| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Torkinib perturbation in NCI-H661 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Torkinib_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| COL11A1 | collagen, type XI, alpha 1 | 0.185211 |
| CDH6 | cadherin 6, type 2, K-cadherin (fetal kidney) | 0.114227 |
| NTM | neurotrimin | 0.101928 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0892042 |
| CADM2 | cell adhesion molecule 2 | 0.0883539 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0793687 |
| COL5A2 | collagen, type V, alpha 2 | 0.0793441 |
| COL3A1 | collagen, type III, alpha 1 | 0.0722308 |
| ENO1 | enolase 1, (alpha) | 0.0693628 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0661844 |
| TENM3 | teneurin transmembrane protein 3 | 0.058958 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.058817 |
| POTEF | POTE ankyrin domain family, member F | 0.0528819 |
| ADGRV1 | adhesion G protein-coupled receptor V1 | 0.0514961 |
| LDHA | lactate dehydrogenase A | 0.0510072 |
| XPO1 | exportin 1 | 0.0503395 |
| SRP54 | signal recognition particle 54kDa | 0.0501482 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0495392 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0494434 |
| HMCN1 | hemicentin 1 | 0.0474709 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0474326 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | 0.046536 |
| PCDH18 | protocadherin 18 | 0.0464302 |
| BBX | bobby sox homolog (Drosophila) | 0.046057 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0460541 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0454772 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.042653 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | 0.0413707 |
| RPLP0 | ribosomal protein, large, P0 | 0.0408757 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0397001 |
| ANK2 | ankyrin 2, neuronal | 0.0388728 |
| RPS3 | ribosomal protein S3 | 0.0385052 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0384668 |
| SETD2 | SET domain containing 2 | 0.0383139 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0380844 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0378646 |
| ZNF608 | zinc finger protein 608 | 0.037628 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0372704 |
| ITGAV | integrin, alpha V | 0.036678 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | 0.0359644 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0356895 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0352888 |
| ARRDC3 | arrestin domain containing 3 | 0.0351786 |
| PCBP2 | poly(rC) binding protein 2 | 0.0349622 |
| NCAM2 | neural cell adhesion molecule 2 | 0.0344175 |
| NHSL1 | NHS-like 1 | 0.0343676 |
| EXOC4 | exocyst complex component 4 | 0.0343498 |
| CALR | calreticulin | 0.0343094 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0339301 |
| HDAC9 | histone deacetylase 9 | 0.0333423 |
| NFIA | nuclear factor I/A | 0.0329832 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.0329738 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0325782 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0322873 |
| RPS4X | ribosomal protein S4, X-linked | 0.031841 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0313004 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0312623 |
| MYO10 | myosin X | 0.0311241 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0311156 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0308849 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0305921 |
| RAD51B | RAD51 paralog B | 0.0302653 |
| GPC4 | glypican 4 | 0.0302453 |
| HAT1 | histone acetyltransferase 1 | 0.029588 |
| FER | fer (fps/fes related) tyrosine kinase | 0.0295843 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0294247 |
| SKIL | SKI-like proto-oncogene | 0.029095 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0288082 |
| G3BP2 | GTPase activating protein (SH3 domain) binding protein 2 | 0.0288073 |
| PHF21A | PHD finger protein 21A | 0.0286896 |
| TOX | thymocyte selection-associated high mobility group box | 0.0286061 |
| CUX1 | cut-like homeobox 1 | 0.0284969 |
| CCDC88A | coiled-coil domain containing 88A | 0.0284841 |
| RPL12 | ribosomal protein L12 | 0.0282755 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0280259 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | 0.0280201 |
| PRKCSH | protein kinase C substrate 80K-H | 0.0278287 |
| STAG2 | stromal antigen 2 | 0.0276979 |
| ZFR | zinc finger RNA binding protein | 0.0271522 |
| YAP1 | Yes-associated protein 1 | 0.0271062 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.027053 |
| SMC1A | structural maintenance of chromosomes 1A | 0.0269974 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0268867 |
| BRCA1 | breast cancer 1, early onset | 0.0267909 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0267438 |
| HMGB2 | high mobility group box 2 | 0.0265757 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0264287 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0263998 |
| HECTD1 | HECT domain containing E3 ubiquitin protein ligase 1 | 0.0263067 |
| HELZ | helicase with zinc finger | 0.0262314 |
| EGFR | epidermal growth factor receptor | 0.0262207 |
| NCOA2 | nuclear receptor coactivator 2 | 0.0261133 |
| EZR | ezrin | 0.026104 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.0258651 |
| PCDH9 | protocadherin 9 | 0.0257196 |
| MKI67 | marker of proliferation Ki-67 | 0.0256465 |
| SERINC1 | serine incorporator 1 | 0.0256317 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | 0.0255681 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0253374 |
| UTRN | utrophin | 0.0252514 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PTMA | prothymosin, alpha | -0.170449 |
| TSC22D2 | TSC22 domain family, member 2 | -0.110286 |
| SPAG9 | sperm associated antigen 9 | -0.0994712 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0939083 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.074273 |
| ANKRD33B | ankyrin repeat domain 33B | -0.07034 |
| GALNTL6 | polypeptide N-acetylgalactosaminyltransferase-like 6 | -0.0685412 |
| ZNF292 | zinc finger protein 292 | -0.0684684 |
| COL1A2 | collagen, type I, alpha 2 | -0.0663938 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0656002 |
| RPS16 | ribosomal protein S16 | -0.0604038 |
| ZNF217 | zinc finger protein 217 | -0.0584589 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0559432 |
| NRG1 | neuregulin 1 | -0.0552326 |
| PGAP1 | post-GPI attachment to proteins 1 | -0.0534726 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.052851 |
| PEG10 | paternally expressed 10 | -0.0525104 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0524066 |
| EMP1 | epithelial membrane protein 1 | -0.052224 |
| RPL35A | ribosomal protein L35a | -0.0514202 |
| GPC3 | glypican 3 | -0.0510456 |
| MAP4 | microtubule-associated protein 4 | -0.0506241 |
| USP3 | ubiquitin specific peptidase 3 | -0.050031 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0497319 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | -0.049525 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0489844 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | -0.0488396 |
| B2M | beta-2-microglobulin | -0.0478691 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0477163 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | -0.0458509 |
| H1-0 | H1.0 linker histone | -0.0451945 |
| MED13L | mediator complex subunit 13-like | -0.0443817 |
| VIM | vimentin | -0.0442782 |
| RTN4 | reticulon 4 | -0.0434449 |
| FBXO11 | F-box protein 11 | -0.0416602 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0412358 |
| RIGI | RNA sensor RIG-I | -0.0400132 |
| JMJD1C | jumonji domain containing 1C | -0.0399832 |
| RHEB | Ras homolog enriched in brain | -0.03969 |
| MRPS30 | mitochondrial ribosomal protein S30 | -0.0395778 |
| CAVIN1 | caveolae associated protein 1 | -0.0392777 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | -0.0392147 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.0390733 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0390282 |
| WDR43 | WD repeat domain 43 | -0.0389721 |
| MDK | midkine (neurite growth-promoting factor 2) | -0.0388975 |
| MB21D2 | Mab-21 domain containing 2 | -0.0388881 |
| CABLES1 | Cdk5 and Abl enzyme substrate 1 | -0.038576 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0380333 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0373386 |
| PFN1 | profilin 1 | -0.0371247 |
| ZNF207 | zinc finger protein 207 | -0.03644 |
| ADGRL3 | adhesion G protein-coupled receptor L3 | -0.0363567 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0362907 |
| TMSB10 | thymosin beta 10 | -0.0360443 |
| DNAJC1 | DnaJ (Hsp40) homolog, subfamily C, member 1 | -0.0358466 |
| CDC73 | cell division cycle 73 | -0.0358144 |
| PDS5A | PDS5 cohesin associated factor A | -0.0356119 |
| ENAH | enabled homolog (Drosophila) | -0.035543 |
| RBM39 | RNA binding motif protein 39 | -0.0355021 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0351249 |
| YES1 | YES proto-oncogene 1, Src family tyrosine kinase | -0.0350765 |
| FAM171B | family with sequence similarity 171, member B | -0.0350518 |
| FOXK1 | forkhead box K1 | -0.0348895 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -0.0338573 |
| GNAS | GNAS complex locus | -0.0338209 |
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | -0.0337292 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0336306 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.0336157 |
| HNRNPK | heterogeneous nuclear ribonucleoprotein K | -0.0335613 |
| G2E3 | G2/M-phase specific E3 ubiquitin protein ligase | -0.033338 |
| VAPA | VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa | -0.0330828 |
| QKI | QKI, KH domain containing, RNA binding | -0.0329604 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0328609 |
| URI1 | URI1, prefoldin-like chaperone | -0.0323848 |
| S100A10 | S100 calcium binding protein A10 | -0.0320277 |
| SEPTIN7 | septin 7 | -0.031981 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.031692 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0313195 |
| ZC3H15 | zinc finger CCCH-type containing 15 | -0.0312933 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0311746 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0307919 |
| HMGA1 | high mobility group AT-hook 1 | -0.0305679 |
| CCNY | cyclin Y | -0.0300688 |
| SCAF11 | SR-related CTD-associated factor 11 | -0.030026 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0299499 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0297465 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0295741 |
| RBM25 | RNA binding motif protein 25 | -0.0295703 |
| MYADM | myeloid-associated differentiation marker | -0.0294579 |
| TMEM123 | transmembrane protein 123 | -0.0294502 |
| COTL1 | coactosin-like F-actin binding protein 1 | -0.0291616 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0291206 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0290536 |
| LHFPL6 | LHFPL tetraspan subfamily member 6 | -0.0287085 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0286448 |
| RPS6 | ribosomal protein S6 | -0.0281376 |
| CERT1 | ceramide transporter 1 | -0.0276566 |
| SRPK2 | SRSF protein kinase 2 | -0.0274935 |
| ADNP | activity-dependent neuroprotector homeobox | -0.0274576 |
