| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Trametinib (DMSO perturbation in AN3 CA cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Trametinib (DMSO_AN3 CA drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NFIB | nuclear factor I/B | 0.167151 |
| MED13L | mediator complex subunit 13-like | 0.126535 |
| ZNF292 | zinc finger protein 292 | 0.124317 |
| PDGFC | platelet derived growth factor C | 0.0982263 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0915864 |
| FGFR2 | fibroblast growth factor receptor 2 | 0.0855328 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0736337 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.0732565 |
| OGA | O-GlcNAcase | 0.0731716 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0728106 |
| QKI | QKI, KH domain containing, RNA binding | 0.0721886 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.071153 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0694094 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0693783 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0681872 |
| UTRN | utrophin | 0.0674952 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0657358 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0625518 |
| CANX | calnexin | 0.0583853 |
| MEST | mesoderm specific transcript | 0.0577447 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0574269 |
| PRELID2 | PRELI domain containing 2 | 0.0565921 |
| CALR | calreticulin | 0.0560729 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.055486 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.055187 |
| PCBP2 | poly(rC) binding protein 2 | 0.0547237 |
| SMAP1 | small ArfGAP 1 | 0.0544141 |
| COL1A2 | collagen, type I, alpha 2 | 0.0536356 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0528478 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.0527564 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0526104 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0512348 |
| HMGB2 | high mobility group box 2 | 0.0495817 |
| BTBD3 | BTB (POZ) domain containing 3 | 0.0480519 |
| ZNF608 | zinc finger protein 608 | 0.0467995 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0449392 |
| VEGFA | vascular endothelial growth factor A | 0.043366 |
| YBX1 | Y box binding protein 1 | 0.0426082 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.0422508 |
| AHNAK | AHNAK nucleoprotein | 0.0420442 |
| DIPK2A | divergent protein kinase domain 2A | 0.0417877 |
| CENPF | centromere protein F, 350/400kDa | 0.0411703 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0408511 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0389764 |
| MB21D2 | Mab-21 domain containing 2 | 0.037953 |
| MEF2A | myocyte enhancer factor 2A | 0.0370439 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.036838 |
| MEOX2 | mesenchyme homeobox 2 | 0.0367971 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0363754 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0362208 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0358323 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.035328 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0352055 |
| SMG7 | SMG7 nonsense mediated mRNA decay factor | 0.0350936 |
| CDK19 | cyclin-dependent kinase 19 | 0.0346227 |
| CNNM2 | cyclin and CBS domain divalent metal cation transport mediator 2 | 0.0344769 |
| ARHGAP21 | Rho GTPase activating protein 21 | 0.0343618 |
| TNKS2 | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 | 0.0343425 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0341843 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0341296 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0340156 |
| SBF2 | SET binding factor 2 | 0.0336455 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0335205 |
| OPTN | optineurin | 0.0332923 |
| CASC3 | cancer susceptibility candidate 3 | 0.0332758 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | 0.0327675 |
| HOXA3 | homeobox A3 | 0.032756 |
| COL5A2 | collagen, type V, alpha 2 | 0.0327012 |
| KMT2A | lysine (K)-specific methyltransferase 2A | 0.0325803 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0320419 |
| SOX6 | SRY (sex determining region Y)-box 6 | 0.0318153 |
| TMSB4X | thymosin beta 4, X-linked | 0.031578 |
| DBN1 | drebrin 1 | 0.0315445 |
| TAB2 | TGF-beta activated kinase 1/MAP3K7 binding protein 2 | 0.0314809 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0308815 |
| RAD51B | RAD51 paralog B | 0.0308095 |
| CNN3 | calponin 3, acidic | 0.0306732 |
| TBC1D12 | TBC1 domain family, member 12 | 0.0303015 |
| TUBB | tubulin, beta class I | 0.0301988 |
| ITM2B | integral membrane protein 2B | 0.0301677 |
| NCOR1 | nuclear receptor corepressor 1 | 0.030106 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0299059 |
| HNRNPH3 | heterogeneous nuclear ribonucleoprotein H3 (2H9) | 0.0298246 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0297369 |
| KIF11 | kinesin family member 11 | 0.029736 |
| ENO1 | enolase 1, (alpha) | 0.0296935 |
| ARRDC3 | arrestin domain containing 3 | 0.0294474 |
| ANLN | anillin, actin binding protein | 0.0293148 |
| FAM168A | family with sequence similarity 168, member A | 0.0292926 |
| ENAH | enabled homolog (Drosophila) | 0.0289003 |
| RHEB | Ras homolog enriched in brain | 0.0288995 |
| PDS5B | PDS5 cohesin associated factor B | 0.0288356 |
| NCKAP1 | NCK-associated protein 1 | 0.0287879 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.028703 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | 0.0286807 |
| SPAG9 | sperm associated antigen 9 | 0.0285389 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | 0.0281443 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0281028 |
| UBQLN1 | ubiquilin 1 | 0.0280665 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | 0.0279632 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HMGA2 | high mobility group AT-hook 2 | -0.109834 |
| VIM | vimentin | -0.0955964 |
| CADM2 | cell adhesion molecule 2 | -0.087268 |
| SEPTIN11 | septin 11 | -0.0787076 |
| RPS6 | ribosomal protein S6 | -0.0773747 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0712607 |
| TSHZ2 | teashirt zinc finger homeobox 2 | -0.0702103 |
| ACTG1 | actin gamma 1 | -0.0681169 |
| TMSB10 | thymosin beta 10 | -0.0657616 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0653167 |
| RPS25 | ribosomal protein S25 | -0.0628666 |
| RPL35A | ribosomal protein L35a | -0.0603888 |
| IER3 | immediate early response 3 | -0.0600785 |
| HMGA1 | high mobility group AT-hook 1 | -0.0591043 |
| EGR1 | early growth response 1 | -0.0581937 |
| PRKG1 | protein kinase, cGMP-dependent, type I | -0.0571689 |
| RPLP1 | ribosomal protein, large, P1 | -0.056999 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0561773 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0550016 |
| RPS8 | ribosomal protein S8 | -0.0549361 |
| RPL31 | ribosomal protein L31 | -0.0533451 |
| RPL37A | ribosomal protein L37a | -0.0509738 |
| RPS24 | ribosomal protein S24 | -0.0505804 |
| EGFR | epidermal growth factor receptor | -0.0454247 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0447751 |
| RPL23 | ribosomal protein L23 | -0.0439153 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0435421 |
| NDRG1 | N-myc downstream regulated 1 | -0.0422318 |
| MT2A | metallothionein 2A | -0.0419747 |
| RPL34 | ribosomal protein L34 | -0.0416245 |
| RPL37 | ribosomal protein L37 | -0.0410121 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0404013 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0399709 |
| RANBP17 | RAN binding protein 17 | -0.0394516 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0392034 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0390163 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.038817 |
| PKM | pyruvate kinase, muscle | -0.038621 |
| PDE10A | phosphodiesterase 10A | -0.0385912 |
| NBEA | neurobeachin | -0.0373983 |
| FTL | ferritin, light polypeptide | -0.0373901 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0369601 |
| MSRB3 | methionine sulfoxide reductase B3 | -0.0366706 |
| MGP | matrix Gla protein | -0.0366505 |
| RPS23 | ribosomal protein S23 | -0.0360651 |
| FBXO11 | F-box protein 11 | -0.035332 |
| KAZN | kazrin, periplakin interacting protein | -0.0352643 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.034633 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0344283 |
| SPRY4 | sprouty homolog 4 (Drosophila) | -0.034203 |
| RPS13 | ribosomal protein S13 | -0.033514 |
| RPLP2 | ribosomal protein, large, P2 | -0.0334374 |
| ATP11A | ATPase, class VI, type 11A | -0.0333546 |
| CUX1 | cut-like homeobox 1 | -0.0326385 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0324207 |
| DUSP6 | dual specificity phosphatase 6 | -0.0314681 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0309273 |
| RPL9 | ribosomal protein L9 | -0.0308788 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0308709 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0307979 |
| RPL7A | ribosomal protein L7a | -0.0300393 |
| NHSL1 | NHS-like 1 | -0.0299284 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.029492 |
| BPTF | bromodomain PHD finger transcription factor | -0.0294591 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0293139 |
| RPS17 | ribosomal protein S17 | -0.0292202 |
| SPRY1 | sprouty homolog 1, antagonist of FGF signaling (Drosophila) | -0.0288301 |
| NF1 | neurofibromin 1 | -0.0287381 |
| RCOR1 | REST corepressor 1 | -0.0286325 |
| INTS6 | integrator complex subunit 6 | -0.0284778 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0284444 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0279279 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0277108 |
| TRIM9 | tripartite motif containing 9 | -0.027671 |
| CREM | cAMP responsive element modulator | -0.0275783 |
| RAPGEF6 | Rap guanine nucleotide exchange factor (GEF) 6 | -0.02649 |
| FN1 | fibronectin 1 | -0.026235 |
| CLMP | CXADR-like membrane protein | -0.0262162 |
| ANO6 | anoctamin 6 | -0.0259824 |
| E2F3 | E2F transcription factor 3 | -0.0259718 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0258711 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0256773 |
| RPS29 | ribosomal protein S29 | -0.0254242 |
| RPS14 | ribosomal protein S14 | -0.0253747 |
| RPS20 | ribosomal protein S20 | -0.0253534 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0253092 |
| RACK1 | receptor for activated C kinase 1 | -0.0251278 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0248113 |
| IPO7 | importin 7 | -0.024724 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0245844 |
| TPK1 | thiamin pyrophosphokinase 1 | -0.0243324 |
| RPS21 | ribosomal protein S21 | -0.0242195 |
| TSC22D1 | TSC22 domain family, member 1 | -0.0239247 |
| RPS16 | ribosomal protein S16 | -0.0238165 |
| GTF2IRD1 | GTF2I repeat domain containing 1 | -0.0237902 |
| RPS12 | ribosomal protein S12 | -0.0235664 |
| LARS1 | leucyl-tRNA synthetase 1 | -0.023436 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.02342 |
| MCL1 | myeloid cell leukemia 1 | -0.0233896 |
| TBCA | tubulin folding cofactor A | -0.0233723 |
