| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Torkinib perturbation in NCI-H2347 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Torkinib_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.181141 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.177849 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.175405 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.171785 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.146627 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.141728 |
| POTEF | POTE ankyrin domain family, member F | 0.136438 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0999798 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0956709 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0888872 |
| LAMC2 | laminin, gamma 2 | 0.0854604 |
| DSPP | dentin sialophosphoprotein | 0.0842417 |
| SQSTM1 | sequestosome 1 | 0.0829276 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0648309 |
| ACTG1 | actin gamma 1 | 0.0613775 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0602714 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0594846 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0589485 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0554334 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0546272 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0544309 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0542692 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0536511 |
| PCBP2 | poly(rC) binding protein 2 | 0.0521364 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0517656 |
| MSN | moesin | 0.0513846 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0510745 |
| KRT7 | keratin 7, type II | 0.0506444 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0461958 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0455504 |
| CALR | calreticulin | 0.0439565 |
| RPLP0 | ribosomal protein, large, P0 | 0.0435049 |
| RACK1 | receptor for activated C kinase 1 | 0.043395 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0416642 |
| RPL3 | ribosomal protein L3 | 0.03976 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0394392 |
| RPL23 | ribosomal protein L23 | 0.0391551 |
| EZR | ezrin | 0.0379588 |
| CANX | calnexin | 0.0374912 |
| UBC | ubiquitin C | 0.0371425 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0371226 |
| PGBD5 | piggyBac transposable element derived 5 | 0.0359514 |
| CTSB | cathepsin B | 0.0359039 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0355666 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0350218 |
| SEPTIN11 | septin 11 | 0.03487 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0333509 |
| TJP1 | tight junction protein 1 | 0.0333295 |
| RPS23 | ribosomal protein S23 | 0.0331344 |
| DST | dystonin | 0.0331208 |
| RAB10 | RAB10, member RAS oncogene family | 0.033116 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0325473 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0322832 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0315837 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0313634 |
| ATF4 | activating transcription factor 4 | 0.0311288 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0310242 |
| TPM3 | tropomyosin 3 | 0.0310057 |
| KHDRBS3 | KH domain containing, RNA binding, signal transduction associated 3 | 0.0305195 |
| MAP1B | microtubule-associated protein 1B | 0.030359 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0302858 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0299933 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.0299422 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0298725 |
| SGMS2 | sphingomyelin synthase 2 | 0.0297849 |
| RPS6 | ribosomal protein S6 | 0.0296455 |
| MYO10 | myosin X | 0.0295829 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0292351 |
| UPP1 | uridine phosphorylase 1 | 0.0292303 |
| RPL7 | ribosomal protein L7 | 0.0291658 |
| SLC38A1 | solute carrier family 38, member 1 | 0.0291245 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0289656 |
| ENO1 | enolase 1, (alpha) | 0.0286414 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0286032 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0283657 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0279065 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0276217 |
| MYO5B | myosin VB | 0.0274517 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0273012 |
| CD9 | CD9 molecule | 0.0270378 |
| HDAC9 | histone deacetylase 9 | 0.0268574 |
| SLC9A1 | solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 | 0.0268464 |
| BAZ1A | bromodomain adjacent to zinc finger domain, 1A | 0.0268459 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0267386 |
| RPS18 | ribosomal protein S18 | 0.0262255 |
| SET | SET nuclear proto-oncogene | 0.0261371 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0258682 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0258182 |
| FHIT | fragile histidine triad | 0.0255461 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0252554 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0251405 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.0250775 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0250131 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | 0.024937 |
| MCL1 | myeloid cell leukemia 1 | 0.0248045 |
| EIF5 | eukaryotic translation initiation factor 5 | 0.0247832 |
| SPSB1 | splA/ryanodine receptor domain and SOCS box containing 1 | 0.0247479 |
| CNBP | CCHC-type zinc finger, nucleic acid binding protein | 0.0247099 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0246294 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0245945 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NDRG1 | N-myc downstream regulated 1 | -0.173232 |
| FTL | ferritin, light polypeptide | -0.123218 |
| FN1 | fibronectin 1 | -0.12088 |
| TSC22D2 | TSC22 domain family, member 2 | -0.086522 |
| TMSB10 | thymosin beta 10 | -0.076839 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0750142 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0640485 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0630641 |
| FAM3C | family with sequence similarity 3, member C | -0.0573373 |
| ASPH | aspartate beta-hydroxylase | -0.0537718 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0518728 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0482042 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0476919 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0461912 |
| GNAS | GNAS complex locus | -0.046169 |
| FAM162A | family with sequence similarity 162, member A | -0.0448556 |
| TFG | TRK-fused gene | -0.0443137 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0442232 |
| HMGA1 | high mobility group AT-hook 1 | -0.0439522 |
| CD2AP | CD2-associated protein | -0.0434152 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0425266 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0407425 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0407161 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0401013 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0397297 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0384102 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0382795 |
| PGK1 | phosphoglycerate kinase 1 | -0.0376436 |
| RPL35A | ribosomal protein L35a | -0.0373669 |
| ARHGAP29 | Rho GTPase activating protein 29 | -0.036842 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0346784 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | -0.0345298 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0344713 |
| EFNA5 | ephrin-A5 | -0.0341569 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.033986 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0338429 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0329424 |
| CCND1 | cyclin D1 | -0.031542 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0313429 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0310962 |
| TMEM263 | transmembrane protein 263 | -0.0308527 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0302129 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0293478 |
| CCNL1 | cyclin L1 | -0.0292498 |
| SACK1A | scaffolding CK1 anchoring protein A | -0.0286186 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.0285898 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0281887 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0277713 |
| TOP1 | topoisomerase (DNA) I | -0.0277046 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0276373 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0276298 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0275155 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0272153 |
| WASF2 | WAS protein family, member 2 | -0.0272031 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0264608 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0263436 |
| COPA | coatomer protein complex, subunit alpha | -0.0262835 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0262044 |
| RBM39 | RNA binding motif protein 39 | -0.0260286 |
| PRRC1 | proline-rich coiled-coil 1 | -0.0256619 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0251711 |
| FLNB | filamin B, beta | -0.0248781 |
| RPS29 | ribosomal protein S29 | -0.024702 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | -0.0246753 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.0244113 |
| OSBPL3 | oxysterol binding protein-like 3 | -0.0242734 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0240325 |
| RRBP1 | ribosome binding protein 1 | -0.0236225 |
| TMEM165 | transmembrane protein 165 | -0.0233589 |
| ZNF292 | zinc finger protein 292 | -0.0232746 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | -0.0230129 |
| CSTB | cystatin B (stefin B) | -0.0230089 |
| RNF145 | ring finger protein 145 | -0.0228431 |
| FAM13A | family with sequence similarity 13, member A | -0.0228092 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | -0.022467 |
| CTSD | cathepsin D | -0.0224364 |
| MXD1 | MAX dimerization protein 1 | -0.0220377 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0219174 |
| CD46 | CD46 molecule, complement regulatory protein | -0.0218115 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.0217804 |
| WTAP | Wilms tumor 1 associated protein | -0.0216755 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0214888 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0211823 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0210192 |
| PKM | pyruvate kinase, muscle | -0.0209737 |
| CDK17 | cyclin-dependent kinase 17 | -0.020761 |
| LMO7 | LIM domain 7 | -0.0205174 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0204753 |
| TMEM123 | transmembrane protein 123 | -0.0201923 |
| RPL37A | ribosomal protein L37a | -0.0199813 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0198495 |
| SEC24D | SEC24 family member D | -0.0197536 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0194263 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0190728 |
| MT2A | metallothionein 2A | -0.0190046 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.018959 |
| RAB6A | RAB6A, member RAS oncogene family | -0.0189325 |
| SKAP2 | src kinase associated phosphoprotein 2 | -0.0189258 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0189199 |
| RPL31 | ribosomal protein L31 | -0.0188923 |
