| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Torkinib perturbation in KATO III cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Torkinib_KATO III drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.170961 |
| LMO7 | LIM domain 7 | 0.160416 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.144087 |
| EZR | ezrin | 0.131032 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.10239 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0978985 |
| ANXA1 | annexin A1 | 0.0869545 |
| MYOF | myoferlin | 0.0817834 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.078531 |
| AREG | amphiregulin | 0.072293 |
| ATXN1 | ataxin 1 | 0.0711898 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0709825 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0673778 |
| ENO1 | enolase 1, (alpha) | 0.064343 |
| KLHL29 | kelch-like family member 29 | 0.0641351 |
| LCN2 | lipocalin 2 | 0.0639664 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0604065 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0598988 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0583774 |
| TES | testin LIM domain protein | 0.0582634 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.0580909 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0577323 |
| GDA | guanine deaminase | 0.0555179 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0535578 |
| FTL | ferritin, light polypeptide | 0.0532581 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0519103 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0512732 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0500947 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0491521 |
| ASPH | aspartate beta-hydroxylase | 0.0480833 |
| SQSTM1 | sequestosome 1 | 0.0466602 |
| ATF4 | activating transcription factor 4 | 0.0457466 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.0453703 |
| GOLGB1 | golgin B1 | 0.0452099 |
| DSPP | dentin sialophosphoprotein | 0.0446982 |
| INTS6 | integrator complex subunit 6 | 0.0441602 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0440801 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0431522 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | 0.0430689 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0424765 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0421914 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0409949 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0408687 |
| HKDC1 | hexokinase domain containing 1 | 0.0404928 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0401319 |
| SLC38A1 | solute carrier family 38, member 1 | 0.0398766 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0395774 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.03775 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0369088 |
| SET | SET nuclear proto-oncogene | 0.0368689 |
| HM13 | histocompatibility (minor) 13 | 0.0364295 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0362777 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0361477 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0359677 |
| KRT18 | keratin 18, type I | 0.0359592 |
| ARHGAP29 | Rho GTPase activating protein 29 | 0.035884 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0358241 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0358051 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0357717 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0355466 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0355178 |
| EEPD1 | endonuclease/exonuclease/phosphatase family domain containing 1 | 0.0341028 |
| RPS12 | ribosomal protein S12 | 0.0340705 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0332266 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0332167 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0331211 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0326671 |
| DSTN | destrin (actin depolymerizing factor) | 0.0323324 |
| SMAD3 | SMAD family member 3 | 0.0318702 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0316904 |
| CATSPERB | catsper channel auxiliary subunit beta | 0.0315402 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0312516 |
| HDAC9 | histone deacetylase 9 | 0.0303056 |
| MYO1E | myosin IE | 0.0295976 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0295654 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0292123 |
| ANXA2 | annexin A2 | 0.0291817 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0290975 |
| SLCO1B3-SLCO1B7 | SLCO1B3-SLCO1B7 readthrough | 0.0290353 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.0288533 |
| RASEF | RAS and EF-hand domain containing | 0.0288524 |
| HYOU1 | hypoxia up-regulated 1 | 0.0288136 |
| FNIP1 | folliculin interacting protein 1 | 0.0286128 |
| EMP1 | epithelial membrane protein 1 | 0.0284293 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0281935 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | 0.0274534 |
| TJP1 | tight junction protein 1 | 0.0273237 |
| MYO5B | myosin VB | 0.0271731 |
| CALR | calreticulin | 0.026744 |
| FRMD5 | FERM domain containing 5 | 0.0267323 |
| SIK3 | SIK family kinase 3 | 0.0266084 |
| TAC4 | tachykinin 4 (hemokinin) | 0.0265512 |
| FAM107B | family with sequence similarity 107, member B | 0.0260253 |
| PGK1 | phosphoglycerate kinase 1 | 0.0259704 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0258949 |
| TXNRD1 | thioredoxin reductase 1 | 0.025701 |
| TOM1L2 | target of myb1-like 2 (chicken) | 0.0252648 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0251904 |
| SOX4 | SRY (sex determining region Y)-box 4 | 0.0251633 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0248816 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NPSR1 | neuropeptide S receptor 1 | -0.171866 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.109632 |
| HSD17B12 | hydroxysteroid (17-beta) dehydrogenase 12 | -0.0934713 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0875975 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0805186 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0708748 |
| PRSS3 | protease, serine, 3 | -0.0643628 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0625378 |
| ITGB4 | integrin, beta 4 | -0.062175 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0593779 |
| MUC17 | mucin 17, cell surface associated | -0.0582797 |
| SAMD12 | sterile alpha motif domain containing 12 | -0.0546756 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0507147 |
| H1-0 | H1.0 linker histone | -0.0499896 |
| ACSS2 | acyl-CoA synthetase short-chain family member 2 | -0.0487961 |
| CD46 | CD46 molecule, complement regulatory protein | -0.0473883 |
| INSIG1 | insulin induced gene 1 | -0.0464486 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | -0.0445434 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0432984 |
| FLNB | filamin B, beta | -0.0426256 |
| GPX2 | glutathione peroxidase 2 | -0.0419409 |
| AVL9 | AVL9 homolog (S. cerevisiase) | -0.0408222 |
| ACACA | acetyl-CoA carboxylase alpha | -0.0407249 |
| MUC1 | mucin 1, cell surface associated | -0.0406374 |
| RRBP1 | ribosome binding protein 1 | -0.0392426 |
| S100A6 | S100 calcium binding protein A6 | -0.0387968 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0386165 |
| TMEM45B | transmembrane protein 45B | -0.0375518 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.0372827 |
| CD2AP | CD2-associated protein | -0.0362382 |
| CCNL1 | cyclin L1 | -0.0360502 |
| MSI2 | musashi RNA-binding protein 2 | -0.0355224 |
| FASN | fatty acid synthase | -0.0351305 |
| FGFR2 | fibroblast growth factor receptor 2 | -0.0339321 |
| ZNF292 | zinc finger protein 292 | -0.0338269 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | -0.0336166 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | -0.0328298 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0315374 |
| PLSCR1 | phospholipid scramblase 1 | -0.0312137 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0310619 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0309779 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.0308002 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0299297 |
| CASK | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | -0.0296794 |
| RNF43 | ring finger protein 43 | -0.0295625 |
| ANLN | anillin, actin binding protein | -0.0289597 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | -0.0288886 |
| AOPEP | aminopeptidase O (putative) | -0.0286558 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0286174 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0285865 |
| RNF213 | ring finger protein 213 | -0.0277035 |
| ACTN4 | actinin, alpha 4 | -0.0276634 |
| LYZ | lysozyme | -0.0276581 |
| RAB6A | RAB6A, member RAS oncogene family | -0.0272115 |
| ETNK1 | ethanolamine kinase 1 | -0.0267881 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0266451 |
| LPIN1 | lipin 1 | -0.0263733 |
| PIAS1 | protein inhibitor of activated STAT, 1 | -0.0259369 |
| SLC6A14 | solute carrier family 6 (amino acid transporter), member 14 | -0.0258831 |
| SHB | Src homology 2 domain containing adaptor protein B | -0.0257387 |
| MECOM | MDS1 and EVI1 complex locus | -0.0255635 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0255356 |
| ACSL1 | acyl-CoA synthetase long-chain family member 1 | -0.0254195 |
| SPINT2 | serine peptidase inhibitor, Kunitz type, 2 | -0.0253322 |
| ST14 | suppression of tumorigenicity 14 (colon carcinoma) | -0.0249324 |
| TRIM31 | tripartite motif containing 31 | -0.0248775 |
| MSMO1 | methylsterol monooxygenase 1 | -0.0245901 |
| ETV6 | ets variant 6 | -0.0245317 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -0.0244354 |
| TNRC18 | trinucleotide repeat containing 18 | -0.0243462 |
| NECTIN2 | nectin cell adhesion molecule 2 | -0.0242178 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.024138 |
| CEACAM1 | carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) | -0.0236989 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0236572 |
| RREB1 | ras responsive element binding protein 1 | -0.0233929 |
| HMGA1 | high mobility group AT-hook 1 | -0.0232813 |
| GNAS | GNAS complex locus | -0.0230329 |
| ABHD17C | abhydrolase domain containing 17C | -0.0229247 |
| C1GALT1 | core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 | -0.0228601 |
| TTYH3 | tweety family member 3 | -0.0224417 |
| ZC3H12B | zinc finger CCCH-type containing 12B | -0.0223977 |
| LAMA5 | laminin, alpha 5 | -0.0222841 |
| SRPK2 | SRSF protein kinase 2 | -0.022133 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0220913 |
| NF1 | neurofibromin 1 | -0.0219856 |
| CTSE | cathepsin E | -0.0219018 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | -0.0218932 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | -0.021836 |
| PLS1 | plastin 1 | -0.0215391 |
| SHROOM3 | shroom family member 3 | -0.0214381 |
| WWC1 | WW and C2 domain containing 1 | -0.0213664 |
| TAPBP | TAP binding protein (tapasin) | -0.0212891 |
| CCDC146 | coiled-coil domain containing 146 | -0.0210986 |
| PRRC2B | proline-rich coiled-coil 2B | -0.0210484 |
| SNX13 | sorting nexin 13 | -0.0209295 |
| JUP | junction plakoglobin | -0.0208815 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -0.0208787 |
| WDR45B | WD repeat domain 45B | -0.0208347 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0207846 |
| SMC5 | structural maintenance of chromosomes 5 | -0.0207385 |
