| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Trametinib (DMSO perturbation in A-172 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Trametinib (DMSO_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.126757 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.091147 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0662728 |
| FLNB | filamin B, beta | 0.0624953 |
| FBN1 | fibrillin 1 | 0.0562363 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0524769 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0501595 |
| LOXL2 | lysyl oxidase-like 2 | 0.0494046 |
| NAV2 | neuron navigator 2 | 0.0418574 |
| ARHGEF10 | Rho guanine nucleotide exchange factor (GEF) 10 | 0.0371125 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0368477 |
| SEPTIN9 | septin 9 | 0.0366831 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0363761 |
| SBF2 | SET binding factor 2 | 0.0357947 |
| OGA | O-GlcNAcase | 0.0355415 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0313221 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | 0.030689 |
| DPYSL2 | dihydropyrimidinase-like 2 | 0.0290601 |
| SQSTM1 | sequestosome 1 | 0.0277086 |
| CD109 | CD109 molecule | 0.0266163 |
| FNIP1 | folliculin interacting protein 1 | 0.0258438 |
| ARRDC3 | arrestin domain containing 3 | 0.0240581 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0239496 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0238146 |
| RUNX1 | runt-related transcription factor 1 | 0.0230487 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0223746 |
| OPTN | optineurin | 0.0218249 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0216923 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0216169 |
| PRKAG2 | protein kinase, AMP-activated, gamma 2 non-catalytic subunit | 0.0213114 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0208519 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0207817 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0203106 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0199831 |
| ATP13A3 | ATPase type 13A3 | 0.0198778 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0191672 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0191342 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | 0.0190015 |
| ZNF292 | zinc finger protein 292 | 0.0187895 |
| ADM | adrenomedullin | 0.0186679 |
| ZBTB7C | zinc finger and BTB domain containing 7C | 0.0185954 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0185642 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | 0.0183672 |
| WDFY1 | WD repeat and FYVE domain containing 1 | 0.0181602 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0181285 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0177786 |
| YEATS2 | YEATS domain containing 2 | 0.0173703 |
| AGPAT5 | 1-acylglycerol-3-phosphate O-acyltransferase 5 | 0.0171381 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0169324 |
| TPM3 | tropomyosin 3 | 0.0168165 |
| THBS2 | thrombospondin 2 | 0.0167745 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.0165395 |
| NGLY1 | N-glycanase 1 | 0.0164199 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.01612 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0159734 |
| NAP1L4 | nucleosome assembly protein 1-like 4 | 0.0158982 |
| SH3BP5 | SH3-domain binding protein 5 (BTK-associated) | 0.0157157 |
| ARHGAP12 | Rho GTPase activating protein 12 | 0.0155902 |
| CAMSAP2 | calmodulin regulated spectrin-associated protein family, member 2 | 0.0155314 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0154797 |
| CLIP2 | CAP-GLY domain containing linker protein 2 | 0.0151625 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0151567 |
| RASA2 | RAS p21 protein activator 2 | 0.0150992 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0150133 |
| SP3 | Sp3 transcription factor | 0.0148124 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0146136 |
| MIMS1 | mitochondrial inner membrane scaffold 1 | 0.0144362 |
| BCL2L1 | BCL2-like 1 | 0.0144304 |
| IQSEC1 | IQ motif and Sec7 domain 1 | 0.0143568 |
| FNBP1 | formin binding protein 1 | 0.0141622 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.0141442 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0139977 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0139062 |
| CD44 | CD44 molecule (Indian blood group) | 0.0137981 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0137893 |
| GOLGA4 | golgin A4 | 0.013735 |
| ANKRD36C | ankyrin repeat domain 36C | 0.0135753 |
| INSIG1 | insulin induced gene 1 | 0.0135657 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.013536 |
| MTCL1 | microtubule crosslinking factor 1 | 0.0134548 |
| MXI1 | MAX interactor 1, dimerization protein | 0.013322 |
| NDST1 | N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 | 0.0131803 |
| VEGFA | vascular endothelial growth factor A | 0.0131018 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0128601 |
| PFKP | phosphofructokinase, platelet | 0.0127783 |
| RNMT | RNA (guanine-7-) methyltransferase | 0.012777 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0127657 |
| AVL9 | AVL9 homolog (S. cerevisiase) | 0.0127403 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0127094 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0126229 |
| FNBP4 | formin binding protein 4 | 0.0125733 |
| RNF168 | ring finger protein 168, E3 ubiquitin protein ligase | 0.0125515 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0124822 |
| PCGF5 | polycomb group ring finger 5 | 0.0123546 |
| ADAR | adenosine deaminase, RNA-specific | 0.0123202 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0122611 |
| INSIG2 | insulin induced gene 2 | 0.012204 |
| RHOBTB3 | Rho-related BTB domain containing 3 | 0.0121867 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | 0.0121041 |
| STK10 | serine/threonine kinase 10 | 0.0119446 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.196417 |
| VIM | vimentin | -0.183974 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.16831 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.165046 |
| MAP1B | microtubule-associated protein 1B | -0.123775 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.119568 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0979789 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0943385 |
| S100A10 | S100 calcium binding protein A10 | -0.0831766 |
| FN1 | fibronectin 1 | -0.0815542 |
| LOX | lysyl oxidase | -0.0676872 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0642283 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0636481 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0595768 |
| PLAT | plasminogen activator, tissue | -0.0583088 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0556312 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0550012 |
| S100A6 | S100 calcium binding protein A6 | -0.0513528 |
| DIRAS3 | DIRAS family, GTP-binding RAS-like 3 | -0.0487063 |
| TAGLN2 | transgelin 2 | -0.0476198 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0464391 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0462344 |
| ASPH | aspartate beta-hydroxylase | -0.0456312 |
| HLA-B | major histocompatibility complex, class I, B | -0.0444917 |
| B2M | beta-2-microglobulin | -0.0442411 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0427045 |
| SUCNR1 | succinate receptor 1 | -0.0422811 |
| NAV1 | neuron navigator 1 | -0.0420664 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0420317 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0414289 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.0399871 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0387261 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0365922 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0365062 |
| MT2A | metallothionein 2A | -0.036413 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0362483 |
| PRSS23 | protease, serine, 23 | -0.0357003 |
| CSTB | cystatin B (stefin B) | -0.0348262 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0347295 |
| CDH13 | cadherin 13 | -0.0346626 |
| SP100 | SP100 nuclear antigen | -0.0330281 |
| LRRC17 | leucine rich repeat containing 17 | -0.0329997 |
| RIGI | RNA sensor RIG-I | -0.0326532 |
| DST | dystonin | -0.0308011 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.030049 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0297973 |
| SORBS2 | sorbin and SH3 domain containing 2 | -0.028951 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.028298 |
| MX2 | MX dynamin-like GTPase 2 | -0.0270462 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0266411 |
| ANXA2 | annexin A2 | -0.0261693 |
| POTEF | POTE ankyrin domain family, member F | -0.0257848 |
| CAVIN1 | caveolae associated protein 1 | -0.0254561 |
| LMNA | lamin A/C | -0.0253337 |
| IL7R | interleukin 7 receptor | -0.0252758 |
| OASL | 2'-5'-oligoadenylate synthetase-like | -0.0250918 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0240425 |
| ARL15 | ADP-ribosylation factor-like 15 | -0.0238701 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0237418 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0236609 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | -0.0235593 |
| TMSB4X | thymosin beta 4, X-linked | -0.0235513 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0235254 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0233406 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0230264 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0229816 |
| CDK6 | cyclin-dependent kinase 6 | -0.0227364 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0225398 |
| S100A11 | S100 calcium binding protein A11 | -0.0224482 |
| COL1A1 | collagen, type I, alpha 1 | -0.0221143 |
| TENM3 | teneurin transmembrane protein 3 | -0.0220294 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0220211 |
| TUBB4B | tubulin, beta 4B class IVb | -0.0218551 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | -0.0217608 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0216782 |
| PKM | pyruvate kinase, muscle | -0.0216561 |
| KRT81 | keratin 81, type II | -0.0216515 |
| HLA-C | major histocompatibility complex, class I, C | -0.021623 |
| RASAL2 | RAS protein activator like 2 | -0.0215453 |
| DGKG | diacylglycerol kinase, gamma 90kDa | -0.0213278 |
| CUX1 | cut-like homeobox 1 | -0.0210931 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0209531 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0208986 |
| S100A4 | S100 calcium binding protein A4 | -0.0207968 |
| BSG | basigin (Ok blood group) | -0.0207494 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | -0.0206048 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0204438 |
| VCL | vinculin | -0.0202665 |
| FLT1 | fms-related tyrosine kinase 1 | -0.0202225 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0200717 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0200187 |
| MT1X | metallothionein 1X | -0.0199721 |
| TPM4 | tropomyosin 4 | -0.019434 |
| FSTL1 | follistatin-like 1 | -0.01923 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0187833 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0185176 |
| PFN1 | profilin 1 | -0.0182881 |
| EGR1 | early growth response 1 | -0.0182362 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0177293 |
| SEPTIN7 | septin 7 | -0.0177288 |
