Trametinib (DMSO_A549 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Trametinib (DMSO perturbation in A549 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Trametinib (DMSO_A549 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKR1C2 aldo-keto reductase family 1, member C2 0.162404
SPTBN1 spectrin, beta, non-erythrocytic 1 0.139173
PTPRJ protein tyrosine phosphatase, receptor type, J 0.11264
CA12 carbonic anhydrase XII 0.103701
PABPC1 poly(A) binding protein, cytoplasmic 1 0.100371
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.096379
TXNRD1 thioredoxin reductase 1 0.0944547
RNF213 ring finger protein 213 0.0912631
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0897417
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0894897
SOD2 superoxide dismutase 2, mitochondrial 0.0880818
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0820279
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0747313
IGFBP3 insulin-like growth factor binding protein 3 0.0742058
TGFBI transforming growth factor, beta-induced, 68kDa 0.0666511
TNS3 tensin 3 0.0645729
ENO1 enolase 1, (alpha) 0.0608508
AOPEP aminopeptidase O (putative) 0.0600598
EXT1 exostosin glycosyltransferase 1 0.0599798
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0588523
CMIP c-Maf inducing protein 0.0584471
FTH1 ferritin, heavy polypeptide 1 0.0579661
GNPDA1 glucosamine-6-phosphate deaminase 1 0.057739
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.056146
ANXA4 annexin A4 0.0542638
KYNU kynureninase 0.053705
MYOF myoferlin 0.0533946
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.050457
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.0496348
LDHA lactate dehydrogenase A 0.0484257
PDE4D phosphodiesterase 4D, cAMP-specific 0.0484071
EEF2 eukaryotic translation elongation factor 2 0.0481618
DAPK1 death-associated protein kinase 1 0.0464104
TBC1D5 TBC1 domain family, member 5 0.0460475
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0457467
DST dystonin 0.0454741
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0449235
PCBP2 poly(rC) binding protein 2 0.0447382
MYO1B myosin IB 0.0446059
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0443001
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0436105
TNIP1 TNFAIP3 interacting protein 1 0.0418054
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0416774
ANXA1 annexin A1 0.0412092
TRIO trio Rho guanine nucleotide exchange factor 0.0411313
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0410015
TNFAIP2 tumor necrosis factor, alpha-induced protein 2 0.0396975
STOM stomatin 0.0389866
AKAP12 A kinase (PRKA) anchor protein 12 0.0381309
PGK1 phosphoglycerate kinase 1 0.0379436
LIMCH1 LIM and calponin homology domains 1 0.0378966
FAM13A family with sequence similarity 13, member A 0.0378709
ADAR adenosine deaminase, RNA-specific 0.0377756
ADAM9 ADAM metallopeptidase domain 9 0.0377695
CP ceruloplasmin (ferroxidase) 0.0368868
IGFBP4 insulin-like growth factor binding protein 4 0.036668
BABAM2 BRISC and BRCA1 A complex member 2 0.0361907
AUTS2 autism susceptibility candidate 2 0.0361447
RAD51B RAD51 paralog B 0.036027
PTGR1 prostaglandin reductase 1 0.0356968
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) 0.0347555
RPS19 ribosomal protein S19 0.0345011
MYH9 myosin, heavy chain 9, non-muscle 0.0340284
ZNF292 zinc finger protein 292 0.033749
CFB complement factor B 0.0337335
GPC6 glypican 6 0.0323367
ADM adrenomedullin 0.0320981
PCSK5 proprotein convertase subtilisin/kexin type 5 0.0317688
DDIT4 DNA-damage-inducible transcript 4 0.0316642
PTBP3 polypyrimidine tract binding protein 3 0.0315093
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0312165
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0308236
MTUS1 microtubule associated tumor suppressor 1 0.0305238
NRP1 neuropilin 1 0.0304562
PTPRM protein tyrosine phosphatase, receptor type, M 0.030347
B2M beta-2-microglobulin 0.0301865
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0301092
MYO10 myosin X 0.0300992
CANX calnexin 0.0300921
AKR1C3 aldo-keto reductase family 1, member C3 0.0300296
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0296879
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0292224
ZBTB20 zinc finger and BTB domain containing 20 0.0290932
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1 0.0287703
COL5A2 collagen, type V, alpha 2 0.0287696
BIRC3 baculoviral IAP repeat containing 3 0.0287277
NR5A2 nuclear receptor subfamily 5, group A, member 2 0.0278834
CDK19 cyclin-dependent kinase 19 0.0277638
TTC28 tetratricopeptide repeat domain 28 0.0277196
GPRIN3 GPRIN family member 3 0.02759
LMNA lamin A/C 0.0275373
KMT2C lysine (K)-specific methyltransferase 2C 0.0269986
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0268557
PLS3 plastin 3 0.0267469
RPS6 ribosomal protein S6 0.0266748
NFIB nuclear factor I/B 0.0263924
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 0.0262492
LPP LIM domain containing preferred translocation partner in lipoma 0.0261516
ANLN anillin, actin binding protein 0.0260422
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 0.0259991

decreased expression

Symbol Name Standardized Value
THSD4 thrombospondin, type I, domain containing 4 -0.170579
EFNA5 ephrin-A5 -0.147343
ARHGAP26 Rho GTPase activating protein 26 -0.139707
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.135891
STC1 stanniocalcin 1 -0.135878
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.12013
GRB10 growth factor receptor-bound protein 10 -0.109125
TMSB10 thymosin beta 10 -0.101256
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0829702
MAML3 mastermind-like 3 (Drosophila) -0.0792925
PDE10A phosphodiesterase 10A -0.0723599
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0656964
ITGB5 integrin, beta 5 -0.0655337
MCL1 myeloid cell leukemia 1 -0.0632389
CEMIP cell migration inducing protein, hyaluronan binding -0.0622424
FMNL2 formin-like 2 -0.0607771
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0605558
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0586657
ANXA2 annexin A2 -0.0563427
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0551998
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0547076
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0546048
FLNB filamin B, beta -0.0528044
VCL vinculin -0.0521465
TM4SF1 transmembrane 4 L six family member 1 -0.0520459
DGKD diacylglycerol kinase, delta 130kDa -0.0499664
NPC1 Niemann-Pick disease, type C1 -0.0497418
RIN2 Ras and Rab interactor 2 -0.0494375
MCTP1 multiple C2 domains, transmembrane 1 -0.0480029
KDM7A lysine (K)-specific demethylase 7A -0.0473762
ATG7 autophagy related 7 -0.0466944
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0457821
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0456162
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0455674
BMAL2 basic helix-loop-helix ARNT like 2 -0.0450912
SLC38A2 solute carrier family 38, member 2 -0.0438518
SH3KBP1 SH3-domain kinase binding protein 1 -0.0438416
FNDC3B fibronectin type III domain containing 3B -0.0434907
BTG1 B-cell translocation gene 1, anti-proliferative -0.043212
NPAS2 neuronal PAS domain protein 2 -0.0420872
EPAS1 endothelial PAS domain protein 1 -0.0419798
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0415514
TOP1 topoisomerase (DNA) I -0.0413228
EGR1 early growth response 1 -0.0400604
CD44 CD44 molecule (Indian blood group) -0.0391182
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0390741
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0388385
OSMR oncostatin M receptor -0.0384561
BMERB1 bMERB domain containing 1 -0.0382992
CCDC88A coiled-coil domain containing 88A -0.0380889
ELL2 elongation factor, RNA polymerase II, 2 -0.0372504
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0369173
RPS24 ribosomal protein S24 -0.0367056
FAM107B family with sequence similarity 107, member B -0.0364402
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 -0.036084
EREG epiregulin -0.0352894
HMGA2 high mobility group AT-hook 2 -0.0350401
RPL4 ribosomal protein L4 -0.0347146
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.034581
RTN4 reticulon 4 -0.0343795
NAV2 neuron navigator 2 -0.0343184
LAMC2 laminin, gamma 2 -0.0342689
NRIP1 nuclear receptor interacting protein 1 -0.0339238
ARHGAP5 Rho GTPase activating protein 5 -0.0339115
KIRREL3 kin of IRRE like 3 (Drosophila) -0.0336846
JMJD1C jumonji domain containing 1C -0.0335713
RPLP1 ribosomal protein, large, P1 -0.0332913
ZC3H12C zinc finger CCCH-type containing 12C -0.0330684
KANK1 KN motif and ankyrin repeat domains 1 -0.0329453
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0325104
AGO2 argonaute RISC catalytic component 2 -0.0319686
CEP95 centrosomal protein 95kDa -0.0319519
RRBP1 ribosome binding protein 1 -0.03193
NCOA7 nuclear receptor coactivator 7 -0.0318423
GRAMD1B GRAM domain containing 1B -0.0315533
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0314451
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 -0.0307786
MT2A metallothionein 2A -0.0307117
SSH1 slingshot protein phosphatase 1 -0.0306861
PAQR5 progestin and adipoQ receptor family member V -0.0302935
DOCK4 dedicator of cytokinesis 4 -0.0294932
HIPK2 homeodomain interacting protein kinase 2 -0.0294439
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0287963
VEZT vezatin, adherens junctions transmembrane protein -0.028766
EGFR epidermal growth factor receptor -0.0281686
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0277556
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0277418
EFL1 elongation factor like GTPase 1 -0.0276546
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 -0.0273741
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0273267
RAB7A RAB7A, member RAS oncogene family -0.0273009
BZW1 basic leucine zipper and W2 domains 1 -0.0272002
APP amyloid beta (A4) precursor protein -0.0270676
CDCP1 CUB domain containing protein 1 -0.0269645
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0263682
SLC38A1 solute carrier family 38, member 1 -0.0262947
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0260863
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0258576
RAP1B RAP1B, member of RAS oncogene family -0.0257735
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0255674