| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Torkinib perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Torkinib_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | 0.29982 |
| KYNU | kynureninase | 0.236923 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.190627 |
| TXNRD1 | thioredoxin reductase 1 | 0.167425 |
| GRB10 | growth factor receptor-bound protein 10 | 0.142148 |
| ARHGAP21 | Rho GTPase activating protein 21 | 0.117301 |
| ASPH | aspartate beta-hydroxylase | 0.115786 |
| LMO7 | LIM domain 7 | 0.104248 |
| KRT17 | keratin 17, type I | 0.0898134 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0879704 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0839968 |
| B2M | beta-2-microglobulin | 0.0787575 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | 0.0744264 |
| PARD3 | par-3 family cell polarity regulator | 0.0737071 |
| ANXA1 | annexin A1 | 0.0731984 |
| SACK1A | scaffolding CK1 anchoring protein A | 0.0721045 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0676971 |
| OSMR | oncostatin M receptor | 0.0660735 |
| LAMC2 | laminin, gamma 2 | 0.062728 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0626934 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.062214 |
| ENO1 | enolase 1, (alpha) | 0.0599922 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0599356 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0594897 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0572759 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0571428 |
| VMP1 | vacuole membrane protein 1 | 0.0570746 |
| EFNA5 | ephrin-A5 | 0.056473 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0552595 |
| MYOF | myoferlin | 0.0535165 |
| POTEF | POTE ankyrin domain family, member F | 0.053294 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0522979 |
| AKR1C2 | aldo-keto reductase family 1, member C2 | 0.0491392 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0487031 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0474207 |
| ISG15 | ISG15 ubiquitin-like modifier | 0.0472868 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0466715 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | 0.0460111 |
| FN1 | fibronectin 1 | 0.0456035 |
| SLC12A6 | solute carrier family 12 (potassium/chloride transporter), member 6 | 0.044982 |
| SEPTIN9 | septin 9 | 0.0446336 |
| STC1 | stanniocalcin 1 | 0.0440522 |
| RBM47 | RNA binding motif protein 47 | 0.0424148 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0407521 |
| VPS72 | vacuolar protein sorting 72 homolog (S. cerevisiae) | 0.0407193 |
| GLCCI1 | glucocorticoid induced 1 | 0.0407039 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | 0.0405301 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | 0.040478 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.040422 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.040302 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0398894 |
| RPL26 | ribosomal protein L26 | 0.0396651 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0390864 |
| PTK2 | protein tyrosine kinase 2 | 0.0385583 |
| RPL12 | ribosomal protein L12 | 0.0383881 |
| PRPF40A | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) | 0.0381944 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0381795 |
| RFFL | ring finger and FYVE-like domain containing E3 ubiquitin protein ligase | 0.0380757 |
| CLIC4 | chloride intracellular channel 4 | 0.0375594 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.036994 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.0361255 |
| CEP350 | centrosomal protein 350kDa | 0.0352757 |
| SMAD3 | SMAD family member 3 | 0.0349157 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | 0.0347791 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0345708 |
| GRAMD1B | GRAM domain containing 1B | 0.0345209 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0342302 |
| RPS14 | ribosomal protein S14 | 0.0341511 |
| RCOR1 | REST corepressor 1 | 0.0340937 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0336811 |
| JMJD1C | jumonji domain containing 1C | 0.0334576 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0328424 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | 0.0327656 |
| S100A10 | S100 calcium binding protein A10 | 0.0326893 |
| ANTXR2 | anthrax toxin receptor 2 | 0.0325167 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0323604 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0321153 |
| TUSC3 | tumor suppressor candidate 3 | 0.0319654 |
| SSH2 | slingshot protein phosphatase 2 | 0.0318345 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.031432 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0313942 |
| HLA-A | major histocompatibility complex, class I, A | 0.0309881 |
| FDPS | farnesyl diphosphate synthase | 0.0309213 |
| MT2A | metallothionein 2A | 0.0305668 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0304479 |
| STK24 | serine/threonine kinase 24 | 0.0303899 |
| UBE3A | ubiquitin protein ligase E3A | 0.0300611 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | 0.0300163 |
| SCAF11 | SR-related CTD-associated factor 11 | 0.0297859 |
| RACK1 | receptor for activated C kinase 1 | 0.0297857 |
| STAU2 | staufen double-stranded RNA binding protein 2 | 0.0296153 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0293098 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0292401 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0292399 |
| RPS16 | ribosomal protein S16 | 0.0291505 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | 0.0289445 |
| AHNAK | AHNAK nucleoprotein | 0.0285137 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0281823 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0281032 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0276626 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SPAG9 | sperm associated antigen 9 | -0.0795977 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0784481 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0596414 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0592628 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | -0.0556905 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0544139 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | -0.0516062 |
| COPA | coatomer protein complex, subunit alpha | -0.05096 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0487172 |
| MUC16 | mucin 16, cell surface associated | -0.047432 |
| PAPOLA | poly(A) polymerase alpha | -0.0472367 |
| NDRG1 | N-myc downstream regulated 1 | -0.046859 |
| TMEM165 | transmembrane protein 165 | -0.0468463 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0464477 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.0457634 |
| NPTN | neuroplastin | -0.0428543 |
| CDK13 | cyclin-dependent kinase 13 | -0.0414858 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.041207 |
| PDE10A | phosphodiesterase 10A | -0.0408586 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0406351 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0405292 |
| CREBBP | CREB binding protein | -0.0404685 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0400102 |
| RTN4 | reticulon 4 | -0.0399475 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0395662 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0386818 |
| GNAS | GNAS complex locus | -0.0386723 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0384348 |
| MORC3 | MORC family CW-type zinc finger 3 | -0.0383617 |
| YME1L1 | YME1-like 1 ATPase | -0.0378878 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0374412 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | -0.0370928 |
| CDH13 | cadherin 13 | -0.0368329 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0366235 |
| RALA | v-ral simian leukemia viral oncogene homolog A (ras related) | -0.0363781 |
| RPS6KA5 | ribosomal protein S6 kinase, 90kDa, polypeptide 5 | -0.0363439 |
| ACTG1 | actin gamma 1 | -0.0359734 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | -0.0359691 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.035692 |
| TUFT1 | tuftelin 1 | -0.0353759 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0353279 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0352591 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | -0.0351513 |
| GNL2 | guanine nucleotide binding protein-like 2 (nucleolar) | -0.0348672 |
| HECTD4 | HECT domain containing E3 ubiquitin protein ligase 4 | -0.0346951 |
| ARHGEF4 | Rho guanine nucleotide exchange factor (GEF) 4 | -0.0346308 |
| EGR1 | early growth response 1 | -0.0342622 |
| ZFC3H1 | zinc finger, C3H1-type containing | -0.0336986 |
| FRYL | FRY-like | -0.0334672 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0333539 |
| SH3GLB1 | SH3-domain GRB2-like endophilin B1 | -0.0331383 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | -0.0329314 |
| GIGYF2 | GRB10 interacting GYF protein 2 | -0.0328392 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0325728 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0325629 |
| RBM5 | RNA binding motif protein 5 | -0.0323236 |
| POU2F1 | POU class 2 homeobox 1 | -0.0322567 |
| GLG1 | golgi glycoprotein 1 | -0.0321466 |
| MYO9A | myosin IXA | -0.0321237 |
| FLNB | filamin B, beta | -0.0320653 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0319039 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0318744 |
| RPS6KC1 | ribosomal protein S6 kinase, 52kDa, polypeptide 1 | -0.0317315 |
| TANC1 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 | -0.031579 |
| SLMAP | sarcolemma associated protein | -0.0314612 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0311389 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0307015 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | -0.0306741 |
| CHD1 | chromodomain helicase DNA binding protein 1 | -0.0303503 |
| FGF13 | fibroblast growth factor 13 | -0.0303024 |
| CHORDC1 | cysteine and histidine-rich domain (CHORD) containing 1 | -0.0301964 |
| SVIL | supervillin | -0.0301673 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0301375 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0300623 |
| VIM | vimentin | -0.029919 |
| TNRC6C | trinucleotide repeat containing 6C | -0.0297565 |
| TPP2 | tripeptidyl peptidase II | -0.0296205 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0294227 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0293366 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0293305 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | -0.0292453 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | -0.0291805 |
| ATP2C1 | ATPase, Ca++ transporting, type 2C, member 1 | -0.0289534 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | -0.0289279 |
| DIS3 | DIS3 exosome endoribonuclease and 3'-5' exoribonuclease | -0.0288154 |
| PALS2 | protein associated with LIN7 2, MAGUK p55 family member | -0.0287361 |
| CTDSPL2 | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2 | -0.028674 |
| MRTFA | myocardin related transcription factor A | -0.0284505 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.0284222 |
| ZNF451 | zinc finger protein 451 | -0.0283672 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | -0.0283536 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0283143 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0282909 |
| ANXA3 | annexin A3 | -0.0282748 |
| HDAC4 | histone deacetylase 4 | -0.028177 |
| RPLP0 | ribosomal protein, large, P0 | -0.0280511 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0278381 |
| CCDC6 | coiled-coil domain containing 6 | -0.0278112 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0277848 |
| PHF21A | PHD finger protein 21A | -0.0277115 |
