Torkinib_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Torkinib perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Torkinib_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.150777
POTEF POTE ankyrin domain family, member F 0.10245
SQSTM1 sequestosome 1 0.0766276
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0729795
INTS6 integrator complex subunit 6 0.0724356
LDHA lactate dehydrogenase A 0.0695536
ZSWIM6 zinc finger, SWIM-type containing 6 0.0691679
SMAD3 SMAD family member 3 0.0669633
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0665046
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0664564
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.065465
RPS12 ribosomal protein S12 0.0599109
LOC102724023 ES1 protein homolog, mitochondrial 0.058895
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0587376
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0585804
ANXA1 annexin A1 0.0576531
BIRC3 baculoviral IAP repeat containing 3 0.0545219
ANO6 anoctamin 6 0.0535494
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0527788
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0492147
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.04758
HSPA8 heat shock 70kDa protein 8 0.0472518
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0470464
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0464716
SH3KBP1 SH3-domain kinase binding protein 1 0.0446614
TPI1 triosephosphate isomerase 1 0.0442161
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0440715
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.043039
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0428422
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.042018
CALR calreticulin 0.0387654
BZW1 basic leucine zipper and W2 domains 1 0.0384533
LOC112694756 uncharaterized LOC112694756 0.0379427
CPNE1 copine I 0.0375845
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0372591
EGFR epidermal growth factor receptor 0.036066
MSN moesin 0.0360423
NFE2L2 nuclear factor, erythroid 2-like 2 0.0359389
RUNX1 runt-related transcription factor 1 0.0355583
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0350785
NAP1L1 nucleosome assembly protein 1-like 1 0.0348115
APLP2 amyloid beta (A4) precursor-like protein 2 0.0345929
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0344495
B2M beta-2-microglobulin 0.0343104
MYOF myoferlin 0.0342615
ANGPTL4 angiopoietin-like 4 0.0335409
RPLP1 ribosomal protein, large, P1 0.0335309
RPLP0 ribosomal protein, large, P0 0.0327056
ENO1 enolase 1, (alpha) 0.0325886
CD59 CD59 molecule, complement regulatory protein 0.0324758
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.032246
SET SET nuclear proto-oncogene 0.0321034
ADM adrenomedullin 0.0318943
RPL37 ribosomal protein L37 0.0315373
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0313029
MBNL2 muscleblind-like splicing regulator 2 0.030801
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0307611
RPS3 ribosomal protein S3 0.0304644
SERINC3 serine incorporator 3 0.0300631
RPS6 ribosomal protein S6 0.029982
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0297718
OXSR1 oxidative stress responsive 1 0.02959
MCL1 myeloid cell leukemia 1 0.0290899
LCOR ligand dependent nuclear receptor corepressor 0.0290304
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0289703
RPL23 ribosomal protein L23 0.0279333
RPL3 ribosomal protein L3 0.0278275
ZFAND3 zinc finger, AN1-type domain 3 0.0275622
CDK6 cyclin-dependent kinase 6 0.0274902
MYH9 myosin, heavy chain 9, non-muscle 0.0274459
ANKRD37 ankyrin repeat domain 37 0.0273009
CANX calnexin 0.0272699
TOM1L2 target of myb1-like 2 (chicken) 0.0272295
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0268173
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0265491
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0261988
TTC3 tetratricopeptide repeat domain 3 0.0260722
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0257426
CTBP2 C-terminal binding protein 2 0.025728
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0256143
SYNJ2 synaptojanin 2 0.0253228
EIF5 eukaryotic translation initiation factor 5 0.0252557
KTN1 kinectin 1 (kinesin receptor) 0.0251906
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0251754
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0249481
NFE2L1 nuclear factor, erythroid 2-like 1 0.0249457
CXCL8 chemokine (C-X-C motif) ligand 8 0.0247322
ARHGAP21 Rho GTPase activating protein 21 0.0246065
SIK2 salt-inducible kinase 2 0.0244827
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.0244358
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0241636
IRF1 interferon regulatory factor 1 0.0240966
SEPTIN9 septin 9 0.0240452
TES testin LIM domain protein 0.0240422
EZR ezrin 0.0234299
FTL ferritin, light polypeptide 0.0232975
TJP1 tight junction protein 1 0.0231556
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.023083
ZFP36L1 ZFP36 ring finger protein-like 1 0.0230749
ITGAV integrin, alpha V 0.0230433

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.349544
IGFBP3 insulin-like growth factor binding protein 3 -0.0873208
TAS2R14 taste receptor, type 2, member 14 -0.0699902
RBM39 RNA binding motif protein 39 -0.0670097
ZMYND8 zinc finger, MYND-type containing 8 -0.061183
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0589327
SPAG9 sperm associated antigen 9 -0.0584152
THSD4 thrombospondin, type I, domain containing 4 -0.05612
DNER delta/notch-like EGF repeat containing -0.0550399
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0539922
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.052997
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0517223
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -0.0517186
NALCN sodium leak channel, non selective -0.0505153
RIN2 Ras and Rab interactor 2 -0.0480703
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0469657
TMEM123 transmembrane protein 123 -0.0443688
YBX3 Y box binding protein 3 -0.0439204
PDE8A phosphodiesterase 8A -0.0437047
MKI67 marker of proliferation Ki-67 -0.0424089
STRN3 striatin, calmodulin binding protein 3 -0.0421719
SMC4 structural maintenance of chromosomes 4 -0.0419578
SETD5 SET domain containing 5 -0.0417148
NCOR1 nuclear receptor corepressor 1 -0.0416938
RSF1 remodeling and spacing factor 1 -0.041561
MAPKAP1 mitogen-activated protein kinase associated protein 1 -0.0407564
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.0405
DIAPH3 diaphanous-related formin 3 -0.040269
RNF213 ring finger protein 213 -0.0400268
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.0397551
AKAP10 A kinase (PRKA) anchor protein 10 -0.0393564
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0391782
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0391022
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.039096
GNAS GNAS complex locus -0.0388006
RB1CC1 RB1-inducible coiled-coil 1 -0.038661
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) -0.0382715
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0381279
PCCA propionyl CoA carboxylase, alpha polypeptide -0.0375832
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0375429
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0375061
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0374974
ANKRD28 ankyrin repeat domain 28 -0.0373085
ZNF644 zinc finger protein 644 -0.0372266
RAB7A RAB7A, member RAS oncogene family -0.037092
ZBTB20 zinc finger and BTB domain containing 20 -0.0370695
ZNF609 zinc finger protein 609 -0.0369813
PRRC2B proline-rich coiled-coil 2B -0.036864
WAC WW domain containing adaptor with coiled-coil -0.0368311
ZNF292 zinc finger protein 292 -0.0368047
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.036418
CKAP2 cytoskeleton associated protein 2 -0.0357461
EFNA5 ephrin-A5 -0.0352665
BCAS3 breast carcinoma amplified sequence 3 -0.0352116
IGF2 insulin-like growth factor 2 -0.0346552
BPTF bromodomain PHD finger transcription factor -0.0344283
ATG7 autophagy related 7 -0.0338976
MIS18BP1 MIS18 binding protein 1 -0.0337776
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.0335749
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -0.0333656
NCOA6 nuclear receptor coactivator 6 -0.0333337
RBM25 RNA binding motif protein 25 -0.0329904
FAF2 Fas associated factor family member 2 -0.0321947
MNAT1 MNAT CDK-activating kinase assembly factor 1 -0.0320442
ETV6 ets variant 6 -0.031856
ATM ATM serine/threonine kinase -0.0315755
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0311797
LCORL ligand dependent nuclear receptor corepressor-like -0.0310413
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0308228
ATF7IP activating transcription factor 7 interacting protein -0.0306746
HJURP Holliday junction recognition protein -0.0306723
PNISR PNN-interacting serine/arginine-rich protein -0.0306623
DOCK4 dedicator of cytokinesis 4 -0.0303725
NEMF nuclear export mediator factor -0.0302172
GLCCI1 glucocorticoid induced 1 -0.0300692
FER fer (fps/fes related) tyrosine kinase -0.0300417
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0300202
NF1 neurofibromin 1 -0.0299483
FBXL17 F-box and leucine-rich repeat protein 17 -0.0293319
ATXN2 ataxin 2 -0.0292328
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0290968
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB -0.0290726
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0288791
THOC2 THO complex 2 -0.0285886
TPST1 tyrosylprotein sulfotransferase 1 -0.0285606
KIAA1328 KIAA1328 -0.0284427
BIRC6 baculoviral IAP repeat containing 6 -0.0284217
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0283404
KIF23 kinesin family member 23 -0.0282584
BAZ2A bromodomain adjacent to zinc finger domain, 2A -0.0282012
GOSR1 golgi SNAP receptor complex member 1 -0.0281442
BASP1 brain abundant, membrane attached signal protein 1 -0.0281178
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0278443
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0277171
NIPBL Nipped-B homolog (Drosophila) -0.027694
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0273178
MBD5 methyl-CpG binding domain protein 5 -0.0271473
ATG10 autophagy related 10 -0.0269506
PCED1B PC-esterase domain containing 1B -0.0266676
CD2AP CD2-associated protein -0.0265497