Trachoma Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
Description A commensal bacterial infectious disease that results_in infection located_in eye, has_material_basis_in Chlamydia trachomatis (A, B, Ba and C serovars), which is transmitted_by contact with eye discharge from the infected person and transmitted_by congenital method. The infection causes eyelid to turn inward which makes eyelashes to scratch the cornea. (Human Disease Ontology, DOID_11265)
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Genes

60 genes co-occuring with the disease Trachoma in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
LTB4R leukotriene B4 receptor 2.254
GATB glutamyl-tRNA(Gln) amidotransferase, subunit B 1.701
LACRT lacritin 1.618
TGFBI transforming growth factor, beta-induced, 68kDa 1.485
SOX3 SRY (sex determining region Y)-box 3 1.456
PPP1R14C protein phosphatase 1, regulatory (inhibitor) subunit 14C 1.403
EDNRB endothelin receptor type B 1.357
LTF lactotransferrin 1.351
ATAD1 ATPase family, AAA domain containing 1 1.342
MMP9 matrix metallopeptidase 9 1.342
IL1B interleukin 1, beta 1.333
LCN1 lipocalin 1 1.33
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 1.304
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 1.3
TMEM37 transmembrane protein 37 1.289
OSTF1 osteoclast stimulating factor 1 1.282
LHFPL1 lipoma HMGIC fusion partner-like 1 1.28
SIGLEC12 sialic acid binding Ig-like lectin 12 (gene/pseudogene) 1.268
PALM2AKAP2 PALM2 and AKAP2 fusion 1.258
TNF tumor necrosis factor 1.245
ECI2 enoyl-CoA delta isomerase 2 1.233
SCGB1D1 secretoglobin, family 1D, member 1 1.231
MMP12 matrix metallopeptidase 12 1.225
S100A7 S100 calcium binding protein A7 1.224
UBL4B ubiquitin-like 4B 1.221
HAMP hepcidin antimicrobial peptide 1.217
IL1A interleukin 1, alpha 1.212
PRR4 proline rich 4 (lacrimal) 1.211
IL10 interleukin 10 1.204
FNDC11 fibronectin type III domain containing 11 1.182
RASSF6 Ras association (RalGDS/AF-6) domain family member 6 1.17
CCN2 cellular communication network factor 2 1.16
MMP1 matrix metallopeptidase 1 1.158
OR4K5 olfactory receptor, family 4, subfamily K, member 5 1.153
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide 1.141
OR4K2 olfactory receptor, family 4, subfamily K, member 2 1.14
OR4K1 olfactory receptor, family 4, subfamily K, member 1 1.124
MMP2 matrix metallopeptidase 2 1.116
OR4C11 olfactory receptor, family 4, subfamily C, member 11 1.107
HARBI1 harbinger transposase derived 1 1.097
OR11H12 olfactory receptor, family 11, subfamily H, member 12 1.093
IL6 interleukin 6 1.083
LYZL1 lysozyme-like 1 1.082
AQP2 aquaporin 2 (collecting duct) 1.065
POTEG POTE ankyrin domain family, member G 1.059
PAX6 paired box 6 1.055
TOR1B torsin family 1, member B (torsin B) 1.052
FGF2 fibroblast growth factor 2 (basic) 1.045
ZNF558 zinc finger protein 558 1.045
SIGLEC6 sialic acid binding Ig-like lectin 6 1.039
KRT3 keratin 3, type II 1.037
RTL4 retrotransposon Gag like 4 1.032
C2ORF69 chromosome 2 open reading frame 69 1.027
SPARCL1 SPARC-like 1 (hevin) 1.022
ENG endoglin 1.012
IFNG interferon, gamma 1.011
MAGEH1 melanoma antigen family H1 1.01
MMP7 matrix metallopeptidase 7 1.005
OR4N2 olfactory receptor, family 4, subfamily N, member 2 1.001
OR4P4 olfactory receptor, family 4, subfamily P, member 4 1.001