0.0428618
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0424324
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0421976
KYNU kynureninase 0.0409809
MBNL1 muscleblind-like splicing regulator 1 0.0377618
MBNL2 muscleblind-like splicing regulator 2 0.0367721
DSTN destrin (actin depolymerizing factor) 0.0364616
RPL3 ribosomal protein L3 0.0346991
MYH9 myosin, heavy chain 9, non-muscle 0.0334754
TXNRD1 thioredoxin reductase 1 0.0329818
ICAM1 intercellular adhesion molecule 1 0.0323409
LIMS1 LIM and senescent cell antigen-like domains 1 0.0307675
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0306119
A2M alpha-2-macroglobulin 0.0301056
JMJD1C jumonji domain containing 1C 0.0294852
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.0294062
SOD2 superoxide dismutase 2, mitochondrial 0.0292045
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.0284148
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0283279
PAWR PRKC, apoptosis, WT1, regulator 0.028245
EEF2 eukaryotic translation elongation factor 2 0.0275039
CRY1 cryptochrome circadian clock 1 0.0274244
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0274236
PDLIM5 PDZ and LIM domain 5 0.0272246
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 0.0269844
SDC4 syndecan 4 0.0267876
TOP1 topoisomerase (DNA) I 0.0261808
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0259362
SYNE1 spectrin repeat containing, nuclear envelope 1 0.0254218
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0246446
CLIC4 chloride intracellular channel 4 0.0246051
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0238255
KIF21A kinesin family member 21A 0.0236335
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0231979
AHR aryl hydrocarbon receptor 0.0224799
MACF1 microtubule-actin crosslinking factor 1 0.0221593
EZR ezrin 0.0221414
PCBP2 poly(rC) binding protein 2 0.0218845
RPS18 ribosomal protein S18 0.0211913
ITGAV integrin, alpha V 0.0209696
DSPP dentin sialophosphoprotein 0.0208943
SIK3 SIK family kinase 3 0.0207734
MRTFA myocardin related transcription factor A 0.0201341
ANO6 anoctamin 6 0.0201009
DIAPH1 diaphanous-related formin 1 0.0200693
HSPA1B heat shock 70kDa protein 1B 0.0199674
CORO1C coronin, actin binding protein, 1C 0.0199203
DDIT4 DNA-damage-inducible transcript 4 0.0198451
RASA2 RAS p21 protein activator 2 0.0197863
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.019747
SAMD4A sterile alpha motif domain containing 4A 0.0196563
NFE2L1 nuclear factor, erythroid 2-like 1 0.0196515
FTH1 ferritin, heavy polypeptide 1 0.0193177
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 0.0192718
TLE4 transducin-like enhancer of split 4 0.019123
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0189287
USP47 ubiquitin specific peptidase 47 0.0183624
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0181125
ITCH itchy E3 ubiquitin protein ligase 0.0180568
ADAM9 ADAM metallopeptidase domain 9 0.01796
CPE carboxypeptidase E 0.0178764
BIRC3 baculoviral IAP repeat containing 3 0.0178042
AKAP13 A kinase (PRKA) anchor protein 13 0.0176459
FOXO1 forkhead box O1 0.0176185
HSPA1A heat shock 70kDa protein 1A 0.017427
EIF4B eukaryotic translation initiation factor 4B 0.0173489
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0170823
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0170604
FERMT2 fermitin family member 2 0.0170185
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0169729
GRB10 growth factor receptor-bound protein 10 0.0168853
SERINC1 serine incorporator 1 0.0168339
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0166625
USP6NL USP6 N-terminal like 0.0166193
ZBTB38 zinc finger and BTB domain containing 38 0.0165892
DSCAM Down syndrome cell adhesion molecule 0.016463
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0164462
OLA1 Obg-like ATPase 1 0.0161944
PDGFC platelet derived growth factor C 0.0160539
BCL2L1 BCL2-like 1 0.0158881
DCBLD1 discoidin, CUB and LCCL domain containing 1 0.0156997
JAK1 Janus kinase 1 0.0156078
CEMIP2 cell migration inducing hyaluronidase 2 0.0155195
UBC ubiquitin C 0.0155013
MAPK8 mitogen-activated protein kinase 8 0.015201
OPTN optineurin 0.0151757
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0151527
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.0151213
ACSL5 acyl-CoA synthetase long-chain family member 5 0.0151033
MYO1B myosin IB 0.0150247

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.527344
GPC6 glypican 6 -0.106293
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0930601
C3 complement component 3 -0.0914879
SLC38A2 solute carrier family 38, member 2 -0.091322
TPT1 tumor protein, translationally-controlled 1 -0.082277
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.072878
FN1 fibronectin 1 -0.0707879
NPAS2 neuronal PAS domain protein 2 -0.0674928
MAML2 mastermind-like 2 (Drosophila) -0.0661336
AKAP12 A kinase (PRKA) anchor protein 12 -0.0656391
CP ceruloplasmin (ferroxidase) -0.0640873
EHBP1 EH domain binding protein 1 -0.061502
MT2A metallothionein 2A -0.0600267
APOA2 apolipoprotein A-II -0.0592698
NDRG1 N-myc downstream regulated 1 -0.0566054
GMDS GDP-mannose 4,6-dehydratase -0.0538776
TMSB10 thymosin beta 10 -0.0530508
RPL37A ribosomal protein L37a -0.0530182
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0463274
ATP10A ATPase, class V, type 10A -0.0437512
RNF213 ring finger protein 213 -0.0418204
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0408883
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0385327
HMGA1 high mobility group AT-hook 1 -0.0382207
FNDC3B fibronectin type III domain containing 3B -0.0379876
EML4 echinoderm microtubule associated protein like 4 -0.0374082
ZMYND8 zinc finger, MYND-type containing 8 -0.0372766
GNAS GNAS complex locus -0.0370819
RPS24 ribosomal protein S24 -0.0362908
IFITM1 interferon induced transmembrane protein 1 -0.0362548
LRMDA leucine rich melanocyte differentiation associated -0.0355392
ZHX2 zinc fingers and homeoboxes 2 -0.034294
RPL35A ribosomal protein L35a -0.0335713
RPLP1 ribosomal protein, large, P1 -0.0329026
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0328601
RPLP2 ribosomal protein, large, P2 -0.0323767
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1 -0.0323506
RPL26 ribosomal protein L26 -0.0322603
RPS27A ribosomal protein S27a -0.0320614
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0316349
RPS29 ribosomal protein S29 -0.0310879
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0306047
FTL ferritin, light polypeptide -0.0305195
RPL11 ribosomal protein L11 -0.0297085
TM4SF1 transmembrane 4 L six family member 1 -0.0295468
FMNL2 formin-like 2 -0.029498
EGR1 early growth response 1 -0.028199
RRBP1 ribosome binding protein 1 -0.0278118
RPS19 ribosomal protein S19 -0.0271527
PEG3 paternally expressed 3 -0.0269661
RIGI RNA sensor RIG-I -0.0269228
PLIN2 perilipin 2 -0.0264987
ISG15 ISG15 ubiquitin-like modifier -0.0263121
TMEM123 transmembrane protein 123 -0.0253917
RPL9 ribosomal protein L9 -0.02537
INTS6 integrator complex subunit 6 -0.0248857
RPL19 ribosomal protein L19 -0.0245811
VEGFA vascular endothelial growth factor A -0.0245574
IFI6 interferon, alpha-inducible protein 6 -0.0236794
PTTG1IP pituitary tumor-transforming 1 interacting protein -0.0236766
H1-0 H1.0 linker histone -0.0236559
RPL28 ribosomal protein L28 -0.023424
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 -0.0233738
GPC3 glypican 3 -0.0231055
MSI2 musashi RNA-binding protein 2 -0.0229925
RNASET2 ribonuclease T2 -0.0228178
PRKCA protein kinase C, alpha -0.0225756
ITGA1 integrin, alpha 1 -0.0224878
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0223425
FOXN3 forkhead box N3 -0.0222692
APOE apolipoprotein E -0.0222665
DHRS3 dehydrogenase/reductase (SDR family) member 3 -0.0220501
PTPRM protein tyrosine phosphatase, receptor type, M -0.021864
MTUS1 microtubule associated tumor suppressor 1 -0.0214414
NKD1 naked cuticle homolog 1 (Drosophila) -0.0208372
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0208177
RPS21 ribosomal protein S21 -0.0207071
FRMD5 FERM domain containing 5 -0.0206148
APOC1 apolipoprotein C-I -0.0206089
ATXN1 ataxin 1 -0.0205578
WSB1 WD repeat and SOCS box containing 1 -0.0205086
CCDC146 coiled-coil domain containing 146 -0.020331
GK glycerol kinase -0.0202815
PLXDC2 plexin domain containing 2 -0.0202249
PDGFB platelet-derived growth factor beta polypeptide -0.0200792
RPL31 ribosomal protein L31 -0.0200136
RPL12 ribosomal protein L12 -0.0199126
ZFHX3 zinc finger homeobox 3 -0.0199002
RPS25 ribosomal protein S25 -0.0196694
RAD51B RAD51 paralog B -0.019459
ZBTB20 zinc finger and BTB domain containing 20 -0.0190722
PKM pyruvate kinase, muscle -0.0189679
MX2 MX dynamin-like GTPase 2 -0.0184883
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae) -0.0184813
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0184762
RPL36 ribosomal protein L36 -0.0183627
RPL23 ribosomal protein L23 -0.0183518
NPR2 natriuretic peptide receptor 2 -0.0182876
SCN9A sodium channel, voltage gated, type IX alpha subunit -0.0182052