| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Torkinib perturbation in Hs 766T cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Torkinib_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.12388 |
| POTEF | POTE ankyrin domain family, member F | 0.104239 |
| MYOF | myoferlin | 0.0903543 |
| B2M | beta-2-microglobulin | 0.0868698 |
| CD44 | CD44 molecule (Indian blood group) | 0.084938 |
| STC1 | stanniocalcin 1 | 0.0805648 |
| CLU | clusterin | 0.0697826 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0679124 |
| ANXA1 | annexin A1 | 0.0668363 |
| ENO1 | enolase 1, (alpha) | 0.0650088 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0645079 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.061823 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.058866 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0541346 |
| TGM2 | transglutaminase 2 | 0.0531913 |
| KRT17 | keratin 17, type I | 0.0514287 |
| LDHA | lactate dehydrogenase A | 0.0497674 |
| ARRDC3 | arrestin domain containing 3 | 0.0483146 |
| SMAD3 | SMAD family member 3 | 0.0470567 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0462309 |
| SERINC3 | serine incorporator 3 | 0.042931 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.042597 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0421206 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0418752 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0418333 |
| DSTN | destrin (actin depolymerizing factor) | 0.0395239 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0384735 |
| ANO6 | anoctamin 6 | 0.0383278 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0377603 |
| RFX2 | regulatory factor X, 2 (influences HLA class II expression) | 0.0369087 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0360988 |
| ATF4 | activating transcription factor 4 | 0.0353026 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0344831 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0344458 |
| SET | SET nuclear proto-oncogene | 0.0344348 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.034303 |
| RPS12 | ribosomal protein S12 | 0.0342993 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0342106 |
| ANGPTL4 | angiopoietin-like 4 | 0.0339547 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0338066 |
| TXNIP | thioredoxin interacting protein | 0.0335041 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0326644 |
| RPL23 | ribosomal protein L23 | 0.0325835 |
| FNIP1 | folliculin interacting protein 1 | 0.0322649 |
| TPX2 | TPX2, microtubule-associated | 0.0319452 |
| MT2A | metallothionein 2A | 0.0316701 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0315434 |
| CENPF | centromere protein F, 350/400kDa | 0.0306988 |
| SIK3 | SIK family kinase 3 | 0.0305656 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0292696 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0287091 |
| SLK | STE20-like kinase | 0.0285737 |
| TPM3 | tropomyosin 3 | 0.028205 |
| SEPTIN9 | septin 9 | 0.0280833 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0279332 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0278412 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0276683 |
| PCBP2 | poly(rC) binding protein 2 | 0.0274137 |
| TLN1 | talin 1 | 0.0272085 |
| SFTPA2 | surfactant protein A2 | 0.0269302 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0268662 |
| PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | 0.0259571 |
| JMJD1C | jumonji domain containing 1C | 0.0257863 |
| LNPEP | leucyl/cystinyl aminopeptidase | 0.0257394 |
| GOLGB1 | golgin B1 | 0.0251615 |
| CALR | calreticulin | 0.0250898 |
| ARHGAP21 | Rho GTPase activating protein 21 | 0.0249382 |
| RPL12 | ribosomal protein L12 | 0.0249143 |
| ADM | adrenomedullin | 0.0247213 |
| ANKH | ANKH inorganic pyrophosphate transport regulator | 0.0243518 |
| RACK1 | receptor for activated C kinase 1 | 0.024339 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0242813 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | 0.0240252 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0237568 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0237281 |
| TES | testin LIM domain protein | 0.0228895 |
| IGFBP6 | insulin-like growth factor binding protein 6 | 0.0227169 |
| RPS13 | ribosomal protein S13 | 0.0226441 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0223262 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0222918 |
| DUSP6 | dual specificity phosphatase 6 | 0.022256 |
| UBC | ubiquitin C | 0.0221794 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.021628 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0216219 |
| DIAPH1 | diaphanous-related formin 1 | 0.0214259 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | 0.0213301 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0212723 |
| RFX3 | regulatory factor X, 3 (influences HLA class II expression) | 0.0212301 |
| SLTM | SAFB-like, transcription modulator | 0.0211146 |
| SQSTM1 | sequestosome 1 | 0.0208227 |
| RPS19 | ribosomal protein S19 | 0.0206313 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0205086 |
| VMP1 | vacuole membrane protein 1 | 0.0204808 |
| IDS | iduronate 2-sulfatase | 0.0204703 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0203397 |
| KRT6A | keratin 6A, type II | 0.0203351 |
| RPS8 | ribosomal protein S8 | 0.0202363 |
| TPI1 | triosephosphate isomerase 1 | 0.0201981 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.0200359 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0199568 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.314228 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.257387 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.19482 |
| FLNB | filamin B, beta | -0.18912 |
| SULF1 | sulfatase 1 | -0.13809 |
| NDRG1 | N-myc downstream regulated 1 | -0.124092 |
| DPYD | dihydropyrimidine dehydrogenase | -0.106937 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.095537 |
| HSPG2 | heparan sulfate proteoglycan 2 | -0.0894535 |
| MTSS1 | metastasis suppressor 1 | -0.0892605 |
| AHNAK | AHNAK nucleoprotein | -0.0861904 |
| PODXL | podocalyxin-like | -0.0827094 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0761534 |
| IGF2 | insulin-like growth factor 2 | -0.072388 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0696143 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0677708 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0671234 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0651681 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | -0.0639146 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0623746 |
| MECOM | MDS1 and EVI1 complex locus | -0.0617509 |
| LAMA5 | laminin, alpha 5 | -0.0612338 |
| ANO1 | anoctamin 1, calcium activated chloride channel | -0.0606881 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0595114 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0591996 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.056274 |
| RAI14 | retinoic acid induced 14 | -0.0521048 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.051884 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0498347 |
| EPB41L1 | erythrocyte membrane protein band 4.1-like 1 | -0.0474955 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | -0.0474492 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0447081 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0445635 |
| TNS3 | tensin 3 | -0.044331 |
| SULF2 | sulfatase 2 | -0.0429421 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0423477 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.0420511 |
| UTRN | utrophin | -0.0413774 |
| ACTN4 | actinin, alpha 4 | -0.0411508 |
| RBM39 | RNA binding motif protein 39 | -0.0399739 |
| FLNA | filamin A, alpha | -0.0397701 |
| ADAMTS16 | ADAM metallopeptidase with thrombospondin type 1 motif, 16 | -0.0397137 |
| HMGA2 | high mobility group AT-hook 2 | -0.0385373 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0381103 |
| LAMC2 | laminin, gamma 2 | -0.0379576 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | -0.0370721 |
| ERGIC1 | endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 | -0.0364643 |
| MEF2A | myocyte enhancer factor 2A | -0.0363807 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.0357159 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0353718 |
| RRBP1 | ribosome binding protein 1 | -0.0353208 |
| THBD | thrombomodulin | -0.0352778 |
| SMYD3 | SET and MYND domain containing 3 | -0.0350462 |
| PALLD | palladin, cytoskeletal associated protein | -0.0350253 |
| C4BPB | complement component 4 binding protein, beta | -0.0342926 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0335273 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.032659 |
| RAD51B | RAD51 paralog B | -0.0326104 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | -0.0323446 |
| MEIS2 | Meis homeobox 2 | -0.0320634 |
| LAMB3 | laminin, beta 3 | -0.0314073 |
| DUSP5 | dual specificity phosphatase 5 | -0.0311857 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0310722 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | -0.0309278 |
| FOSL1 | FOS-like antigen 1 | -0.0307201 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0304292 |
| COL4A5 | collagen, type IV, alpha 5 | -0.0303938 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | -0.0303842 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0302992 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 | -0.0299957 |
| COL17A1 | collagen, type XVII, alpha 1 | -0.0299616 |
| OXR1 | oxidation resistance 1 | -0.0294704 |
| CUX1 | cut-like homeobox 1 | -0.0290971 |
| GNAS | GNAS complex locus | -0.0290532 |
| MPRIP | myosin phosphatase Rho interacting protein | -0.0290485 |
| BCL2L1 | BCL2-like 1 | -0.0289883 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0289609 |
| ITGBL1 | integrin, beta-like 1 (with EGF-like repeat domains) | -0.0287143 |
| DGKH | diacylglycerol kinase, eta | -0.0280617 |
| CALB1 | calbindin 1, 28kDa | -0.0278676 |
| CDK6 | cyclin-dependent kinase 6 | -0.0278338 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0274847 |
| RIGI | RNA sensor RIG-I | -0.0273185 |
| LDLR | low density lipoprotein receptor | -0.0271992 |
| OSMR | oncostatin M receptor | -0.0269521 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.026753 |
| MUC5AC | mucin 5AC, oligomeric mucus/gel-forming | -0.0265117 |
| KIAA1549L | KIAA1549-like | -0.0265089 |
| ITGB4 | integrin, beta 4 | -0.0264594 |
| RCOR1 | REST corepressor 1 | -0.025738 |
| TPM4 | tropomyosin 4 | -0.0257258 |
| EGFR | epidermal growth factor receptor | -0.0257159 |
| DENND1A | DENN/MADD domain containing 1A | -0.0254434 |
| PTPRB | protein tyrosine phosphatase, receptor type, B | -0.0254312 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | -0.0253338 |
| MYO10 | myosin X | -0.0246433 |
| CPEB2 | cytoplasmic polyadenylation element binding protein 2 | -0.0244084 |
| EXOC6B | exocyst complex component 6B | -0.0243742 |
| HMGA1 | high mobility group AT-hook 1 | -0.0242944 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0241915 |
