| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Torkinib perturbation in SW 900 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Torkinib_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ASPH | aspartate beta-hydroxylase | 0.142476 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.10276 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.095024 |
| RPS12 | ribosomal protein S12 | 0.0826937 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0799315 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0693205 |
| ENO1 | enolase 1, (alpha) | 0.0525437 |
| FAT1 | FAT atypical cadherin 1 | 0.0505988 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0502468 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0501073 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0465182 |
| DST | dystonin | 0.0456705 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0445673 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0437655 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0437286 |
| SEMA4A | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A | 0.0420956 |
| RPL37A | ribosomal protein L37a | 0.0409295 |
| ANKRD28 | ankyrin repeat domain 28 | 0.039995 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0396505 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0391068 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.0386013 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0383444 |
| RPL26 | ribosomal protein L26 | 0.0378569 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0375981 |
| SVIL | supervillin | 0.0357289 |
| PLIN2 | perilipin 2 | 0.0354284 |
| RACK1 | receptor for activated C kinase 1 | 0.035275 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0350986 |
| POTEF | POTE ankyrin domain family, member F | 0.0349931 |
| RFX2 | regulatory factor X, 2 (influences HLA class II expression) | 0.0348881 |
| MYOF | myoferlin | 0.0347313 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0346027 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0343512 |
| EZR | ezrin | 0.0322934 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0319566 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0317411 |
| RASAL2 | RAS protein activator like 2 | 0.0317199 |
| RPS3 | ribosomal protein S3 | 0.0313429 |
| EFNA5 | ephrin-A5 | 0.0305458 |
| ATF6 | activating transcription factor 6 | 0.0304642 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0297219 |
| SGMS2 | sphingomyelin synthase 2 | 0.0291957 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.029147 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0289785 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0289293 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0286297 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | 0.0279431 |
| ABLIM1 | actin binding LIM protein 1 | 0.0276054 |
| ATXN1 | ataxin 1 | 0.0276035 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0274894 |
| SERINC1 | serine incorporator 1 | 0.0273508 |
| SIK3 | SIK family kinase 3 | 0.0264091 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0261005 |
| MT2A | metallothionein 2A | 0.0259577 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0258902 |
| RO60 | Ro60, Y RNA binding protein | 0.0258329 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0257222 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0252563 |
| SET | SET nuclear proto-oncogene | 0.0252369 |
| IFI44L | interferon-induced protein 44-like | 0.0250577 |
| CCSER1 | coiled-coil serine-rich protein 1 | 0.0247921 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0244569 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0235587 |
| ZC3H11A | zinc finger CCCH-type containing 11A | 0.0233968 |
| GPATCH2L | G patch domain containing 2-like | 0.0230494 |
| AGPAT4 | 1-acylglycerol-3-phosphate O-acyltransferase 4 | 0.0228953 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.022529 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0224196 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.022176 |
| CAPN2 | calpain 2, (m/II) large subunit | 0.0221475 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.022142 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0221388 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0218802 |
| SMAD3 | SMAD family member 3 | 0.0217921 |
| FAM107B | family with sequence similarity 107, member B | 0.021542 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | 0.021514 |
| CRY1 | cryptochrome circadian clock 1 | 0.0214653 |
| RASEF | RAS and EF-hand domain containing | 0.0212322 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0211899 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0210881 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0210346 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0209799 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0208062 |
| GOLGB1 | golgin B1 | 0.0206682 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0205859 |
| ARHGAP21 | Rho GTPase activating protein 21 | 0.0203523 |
| RPL12 | ribosomal protein L12 | 0.0202923 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0202713 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0201353 |
| TPM3 | tropomyosin 3 | 0.020125 |
| ANO6 | anoctamin 6 | 0.0200775 |
| RPS18 | ribosomal protein S18 | 0.0200392 |
| ARB2A | ARB2 cotranscriptional regulator A | 0.0200012 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0198663 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0198098 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0197869 |
| ANGPTL4 | angiopoietin-like 4 | 0.0193126 |
| TPI1 | triosephosphate isomerase 1 | 0.0193017 |
| RPL31 | ribosomal protein L31 | 0.0192631 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0191389 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.447385 |
| FN1 | fibronectin 1 | -0.161819 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.15279 |
| PTMA | prothymosin, alpha | -0.144812 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.139121 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.106698 |
| NRG1 | neuregulin 1 | -0.100358 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0957618 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.073944 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0654822 |
| HLA-B | major histocompatibility complex, class I, B | -0.0648926 |
| TMSB10 | thymosin beta 10 | -0.0603837 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0572583 |
| NDRG1 | N-myc downstream regulated 1 | -0.0568799 |
| TMEM165 | transmembrane protein 165 | -0.0544379 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0482271 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.047877 |
| EGR1 | early growth response 1 | -0.0459123 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0457932 |
| CANX | calnexin | -0.0456903 |
| RPS11 | ribosomal protein S11 | -0.0456478 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.044691 |
| HMGA2 | high mobility group AT-hook 2 | -0.0432684 |
| SQSTM1 | sequestosome 1 | -0.043035 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0423653 |
| S100A6 | S100 calcium binding protein A6 | -0.0411954 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0403082 |
| RPS23 | ribosomal protein S23 | -0.0400505 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0392526 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.039044 |
| GNAS | GNAS complex locus | -0.0386576 |
| RPS6 | ribosomal protein S6 | -0.0381375 |
| IRAK3 | interleukin-1 receptor-associated kinase 3 | -0.0380025 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0369183 |
| RPL8 | ribosomal protein L8 | -0.0354832 |
| COPA | coatomer protein complex, subunit alpha | -0.0350021 |
| RPS21 | ribosomal protein S21 | -0.0349955 |
| HMGA1 | high mobility group AT-hook 1 | -0.033555 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0329893 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0326465 |
| ATN1 | atrophin 1 | -0.0319424 |
| RPL34 | ribosomal protein L34 | -0.0313242 |
| RPS24 | ribosomal protein S24 | -0.0309986 |
| RRBP1 | ribosome binding protein 1 | -0.0309732 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0307785 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.0305157 |
| TMEM263 | transmembrane protein 263 | -0.0300599 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0299285 |
| UBE2K | ubiquitin-conjugating enzyme E2K | -0.0297015 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0289679 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.028134 |
| GOLGA4 | golgin A4 | -0.0279286 |
| RBM25 | RNA binding motif protein 25 | -0.027866 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0278385 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0272278 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | -0.0271809 |
| ITGA1 | integrin, alpha 1 | -0.0269584 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0268054 |
| RTN4 | reticulon 4 | -0.0266924 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0266661 |
| ACTG1 | actin gamma 1 | -0.0266636 |
| FTL | ferritin, light polypeptide | -0.026519 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | -0.0264911 |
| PIM3 | Pim-3 proto-oncogene, serine/threonine kinase | -0.0262237 |
| SYT1 | synaptotagmin I | -0.0256498 |
| HPCAL1 | hippocalcin-like 1 | -0.025432 |
| IER3 | immediate early response 3 | -0.025357 |
| CTSD | cathepsin D | -0.0251966 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0250665 |
| WASF2 | WAS protein family, member 2 | -0.025018 |
| S100A10 | S100 calcium binding protein A10 | -0.0249905 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0248824 |
| RBM39 | RNA binding motif protein 39 | -0.0247506 |
| KRT81 | keratin 81, type II | -0.0247464 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | -0.02464 |
| COG5 | component of oligomeric golgi complex 5 | -0.0245254 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0244332 |
| FOXO3 | forkhead box O3 | -0.0243224 |
| CALR | calreticulin | -0.0242265 |
| WDR45B | WD repeat domain 45B | -0.0239825 |
| SEPTIN7 | septin 7 | -0.0238606 |
| RPL35A | ribosomal protein L35a | -0.0237632 |
| RAB7A | RAB7A, member RAS oncogene family | -0.023681 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0236785 |
| RPS29 | ribosomal protein S29 | -0.0235756 |
| TMSB4X | thymosin beta 4, X-linked | -0.0235356 |
| KMT2A | lysine (K)-specific methyltransferase 2A | -0.0233586 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0230808 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0227063 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | -0.0226566 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.022635 |
| RPS5 | ribosomal protein S5 | -0.022504 |
| PPIB | peptidylprolyl isomerase B (cyclophilin B) | -0.022376 |
| CALU | calumenin | -0.0223585 |
| RAB6A | RAB6A, member RAS oncogene family | -0.0220924 |
| RAB1A | RAB1A, member RAS oncogene family | -0.022051 |
| IBTK | inhibitor of Bruton agammaglobulinemia tyrosine kinase | -0.0218797 |
| GLG1 | golgi glycoprotein 1 | -0.0218756 |
| RAI14 | retinoic acid induced 14 | -0.0216989 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0216881 |
