| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Torkinib perturbation in NCI-H460 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Torkinib_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.112548 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.1112 |
| MYOF | myoferlin | 0.110905 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.106847 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | 0.100006 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0998391 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0984286 |
| LDHA | lactate dehydrogenase A | 0.096453 |
| RGS2 | regulator of G-protein signaling 2 | 0.0914838 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0779585 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0762594 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0753948 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0746138 |
| ENO1 | enolase 1, (alpha) | 0.0736959 |
| PGK1 | phosphoglycerate kinase 1 | 0.0730681 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0704684 |
| ASPH | aspartate beta-hydroxylase | 0.0700768 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0688195 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0686945 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.0669645 |
| RPS12 | ribosomal protein S12 | 0.0659294 |
| COL8A1 | collagen, type VIII, alpha 1 | 0.0589677 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0586265 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0572883 |
| RPLP0 | ribosomal protein, large, P0 | 0.0556213 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.0545038 |
| RAB3B | RAB3B, member RAS oncogene family | 0.05273 |
| EZR | ezrin | 0.0526548 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0510409 |
| RPL12 | ribosomal protein L12 | 0.0494659 |
| STC1 | stanniocalcin 1 | 0.0488514 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0484064 |
| GRAMD1B | GRAM domain containing 1B | 0.0479856 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.047326 |
| RACK1 | receptor for activated C kinase 1 | 0.0470585 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 0.046221 |
| KYNU | kynureninase | 0.0453451 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0450703 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0448716 |
| GDA | guanine deaminase | 0.044542 |
| RPS3 | ribosomal protein S3 | 0.0428323 |
| TXNRD1 | thioredoxin reductase 1 | 0.0426335 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0425459 |
| TGFBR1 | transforming growth factor, beta receptor 1 | 0.0412645 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0407954 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0386188 |
| ANXA2 | annexin A2 | 0.0371998 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.036685 |
| NCOA7 | nuclear receptor coactivator 7 | 0.0362962 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0357979 |
| INHBA | inhibin, beta A | 0.0350024 |
| CANX | calnexin | 0.0349716 |
| B2M | beta-2-microglobulin | 0.0347301 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0346471 |
| SQSTM1 | sequestosome 1 | 0.0345113 |
| RPL26 | ribosomal protein L26 | 0.0341417 |
| SET | SET nuclear proto-oncogene | 0.0339379 |
| OGA | O-GlcNAcase | 0.0338743 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.032956 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0324353 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.0323948 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.0315483 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0313089 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0311686 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0309788 |
| VDAC1 | voltage-dependent anion channel 1 | 0.0292333 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0290663 |
| ZC3H11A | zinc finger CCCH-type containing 11A | 0.0290218 |
| RPS4X | ribosomal protein S4, X-linked | 0.0283262 |
| RPS27A | ribosomal protein S27a | 0.0282483 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0281748 |
| TPI1 | triosephosphate isomerase 1 | 0.0275769 |
| NRCAM | neuronal cell adhesion molecule | 0.0270915 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.0267408 |
| RPL19 | ribosomal protein L19 | 0.026721 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0261633 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0259489 |
| BLTP2 | bridge-like lipid transfer protein family member 2 | 0.0256666 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0256444 |
| RPL4 | ribosomal protein L4 | 0.0256208 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0253642 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0248864 |
| SPAG9 | sperm associated antigen 9 | 0.0247962 |
| BDNF | brain-derived neurotrophic factor | 0.0246202 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0245618 |
| CDK6 | cyclin-dependent kinase 6 | 0.024465 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0244249 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0240167 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0240058 |
| DDX3Y | DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked | 0.0236049 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | 0.0235004 |
| MT2A | metallothionein 2A | 0.0234007 |
| ANXA1 | annexin A1 | 0.0233587 |
| NEK7 | NIMA-related kinase 7 | 0.0231204 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.0228109 |
| KPNB1 | karyopherin (importin) beta 1 | 0.0227581 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0225508 |
| TMSB4X | thymosin beta 4, X-linked | 0.0222284 |
| FTL | ferritin, light polypeptide | 0.0217554 |
| RPL7 | ribosomal protein L7 | 0.0217355 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NALF1 | NALCN channel auxiliary factor 1 | -0.126518 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.113212 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.110328 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0906678 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0898499 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0822493 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0806889 |
| EFNA5 | ephrin-A5 | -0.0761056 |
| AUTS2 | autism susceptibility candidate 2 | -0.0742954 |
| SMYD3 | SET and MYND domain containing 3 | -0.0729192 |
| CDH13 | cadherin 13 | -0.0656716 |
| RAD51B | RAD51 paralog B | -0.060397 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0584125 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0574577 |
| LAMA5 | laminin, alpha 5 | -0.0522543 |
| RPS6 | ribosomal protein S6 | -0.0519362 |
| DPP10 | dipeptidyl-peptidase 10 (non-functional) | -0.048842 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0471798 |
| TMSB10 | thymosin beta 10 | -0.0471344 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0454547 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0438572 |
| NCKAP5 | NCK-associated protein 5 | -0.0429788 |
| MCL1 | myeloid cell leukemia 1 | -0.0428826 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0405313 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0395488 |
| ADGRD1 | adhesion G protein-coupled receptor D1 | -0.0391866 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.037939 |
| CTNND2 | catenin (cadherin-associated protein), delta 2 | -0.0375245 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | -0.0369884 |
| CUX1 | cut-like homeobox 1 | -0.0367283 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0360057 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0343015 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0339598 |
| RPS23 | ribosomal protein S23 | -0.0333369 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | -0.0328928 |
| EXOC4 | exocyst complex component 4 | -0.0327121 |
| PDE10A | phosphodiesterase 10A | -0.0324348 |
| TENM3 | teneurin transmembrane protein 3 | -0.0320737 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0318931 |
| SMOC1 | SPARC related modular calcium binding 1 | -0.0318853 |
| CADM2 | cell adhesion molecule 2 | -0.0316893 |
| PTEN | phosphatase and tensin homolog | -0.0316402 |
| DENND1A | DENN/MADD domain containing 1A | -0.0306204 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0298737 |
| LAMB1 | laminin, beta 1 | -0.0295575 |
| COL4A6 | collagen, type IV, alpha 6 | -0.0288052 |
| RPS19 | ribosomal protein S19 | -0.0278644 |
| HDAC4 | histone deacetylase 4 | -0.0275889 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0275875 |
| RANBP17 | RAN binding protein 17 | -0.0274889 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0267148 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0262569 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0259821 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0252151 |
| ZNF638 | zinc finger protein 638 | -0.0250136 |
| DIAPH2 | diaphanous-related formin 2 | -0.0248587 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0243501 |
| TMEM165 | transmembrane protein 165 | -0.0242281 |
| GABRE | gamma-aminobutyric acid (GABA) A receptor, epsilon | -0.0242015 |
| FBXO11 | F-box protein 11 | -0.0241102 |
| RPS21 | ribosomal protein S21 | -0.0239587 |
| PCDH15 | protocadherin-related 15 | -0.0239112 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0236142 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0235047 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0233466 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0233393 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0232241 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0231247 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0229974 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0229839 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0229598 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0227225 |
| LSAMP | limbic system-associated membrane protein | -0.0226175 |
| ASTN2 | astrotactin 2 | -0.0225166 |
| SOX6 | SRY (sex determining region Y)-box 6 | -0.0225023 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0217377 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | -0.0216086 |
| JMJD1C | jumonji domain containing 1C | -0.0214648 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0213155 |
| RPS11 | ribosomal protein S11 | -0.0213 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.020986 |
| ZNF207 | zinc finger protein 207 | -0.0209722 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | -0.0204439 |
| ZFHX3 | zinc finger homeobox 3 | -0.0203521 |
| PRKCA | protein kinase C, alpha | -0.0202804 |
| RPL34 | ribosomal protein L34 | -0.0200939 |
| PFN1 | profilin 1 | -0.0199574 |
| SCARB1 | scavenger receptor class B, member 1 | -0.0199358 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0197589 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0197459 |
| GPC6 | glypican 6 | -0.0194053 |
| SRPK2 | SRSF protein kinase 2 | -0.0192791 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0190634 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0188682 |
| ARB2A | ARB2 cotranscriptional regulator A | -0.0188181 |
| KDM4C | lysine (K)-specific demethylase 4C | -0.0188052 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0185518 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.0182979 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.018248 |
| FSTL4 | follistatin-like 4 | -0.0182477 |
