Torsades de Pointes Gene Set

Dataset CTD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A type of ventricular tachycardia characterized by polymorphioc QRS complexes that change in amplitue and cycle length, and thus have the appearance of oscillating around the baseline in the EKG. (Human Phenotype Ontology, HP_0001664)
External Link http://ctdbase.org/detail.go?type=disease&acc=MESH:D016171
Similar Terms
Downloads & Tools

Genes

206 genes/proteins associated with the disease Torsades de Pointes from the curated CTD Gene-Disease Associations dataset.

Symbol Name Standardized Value
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2 2.88009
SCN5A sodium channel, voltage gated, type V alpha subunit 2.88009
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 2.88009
SLC22A2 solute carrier family 22 (organic cation transporter), member 2 2.48317
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 2.28216
TNF tumor necrosis factor 2.2783
CASP3 caspase 3, apoptosis-related cysteine peptidase 2.27513
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 2.23347
FOS FBJ murine osteosarcoma viral oncogene homolog 2.13114
NUPR1 nuclear protein, transcriptional regulator, 1 2.08977
PRL prolactin 2.0844
INHBE inhibin, beta E 2.02006
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 2.01595
ASNS asparagine synthetase (glutamine-hydrolyzing) 2.01146
BDNF brain-derived neurotrophic factor 2.00884
C10ORF10 chromosome 10 open reading frame 10 1.99786
IL6 interleukin 6 1.99091
DRD2 dopamine receptor D2 1.97954
SLC22A1 solute carrier family 22 (organic cation transporter), member 1 1.96432
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 1.95345
SLC22A3 solute carrier family 22 (organic cation transporter), member 3 1.9469
REN renin 1.92849
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 1.92548
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1 1.90853
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) 1.90476
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3 1.88704
MAPK3 mitogen-activated protein kinase 3 1.88638
TAGLN transgelin 1.88425
CXCL8 chemokine (C-X-C motif) ligand 8 1.87459
MAPK1 mitogen-activated protein kinase 1 1.87426
IL1B interleukin 1, beta 1.87261
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 1.85642
WIPI1 WD repeat domain, phosphoinositide interacting 1 1.84162
NOS2 nitric oxide synthase 2, inducible 1.83325
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 1.80699
CASP7 caspase 7, apoptosis-related cysteine peptidase 1.79465
EGR1 early growth response 1 1.78606
CREB1 cAMP responsive element binding protein 1 1.7714
GSTP1 glutathione S-transferase pi 1 1.77101
BCL2 B-cell CLL/lymphoma 2 1.7625
FABP1 fatty acid binding protein 1, liver 1.74701
CAT catalase 1.74661
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 1.74521
FNDC4 fibronectin type III domain containing 4 1.73838
BAX BCL2-associated X protein 1.73251
IL4 interleukin 4 1.72696
JUN jun proto-oncogene 1.71193
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 1.7107
CCL2 chemokine (C-C motif) ligand 2 1.67202
CYP3A cytochrome P450, family 3, subfamily A 1.65974
CRH corticotropin releasing hormone 1.65952
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 1.62893
NR0B2 nuclear receptor subfamily 0, group B, member 2 1.62825
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 1.62199
HPN hepsin 1.6169
ADRB1 adrenoceptor beta 1 1.58983
NPPA natriuretic peptide A 1.58398
HRH1 histamine receptor H1 1.579
AP1S1 adaptor-related protein complex 1, sigma 1 subunit 1.56509
INS insulin 1.5555
POMC proopiomelanocortin 1.54839
HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 1.53283
SOD1 superoxide dismutase 1, soluble 1.52413
CASP9 caspase 9, apoptosis-related cysteine peptidase 1.51531
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 1.50953
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 1.50549
MAPK8 mitogen-activated protein kinase 8 1.50146
ADRB2 adrenoceptor beta 2, surface 1.46832
NPY neuropeptide Y 1.46462
DRD1 dopamine receptor D1 1.46015
ARC activity-regulated cytoskeleton-associated protein 1.45989
CALCA calcitonin-related polypeptide alpha 1.45299
CASP8 caspase 8, apoptosis-related cysteine peptidase 1.45273
SOD2 superoxide dismutase 2, mitochondrial 1.44409
FKBP1B FK506 binding protein 1B, 12.6 kDa 1.43892
TGFB1 transforming growth factor, beta 1 1.43428
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled 1.42831
PENK proenkephalin 1.41035
MPO myeloperoxidase 1.40705
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5 1.40568
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 1.39002
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 1.39002
CREM cAMP responsive element modulator 1.39002
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 1.38327
IL10 interleukin 10 1.36763
APP amyloid beta (A4) precursor protein 1.36735
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 1.36047
PHYH phytanoyl-CoA 2-hydroxylase 1.36047
FAS Fas cell surface death receptor 1.35155
NGF nerve growth factor (beta polypeptide) 1.34897
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8 1.34372
EDN1 endothelin 1 1.33405
HMOX1 heme oxygenase 1 1.33375
IFNG interferon, gamma 1.32905
CES2 carboxylesterase 2 1.32756
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.32162
CLU clusterin 1.31985
VEGFA vascular endothelial growth factor A 1.31626
PRKCE protein kinase C, epsilon 1.30911
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 1.30881
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 1.30147
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 1.29688
GFAP glial fibrillary acidic protein 1.29502
EGFR epidermal growth factor receptor 1.29225
NOS3 nitric oxide synthase 3 (endothelial cell) 1.29225
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 1.28889
TH tyrosine hydroxylase 1.28395
NR1I2 nuclear receptor subfamily 1, group I, member 2 1.28149
ICAM1 intercellular adhesion molecule 1 1.27564
TP53 tumor protein p53 1.26576
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 1.26359
IL1A interleukin 1, alpha 1.26175
IL2 interleukin 2 1.25713
FOSB FBJ murine osteosarcoma viral oncogene homolog B 1.2415
JUNB jun B proto-oncogene 1.23993
MMP9 matrix metallopeptidase 9 1.2352
MAPK14 mitogen-activated protein kinase 14 1.23201
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 1.23137
AVP arginine vasopressin 1.23042
CAMK4 calcium/calmodulin-dependent protein kinase IV 1.22696
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 1.21239
CALR calreticulin 1.20654
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 1.2013
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 1.2013
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 1.2013
GRIA2 glutamate receptor, ionotropic, AMPA 2 1.19868
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2 1.18783
GSK3B glycogen synthase kinase 3 beta 1.18587
TAC1 tachykinin, precursor 1 1.18456
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4 1.17662
ERP29 endoplasmic reticulum protein 29 1.16833
BIRC5 baculoviral IAP repeat containing 5 1.16533
NEFH neurofilament, heavy polypeptide 1.16467
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5 1.16302
CCND3 cyclin D3 1.16236
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.15695
ADCY5 adenylate cyclase 5 1.15156
OPRM1 opioid receptor, mu 1 1.15089
IGF1 insulin-like growth factor 1 (somatomedin C) 1.15055
MAOA monoamine oxidase A 1.14644
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6 1.14644
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 1.14098
CKM creatine kinase, muscle 1.1403
DDIT3 DNA-damage-inducible transcript 3 1.1403
BCL2L1 BCL2-like 1 1.13621
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 1.12737
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1 1.12461
VIM vimentin 1.11945
DCAF8 DDB1 and CUL4 associated factor 8 1.1136
ADORA1 adenosine A1 receptor 1.11081
EGR2 early growth response 2 1.11081
GAL galanin/GMAP prepropeptide 1.11081
GRIA1 glutamate receptor, ionotropic, AMPA 1 1.10734
S100A9 S100 calcium binding protein A9 1.10562
NTF3 neurotrophin 3 1.10033
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 1.09892
ADRB3 adrenoceptor beta 3 1.09716
CASP2 caspase 2, apoptosis-related cysteine peptidase 1.09506
PRKCD protein kinase C, delta 1.08904
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 1.08762
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 1.08762
RGS2 regulator of G-protein signaling 2 1.08513
GRM1 glutamate receptor, metabotropic 1 1.08442
RYR2 ryanodine receptor 2 (cardiac) 1.08442
ANGPT2 angiopoietin 2 1.08407
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 1.08266
CA2 carbonic anhydrase II 1.08019
PER2 period circadian clock 2 1.07696
TIMP1 TIMP metallopeptidase inhibitor 1 1.07696
APAF1 apoptotic peptidase activating factor 1 1.07518
NCF2 neutrophil cytosolic factor 2 1.07376
S100B S100 calcium binding protein B 1.07376
NR4A1 nuclear receptor subfamily 4, group A, member 1 1.07163
SCNN1A sodium channel, non voltage gated 1 alpha subunit 1.07057
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) 1.07057
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2 1.06952
GRIK2 glutamate receptor, ionotropic, kainate 2 1.06917
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1 1.06625
SCD stearoyl-CoA desaturase (delta-9-desaturase) 1.06297
PARP1 poly (ADP-ribose) polymerase 1 1.05864
BCL2L11 BCL2-like 11 (apoptosis facilitator) 1.05828
CCL3 chemokine (C-C motif) ligand 3 1.05757
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1 1.05721
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 1.05052
UGT1A9 UDP glucuronosyltransferase 1 family, polypeptide A9 1.04427
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 1.04427
IL33 interleukin 33 1.04427
HEXA hexosaminidase A (alpha polypeptide) 1.04276
OMD osteomodulin 1.04239
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 1.04014
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 1.03939
TSHB thyroid stimulating hormone, beta 1.03939
STXBP1 syntaxin binding protein 1 1.03604
HOMER1 homer scaffolding protein 1 1.03604
HSPA8 heat shock 70kDa protein 8 1.03419
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3 1.03197
DRD3 dopamine receptor D3 1.03084
VCAM1 vascular cell adhesion molecule 1 1.03009
MMP2 matrix metallopeptidase 2 1.02522
PDE4A phosphodiesterase 4A, cAMP-specific 1.02373
PLAT plasminogen activator, tissue 1.02336
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17 1.01928
CES1 carboxylesterase 1 1.01739
F3 coagulation factor III (thromboplastin, tissue factor) 1.01739
GJA1 gap junction protein, alpha 1, 43kDa 1.01474
MYH6 myosin, heavy chain 6, cardiac muscle, alpha 1.01212