| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Trametinib (DMSO perturbation in A498 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Trametinib (DMSO_A498 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GPC6 | glypican 6 | 0.159146 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.111666 |
| AKR1B1 | aldo-keto reductase family 1, member B1 (aldose reductase) | 0.0764283 |
| CSF1 | colony stimulating factor 1 (macrophage) | 0.0743022 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0714556 |
| CALR | calreticulin | 0.0628907 |
| PBX1 | pre-B-cell leukemia homeobox 1 | 0.0623103 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0605855 |
| PLK2 | polo-like kinase 2 | 0.0599747 |
| G0S2 | G0/G1 switch 2 | 0.0588362 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | 0.0515258 |
| ANXA1 | annexin A1 | 0.0506758 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0499314 |
| STOM | stomatin | 0.0498717 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0492515 |
| PTGR1 | prostaglandin reductase 1 | 0.0453758 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0446396 |
| B2M | beta-2-microglobulin | 0.0436552 |
| DENND2B | DENN domain containing 2B | 0.0435279 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0432594 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0414899 |
| CCL2 | chemokine (C-C motif) ligand 2 | 0.0407929 |
| ARRDC3 | arrestin domain containing 3 | 0.0407916 |
| TNFAIP2 | tumor necrosis factor, alpha-induced protein 2 | 0.0399982 |
| PAX8 | paired box 8 | 0.039562 |
| CANX | calnexin | 0.0387841 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0383296 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0378031 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0373529 |
| ITM2B | integral membrane protein 2B | 0.0372524 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.037169 |
| GCLM | glutamate-cysteine ligase, modifier subunit | 0.0365383 |
| NFIB | nuclear factor I/B | 0.0363054 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0361304 |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | 0.0355675 |
| RHEX | regulator of hemoglobinization and erythroid cell expansion | 0.0355288 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0340565 |
| VCAM1 | vascular cell adhesion molecule 1 | 0.0331585 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0326117 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0325878 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0325222 |
| KYNU | kynureninase | 0.0314821 |
| TRAM1 | translocation associated membrane protein 1 | 0.0312033 |
| PLPP3 | phospholipid phosphatase 3 | 0.0310196 |
| LYN | LYN proto-oncogene, Src family tyrosine kinase | 0.0305301 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0303437 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0303348 |
| WAC | WW domain containing adaptor with coiled-coil | 0.029844 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.029749 |
| ADM | adrenomedullin | 0.0295809 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0295418 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0289989 |
| RPS2 | ribosomal protein S2 | 0.0282604 |
| SBF2 | SET binding factor 2 | 0.0282528 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0280872 |
| HDGF | hepatoma-derived growth factor | 0.0279978 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0278608 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0275357 |
| DAPK1 | death-associated protein kinase 1 | 0.0273349 |
| TXNRD1 | thioredoxin reductase 1 | 0.0271877 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.027112 |
| CP | ceruloplasmin (ferroxidase) | 0.0269678 |
| LRRFIP2 | leucine rich repeat (in FLII) interacting protein 2 | 0.0268959 |
| SDCBP | syndecan binding protein (syntenin) | 0.0266798 |
| PCMTD1 | protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 | 0.0264773 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0262029 |
| PCBP2 | poly(rC) binding protein 2 | 0.0258545 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0255837 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.025529 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0249274 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0248286 |
| MGST1 | microsomal glutathione S-transferase 1 | 0.024826 |
| MYO10 | myosin X | 0.0247383 |
| RCN1 | reticulocalbin 1, EF-hand calcium binding domain | 0.0245571 |
| RPS8 | ribosomal protein S8 | 0.0243802 |
| SQSTM1 | sequestosome 1 | 0.0240803 |
| ANKRD33B | ankyrin repeat domain 33B | 0.0238201 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | 0.0237387 |
| RPL12 | ribosomal protein L12 | 0.0235291 |
| SLMAP | sarcolemma associated protein | 0.0233456 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0230889 |
| ADAM10 | ADAM metallopeptidase domain 10 | 0.0230866 |
| AKR1C2 | aldo-keto reductase family 1, member C2 | 0.0229929 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.0227066 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0222673 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0219945 |
| APP | amyloid beta (A4) precursor protein | 0.0219153 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0217253 |
| ATXN10 | ataxin 10 | 0.0214874 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0213806 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.0213774 |
| RNASE1 | ribonuclease, RNase A family, 1 (pancreatic) | 0.0213669 |
| FTL | ferritin, light polypeptide | 0.021345 |
| GBP2 | guanylate binding protein 2, interferon-inducible | 0.0212939 |
| NAP1L4 | nucleosome assembly protein 1-like 4 | 0.0212883 |
| TM9SF2 | transmembrane 9 superfamily member 2 | 0.0211698 |
| CXCL3 | chemokine (C-X-C motif) ligand 3 | 0.0209626 |
| IFRD1 | interferon-related developmental regulator 1 | 0.0209214 |
| RPS12 | ribosomal protein S12 | 0.0207624 |
| ADAR | adenosine deaminase, RNA-specific | 0.0205611 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CD44 | CD44 molecule (Indian blood group) | -0.227186 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.159128 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.153759 |
| FRMD4A | FERM domain containing 4A | -0.151379 |
| TMSB10 | thymosin beta 10 | -0.139235 |
| VIM | vimentin | -0.123881 |
| RAI14 | retinoic acid induced 14 | -0.10313 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0956207 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0859864 |
| VCL | vinculin | -0.0826853 |
| RTN4 | reticulon 4 | -0.0714908 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0701803 |
| NAV2 | neuron navigator 2 | -0.0662448 |
| CDCP1 | CUB domain containing protein 1 | -0.0645325 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0640934 |
| SMAD3 | SMAD family member 3 | -0.0630381 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0629665 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0626155 |
| ASPH | aspartate beta-hydroxylase | -0.0582991 |
| EFNA5 | ephrin-A5 | -0.055239 |
| OSMR | oncostatin M receptor | -0.0538039 |
| GLIS3 | GLIS family zinc finger 3 | -0.0529311 |
| NDRG1 | N-myc downstream regulated 1 | -0.0513244 |
| MT2A | metallothionein 2A | -0.0510683 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0505546 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0492676 |
| RRBP1 | ribosome binding protein 1 | -0.0489756 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0486235 |
| LOXL2 | lysyl oxidase-like 2 | -0.0479236 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0440935 |
| ABTB3 | ankyrin repeat and BTB domain containing 3 | -0.0440402 |
| RRM2 | ribonucleotide reductase M2 | -0.0427537 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0425588 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0422744 |
| SHB | Src homology 2 domain containing adaptor protein B | -0.0417783 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0416395 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0410445 |
| FAM107B | family with sequence similarity 107, member B | -0.0409055 |
| DIAPH3 | diaphanous-related formin 3 | -0.0408144 |
| CD82 | CD82 molecule | -0.0403863 |
| TGFA | transforming growth factor, alpha | -0.0395769 |
| CCND1 | cyclin D1 | -0.0380504 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0376801 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0373529 |
| COTL1 | coactosin-like F-actin binding protein 1 | -0.0369106 |
| MYO1E | myosin IE | -0.0351829 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.035099 |
| DGKI | diacylglycerol kinase, iota | -0.0348861 |
| TGM2 | transglutaminase 2 | -0.0346666 |
| ARL4C | ADP-ribosylation factor-like 4C | -0.03367 |
| KIRREL3 | kin of IRRE like 3 (Drosophila) | -0.0331252 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0329133 |
| EGR1 | early growth response 1 | -0.0328119 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0326423 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0325545 |
| HLA-B | major histocompatibility complex, class I, B | -0.0324503 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0322645 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0314372 |
| TPM1 | tropomyosin 1 (alpha) | -0.031106 |
| CALU | calumenin | -0.0311031 |
| PKM | pyruvate kinase, muscle | -0.0307007 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0306026 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0305247 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0302971 |
| MAP1B | microtubule-associated protein 1B | -0.0295834 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0293434 |
| RND3 | Rho family GTPase 3 | -0.0290271 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0281389 |
| CTSD | cathepsin D | -0.0279929 |
| STK17A | serine/threonine kinase 17a | -0.0278073 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0277118 |
| HPCAL1 | hippocalcin-like 1 | -0.0273226 |
| SRRM2 | serine/arginine repetitive matrix 2 | -0.027266 |
| ECE1 | endothelin converting enzyme 1 | -0.0271329 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0268386 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0258422 |
| RPS24 | ribosomal protein S24 | -0.0258354 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0257602 |
| MYADM | myeloid-associated differentiation marker | -0.0254483 |
| TMEM165 | transmembrane protein 165 | -0.0254179 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0252353 |
| SP100 | SP100 nuclear antigen | -0.0252305 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0252207 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0250969 |
| CLMP | CXADR-like membrane protein | -0.0250467 |
| CBX3 | chromobox homolog 3 | -0.0250288 |
| ARF1 | ADP-ribosylation factor 1 | -0.0246898 |
| HM13 | histocompatibility (minor) 13 | -0.0245882 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0243357 |
| FLNB | filamin B, beta | -0.0241525 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | -0.0239734 |
| EGFR | epidermal growth factor receptor | -0.0237669 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0237001 |
| NPC1 | Niemann-Pick disease, type C1 | -0.023548 |
| MSR1 | macrophage scavenger receptor 1 | -0.0233385 |
| EHBP1 | EH domain binding protein 1 | -0.023313 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0229749 |
| PRKCA | protein kinase C, alpha | -0.0229288 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0229255 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0228227 |
