Toxic Shock Syndrome Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A commensal bacterial infectious disease that results_in infection, has_material_basis_in Streptococcus pyogenes or has_material_basis_in Staphylococcus aureus , which produce toxins that are absorbed systemically and produce the systemic manifestations. The infection has_symptom fever, has_symptom rash, has_symptom hypotension, has_symptom multiorgan failure, has_symptom desquamation, has_symptom vomiting, has_symptom diarrhea, has_symptom headache, and has_symptom nonfocal neurologic abnormalities. (Human Disease Ontology, DOID_14115)
External Link https://www.disgenet.org/browser/0/1/0/C0600327
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Genes

57 genes associated with the disease Toxic Shock Syndrome in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
A2M alpha-2-macroglobulin
ADM adrenomedullin
AGR2 anterior gradient 2
ALB albumin
AQP1 aquaporin 1 (Colton blood group)
C5AR1 complement component 5a receptor 1
CASR calcium-sensing receptor
CCKBR cholecystokinin B receptor
CCL20 chemokine (C-C motif) ligand 20
CCL28 chemokine (C-C motif) ligand 28
CD40 CD40 molecule, TNF receptor superfamily member 5
CXCL8 chemokine (C-X-C motif) ligand 8
EDNRB endothelin receptor type B
ELANE elastase, neutrophil expressed
ENO2 enolase 2 (gamma, neuronal)
EPHB2 EPH receptor B2
FN1 fibronectin 1
FUT2 fucosyltransferase 2 (secretor status included)
GC group-specific component (vitamin D binding protein)
GSTO1 glutathione S-transferase omega 1
GSTO2 glutathione S-transferase omega 2
HLA-A major histocompatibility complex, class I, A
HLA-DRA major histocompatibility complex, class II, DR alpha
HMOX1 heme oxygenase 1
HSPG2 heparan sulfate proteoglycan 2
IFNG interferon, gamma
IL10 interleukin 10
IL17A interleukin 17A
IL1B interleukin 1, beta
IL23A interleukin 23, alpha subunit p19
IL6 interleukin 6
LAMA2 laminin, alpha 2
MAPK1 mitogen-activated protein kinase 1
MAVS mitochondrial antiviral signaling protein
MC2R melanocortin 2 receptor (adrenocorticotropic hormone)
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MYD88 myeloid differentiation primary response 88
MYOM2 myomesin 2
NOS2 nitric oxide synthase 2, inducible
OXA1L oxidase (cytochrome c) assembly 1-like
PCSK9 proprotein convertase subtilisin/kexin type 9
RAB1B RAB1B, member RAS oncogene family
RAB7A RAB7A, member RAS oncogene family
RAB7B RAB7B, member RAS oncogene family
SAG S-antigen; retina and pineal gland (arrestin)
SEA S13 erythroblastosis (avian) oncogene homolog
SELL selectin L
SETBP1 SET binding protein 1
SLC9A6 solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6
SUMF2 sulfatase modifying factor 2
SYN1 synapsin I
TBXA2R thromboxane A2 receptor
TLR2 toll-like receptor 2
TNF tumor necrosis factor
TREM1 triggering receptor expressed on myeloid cells 1
TST thiosulfate sulfurtransferase (rhodanese)
VEGFA vascular endothelial growth factor A