Torkinib_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Torkinib perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Torkinib_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RPS3 ribosomal protein S3 0.0910146
RPL37A ribosomal protein L37a 0.0789958
RPS12 ribosomal protein S12 0.0751928
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0631366
RPS27 ribosomal protein S27 0.0616164
SFPQ splicing factor proline/glutamine-rich 0.0589351
MCL1 myeloid cell leukemia 1 0.05868
POTEF POTE ankyrin domain family, member F 0.0577688
PCBP2 poly(rC) binding protein 2 0.0550877
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0540964
RPL11 ribosomal protein L11 0.0509214
EXT1 exostosin glycosyltransferase 1 0.0503876
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0496941
RPL37 ribosomal protein L37 0.0487937
RPS4X ribosomal protein S4, X-linked 0.0486912
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0436894
ATP11A ATPase, class VI, type 11A 0.043388
ERRFI1 ERBB receptor feedback inhibitor 1 0.0425782
WNK1 WNK lysine deficient protein kinase 1 0.0419765
RPS17 ribosomal protein S17 0.0399996
RPL31 ribosomal protein L31 0.0396805
RPL9 ribosomal protein L9 0.0385885
TPM3 tropomyosin 3 0.0366857
ZCCHC7 zinc finger, CCHC domain containing 7 0.0359501
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0358221
RPL27 ribosomal protein L27 0.0357205
TPI1 triosephosphate isomerase 1 0.0354997
GPHN gephyrin 0.0351047
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.032364
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0318865
ANO6 anoctamin 6 0.0318003
SMYD3 SET and MYND domain containing 3 0.0312076
ENO1 enolase 1, (alpha) 0.0309287
RACK1 receptor for activated C kinase 1 0.0301884
RPL3 ribosomal protein L3 0.0298799
RPS18 ribosomal protein S18 0.0296422
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0291568
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0290152
RPL28 ribosomal protein L28 0.0285028
RPL27A ribosomal protein L27a 0.0282084
RPL5 ribosomal protein L5 0.0281652
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.02814
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0279563
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0277918
HSPA8 heat shock 70kDa protein 8 0.027382
CMIP c-Maf inducing protein 0.0273786
RPS23 ribosomal protein S23 0.0272604
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0270745
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0268682
B2M beta-2-microglobulin 0.0267279
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0266948
PRKCE protein kinase C, epsilon 0.0266863
RPS25 ribosomal protein S25 0.0265513
RPS29 ribosomal protein S29 0.0264861
C6ORF62 chromosome 6 open reading frame 62 0.0264636
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0263312
DST dystonin 0.0262535
RPLP1 ribosomal protein, large, P1 0.0262239
PRDX1 peroxiredoxin 1 0.0261995
JMJD1C jumonji domain containing 1C 0.0261799
BRD2 bromodomain containing 2 0.0260508
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B 0.0256574
R3HDM2 R3H domain containing 2 0.0254069
RRM2 ribonucleotide reductase M2 0.0251314
RPS10 ribosomal protein S10 0.0249902
RPLP2 ribosomal protein, large, P2 0.0248559
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0247706
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0246025
CAMKMT calmodulin-lysine N-methyltransferase 0.0244452
RPL26 ribosomal protein L26 0.0241186
RPS8 ribosomal protein S8 0.0240906
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0238547
PUM1 pumilio RNA-binding family member 1 0.0238103
EEF1G eukaryotic translation elongation factor 1 gamma 0.0234541
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0233828
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0232578
RPL36 ribosomal protein L36 0.0231917
TMSB10 thymosin beta 10 0.0231795
HOMER1 homer scaffolding protein 1 0.0231642
RPL12 ribosomal protein L12 0.0231402
IPO7 importin 7 0.0230328
RPS20 ribosomal protein S20 0.0226816
GRAMD1B GRAM domain containing 1B 0.0222711
RPL7 ribosomal protein L7 0.0219792
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0217334
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.021622
LPP LIM domain containing preferred translocation partner in lipoma 0.0216093
RPS13 ribosomal protein S13 0.0214485
RPL35A ribosomal protein L35a 0.0214052
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0214015
TXNRD1 thioredoxin reductase 1 0.0213731
MARCHF4 membrane associated ring-CH-type finger 4 0.0213131
RPL19 ribosomal protein L19 0.0212687
INO80 INO80 complex subunit 0.021009
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0210032
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0207268
MT2A metallothionein 2A 0.020576
FAF1 Fas (TNFRSF6) associated factor 1 0.0205456
FTH1 ferritin, heavy polypeptide 1 0.0205408
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0203602

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.378838
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.170457
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.112667
AKAP12 A kinase (PRKA) anchor protein 12 -0.080175
PTMA prothymosin, alpha -0.0714039
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0584332
H1-0 H1.0 linker histone -0.054121
RSF1 remodeling and spacing factor 1 -0.0528859
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0497376
CANX calnexin -0.0490689
GNAS GNAS complex locus -0.0467649
CD2AP CD2-associated protein -0.0438951
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0436677
KDM3A lysine (K)-specific demethylase 3A -0.0427118
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0424025
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0407167
YBX3 Y box binding protein 3 -0.0401696
NCOA7 nuclear receptor coactivator 7 -0.0391671
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0390886
TAS2R14 taste receptor, type 2, member 14 -0.0389534
KTN1 kinectin 1 (kinesin receptor) -0.0380623
ZFR zinc finger RNA binding protein -0.0371345
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0369193
OSMR oncostatin M receptor -0.0368408
TPM4 tropomyosin 4 -0.0357923
VCL vinculin -0.0352639
CSDE1 cold shock domain containing E1, RNA-binding -0.0350223
RTN4 reticulon 4 -0.0347524
FBXO11 F-box protein 11 -0.0347278
CDK17 cyclin-dependent kinase 17 -0.0346466
WASF2 WAS protein family, member 2 -0.0343725
KPNB1 karyopherin (importin) beta 1 -0.0340854
WWTR1 WW domain containing transcription regulator 1 -0.0340144
MYL12B myosin, light chain 12B, regulatory -0.0330833
PDIA3 protein disulfide isomerase family A, member 3 -0.0327871
CAMTA1 calmodulin binding transcription activator 1 -0.0323172
SRP72 signal recognition particle 72kDa -0.0322289
NCOR1 nuclear receptor corepressor 1 -0.0317377
ZNF217 zinc finger protein 217 -0.0306736
MON2 MON2 homolog (S. cerevisiae) -0.0298968
ANKRD12 ankyrin repeat domain 12 -0.0298412
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0292251
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0290774
TNRC6B trinucleotide repeat containing 6B -0.0290769
SENP6 SUMO1/sentrin specific peptidase 6 -0.0288844
XPO1 exportin 1 -0.0288492
BAZ2A bromodomain adjacent to zinc finger domain, 2A -0.0281288
ADGRG6 adhesion G protein-coupled receptor G6 -0.0278819
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -0.0272975
ATXN1 ataxin 1 -0.026983
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0267336
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0267038
CCNL1 cyclin L1 -0.0265066
SMC4 structural maintenance of chromosomes 4 -0.0262404
NAMPT nicotinamide phosphoribosyltransferase -0.0261462
MIS18BP1 MIS18 binding protein 1 -0.0260743
NPEPPS aminopeptidase puromycin sensitive -0.0257386
KLF6 Kruppel-like factor 6 -0.0255624
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0253713
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0251793
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0250487
TNPO3 transportin 3 -0.0249169
HMGA2 high mobility group AT-hook 2 -0.0247635
RRBP1 ribosome binding protein 1 -0.024417
TM4SF1 transmembrane 4 L six family member 1 -0.0241272
PCNP PEST proteolytic signal containing nuclear protein -0.0240098
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0240065
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa -0.0239325
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1 -0.0237933
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0237902
PHF21A PHD finger protein 21A -0.0237196
DEK DEK proto-oncogene -0.0237109
SBNO1 strawberry notch homolog 1 (Drosophila) -0.0236549
ZBTB35 zinc finger and BTB domain containing 35 -0.0236012
MAP4 microtubule-associated protein 4 -0.0233647
S100A10 S100 calcium binding protein A10 -0.0232669
EML4 echinoderm microtubule associated protein like 4 -0.0232412
PDIA6 protein disulfide isomerase family A, member 6 -0.0232336
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae) -0.0231678
HDAC8 histone deacetylase 8 -0.0231255
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0230966
ZNF292 zinc finger protein 292 -0.0229715
TMEM131 transmembrane protein 131 -0.0229666
ZBTB20 zinc finger and BTB domain containing 20 -0.0228274
AHNAK AHNAK nucleoprotein -0.0228235
VIM vimentin -0.0227251
STRN3 striatin, calmodulin binding protein 3 -0.0226418
ZMYND8 zinc finger, MYND-type containing 8 -0.0226347
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0226308
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0225978
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0225387
TLK1 tousled-like kinase 1 -0.022309
GARS1 glycyl-tRNA synthetase 1 -0.0221018
MKI67 marker of proliferation Ki-67 -0.0219799
KMT2A lysine (K)-specific methyltransferase 2A -0.0219726
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0219097
PDIA4 protein disulfide isomerase family A, member 4 -0.0217751
SEPTIN7 septin 7 -0.0217193
RPL6 ribosomal protein L6 -0.02161
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0214805