Torkinib_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Torkinib perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Torkinib_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.171506
RPS12 ribosomal protein S12 0.126892
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0717002
RPL37A ribosomal protein L37a 0.0687574
B2M beta-2-microglobulin 0.0656083
TPT1 tumor protein, translationally-controlled 1 0.0592859
HSPA8 heat shock 70kDa protein 8 0.0587586
RPL31 ribosomal protein L31 0.0551334
EXT1 exostosin glycosyltransferase 1 0.054191
FTL ferritin, light polypeptide 0.0538888
RPL9 ribosomal protein L9 0.0515584
RPL12 ribosomal protein L12 0.0511647
LMO7 LIM domain 7 0.0508837
ENO1 enolase 1, (alpha) 0.0508301
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0475388
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0475047
RPS17 ribosomal protein S17 0.0471022
MT2A metallothionein 2A 0.045061
RPS3 ribosomal protein S3 0.0446156
FAT1 FAT atypical cadherin 1 0.0407008
LDHA lactate dehydrogenase A 0.0404425
RPL26 ribosomal protein L26 0.0403993
RPS27A ribosomal protein S27a 0.038551
RPS27 ribosomal protein S27 0.0373679
RPS8 ribosomal protein S8 0.0361935
LOC102724023 ES1 protein homolog, mitochondrial 0.0359423
POTEF POTE ankyrin domain family, member F 0.0338289
RPL35A ribosomal protein L35a 0.0330891
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0326793
ZSWIM6 zinc finger, SWIM-type containing 6 0.0326231
UNC13B unc-13 homolog B (C. elegans) 0.032603
RPS19 ribosomal protein S19 0.0322105
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.03172
MARCHF3 membrane associated ring-CH-type finger 3 0.0312338
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0310876
RPL7 ribosomal protein L7 0.0300178
SQSTM1 sequestosome 1 0.0291772
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0288941
AFF1 AF4/FMR2 family, member 1 0.0286916
CLCN3 chloride channel, voltage-sensitive 3 0.028638
RPL37 ribosomal protein L37 0.0278327
RPL11 ribosomal protein L11 0.0278037
RPL36 ribosomal protein L36 0.0277173
RPLP2 ribosomal protein, large, P2 0.0276456
RPS25 ribosomal protein S25 0.0269192
SIK3 SIK family kinase 3 0.0265706
MBNL1 muscleblind-like splicing regulator 1 0.0262792
RPL7A ribosomal protein L7a 0.0261828
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0254809
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0253049
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0246387
RPS18 ribosomal protein S18 0.0240775
PARD3B par-3 family cell polarity regulator beta 0.024016
SLC38A2 solute carrier family 38, member 2 0.0239642
ISG15 ISG15 ubiquitin-like modifier 0.0237684
JARID2 jumonji, AT rich interactive domain 2 0.0235049
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0232224
ASPH aspartate beta-hydroxylase 0.023089
PRDX1 peroxiredoxin 1 0.0228801
EGFR epidermal growth factor receptor 0.0228736
RPS13 ribosomal protein S13 0.02271
RPL36A ribosomal protein L36a 0.0224609
CRY1 cryptochrome circadian clock 1 0.0221123
ERRFI1 ERBB receptor feedback inhibitor 1 0.0220123
SPDYA speedy/RINGO cell cycle regulator family member A 0.0219708
EIF5 eukaryotic translation initiation factor 5 0.0218551
RPL19 ribosomal protein L19 0.0215919
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0215847
TUBB4B tubulin, beta 4B class IVb 0.0212766
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0209646
CALR calreticulin 0.0208428
TGFBR3 transforming growth factor, beta receptor III 0.0206915
TPI1 triosephosphate isomerase 1 0.0206881
MYO5B myosin VB 0.0206617
RPL3 ribosomal protein L3 0.0205932
INTS6 integrator complex subunit 6 0.0203728
RPL30 ribosomal protein L30 0.0202359
RACK1 receptor for activated C kinase 1 0.0194761
SGMS2 sphingomyelin synthase 2 0.0193013
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.019294
IFI27 interferon, alpha-inducible protein 27 0.0190286
RPS6 ribosomal protein S6 0.0190073
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0189712
KLF5 Kruppel-like factor 5 (intestinal) 0.0186021
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.0185085
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0184183
MYO1E myosin IE 0.0179438
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0179274
ENO2 enolase 2 (gamma, neuronal) 0.0176033
RPL15 ribosomal protein L15 0.0175959
HSPE1 heat shock 10kDa protein 1 0.0175545
NEBL nebulette 0.0174816
ARHGAP21 Rho GTPase activating protein 21 0.0174121
EZR ezrin 0.0173706
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.017295
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0171649
RPL23 ribosomal protein L23 0.0169157
APLP2 amyloid beta (A4) precursor-like protein 2 0.0168827
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0166189
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0162147

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.250975
NPSR1 neuropeptide S receptor 1 -0.154526
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.146651
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.131639
MUC6 mucin 6, oligomeric mucus/gel-forming -0.116823
ITGA6 integrin, alpha 6 -0.0949695
TNS4 tensin 4 -0.0943598
PTMA prothymosin, alpha -0.0933224
ANXA2 annexin A2 -0.0884015
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0849101
FLNB filamin B, beta -0.0824434
NALF1 NALCN channel auxiliary factor 1 -0.0808902
CEMIP cell migration inducing protein, hyaluronan binding -0.0789394
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0727446
RNF43 ring finger protein 43 -0.0687877
GPHN gephyrin -0.0677038
GOLGA4 golgin A4 -0.0675666
NCOR1 nuclear receptor corepressor 1 -0.0618539
ACTN4 actinin, alpha 4 -0.0618393
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0612025
MED13L mediator complex subunit 13-like -0.0579772
PRSS3 protease, serine, 3 -0.0579147
H1-0 H1.0 linker histone -0.0562805
PIGR polymeric immunoglobulin receptor -0.0540471
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0538865
PNISR PNN-interacting serine/arginine-rich protein -0.0535525
SETD5 SET domain containing 5 -0.0530441
PPARG peroxisome proliferator-activated receptor gamma -0.0509336
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0507559
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0500411
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0498884
CD46 CD46 molecule, complement regulatory protein -0.0488736
ZFAND3 zinc finger, AN1-type domain 3 -0.04884
ANTXR2 anthrax toxin receptor 2 -0.0485466
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0465739
AHNAK AHNAK nucleoprotein -0.045788
ITGB4 integrin, beta 4 -0.0451763
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B -0.0451655
CALB1 calbindin 1, 28kDa -0.045099
ONECUT3 one cut homeobox 3 -0.0445929
CADPS Ca++-dependent secretion activator -0.0442986
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0437758
SBF2 SET binding factor 2 -0.0425937
ANKRD17 ankyrin repeat domain 17 -0.042473
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) -0.0424386
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0422676
RNF145 ring finger protein 145 -0.0420422
NF1 neurofibromin 1 -0.0418003
RRBP1 ribosome binding protein 1 -0.0412008
FAM13A family with sequence similarity 13, member A -0.0410054
IARS1 isoleucyl-tRNA synthetase 1 -0.040984
FERMT1 fermitin family member 1 -0.0407897
NFIA nuclear factor I/A -0.0405901
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase -0.0399529
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0397951
NDRG1 N-myc downstream regulated 1 -0.0391427
RBM39 RNA binding motif protein 39 -0.0391354
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0391192
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0390132
MBD5 methyl-CpG binding domain protein 5 -0.0388654
VCL vinculin -0.0386296
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 -0.0385766
GSK3B glycogen synthase kinase 3 beta -0.0382983
COG5 component of oligomeric golgi complex 5 -0.0378645
RREB1 ras responsive element binding protein 1 -0.0374979
BIRC6 baculoviral IAP repeat containing 6 -0.0372028
DLG1 discs, large homolog 1 (Drosophila) -0.0369329
MON2 MON2 homolog (S. cerevisiae) -0.036829
PUM2 pumilio RNA-binding family member 2 -0.0368115
RAB1A RAB1A, member RAS oncogene family -0.0366541
USP3 ubiquitin specific peptidase 3 -0.0365057
GDF15 growth differentiation factor 15 -0.0363142
GREB1L growth regulation by estrogen in breast cancer-like -0.0363087
GCC2 GRIP and coiled-coil domain containing 2 -0.0362587
KDM7A lysine (K)-specific demethylase 7A -0.0352973
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0350737
MSI2 musashi RNA-binding protein 2 -0.0344741
STRN3 striatin, calmodulin binding protein 3 -0.0344325
OGA O-GlcNAcase -0.0343342
PTBP3 polypyrimidine tract binding protein 3 -0.0342102
WDR45B WD repeat domain 45B -0.034094
ANKRD11 ankyrin repeat domain 11 -0.0337163
ARHGAP32 Rho GTPase activating protein 32 -0.0336417
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0333953
INSIG1 insulin induced gene 1 -0.0333859
WASF2 WAS protein family, member 2 -0.0332704
DERA deoxyribose-phosphate aldolase (putative) -0.0331537
SREBF2 sterol regulatory element binding transcription factor 2 -0.0331273
ABHD2 abhydrolase domain containing 2 -0.0328079
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0324517
PTPRR protein tyrosine phosphatase, receptor type, R -0.0321411
GARS1 glycyl-tRNA synthetase 1 -0.0321188
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0320825
EPCAM epithelial cell adhesion molecule -0.0320344
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 -0.0320281
EXOC1 exocyst complex component 1 -0.0320115
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0318873
ESYT2 extended synaptotagmin-like protein 2 -0.0316054
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0315405
TM9SF3 transmembrane 9 superfamily member 3 -0.0314378