Torkinib_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Torkinib perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

167 genes differentially expressed following the Torkinib_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 0.268648
SLIT2 slit homolog 2 (Drosophila) 0.155156
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.136815
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.123616
PDE4D phosphodiesterase 4D, cAMP-specific 0.123268
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.119304
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.118292
ENO1 enolase 1, (alpha) 0.0978383
JARID2 jumonji, AT rich interactive domain 2 0.0944717
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0937959
CD44 CD44 molecule (Indian blood group) 0.0902969
ASPH aspartate beta-hydroxylase 0.0894374
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0854715
POTEF POTE ankyrin domain family, member F 0.0788493
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0772261
GRB10 growth factor receptor-bound protein 10 0.0741899
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0740718
RPS8 ribosomal protein S8 0.0676607
FNDC3A fibronectin type III domain containing 3A 0.0668998
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0620611
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0614949
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0612873
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.05355
ENO2 enolase 2 (gamma, neuronal) 0.0532383
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.052965
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0524067
JMJD1C jumonji domain containing 1C 0.0508962
TGFBI transforming growth factor, beta-induced, 68kDa 0.0501812
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0497837
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0481992
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0463304
EGFR epidermal growth factor receptor 0.0452381
KTN1 kinectin 1 (kinesin receptor) 0.0444543
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0440939
PGK1 phosphoglycerate kinase 1 0.0436233
SKIC3 SKI3 subunit of superkiller complex 0.0433015
LRP12 low density lipoprotein receptor-related protein 12 0.0426568
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0426403
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0419477
FNDC3B fibronectin type III domain containing 3B 0.0402947
SP100 SP100 nuclear antigen 0.0390831
RPS27 ribosomal protein S27 0.0381378
LAMA4 laminin, alpha 4 0.0377448
RPLP0 ribosomal protein, large, P0 0.0354488
RPL11 ribosomal protein L11 0.0348985
MKI67 marker of proliferation Ki-67 0.0330818
AKAP12 A kinase (PRKA) anchor protein 12 0.0321757
RNF213 ring finger protein 213 0.0306879
MRPS6 mitochondrial ribosomal protein S6 0.0298686
EEF2 eukaryotic translation elongation factor 2 0.0296958
ESYT2 extended synaptotagmin-like protein 2 0.0292974
RPL5 ribosomal protein L5 0.0287236
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0285974
RPS3 ribosomal protein S3 0.0277158
PNN pinin, desmosome associated protein 0.027674
PICALM phosphatidylinositol binding clathrin assembly protein 0.0273462
NEBL nebulette 0.0270217
PTEN phosphatase and tensin homolog 0.0268423
SDC4 syndecan 4 0.026506
COL6A3 collagen, type VI, alpha 3 0.0252605
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 0.0238972
ZFAND3 zinc finger, AN1-type domain 3 0.023835
COG5 component of oligomeric golgi complex 5 0.0237432
SETD5 SET domain containing 5 0.0234459
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0218799
RPL15 ribosomal protein L15 0.0215414
FN1 fibronectin 1 0.0198147
PDLIM5 PDZ and LIM domain 5 0.0197522
RPL37A ribosomal protein L37a 0.0193646
LDHA lactate dehydrogenase A 0.0190298
SLTM SAFB-like, transcription modulator 0.0181007
ACTG1 actin gamma 1 0.0175636
IGFBP3 insulin-like growth factor binding protein 3 0.0146303
ELL2 elongation factor, RNA polymerase II, 2 0.0137118
TBC1D22A TBC1 domain family, member 22A 0.0131449
ERRFI1 ERBB receptor feedback inhibitor 1 0.0126195
PSD3 pleckstrin and Sec7 domain containing 3 0.0123403
RPL35 ribosomal protein L35 0.012006
SEC31A SEC31 homolog A (S. cerevisiae) 0.0115997
AGO3 argonaute RISC catalytic component 3 0.00980019
NKD1 naked cuticle homolog 1 (Drosophila) 0.0093663
BHLHE40 basic helix-loop-helix family, member e40 0.00848319
RPS20 ribosomal protein S20 0.00789131
AKAP13 A kinase (PRKA) anchor protein 13 0.00736632
CANX calnexin 0.00666517
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.00519029
S100A10 S100 calcium binding protein A10 0.00423319
S100A9 S100 calcium binding protein A9 0.00365992
ZMYND8 zinc finger, MYND-type containing 8 0.00307599
KDM6A lysine (K)-specific demethylase 6A 0.00212901
HDLBP high density lipoprotein binding protein 0.00200195
RAD51B RAD51 paralog B 0.00143031
RPS6 ribosomal protein S6 0.00125958
EGR1 early growth response 1 7.36715E-4

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.371312
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.20479
SMYD3 SET and MYND domain containing 3 -0.169476
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.161243
TPT1 tumor protein, translationally-controlled 1 -0.132623
RICTOR RPTOR independent companion of MTOR, complex 2 -0.125012
EXT1 exostosin glycosyltransferase 1 -0.111912
HMGA2 high mobility group AT-hook 2 -0.107058
RPL23 ribosomal protein L23 -0.102231
PKM pyruvate kinase, muscle -0.0898531
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0897215
TRIO trio Rho guanine nucleotide exchange factor -0.0888801
PTMA prothymosin, alpha -0.083521
MT2A metallothionein 2A -0.0824094
NDRG1 N-myc downstream regulated 1 -0.0820222
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0803055
PDE10A phosphodiesterase 10A -0.0750087
PTK2 protein tyrosine kinase 2 -0.0657996
GPC6 glypican 6 -0.0643581
RPS25 ribosomal protein S25 -0.0641685
RPS24 ribosomal protein S24 -0.0632944
NALF1 NALCN channel auxiliary factor 1 -0.0630942
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0624595
TMSB10 thymosin beta 10 -0.0615683
FTL ferritin, light polypeptide -0.0585199
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0562231
USP34 ubiquitin specific peptidase 34 -0.0557007
DSCAM Down syndrome cell adhesion molecule -0.0545138
RPL12 ribosomal protein L12 -0.054011
PRRC2C proline-rich coiled-coil 2C -0.0538906
NT5C2 5'-nucleotidase, cytosolic II -0.0538719
MCL1 myeloid cell leukemia 1 -0.0537212
COL5A1 collagen, type V, alpha 1 -0.0520371
CDH13 cadherin 13 -0.0516635
LOXL2 lysyl oxidase-like 2 -0.0458085
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0453548
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0437418
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0435383
MNAT1 MNAT CDK-activating kinase assembly factor 1 -0.0400938
NAV2 neuron navigator 2 -0.0375711
ANXA2 annexin A2 -0.037215
VIM vimentin -0.0340622
EIF1 eukaryotic translation initiation factor 1 -0.0339349
MTDH metadherin -0.0332349
RPL10A ribosomal protein L10a -0.03185
RPL30 ribosomal protein L30 -0.0303973
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0282104
VCL vinculin -0.0275117
SAMD4A sterile alpha motif domain containing 4A -0.0260798
RPS16 ribosomal protein S16 -0.025985
IER3 immediate early response 3 -0.0252997
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0241012
EFNA5 ephrin-A5 -0.0228261
SPAG9 sperm associated antigen 9 -0.0226147
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.0207284
DLG1 discs, large homolog 1 (Drosophila) -0.020675
EIF5B eukaryotic translation initiation factor 5B -0.0200007
CSNK1A1 casein kinase 1, alpha 1 -0.0189574
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0137258
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0133775
ATP13A3 ATPase type 13A3 -0.0122809
RACK1 receptor for activated C kinase 1 -0.0113526
STC1 stanniocalcin 1 -0.0107567
VEGFA vascular endothelial growth factor A -0.0107343
RPS12 ribosomal protein S12 -0.00992876
RPS19 ribosomal protein S19 -0.0090925
MYO9B myosin IXB -0.00891996
KMT2C lysine (K)-specific methyltransferase 2C -0.00444879
MYOF myoferlin -0.00397425
MYO1E myosin IE -0.00282385
LPP LIM domain containing preferred translocation partner in lipoma -0.00266972
TPI1 triosephosphate isomerase 1 -0.00239621
NFIA nuclear factor I/A -0.00114186