| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Torkinib perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Torkinib_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0849697 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0832178 |
| ENO1 | enolase 1, (alpha) | 0.0774451 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0755372 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.071073 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0707306 |
| MCL1 | myeloid cell leukemia 1 | 0.0673203 |
| GRAMD1B | GRAM domain containing 1B | 0.0640835 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0600207 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0597518 |
| MYOF | myoferlin | 0.0559964 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0541548 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0498769 |
| RPS3 | ribosomal protein S3 | 0.0461936 |
| PCBP2 | poly(rC) binding protein 2 | 0.0434168 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0428006 |
| RPS12 | ribosomal protein S12 | 0.0391026 |
| POTEF | POTE ankyrin domain family, member F | 0.0388253 |
| SIK3 | SIK family kinase 3 | 0.0381018 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0372146 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0351663 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0348176 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0346539 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0344169 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0338933 |
| SMAD3 | SMAD family member 3 | 0.0337232 |
| STC1 | stanniocalcin 1 | 0.0336359 |
| TNFAIP8 | tumor necrosis factor, alpha-induced protein 8 | 0.0336176 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0333552 |
| RPL37A | ribosomal protein L37a | 0.0321067 |
| CUL4A | cullin 4A | 0.031024 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.030529 |
| RPL3 | ribosomal protein L3 | 0.0294996 |
| RPS6 | ribosomal protein S6 | 0.0283163 |
| RPS4X | ribosomal protein S4, X-linked | 0.0282683 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0280782 |
| LOC112694756 | uncharaterized LOC112694756 | 0.027594 |
| MLF1 | myeloid leukemia factor 1 | 0.0275918 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0274597 |
| SLTM | SAFB-like, transcription modulator | 0.0273594 |
| HOMER1 | homer scaffolding protein 1 | 0.0271079 |
| ATF4 | activating transcription factor 4 | 0.0269846 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0269162 |
| RPL7 | ribosomal protein L7 | 0.0268837 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0268623 |
| RPL11 | ribosomal protein L11 | 0.0267068 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0265972 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0260106 |
| HBP1 | HMG-box transcription factor 1 | 0.0256194 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0254452 |
| RPS17 | ribosomal protein S17 | 0.0254144 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.025146 |
| RPS8 | ribosomal protein S8 | 0.0249466 |
| ENSA | endosulfine alpha | 0.0247976 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0246012 |
| RPS27 | ribosomal protein S27 | 0.0242586 |
| RPLP1 | ribosomal protein, large, P1 | 0.02394 |
| EIF5 | eukaryotic translation initiation factor 5 | 0.0234653 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0230288 |
| ATF6 | activating transcription factor 6 | 0.0229218 |
| EZR | ezrin | 0.0229177 |
| C15ORF48 | chromosome 15 open reading frame 48 | 0.022749 |
| SMYD3 | SET and MYND domain containing 3 | 0.0226699 |
| ARRDC3 | arrestin domain containing 3 | 0.0225716 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0224374 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0224268 |
| RPLP0 | ribosomal protein, large, P0 | 0.0223771 |
| RPL12 | ribosomal protein L12 | 0.0218977 |
| HYOU1 | hypoxia up-regulated 1 | 0.0218578 |
| MT2A | metallothionein 2A | 0.0218208 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0216562 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0215195 |
| FAM107B | family with sequence similarity 107, member B | 0.0214322 |
| TBC1D15 | TBC1 domain family, member 15 | 0.0214076 |
| PYGL | phosphorylase, glycogen, liver | 0.0211649 |
| RACK1 | receptor for activated C kinase 1 | 0.0208994 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0208971 |
| FNIP1 | folliculin interacting protein 1 | 0.0206447 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.020599 |
| GOLGB1 | golgin B1 | 0.0203068 |
| EXT1 | exostosin glycosyltransferase 1 | 0.020211 |
| BMP6 | bone morphogenetic protein 6 | 0.0201287 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.0198045 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0197972 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0197411 |
| ATP1A4 | ATPase, Na+/K+ transporting, alpha 4 polypeptide | 0.0196654 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | 0.0196378 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0196122 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0194864 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0194619 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0194011 |
| RAD51B | RAD51 paralog B | 0.0192279 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0191294 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0191107 |
| MSN | moesin | 0.01905 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0187655 |
| GPC5 | glypican 5 | 0.0186814 |
| ANO6 | anoctamin 6 | 0.018369 |
| TMCO3 | transmembrane and coiled-coil domains 3 | 0.0183131 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0182853 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.165765 |
| TXNRD1 | thioredoxin reductase 1 | -0.159696 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.135269 |
| LRP1B | low density lipoprotein receptor-related protein 1B | -0.127384 |
| EGFR | epidermal growth factor receptor | -0.11868 |
| ASPH | aspartate beta-hydroxylase | -0.117494 |
| LAMC2 | laminin, gamma 2 | -0.115859 |
| NDRG1 | N-myc downstream regulated 1 | -0.111062 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0917622 |
| LMO7 | LIM domain 7 | -0.0902433 |
| TMSB10 | thymosin beta 10 | -0.0805075 |
| H1-0 | H1.0 linker histone | -0.0797512 |
| OSMR | oncostatin M receptor | -0.0796965 |
| AHNAK | AHNAK nucleoprotein | -0.0731215 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0636405 |
| EFNA5 | ephrin-A5 | -0.0622085 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0621361 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0600369 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0590233 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0589073 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0564444 |
| EGR1 | early growth response 1 | -0.0560373 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0554289 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.055076 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0541606 |
| TMEM165 | transmembrane protein 165 | -0.0536467 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0535614 |
| ACTG1 | actin gamma 1 | -0.0528728 |
| PKM | pyruvate kinase, muscle | -0.0510529 |
| SCEL | sciellin | -0.0504172 |
| VCL | vinculin | -0.0501286 |
| ANXA2 | annexin A2 | -0.0491344 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.046911 |
| CES1 | carboxylesterase 1 | -0.0455652 |
| WASF2 | WAS protein family, member 2 | -0.0445345 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0439503 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0432962 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0429399 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.0426331 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0419027 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0416011 |
| USP53 | ubiquitin specific peptidase 53 | -0.0402725 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0400447 |
| FBXO11 | F-box protein 11 | -0.0399909 |
| ARHGAP32 | Rho GTPase activating protein 32 | -0.0398282 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | -0.0393941 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0384052 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0382228 |
| CUX1 | cut-like homeobox 1 | -0.0380833 |
| S100A10 | S100 calcium binding protein A10 | -0.0377105 |
| GNAS | GNAS complex locus | -0.0375267 |
| CCND1 | cyclin D1 | -0.0367963 |
| LAMA4 | laminin, alpha 4 | -0.0367378 |
| CCNL1 | cyclin L1 | -0.0366806 |
| PRKCA | protein kinase C, alpha | -0.0365299 |
| MGAT4C | MGAT4 family, member C | -0.0363708 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0363113 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | -0.0353865 |
| MYO1D | myosin ID | -0.0352496 |
| NABP1 | nucleic acid binding protein 1 | -0.0351982 |
| MKI67 | marker of proliferation Ki-67 | -0.0351702 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0349404 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0349348 |
| RAB27B | RAB27B, member RAS oncogene family | -0.0338106 |
| PDE8A | phosphodiesterase 8A | -0.0334721 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0331145 |
| AGR2 | anterior gradient 2 | -0.0327648 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.032733 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | -0.0327085 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0323645 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0320831 |
| RIN2 | Ras and Rab interactor 2 | -0.031991 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0315545 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0311938 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | -0.0311705 |
| ZFAND6 | zinc finger, AN1-type domain 6 | -0.030779 |
| TNS3 | tensin 3 | -0.0307685 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0307025 |
| RAB10 | RAB10, member RAS oncogene family | -0.030613 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0305932 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0305038 |
| KCMF1 | potassium channel modulatory factor 1 | -0.0303776 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0302581 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | -0.0301396 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.029882 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0289319 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0288202 |
| ST14 | suppression of tumorigenicity 14 (colon carcinoma) | -0.0286213 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0284591 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0281506 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0279133 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0279021 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | -0.0278816 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.027434 |
| LAMB3 | laminin, beta 3 | -0.0273127 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0272816 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0272355 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0265933 |
| BBX | bobby sox homolog (Drosophila) | -0.026492 |
| NCOA3 | nuclear receptor coactivator 3 | -0.0264028 |
