Torkinib_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Torkinib perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Torkinib_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
POTEF POTE ankyrin domain family, member F 0.154241
MT2A metallothionein 2A 0.129412
RPS12 ribosomal protein S12 0.120892
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.092317
FTH1 ferritin, heavy polypeptide 1 0.0770572
RPL12 ribosomal protein L12 0.0589783
ZSWIM6 zinc finger, SWIM-type containing 6 0.0550763
CAPRIN2 caprin family member 2 0.0542254
RPL37A ribosomal protein L37a 0.0523186
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0517446
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0504039
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0499734
RPL31 ribosomal protein L31 0.0471928
ENO2 enolase 2 (gamma, neuronal) 0.0457382
ENO1 enolase 1, (alpha) 0.0457069
RPS17 ribosomal protein S17 0.0452017
RPL23 ribosomal protein L23 0.0437174
RPS3 ribosomal protein S3 0.0427249
HOMER1 homer scaffolding protein 1 0.0410346
ERRFI1 ERBB receptor feedback inhibitor 1 0.0395197
RPS8 ribosomal protein S8 0.0381145
TXNIP thioredoxin interacting protein 0.03742
INTS6 integrator complex subunit 6 0.037417
MT1E metallothionein 1E 0.0364722
HSPA8 heat shock 70kDa protein 8 0.0355447
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0335624
RPL26 ribosomal protein L26 0.0335086
RPS18 ribosomal protein S18 0.0333793
B2M beta-2-microglobulin 0.0326364
NEK10 NIMA-related kinase 10 0.0321983
RPS27 ribosomal protein S27 0.0317341
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0295957
RACK1 receptor for activated C kinase 1 0.0283808
PRELID2 PRELI domain containing 2 0.0282994
RPL3 ribosomal protein L3 0.028181
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0280526
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0268345
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.0266727
CXCL8 chemokine (C-X-C motif) ligand 8 0.0265969
PLIN2 perilipin 2 0.026417
AKAP9 A kinase (PRKA) anchor protein 9 0.026022
RPL37 ribosomal protein L37 0.0257068
APLP2 amyloid beta (A4) precursor-like protein 2 0.0256789
TTC3 tetratricopeptide repeat domain 3 0.025618
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0255623
TPM3 tropomyosin 3 0.0254229
FTL ferritin, light polypeptide 0.0252669
PDIA4 protein disulfide isomerase family A, member 4 0.025086
EEF1G eukaryotic translation elongation factor 1 gamma 0.0248708
SQSTM1 sequestosome 1 0.0246881
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0244229
PCDH1 protocadherin 1 0.0243826
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0236211
MCL1 myeloid cell leukemia 1 0.0235592
RPL36 ribosomal protein L36 0.0234553
EIF5 eukaryotic translation initiation factor 5 0.0230395
RPS19 ribosomal protein S19 0.0228873
BIRC3 baculoviral IAP repeat containing 3 0.0224135
RPL19 ribosomal protein L19 0.0220379
RPS13 ribosomal protein S13 0.0217053
GOLGB1 golgin B1 0.021689
RPL27 ribosomal protein L27 0.0215473
NPAS2 neuronal PAS domain protein 2 0.0214369
TPI1 triosephosphate isomerase 1 0.0213077
NFE2L1 nuclear factor, erythroid 2-like 1 0.0211035
PCBP2 poly(rC) binding protein 2 0.0203648
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0199158
RPS20 ribosomal protein S20 0.0198864
DDX41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 0.0196486
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0191879
ARF6 ADP-ribosylation factor 6 0.0189626
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0189589
AREG amphiregulin 0.018895
RPL11 ribosomal protein L11 0.0187339
LOC102724023 ES1 protein homolog, mitochondrial 0.0185752
WWTR1 WW domain containing transcription regulator 1 0.0185227
SOX9 SRY (sex determining region Y)-box 9 0.0178633
MSN moesin 0.0177677
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough 0.0177661
MYOF myoferlin 0.0176983
DST dystonin 0.0176814
RPL9 ribosomal protein L9 0.0173939
KRT18 keratin 18, type I 0.0170367
SRRM2 serine/arginine repetitive matrix 2 0.0169821
RCOR1 REST corepressor 1 0.0169609
TLN1 talin 1 0.0166943
RPS4X ribosomal protein S4, X-linked 0.0165934
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0165391
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.0159325
LRRC23 leucine rich repeat containing 23 0.0159257
SGMS2 sphingomyelin synthase 2 0.0158306
CALR calreticulin 0.0157792
HLA-A major histocompatibility complex, class I, A 0.0156736
ATF4 activating transcription factor 4 0.0156119
ANGPTL4 angiopoietin-like 4 0.0154973
PGM3 phosphoglucomutase 3 0.0151096
EZR ezrin 0.015079
CFLAR CASP8 and FADD-like apoptosis regulator 0.014914
LDHA lactate dehydrogenase A 0.0145456
MKRN1 makorin ring finger protein 1 0.0145154

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.209989
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.144904
PTMA prothymosin, alpha -0.144328
TMSB4X thymosin beta 4, X-linked -0.134039
DLG1 discs, large homolog 1 (Drosophila) -0.131046
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.111805
CD44 CD44 molecule (Indian blood group) -0.107874
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0923013
APP amyloid beta (A4) precursor protein -0.0857719
ZMYND8 zinc finger, MYND-type containing 8 -0.0856638
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0849387
RAI1 retinoic acid induced 1 -0.0786016
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0758198
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0756945
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0724097
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0696609
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0654654
WSB1 WD repeat and SOCS box containing 1 -0.0653134
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0624904
SRGN serglycin -0.0598824
PTK2 protein tyrosine kinase 2 -0.0598332
TM4SF1 transmembrane 4 L six family member 1 -0.0580286
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0574871
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0569666
TP63 tumor protein p63 -0.0563312
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0553835
TXNRD1 thioredoxin reductase 1 -0.0547572
NAMPT nicotinamide phosphoribosyltransferase -0.052812
RIGI RNA sensor RIG-I -0.0523051
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0520759
RBM25 RNA binding motif protein 25 -0.0508565
EHBP1 EH domain binding protein 1 -0.0505276
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0498461
AHNAK AHNAK nucleoprotein -0.049823
VIM vimentin -0.0489068
ACTG1 actin gamma 1 -0.0486265
ZNF292 zinc finger protein 292 -0.0480195
TMEM123 transmembrane protein 123 -0.0473911
RTN4 reticulon 4 -0.0469597
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0469329
KDM3A lysine (K)-specific demethylase 3A -0.0456797
CANX calnexin -0.0448384
FBXO11 F-box protein 11 -0.0445056
RLF rearranged L-myc fusion -0.0439597
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0436009
KPNB1 karyopherin (importin) beta 1 -0.0433677
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0423616
PRRC2B proline-rich coiled-coil 2B -0.0423469
SEPTIN7 septin 7 -0.0417016
NPEPPS aminopeptidase puromycin sensitive -0.0416726
GARS1 glycyl-tRNA synthetase 1 -0.0414433
ZNF217 zinc finger protein 217 -0.0410032
FMNL2 formin-like 2 -0.0407412
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0406802
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein -0.0386553
FUS FUS RNA binding protein -0.0381084
TMEM41B transmembrane protein 41B -0.038021
RBM39 RNA binding motif protein 39 -0.0377416
PARD3 par-3 family cell polarity regulator -0.0372024
SPAG9 sperm associated antigen 9 -0.0369388
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) -0.0364829
YEATS2 YEATS domain containing 2 -0.0364685
BRWD1 bromodomain and WD repeat domain containing 1 -0.0356845
PUM1 pumilio RNA-binding family member 1 -0.0356374
TNS3 tensin 3 -0.0354749
ARHGAP5 Rho GTPase activating protein 5 -0.0353929
NCOR1 nuclear receptor corepressor 1 -0.0353923
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0353584
PNISR PNN-interacting serine/arginine-rich protein -0.0351468
XPO1 exportin 1 -0.0351031
TRA2A transformer 2 alpha homolog (Drosophila) -0.0346146
OGA O-GlcNAcase -0.0346031
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0344553
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0343294
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0342533
HLA-B major histocompatibility complex, class I, B -0.0340857
GNAS GNAS complex locus -0.0340549
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0339637
OLA1 Obg-like ATPase 1 -0.0338238
FAF1 Fas (TNFRSF6) associated factor 1 -0.03382
ADGRG6 adhesion G protein-coupled receptor G6 -0.0336485
PTPRF protein tyrosine phosphatase, receptor type, F -0.0336299
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0336018
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0335498
FLNB filamin B, beta -0.0333636
SRPK2 SRSF protein kinase 2 -0.033356
EFNA5 ephrin-A5 -0.0333064
PUM2 pumilio RNA-binding family member 2 -0.0330383
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.0330288
AMBRA1 autophagy/beclin-1 regulator 1 -0.0329102
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0328558
THOC2 THO complex 2 -0.0327837
CAVIN1 caveolae associated protein 1 -0.0327538
ACACA acetyl-CoA carboxylase alpha -0.0326953
TMSB10 thymosin beta 10 -0.0326944
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0323911
NEMF nuclear export mediator factor -0.0323287
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0322175
DPYD dihydropyrimidine dehydrogenase -0.0318563
NF1 neurofibromin 1 -0.0317482