| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Trametinib (DMSO perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Trametinib (DMSO_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TENM3 | teneurin transmembrane protein 3 | 0.18627 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | 0.164758 |
| CRISPLD1 | cysteine-rich secretory protein LCCL domain containing 1 | 0.113996 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.107085 |
| ANXA1 | annexin A1 | 0.105321 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | 0.0992078 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0935182 |
| CPOX | coproporphyrinogen oxidase | 0.0732039 |
| SYT1 | synaptotagmin I | 0.0729383 |
| NLGN1 | neuroligin 1 | 0.0727566 |
| MGAT4C | MGAT4 family, member C | 0.0722672 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0693096 |
| EPHA5 | EPH receptor A5 | 0.066604 |
| EPHA6 | EPH receptor A6 | 0.065624 |
| DST | dystonin | 0.065148 |
| CALR | calreticulin | 0.0646717 |
| PDGFC | platelet derived growth factor C | 0.0642853 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | 0.0617101 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0607485 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0604622 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0589265 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0588974 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.058184 |
| CXADR | coxsackie virus and adenovirus receptor | 0.056839 |
| NRXN3 | neurexin 3 | 0.0545912 |
| AHNAK | AHNAK nucleoprotein | 0.0542498 |
| MED13L | mediator complex subunit 13-like | 0.0538869 |
| HSPB1 | heat shock 27kDa protein 1 | 0.0521113 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.052083 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0504421 |
| FSTL5 | follistatin-like 5 | 0.0503924 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0499027 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0484806 |
| CCSER1 | coiled-coil serine-rich protein 1 | 0.0473427 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0452163 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0447094 |
| PCBP2 | poly(rC) binding protein 2 | 0.0440672 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | 0.0435496 |
| CDK6 | cyclin-dependent kinase 6 | 0.0425819 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0410891 |
| CANX | calnexin | 0.041063 |
| AXIN2 | axin 2 | 0.0386464 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0382386 |
| ZNF292 | zinc finger protein 292 | 0.0375854 |
| TPI1 | triosephosphate isomerase 1 | 0.0368561 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0368243 |
| RPS12 | ribosomal protein S12 | 0.0355439 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0353256 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0334585 |
| NEBL | nebulette | 0.0333161 |
| PDK4 | pyruvate dehydrogenase kinase, isozyme 4 | 0.0328816 |
| PTMA | prothymosin, alpha | 0.0326622 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | 0.0323912 |
| RPS8 | ribosomal protein S8 | 0.0320194 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0317383 |
| EXOC6B | exocyst complex component 6B | 0.0311109 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0309588 |
| ATP5F1B | ATP synthase F1 subunit beta | 0.0309515 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | 0.030857 |
| PRKCI | protein kinase C, iota | 0.0305862 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0304236 |
| RPS3 | ribosomal protein S3 | 0.0300407 |
| GASK1B | golgi associated kinase 1B | 0.029744 |
| HDAC9 | histone deacetylase 9 | 0.0295292 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0293101 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.0287679 |
| PRR16 | proline rich 16 | 0.0283768 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0283494 |
| DSPP | dentin sialophosphoprotein | 0.0282635 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0277979 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0276623 |
| SNCA | synuclein, alpha (non A4 component of amyloid precursor) | 0.0276286 |
| RNF213 | ring finger protein 213 | 0.0270117 |
| ARRDC3 | arrestin domain containing 3 | 0.0269325 |
| CDK19 | cyclin-dependent kinase 19 | 0.0267545 |
| OXR1 | oxidation resistance 1 | 0.0267435 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0267191 |
| CLDND1 | claudin domain containing 1 | 0.0264799 |
| MPG | N-methylpurine-DNA glycosylase | 0.02602 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0256606 |
| DSG2 | desmoglein 2 | 0.025276 |
| SACS | sacsin molecular chaperone | 0.0250801 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0249943 |
| ADAR | adenosine deaminase, RNA-specific | 0.0245857 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | 0.0244637 |
| ARL15 | ADP-ribosylation factor-like 15 | 0.0243437 |
| MAP4 | microtubule-associated protein 4 | 0.0243247 |
| TMEM106B | transmembrane protein 106B | 0.0242857 |
| FER | fer (fps/fes related) tyrosine kinase | 0.0241586 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0240359 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | 0.0235713 |
| RPL7 | ribosomal protein L7 | 0.0234343 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0233013 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.0232839 |
| THSD7A | thrombospondin, type I, domain containing 7A | 0.023166 |
| RPS29 | ribosomal protein S29 | 0.0230797 |
| VTI1A | vesicle transport through interaction with t-SNAREs 1A | 0.0230452 |
| ENO1 | enolase 1, (alpha) | 0.022905 |
| SMYD3 | SET and MYND domain containing 3 | 0.0228054 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.022738 |
| Symbol | Name | Standardized Value |
|---|---|---|
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.163858 |
| PCDH7 | protocadherin 7 | -0.117357 |
| AREG | amphiregulin | -0.116512 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.115128 |
| VIM | vimentin | -0.110087 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0980076 |
| TMSB10 | thymosin beta 10 | -0.0942192 |
| TMEM41B | transmembrane protein 41B | -0.0938076 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | -0.0824433 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | -0.0822973 |
| EGR1 | early growth response 1 | -0.0819569 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0799369 |
| NHSL1 | NHS-like 1 | -0.0737948 |
| HMGA2 | high mobility group AT-hook 2 | -0.0655738 |
| CCN2 | cellular communication network factor 2 | -0.0647191 |
| YAP1 | Yes-associated protein 1 | -0.0642798 |
| MMP12 | matrix metallopeptidase 12 | -0.0618207 |
| ASPH | aspartate beta-hydroxylase | -0.0618136 |
| CUBN | cubilin (intrinsic factor-cobalamin receptor) | -0.0616862 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0574392 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0549334 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | -0.0532781 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0502729 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0498012 |
| EDARADD | EDAR-associated death domain | -0.0470961 |
| JMJD1C | jumonji domain containing 1C | -0.0445619 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.043867 |
| BCHE | butyrylcholinesterase | -0.0413373 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0411875 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0409051 |
| ZNF804A | zinc finger protein 804A | -0.0397317 |
| CDK17 | cyclin-dependent kinase 17 | -0.0388206 |
| MTAP | methylthioadenosine phosphorylase | -0.0387131 |
| CCND1 | cyclin D1 | -0.038659 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0380811 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0380308 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0373639 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0372861 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0369367 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0364433 |
| CELF2 | CUGBP, Elav-like family member 2 | -0.0363727 |
| IPO7 | importin 7 | -0.0353595 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.034873 |
| NAV3 | neuron navigator 3 | -0.0343341 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0340793 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0339178 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0339164 |
| ETV5 | ets variant 5 | -0.0331192 |
| CCNL1 | cyclin L1 | -0.0323775 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | -0.0320759 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0313536 |
| PFN1 | profilin 1 | -0.0308707 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0308098 |
| MKI67 | marker of proliferation Ki-67 | -0.0306407 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | -0.0306226 |
| RAPGEF6 | Rap guanine nucleotide exchange factor (GEF) 6 | -0.0305265 |
| EDN1 | endothelin 1 | -0.0295454 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0291388 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | -0.0290785 |
| DHX36 | DEAH (Asp-Glu-Ala-His) box polypeptide 36 | -0.0288517 |
| ADIPOR2 | adiponectin receptor 2 | -0.0285545 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0282898 |
| TUBA1B | tubulin, alpha 1b | -0.0279352 |
| OSBPL8 | oxysterol binding protein-like 8 | -0.027196 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0271095 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0270474 |
| USP34 | ubiquitin specific peptidase 34 | -0.0269524 |
| SETX | senataxin | -0.026762 |
| ARL5B | ADP-ribosylation factor-like 5B | -0.0265699 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0263809 |
| DUSP6 | dual specificity phosphatase 6 | -0.0262927 |
| TMEM131 | transmembrane protein 131 | -0.0261361 |
| YBX3 | Y box binding protein 3 | -0.0259171 |
| VMP1 | vacuole membrane protein 1 | -0.0255136 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0252054 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | -0.0239348 |
| RASAL2 | RAS protein activator like 2 | -0.0236486 |
| HMGA1 | high mobility group AT-hook 1 | -0.0235308 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | -0.0234594 |
| RRM2 | ribonucleotide reductase M2 | -0.0231495 |
| NOP58 | NOP58 ribonucleoprotein | -0.022755 |
| LMO7 | LIM domain 7 | -0.0226581 |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | -0.0225888 |
| WDR43 | WD repeat domain 43 | -0.0225445 |
| PRIM2 | primase, DNA, polypeptide 2 (58kDa) | -0.0223718 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0222109 |
| MAP3K14 | mitogen-activated protein kinase kinase kinase 14 | -0.0220868 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0216544 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0215766 |
| RBM25 | RNA binding motif protein 25 | -0.0214342 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0214232 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0211819 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0208216 |
| ATP11A | ATPase, class VI, type 11A | -0.0207469 |
| ZNF638 | zinc finger protein 638 | -0.0207137 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0206049 |
| KRR1 | KRR1, small subunit (SSU) processome component, homolog (yeast) | -0.0203346 |
| EHBP1 | EH domain binding protein 1 | -0.0202361 |
| KIF18B | kinesin family member 18B | -0.0198175 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.019438 |
