| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Torkinib perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Torkinib_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FTH1 | ferritin, heavy polypeptide 1 | 0.181074 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.136987 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.105027 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.104407 |
| VIM | vimentin | 0.096502 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0865627 |
| STC1 | stanniocalcin 1 | 0.0775363 |
| MT2A | metallothionein 2A | 0.0581167 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0572056 |
| TPM3 | tropomyosin 3 | 0.0544249 |
| RPS12 | ribosomal protein S12 | 0.053664 |
| FAM107B | family with sequence similarity 107, member B | 0.0527128 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.051852 |
| POTEF | POTE ankyrin domain family, member F | 0.0516537 |
| TPI1 | triosephosphate isomerase 1 | 0.0515943 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0488371 |
| KIF5B | kinesin family member 5B | 0.0488088 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0486814 |
| LDHA | lactate dehydrogenase A | 0.0474838 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0460129 |
| C15ORF48 | chromosome 15 open reading frame 48 | 0.0446749 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0443219 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | 0.0442376 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0441412 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0440927 |
| FMNL2 | formin-like 2 | 0.043061 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0419141 |
| ENO1 | enolase 1, (alpha) | 0.0389026 |
| RPL3 | ribosomal protein L3 | 0.0389007 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0372045 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0365945 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0362872 |
| PCBP2 | poly(rC) binding protein 2 | 0.0360423 |
| SERINC3 | serine incorporator 3 | 0.0356276 |
| RPLP0 | ribosomal protein, large, P0 | 0.0352979 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0352589 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0350624 |
| MYOF | myoferlin | 0.0350145 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.0348121 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0344515 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0342932 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0338895 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0336371 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.033608 |
| ASPH | aspartate beta-hydroxylase | 0.0334458 |
| LAMC2 | laminin, gamma 2 | 0.0327164 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0327035 |
| MSN | moesin | 0.0315677 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0309977 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0309802 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0306348 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0305901 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0305506 |
| FLNB | filamin B, beta | 0.0304722 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | 0.0303172 |
| SFTPA2 | surfactant protein A2 | 0.0302563 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0302209 |
| ANO6 | anoctamin 6 | 0.0294961 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0294844 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0290669 |
| B2M | beta-2-microglobulin | 0.0290399 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0285995 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | 0.0284571 |
| IDS | iduronate 2-sulfatase | 0.02838 |
| CALR | calreticulin | 0.0280379 |
| EZR | ezrin | 0.0278498 |
| PYGL | phosphorylase, glycogen, liver | 0.0277589 |
| TLN1 | talin 1 | 0.0266219 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0263567 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0262238 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0261644 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | 0.0261232 |
| RPL12 | ribosomal protein L12 | 0.0252666 |
| RPL37A | ribosomal protein L37a | 0.0250613 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.024529 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0243512 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0243154 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0242741 |
| SERINC1 | serine incorporator 1 | 0.024183 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0232189 |
| MCFD2 | multiple coagulation factor deficiency 2 | 0.0228642 |
| ATF4 | activating transcription factor 4 | 0.0222625 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0221792 |
| AP2M1 | adaptor-related protein complex 2, mu 1 subunit | 0.0221682 |
| ANXA1 | annexin A1 | 0.0220526 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.0218524 |
| ZC3H11A | zinc finger CCCH-type containing 11A | 0.0217091 |
| ATP1A4 | ATPase, Na+/K+ transporting, alpha 4 polypeptide | 0.0216248 |
| PRDX1 | peroxiredoxin 1 | 0.0215263 |
| RPS3 | ribosomal protein S3 | 0.0213871 |
| RACK1 | receptor for activated C kinase 1 | 0.0213331 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0210783 |
| TMSB10 | thymosin beta 10 | 0.020902 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0201328 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0200041 |
| ADM | adrenomedullin | 0.0199687 |
| RPS17 | ribosomal protein S17 | 0.0198287 |
| S100A6 | S100 calcium binding protein A6 | 0.019671 |
| RPS18 | ribosomal protein S18 | 0.0195203 |
| DHRS7 | dehydrogenase/reductase (SDR family) member 7 | 0.0193717 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.365893 |
| IGF2 | insulin-like growth factor 2 | -0.12898 |
| TXNRD1 | thioredoxin reductase 1 | -0.127902 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.103434 |
| GRAMD1B | GRAM domain containing 1B | -0.0991585 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0866648 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.075876 |
| ACTG1 | actin gamma 1 | -0.0697764 |
| RPS21 | ribosomal protein S21 | -0.0622593 |
| EGR1 | early growth response 1 | -0.0584057 |
| PTMA | prothymosin, alpha | -0.0573183 |
| RPL35A | ribosomal protein L35a | -0.0563755 |
| RTN4 | reticulon 4 | -0.0556273 |
| IER3 | immediate early response 3 | -0.0522298 |
| WDR43 | WD repeat domain 43 | -0.051125 |
| HDAC9 | histone deacetylase 9 | -0.0501015 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0499113 |
| RPS29 | ribosomal protein S29 | -0.0490942 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0473148 |
| BICC1 | BicC family RNA binding protein 1 | -0.0471334 |
| DENND4A | DENN/MADD domain containing 4A | -0.044922 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0434536 |
| FUS | FUS RNA binding protein | -0.0431507 |
| RPS15 | ribosomal protein S15 | -0.0430287 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0422739 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.041634 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0402774 |
| RPS23 | ribosomal protein S23 | -0.0389452 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0388746 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0377135 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0371631 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0370163 |
| PPIB | peptidylprolyl isomerase B (cyclophilin B) | -0.0367057 |
| RPL34 | ribosomal protein L34 | -0.0366361 |
| RBM39 | RNA binding motif protein 39 | -0.0365791 |
| RPL8 | ribosomal protein L8 | -0.0360772 |
| SRGN | serglycin | -0.0353647 |
| KHDC4 | KH domain containing 4, pre-mRNA splicing factor | -0.0352216 |
| FBXO11 | F-box protein 11 | -0.0349227 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0339009 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0335671 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0335571 |
| RPS11 | ribosomal protein S11 | -0.0328425 |
| IGFBP4 | insulin-like growth factor binding protein 4 | -0.0320015 |
| DEK | DEK proto-oncogene | -0.0317754 |
| GNAS | GNAS complex locus | -0.0315236 |
| RPS5 | ribosomal protein S5 | -0.0314161 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0310988 |
| ZNF292 | zinc finger protein 292 | -0.0306596 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0306263 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0305439 |
| RHOA | ras homolog family member A | -0.0304352 |
| RPS24 | ribosomal protein S24 | -0.0304258 |
| RPS8 | ribosomal protein S8 | -0.0301304 |
| NCOA7 | nuclear receptor coactivator 7 | -0.030096 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0298691 |
| OSMR | oncostatin M receptor | -0.0297056 |
| EFNA5 | ephrin-A5 | -0.0293212 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.029191 |
| NOP58 | NOP58 ribonucleoprotein | -0.0291713 |
| USP3 | ubiquitin specific peptidase 3 | -0.0286001 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0285059 |
| HMGA1 | high mobility group AT-hook 1 | -0.0281792 |
| RFWD3 | ring finger and WD repeat domain 3 | -0.0280006 |
| PDE8A | phosphodiesterase 8A | -0.0279752 |
| FKBP10 | FK506 binding protein 10, 65 kDa | -0.0279628 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0278277 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0278115 |
| BIRC2 | baculoviral IAP repeat containing 2 | -0.0277999 |
| WTAP | Wilms tumor 1 associated protein | -0.0277081 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0276294 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | -0.0276135 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0274398 |
| ERBIN | erbb2 interacting protein | -0.027423 |
| YBX3 | Y box binding protein 3 | -0.0270167 |
| MKI67 | marker of proliferation Ki-67 | -0.0268323 |
| AK1 | adenylate kinase 1 | -0.0268004 |
| RPL4 | ribosomal protein L4 | -0.0260662 |
| KLF6 | Kruppel-like factor 6 | -0.0257671 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | -0.0257423 |
| COG5 | component of oligomeric golgi complex 5 | -0.0256914 |
| DGKD | diacylglycerol kinase, delta 130kDa | -0.0249583 |
| RPL38 | ribosomal protein L38 | -0.0249013 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0248987 |
| PKM | pyruvate kinase, muscle | -0.0247407 |
| PTK2 | protein tyrosine kinase 2 | -0.0246357 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0245672 |
| FTL | ferritin, light polypeptide | -0.0244982 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0242861 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0240604 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.024013 |
| FAM168A | family with sequence similarity 168, member A | -0.0239813 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0238739 |
| WASF2 | WAS protein family, member 2 | -0.023626 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0231297 |
| NAV3 | neuron navigator 3 | -0.0230741 |
| CHN1 | chimerin 1 | -0.0230696 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | -0.0230661 |
| SETD5 | SET domain containing 5 | -0.0227576 |
| KPNB1 | karyopherin (importin) beta 1 | -0.022683 |
