| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Torkinib perturbation in SW 1088 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Torkinib_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FTH1 | ferritin, heavy polypeptide 1 | 0.136274 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.109088 |
| VIM | vimentin | 0.108206 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0937418 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0751405 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0730314 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0713284 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0696207 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0655719 |
| PRELID2 | PRELI domain containing 2 | 0.0648994 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0635019 |
| FAM13A | family with sequence similarity 13, member A | 0.0623724 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | 0.0603703 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0599 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0594745 |
| ENO1 | enolase 1, (alpha) | 0.057633 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0546528 |
| SEC24A | SEC24 family member A | 0.0541921 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0530614 |
| STC1 | stanniocalcin 1 | 0.0522965 |
| ADM | adrenomedullin | 0.0503776 |
| SDC4 | syndecan 4 | 0.0494788 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0490566 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0489449 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0484249 |
| INTS6 | integrator complex subunit 6 | 0.0473129 |
| KYNU | kynureninase | 0.0448874 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0444456 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0421841 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0418189 |
| FNIP1 | folliculin interacting protein 1 | 0.0418017 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | 0.0412402 |
| NDRG1 | N-myc downstream regulated 1 | 0.0405872 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0404636 |
| RND3 | Rho family GTPase 3 | 0.0393915 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0388197 |
| POTEF | POTE ankyrin domain family, member F | 0.038253 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0376603 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0375707 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.037196 |
| RPS12 | ribosomal protein S12 | 0.0369035 |
| INSIG2 | insulin induced gene 2 | 0.0366673 |
| B2M | beta-2-microglobulin | 0.0362108 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0360748 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | 0.035981 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | 0.0358621 |
| SEPTIN2 | septin 2 | 0.0358481 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0354077 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0346824 |
| COPB1 | coatomer protein complex, subunit beta 1 | 0.0346368 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0344689 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0339547 |
| HBP1 | HMG-box transcription factor 1 | 0.0336798 |
| LDHA | lactate dehydrogenase A | 0.0332131 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0331905 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0327831 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0327504 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | 0.032671 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0323197 |
| HIP1 | huntingtin interacting protein 1 | 0.0319677 |
| ZNF395 | zinc finger protein 395 | 0.03142 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | 0.031291 |
| ALK | anaplastic lymphoma receptor tyrosine kinase | 0.0308689 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0308245 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0307445 |
| ANXA5 | annexin A5 | 0.030597 |
| SUCO | SUN domain containing ossification factor | 0.0304421 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0303437 |
| MTPN | myotrophin | 0.0301454 |
| SEC24D | SEC24 family member D | 0.0299869 |
| IL6 | interleukin 6 | 0.0297099 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0295276 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0293985 |
| CYLD | cylindromatosis (turban tumor syndrome) | 0.0286473 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0283024 |
| MCL1 | myeloid cell leukemia 1 | 0.0281908 |
| FAM107B | family with sequence similarity 107, member B | 0.0279648 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0278417 |
| PGM3 | phosphoglucomutase 3 | 0.0277927 |
| MYDGF | myeloid-derived growth factor | 0.0275397 |
| MT2A | metallothionein 2A | 0.0273633 |
| ARFIP1 | ADP-ribosylation factor interacting protein 1 | 0.0272085 |
| ARRDC3 | arrestin domain containing 3 | 0.0269155 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0268961 |
| PTGES2 | prostaglandin E synthase 2 | 0.0268743 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0268349 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.0266587 |
| HELZ | helicase with zinc finger | 0.0265176 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0262111 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0259659 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | 0.0258775 |
| ATP2C1 | ATPase, Ca++ transporting, type 2C, member 1 | 0.0257987 |
| WASHC4 | WASH complex subunit 4 | 0.0257835 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.025765 |
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | 0.0257507 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0257189 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | 0.0255833 |
| RAB10 | RAB10, member RAS oncogene family | 0.0255462 |
| TPM3 | tropomyosin 3 | 0.0254281 |
| C1D | C1D nuclear receptor corepressor | 0.0254279 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.234548 |
| COL1A1 | collagen, type I, alpha 1 | -0.198456 |
| FN1 | fibronectin 1 | -0.188157 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.18132 |
| COL6A3 | collagen, type VI, alpha 3 | -0.16192 |
| COL1A2 | collagen, type I, alpha 2 | -0.159733 |
| LOX | lysyl oxidase | -0.101187 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0932734 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.071246 |
| HLA-B | major histocompatibility complex, class I, B | -0.0696303 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0655083 |
| GLIS3 | GLIS family zinc finger 3 | -0.0645749 |
| CDK6 | cyclin-dependent kinase 6 | -0.0616695 |
| HLA-C | major histocompatibility complex, class I, C | -0.0592991 |
| MT1X | metallothionein 1X | -0.0584233 |
| EGR1 | early growth response 1 | -0.0536327 |
| MAP1B | microtubule-associated protein 1B | -0.0520431 |
| ACTG1 | actin gamma 1 | -0.0498458 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0484308 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.048142 |
| RRBP1 | ribosome binding protein 1 | -0.0473129 |
| COL3A1 | collagen, type III, alpha 1 | -0.0460616 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0456049 |
| AHNAK | AHNAK nucleoprotein | -0.0455138 |
| COL5A2 | collagen, type V, alpha 2 | -0.0451291 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0449323 |
| CCNI | cyclin I | -0.0440072 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0437516 |
| H3-3B | H3.3 histone B | -0.043368 |
| TNNC1 | troponin C type 1 (slow) | -0.0430775 |
| CALU | calumenin | -0.042685 |
| COL6A2 | collagen, type VI, alpha 2 | -0.0423332 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0401782 |
| LOXL2 | lysyl oxidase-like 2 | -0.0385212 |
| PLCB4 | phospholipase C, beta 4 | -0.0382124 |
| PXDN | peroxidasin | -0.0382061 |
| MMP14 | matrix metallopeptidase 14 (membrane-inserted) | -0.0369576 |
| SMYD3 | SET and MYND domain containing 3 | -0.0367927 |
| LAMA4 | laminin, alpha 4 | -0.0348939 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0347673 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0338685 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0337496 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0336673 |
| RPS24 | ribosomal protein S24 | -0.0333543 |
| DKK3 | dickkopf WNT signaling pathway inhibitor 3 | -0.0331638 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.032787 |
| TPM1 | tropomyosin 1 (alpha) | -0.0321348 |
| TXNRD1 | thioredoxin reductase 1 | -0.0320258 |
| TUBB | tubulin, beta class I | -0.0316847 |
| S100A6 | S100 calcium binding protein A6 | -0.031241 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0311632 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0311546 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.030811 |
| EFNA5 | ephrin-A5 | -0.0304769 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.030237 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0301252 |
| PTMA | prothymosin, alpha | -0.028619 |
| PIAS1 | protein inhibitor of activated STAT, 1 | -0.0282452 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | -0.0282328 |
| FBN1 | fibrillin 1 | -0.0281483 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0279786 |
| PIK3R1 | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | -0.0277031 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | -0.0275449 |
| ERCC6L2 | excision repair cross-complementation group 6-like 2 | -0.0271726 |
| GRIK5 | glutamate receptor, ionotropic, kainate 5 | -0.0271324 |
| PDE10A | phosphodiesterase 10A | -0.0270256 |
| HIPK2 | homeodomain interacting protein kinase 2 | -0.0269984 |
| ERGIC1 | endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 | -0.0268247 |
| TNS3 | tensin 3 | -0.0261827 |
| S100A9 | S100 calcium binding protein A9 | -0.0260783 |
| TENT5A | terminal nucleotidyltransferase 5A | -0.0260447 |
| CENPF | centromere protein F, 350/400kDa | -0.0260307 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0257522 |
| KCNE4 | potassium channel, voltage gated subfamily E regulatory beta subunit 4 | -0.0254735 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0254709 |
| RPS11 | ribosomal protein S11 | -0.0252849 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -0.0252573 |
| ERBIN | erbb2 interacting protein | -0.0251309 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0250769 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0249838 |
| SEPTIN7 | septin 7 | -0.0249599 |
| ZFHX3 | zinc finger homeobox 3 | -0.0245716 |
| PFN1 | profilin 1 | -0.0245566 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.0243497 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0242737 |
| CALD1 | caldesmon 1 | -0.0242655 |
| KLHL5 | kelch-like family member 5 | -0.0242328 |
| GNAS | GNAS complex locus | -0.0240927 |
| FKBP10 | FK506 binding protein 10, 65 kDa | -0.0240737 |
| VCL | vinculin | -0.0240674 |
| CD99 | CD99 molecule | -0.024048 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0240161 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0239224 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0239177 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0237683 |
| AK1 | adenylate kinase 1 | -0.02367 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0236397 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0235406 |
| PGK1 | phosphoglycerate kinase 1 | -0.023256 |
| TMEM123 | transmembrane protein 123 | -0.0232046 |
